C8B (complement C8 beta chain) - Rat Genome Database

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Gene: C8B (complement C8 beta chain) Sus scrofa
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Symbol: C8B
Name: complement C8 beta chain
RGD ID: 14033388
Description: ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN complement activation (inferred); complement activation, alternative pathway (inferred); complement activation, classical pathway (inferred); ASSOCIATED WITH complement component 6 deficiency (ortholog); juvenile rheumatoid arthritis (ortholog); meningitis (ortholog); FOUND IN extracellular region (ortholog); extracellular space (ortholog); membrane attack complex (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: complement component 8, beta polypeptide; complement component C8 beta chain
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6155,387,145 - 155,453,438 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16155,411,982 - 155,453,034 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26143,164,801 - 143,205,861 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463  


Genomics

Comparative Map Data
C8B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6155,387,145 - 155,453,438 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16155,411,982 - 155,453,034 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26143,164,801 - 143,205,861 (+)NCBISscrofa10.2Sscrofa10.2susScr3
C8B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38156,929,207 - 56,966,015 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl156,929,207 - 56,974,383 (-)EnsemblGRCh38hg38GRCh38
GRCh37157,394,880 - 57,431,688 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36157,167,471 - 57,204,276 (-)NCBINCBI36hg18NCBI36
Build 34157,106,905 - 57,143,670NCBI
Celera155,679,648 - 55,716,484 (-)NCBI
Cytogenetic Map1p32.2NCBI
HuRef155,507,178 - 55,544,141 (-)NCBIHuRef
CHM1_1157,510,118 - 57,547,015 (-)NCBICHM1_1
T2T-CHM13v2.0156,807,996 - 56,844,833 (-)NCBI
C8b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394104,623,514 - 104,661,745 (+)NCBIGRCm39mm39
GRCm39 Ensembl4104,623,514 - 104,661,745 (+)Ensembl
GRCm384104,766,317 - 104,804,548 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4104,766,317 - 104,804,548 (+)EnsemblGRCm38mm10GRCm38
MGSCv374104,438,922 - 104,477,153 (+)NCBIGRCm37mm9NCBIm37
MGSCv364104,264,249 - 104,302,480 (+)NCBImm8
Celera4103,118,327 - 103,156,421 (+)NCBICelera
Cytogenetic Map4C6NCBI
cM Map448.61NCBI
C8b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25119,535,009 - 119,572,565 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl5119,535,146 - 119,572,565 (+)Ensembl
Rnor_6.05124,298,269 - 124,338,055 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5124,300,477 - 124,338,053 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05128,157,620 - 128,196,920 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45125,728,606 - 125,766,093 (+)NCBIRGSC3.4rn4RGSC3.4
Celera5118,092,231 - 118,129,546 (+)NCBICelera
Cytogenetic Map5q34NCBI
C8b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554642,754,655 - 2,796,423 (+)NCBIChiLan1.0ChiLan1.0
C8B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1157,923,720 - 57,960,674 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl157,923,720 - 57,960,674 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0156,213,618 - 56,250,488 (-)NCBIMhudiblu_PPA_v0panPan3
C8B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1552,535,359 - 52,574,872 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl552,532,481 - 52,574,182 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha552,603,051 - 52,642,024 (+)NCBI
ROS_Cfam_1.0552,722,538 - 52,761,347 (+)NCBI
ROS_Cfam_1.0 Ensembl552,722,355 - 52,761,221 (+)Ensembl
UMICH_Zoey_3.1552,666,856 - 52,705,559 (+)NCBI
UNSW_CanFamBas_1.0552,613,006 - 52,651,475 (+)NCBI
UU_Cfam_GSD_1.0552,897,315 - 52,936,322 (+)NCBI
C8b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505870,742,662 - 70,778,205 (-)NCBI
SpeTri2.0NW_0049365224,638,111 - 4,673,388 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
C8B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12075,996,626 - 76,034,395 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2075,996,823 - 76,035,292 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603341,262,435 - 41,300,129 (-)NCBIVero_WHO_p1.0
C8b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248623,187,120 - 3,225,751 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046248623,187,573 - 3,224,895 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system nervous system renal system
High
Medium
Low 2 2
Below cutoff 4 1 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000004245   ⟹   ENSSSCP00000004150
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl6155,412,108 - 155,452,609 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000053724   ⟹   ENSSSCP00000047073
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl6155,409,667 - 155,453,438 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000067850   ⟹   ENSSSCP00000065660
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl6155,387,145 - 155,452,462 (+)Ensembl
RefSeq Acc Id: NM_001097451   ⟹   NP_001090920
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.16155,411,982 - 155,453,034 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001090920 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABD13969 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001090920   ⟸   NM_001097451
- Peptide Label: precursor
- UniProtKB: A0A287AT36 (UniProtKB/TrEMBL),   A0SEH2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000065660   ⟸   ENSSSCT00000067850
RefSeq Acc Id: ENSSSCP00000004150   ⟸   ENSSSCT00000004245
RefSeq Acc Id: ENSSSCP00000047073   ⟸   ENSSSCT00000053724
Protein Domains
MACPF


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000003834 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005005284 UniProtKB/TrEMBL
  ENSSSCG00025002531 UniProtKB/TrEMBL
  ENSSSCG00065055358 UniProtKB/TrEMBL
  ENSSSCG00070030151 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000004150.4 UniProtKB/TrEMBL
  ENSSSCP00000047073 ENTREZGENE
  ENSSSCP00000047073.2 UniProtKB/TrEMBL
  ENSSSCP00000065660.1 UniProtKB/TrEMBL
  ENSSSCP00005005320.1 UniProtKB/TrEMBL
  ENSSSCP00005005387.1 UniProtKB/TrEMBL
  ENSSSCP00005005504.1 UniProtKB/TrEMBL
  ENSSSCP00025001233.1 UniProtKB/TrEMBL
  ENSSSCP00065032953.1 UniProtKB/TrEMBL
  ENSSSCP00070051673.1 UniProtKB/TrEMBL
  ENSSSCP00070051674.1 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000004245.4 UniProtKB/TrEMBL
  ENSSSCT00000053724 ENTREZGENE
  ENSSSCT00000053724.2 UniProtKB/TrEMBL
  ENSSSCT00000067850.1 UniProtKB/TrEMBL
  ENSSSCT00005008982.1 UniProtKB/TrEMBL
  ENSSSCT00005009108.1 UniProtKB/TrEMBL
  ENSSSCT00005009269.1 UniProtKB/TrEMBL
  ENSSSCT00025003327.1 UniProtKB/TrEMBL
  ENSSSCT00065075785.1 UniProtKB/TrEMBL
  ENSSSCT00070060631.1 UniProtKB/TrEMBL
  ENSSSCT00070060632.1 UniProtKB/TrEMBL
Gene3D-CATH 2.20.100.10 UniProtKB/TrEMBL
  4.10.400.10 UniProtKB/TrEMBL
InterPro Complement_C8_beta UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  LDL_receptor-like_sf UniProtKB/TrEMBL
  LDLR_class-A_CS UniProtKB/TrEMBL
  LDrepeatLR_classA_rpt UniProtKB/TrEMBL
  MAC_perforin UniProtKB/TrEMBL
  MACPF UniProtKB/TrEMBL
  MACPF_CS UniProtKB/TrEMBL
  TSP1_rpt UniProtKB/TrEMBL
  TSP1_rpt_sf UniProtKB/TrEMBL
KEGG Report ssc:100037954 UniProtKB/TrEMBL
NCBI Gene C8B ENTREZGENE
PANTHER PTHR45742:SF5 UniProtKB/TrEMBL
Pfam Ldl_recept_a UniProtKB/TrEMBL
  MACPF UniProtKB/TrEMBL
  TSP_1 UniProtKB/TrEMBL
PRINTS COMPLEMENTC9 UniProtKB/TrEMBL
PROSITE LDLRA_1 UniProtKB/TrEMBL
  LDLRA_2 UniProtKB/TrEMBL
  MACPF_1 UniProtKB/TrEMBL
  MACPF_2 UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
SMART LDLa UniProtKB/TrEMBL
  MACPF UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
Superfamily-SCOP SSF57184 UniProtKB/TrEMBL
  SSF57424 UniProtKB/TrEMBL
  SSF82895 UniProtKB/TrEMBL
UniProt A0A287AT36 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1WB34_PIG UniProtKB/TrEMBL
  A0A4X1WBB3_PIG UniProtKB/TrEMBL
  A0A5G2QNM7_PIG UniProtKB/TrEMBL
  A0A8D0HWF8_PIG UniProtKB/TrEMBL
  A0A8D0I7C4_PIG UniProtKB/TrEMBL
  A0A8D0I9B0_PIG UniProtKB/TrEMBL
  A0SEH2 ENTREZGENE, UniProtKB/TrEMBL
  F1S790_PIG UniProtKB/TrEMBL
VGNC ID VGNC:86077 ENTREZGENE