VDAC2 (voltage dependent anion channel 2) - Rat Genome Database

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Gene: VDAC2 (voltage dependent anion channel 2) Sus scrofa
Analyze
Symbol: VDAC2
Name: voltage dependent anion channel 2
RGD ID: 14027591
Description: ENCODES a protein that exhibits ceramide binding (ortholog); cholesterol binding (ortholog); oxysterol binding (ortholog); INVOLVED IN mitochondrial outer membrane permeabilization (ortholog); ASSOCIATED WITH Burns (ortholog); Diabetic Nephropathies (ortholog); epilepsy (ortholog); FOUND IN membrane (ortholog); membrane raft (ortholog); mitochondrial outer membrane (ortholog); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: VDAC-2; voltage-dependent anion-selective channel protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1477,766,686 - 77,782,321 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11477,767,165 - 77,782,327 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:19630752   PMID:22301074   PMID:26060891   PMID:30032202   PMID:37797697  


Genomics

Comparative Map Data
VDAC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1477,766,686 - 77,782,321 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11477,767,165 - 77,782,327 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
VDAC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381075,210,170 - 75,231,448 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1075,210,154 - 75,231,448 (+)EnsemblGRCh38hg38GRCh38
GRCh371076,969,928 - 76,991,206 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361076,640,569 - 76,661,212 (+)NCBINCBI36Build 36hg18NCBI36
Build 341076,640,568 - 76,661,210NCBI
Celera1070,258,168 - 70,279,465 (+)NCBICelera
Cytogenetic Map10q22.2NCBI
HuRef1070,968,331 - 70,989,598 (+)NCBIHuRef
CHM1_11077,251,734 - 77,273,028 (+)NCBICHM1_1
T2T-CHM13v2.01076,083,655 - 76,104,942 (+)NCBIT2T-CHM13v2.0
Vdac2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391421,881,629 - 21,895,947 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1421,875,306 - 21,895,947 (+)EnsemblGRCm39 Ensembl
GRCm381421,831,561 - 21,845,879 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1421,825,238 - 21,845,879 (+)EnsemblGRCm38mm10GRCm38
MGSCv371422,650,783 - 22,665,101 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361420,620,113 - 20,634,431 (+)NCBIMGSCv36mm8
Celera1418,214,291 - 18,228,576 (+)NCBICelera
Cytogenetic Map14A3NCBI
cM Map1411.91NCBI
Vdac2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8152,512,214 - 2,526,105 (-)NCBIGRCr8
mRatBN7.2152,462,877 - 2,476,802 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl152,463,056 - 2,476,553 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx152,470,328 - 2,484,006 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0153,856,774 - 3,870,452 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0152,469,123 - 2,482,800 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0152,634,622 - 2,648,548 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl152,634,624 - 2,648,551 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0152,615,635 - 2,629,561 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4152,515,297 - 2,528,969 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1152,515,298 - 2,528,969 (-)NCBI
Celera152,105,517 - 2,119,199 (+)NCBICelera
Cytogenetic Map15p16NCBI
Vdac2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543716,853,433 - 16,872,345 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543716,857,715 - 16,871,717 (-)NCBIChiLan1.0ChiLan1.0
VDAC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2887,366,329 - 87,391,550 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11087,372,155 - 87,397,048 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01071,739,395 - 71,763,835 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11074,403,221 - 74,411,762 (+)NCBIpanpan1.1PanPan1.1panPan2
VDAC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1425,449,926 - 25,462,147 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl425,449,442 - 25,462,335 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha425,585,079 - 25,597,491 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0425,732,572 - 25,744,990 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl425,732,597 - 25,753,031 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1425,627,631 - 25,640,037 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0425,828,227 - 25,840,628 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0426,184,477 - 26,196,904 (+)NCBIUU_Cfam_GSD_1.0
Vdac2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721355,629,722 - 55,643,567 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365214,122,270 - 4,136,380 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365214,122,447 - 4,136,228 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VDAC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1956,141,153 - 56,160,378 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl956,136,756 - 56,157,173 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604816,628,451 - 16,649,525 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Vdac2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247548,587,920 - 8,602,761 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247548,587,698 - 8,601,757 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in VDAC2
119 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 4 3 5 2 23 2 3 3
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000011297   ⟹   ENSSSCP00000011005
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1477,766,686 - 77,782,321 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000048217   ⟹   ENSSSCP00000051261
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1477,767,357 - 77,782,100 (+)Ensembl
RefSeq Acc Id: NM_214369   ⟹   NP_999534
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11477,767,695 - 77,782,047 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021072175   ⟹   XP_020927834
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11477,767,165 - 77,782,327 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020927834   ⟸   XM_021072175
- Peptide Label: isoform X1
- UniProtKB: A0A4X1SP14 (UniProtKB/TrEMBL),   F1S2F6 (UniProtKB/TrEMBL),   A0A8D1S295 (UniProtKB/TrEMBL),   A0A8D0JI73 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_999534   ⟸   NM_214369
- UniProtKB: Q9MZ15 (UniProtKB/Swiss-Prot),   A0A8D1S295 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000011005   ⟸   ENSSSCT00000011297
RefSeq Acc Id: ENSSSCP00000051261   ⟸   ENSSSCT00000048217


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000010320 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005026879 UniProtKB/TrEMBL
  ENSSSCG00015030801 UniProtKB/TrEMBL
  ENSSSCG00025077146 UniProtKB/TrEMBL
  ENSSSCG00030044517 UniProtKB/TrEMBL
  ENSSSCG00035025179 UniProtKB/TrEMBL
  ENSSSCG00040002461 UniProtKB/TrEMBL
  ENSSSCG00045015839 UniProtKB/TrEMBL
  ENSSSCG00050025508 UniProtKB/TrEMBL
  ENSSSCG00055027848 UniProtKB/TrEMBL
  ENSSSCG00060004946 UniProtKB/TrEMBL
  ENSSSCG00065000976 UniProtKB/TrEMBL
  ENSSSCG00070002487 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000011297 ENTREZGENE
  ENSSSCT00000011297.5 UniProtKB/TrEMBL
  ENSSSCT00005042475.1 UniProtKB/TrEMBL
  ENSSSCT00005042491.1 UniProtKB/TrEMBL
  ENSSSCT00005042527.1 UniProtKB/TrEMBL
  ENSSSCT00015040737.1 UniProtKB/TrEMBL
  ENSSSCT00025107135.1 UniProtKB/TrEMBL
  ENSSSCT00030062077.1 UniProtKB/TrEMBL
  ENSSSCT00035033121.1 UniProtKB/TrEMBL
  ENSSSCT00040002992.1 UniProtKB/TrEMBL
  ENSSSCT00045026898.1 UniProtKB/TrEMBL
  ENSSSCT00045026962.1 UniProtKB/TrEMBL
  ENSSSCT00050034334.1 UniProtKB/TrEMBL
  ENSSSCT00055055092.1 UniProtKB/TrEMBL
  ENSSSCT00055055142.1 UniProtKB/TrEMBL
  ENSSSCT00060006163.1 UniProtKB/TrEMBL
  ENSSSCT00065001167.1 UniProtKB/TrEMBL
  ENSSSCT00070004647.1 UniProtKB/TrEMBL
  ENSSSCT00070004665.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.160.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Porin_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Porin_Euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Porin_Euk/Tom40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:397659 UniProtKB/Swiss-Prot
NCBI Gene VDAC2 ENTREZGENE
PANTHER PTHR11743 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11743:SF12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Porin_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS EUKARYTPORIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE EUKARYOTIC_PORIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A4X1SP14 ENTREZGENE
  A0A8D0JI73 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1S295 ENTREZGENE, UniProtKB/TrEMBL
  F1S2F6 ENTREZGENE, UniProtKB/TrEMBL
  Q9MZ15 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A0A4X1SP14 UniProtKB/TrEMBL
VGNC ID VGNC:111154 ENTREZGENE