LRRC8C (leucine rich repeat containing 8 VRAC subunit C) - Rat Genome Database
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Gene: LRRC8C (leucine rich repeat containing 8 VRAC subunit C) Sus scrofa
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Symbol: LRRC8C
Name: leucine rich repeat containing 8 VRAC subunit C
RGD ID: 14038071
Description: ENCODES a protein that exhibits volume-sensitive anion channel activity (ortholog); INVOLVED IN anion transmembrane transport (ortholog); aspartate transmembrane transport (ortholog); cellular response to osmotic stress (ortholog); ASSOCIATED WITH multiple sclerosis (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulum (ortholog); integral component of plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: leucine rich repeat containing 8 family member C; leucine-rich repeat-containing protein 8C; volume-regulated anion channel subunit LRRC8C
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4126,931,849 - 127,079,843 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14126,957,099 - 127,079,042 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24138,996,955 - 139,119,829 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Genomics

Comparative Map Data
LRRC8C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4126,931,849 - 127,079,843 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14126,957,099 - 127,079,042 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24138,996,955 - 139,119,829 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LRRC8C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl189,633,072 - 89,769,903 (+)EnsemblGRCh38hg38GRCh38
GRCh38189,615,810 - 89,719,533 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37190,098,679 - 90,185,092 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36189,871,350 - 89,953,169 (+)NCBINCBI36hg18NCBI36
Celera188,344,351 - 88,430,780 (+)NCBI
Cytogenetic Map1p22.2NCBI
HuRef188,215,951 - 88,302,419 (+)NCBIHuRef
CHM1_1190,213,622 - 90,300,056 (+)NCBICHM1_1
Lrrc8c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395105,666,850 - 105,760,884 (+)NCBIGRCm39mm39
GRCm39 Ensembl5105,667,254 - 105,760,884 (+)Ensembl
GRCm385105,519,345 - 105,613,018 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5105,519,388 - 105,613,018 (+)EnsemblGRCm38mm10GRCm38
MGSCv375105,948,490 - 106,037,973 (+)NCBIGRCm37mm9NCBIm37
MGSCv365105,759,773 - 105,849,256 (+)NCBImm8
Celera5102,631,726 - 102,729,227 (+)NCBICelera
Cytogenetic Map5E5NCBI
Lrrc8c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2144,223,901 - 4,315,590 (-)NCBI
Rnor_6.0 Ensembl145,283,647 - 5,378,726 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0145,283,655 - 5,378,738 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0145,274,372 - 5,369,435 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4145,306,227 - 5,393,820 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1145,306,353 - 5,393,463 (-)NCBI
Celera144,390,675 - 4,477,877 (-)NCBICelera
Cytogenetic Map14p22NCBI
Lrrc8c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554234,460,212 - 4,494,317 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554234,460,212 - 4,494,317 (-)NCBIChiLan1.0ChiLan1.0
LRRC8C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1191,001,695 - 91,134,865 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl191,105,551 - 91,138,447 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0192,299,691 - 92,384,733 (+)NCBIMhudiblu_PPA_v0panPan3
LRRC8C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl658,899,996 - 58,932,729 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1658,895,769 - 58,932,729 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Lrrc8c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365379,050,495 - 9,124,649 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRRC8C
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12043,752,341 - 43,842,958 (-)NCBI
ChlSab1.1 Ensembl2043,752,370 - 43,842,766 (-)Ensembl
Lrrc8c
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247428,010,849 - 8,096,567 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1 1
Low 10 4 3 4 2 22 2 3 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000007575   ⟹   ENSSSCP00000007374
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl4126,957,106 - 127,037,219 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000044064   ⟹   ENSSSCP00000059538
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl4126,957,106 - 127,010,970 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000071025   ⟹   ENSSSCP00000067877
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl4126,931,849 - 127,079,843 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000071159   ⟹   ENSSSCP00000068510
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl4126,957,104 - 127,037,587 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000085453   ⟹   ENSSSCP00000062043
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl4126,959,435 - 127,037,159 (-)Ensembl
RefSeq Acc Id: XM_001929205   ⟹   XP_001929240
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14126,957,099 - 127,079,042 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005663701   ⟹   XP_005663758
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14126,957,099 - 127,037,234 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013997403   ⟹   XP_013852857
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14126,957,099 - 127,000,968 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_001929240 (Get FASTA)   NCBI Sequence Viewer  
  XP_005663758 (Get FASTA)   NCBI Sequence Viewer  
  XP_013852857 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABL63842 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_001929240   ⟸   XM_001929205
- Sequence:
RefSeq Acc Id: XP_005663758   ⟸   XM_005663701
- Sequence:
RefSeq Acc Id: XP_013852857   ⟸   XM_013997403
- Sequence:
RefSeq Acc Id: ENSSSCP00000059538   ⟸   ENSSSCT00000044064
RefSeq Acc Id: ENSSSCP00000062043   ⟸   ENSSSCT00000085453
RefSeq Acc Id: ENSSSCP00000067877   ⟸   ENSSSCT00000071025
RefSeq Acc Id: ENSSSCP00000068510   ⟸   ENSSSCT00000071159
RefSeq Acc Id: ENSSSCP00000007374   ⟸   ENSSSCT00000007575
Protein Domains
Pannexin_like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000006917 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070014856 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000007374 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000059538 UniProtKB/TrEMBL
  ENSSSCP00000062043 UniProtKB/TrEMBL
  ENSSSCP00000067877 UniProtKB/TrEMBL
  ENSSSCP00000068510 UniProtKB/TrEMBL
  ENSSSCP00070024294 UniProtKB/TrEMBL
  ENSSSCP00070024303 UniProtKB/TrEMBL
  ENSSSCP00070024310 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000007575 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000044064 UniProtKB/TrEMBL
  ENSSSCT00000071025 UniProtKB/TrEMBL
  ENSSSCT00000071159 UniProtKB/TrEMBL
  ENSSSCT00000085453 UniProtKB/TrEMBL
  ENSSSCT00070029144 UniProtKB/TrEMBL
  ENSSSCT00070029157 UniProtKB/TrEMBL
  ENSSSCT00070029165 UniProtKB/TrEMBL
Gene3D-CATH 3.80.10.10 UniProtKB/TrEMBL
InterPro Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
  LRRC8_Pannexin-like UniProtKB/TrEMBL
NCBI Gene LRRC8C ENTREZGENE
Pfam LRR_8 UniProtKB/TrEMBL
  Pannexin_like UniProtKB/TrEMBL
PROSITE LRR UniProtKB/TrEMBL
SMART LRR_TYP UniProtKB/TrEMBL
UniProt A0A287BSW1_PIG UniProtKB/TrEMBL
  A0A4X1U3P1_PIG UniProtKB/TrEMBL
  A0A4X1U836_PIG UniProtKB/TrEMBL
  A0A5G2QBY6_PIG UniProtKB/TrEMBL
  A0A5G2QSR9_PIG UniProtKB/TrEMBL
  A0A5G2QWI5_PIG UniProtKB/TrEMBL
  F1S4E4_PIG UniProtKB/TrEMBL
VGNC ID VGNC:98087 ENTREZGENE