PDE6C (phosphodiesterase 6C) - Rat Genome Database
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Gene: PDE6C (phosphodiesterase 6C) Sus scrofa
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Symbol: PDE6C
Name: phosphodiesterase 6C
RGD ID: 14028181
Description: ENCODES a protein that exhibits G protein-coupled receptor activity (inferred); metal ion binding (inferred); INVOLVED IN phototransduction, visible light (ortholog); retinal cone cell development (ortholog); sensory perception of light stimulus (ortholog); PARTICIPATES IN visual phototransduction pathway; ASSOCIATED WITH achromatopsia (ortholog); Achromatopsia 5 (ortholog); amphetamine abuse (ortholog); FOUND IN integral component of membrane (inferred); INTERACTS WITH 3',5'-cyclic GMP
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'; G protein-coupled receptor 120; GPR120; O3FAR1; omega-3 fatty acid receptor 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14105,051,920 - 105,123,022 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1 Ensembl14105,011,922 - 105,037,498 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114105,010,974 - 105,122,628 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214114,743,150 - 114,854,527 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:26576644   PMID:26909944  


Genomics

Comparative Map Data
PDE6C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14105,051,920 - 105,123,022 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1 Ensembl14105,011,922 - 105,037,498 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114105,010,974 - 105,122,628 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214114,743,150 - 114,854,527 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PDE6C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1093,612,537 - 93,666,010 (+)EnsemblGRCh38hg38GRCh38
GRCh381093,612,537 - 93,666,010 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371095,372,294 - 95,425,767 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361095,362,335 - 95,415,420 (+)NCBINCBI36hg18NCBI36
Build 341095,362,334 - 95,415,418NCBI
Celera1089,113,470 - 89,166,556 (+)NCBI
Cytogenetic Map10q23.33NCBI
HuRef1089,000,108 - 89,053,208 (+)NCBIHuRef
CHM1_11095,654,899 - 95,708,001 (+)NCBICHM1_1
Pde6c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391938,121,229 - 38,172,403 (+)NCBIGRCm39mm39
GRCm39 Ensembl1938,121,229 - 38,172,406 (+)Ensembl
GRCm381938,132,781 - 38,183,955 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1938,132,781 - 38,183,958 (+)EnsemblGRCm38mm10GRCm38
MGSCv371938,207,271 - 38,258,445 (+)NCBIGRCm37mm9NCBIm37
MGSCv361938,198,090 - 38,248,883 (+)NCBImm8
Celera1938,926,729 - 38,979,099 (+)NCBICelera
Cytogenetic Map19C2NCBI
Pde6c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21235,909,473 - 235,965,460 (+)NCBI
Rnor_6.0 Ensembl1256,822,334 - 256,877,810 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01256,822,099 - 256,885,879 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01264,302,622 - 264,358,510 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41242,459,653 - 242,515,102 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11242,652,932 - 242,727,438 (+)NCBI
Celera1233,003,126 - 233,058,624 (+)NCBICelera
Cytogenetic Map1q53NCBI
Pde6c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955507129,678 - 179,305 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955507129,678 - 179,586 (+)NCBIChiLan1.0ChiLan1.0
PDE6C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11093,871,704 - 93,924,654 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1093,871,704 - 93,924,654 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01090,361,003 - 90,414,169 (+)NCBIMhudiblu_PPA_v0panPan3
PDE6C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl287,839,847 - 7,887,776 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1287,839,604 - 7,887,827 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Pde6c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366011,343,538 - 1,393,605 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDE6C
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1986,850,500 - 86,904,853 (+)NCBI
ChlSab1.1 Ensembl986,851,867 - 86,904,481 (+)Ensembl
Pde6c
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247374,804,630 - 4,867,565 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 15 3 5 6 2 29 2 4 1
Below cutoff 3 2 2 5 2 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000011466   ⟹   ENSSSCP00000011167
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl14105,011,973 - 105,033,529 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000011468   ⟹   ENSSSCP00000011169
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl14105,051,920 - 105,123,022 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000054114   ⟹   ENSSSCP00000059157
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl14105,011,922 - 105,033,806 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000072134   ⟹   ENSSSCP00000071608
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl14105,011,955 - 105,037,498 (+)Ensembl
RefSeq Acc Id: XM_003133150   ⟹   XP_003133198
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.114105,050,691 - 105,122,628 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021071777   ⟹   XP_020927436
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.114105,010,974 - 105,122,628 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021071778   ⟹   XP_020927437
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.114105,012,006 - 105,122,628 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021071779   ⟹   XP_020927438
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.114105,047,816 - 105,122,628 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_020927436   ⟸   XM_021071777
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020927437   ⟸   XM_021071778
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_020927438   ⟸   XM_021071779
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_003133198   ⟸   XM_003133150
- Peptide Label: isoform X3
- UniProtKB: F1SC79 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000059157   ⟸   ENSSSCT00000054114
RefSeq Acc Id: ENSSSCP00000011167   ⟸   ENSSSCT00000011466
RefSeq Acc Id: ENSSSCP00000011169   ⟸   ENSSSCT00000011468
RefSeq Acc Id: ENSSSCP00000071608   ⟸   ENSSSCT00000072134
Protein Domains
G_PROTEIN_RECEP_F1_2   PDEase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000010478 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00000010480 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070019577 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000011169 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000059157 UniProtKB/TrEMBL
  ENSSSCP00000071608 UniProtKB/TrEMBL
  ENSSSCP00070032417 UniProtKB/TrEMBL
  ENSSSCP00070032421 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000011468 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000054114 UniProtKB/TrEMBL
  ENSSSCT00000072134 UniProtKB/TrEMBL
  ENSSSCT00070038739 UniProtKB/TrEMBL
  ENSSSCT00070038743 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1300.10 UniProtKB/TrEMBL
  3.30.450.40 UniProtKB/TrEMBL
InterPro GAF UniProtKB/TrEMBL
  GAF-like_dom_sf UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
  HD/PDEase_dom UniProtKB/TrEMBL
  PDEase UniProtKB/TrEMBL
  PDEase_catalytic_dom UniProtKB/TrEMBL
  PDEase_catalytic_dom_sf UniProtKB/TrEMBL
  PDEase_CS UniProtKB/TrEMBL
NCBI Gene PDE6C ENTREZGENE
Pfam 7tm_1 UniProtKB/TrEMBL
  GAF UniProtKB/TrEMBL
  PDEase_I UniProtKB/TrEMBL
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  PDIESTERASE1 UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
  PDEASE_I_1 UniProtKB/TrEMBL
  PDEASE_I_2 UniProtKB/TrEMBL
SMART GAF UniProtKB/TrEMBL
  HDc UniProtKB/TrEMBL
UniProt A0A4X1UQX4_PIG UniProtKB/TrEMBL
  A0A4X1UUQ2_PIG UniProtKB/TrEMBL
  F1SC79 ENTREZGENE, UniProtKB/TrEMBL
  I6Q9U1_PIG UniProtKB/TrEMBL
  I6QFQ7_PIG UniProtKB/TrEMBL
VGNC ID VGNC:91260 ENTREZGENE