SLC1A1 (solute carrier family 1 member 1) - Rat Genome Database

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Gene: SLC1A1 (solute carrier family 1 member 1) Sus scrofa
Analyze
Symbol: SLC1A1
Name: solute carrier family 1 member 1
RGD ID: 14025247
Description: ENCODES a protein that exhibits glutamate binding (ortholog); glutamate:sodium symporter activity (ortholog); identical protein binding (ortholog); INVOLVED IN activation of protein kinase B activity (ortholog); glutathione metabolic process (ortholog); intracellular zinc ion homeostasis (ortholog); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; ASSOCIATED WITH Atrophy (ortholog); autism spectrum disorder (ortholog); brain disease (ortholog); FOUND IN apical dendrite (ortholog); asymmetric synapse (ortholog); axon (ortholog); INTERACTS WITH amino acid; deoxynivalenol; fumonisin B1
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: EAAC1; excitatory amino acid transporter 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1217,366,499 - 217,441,674 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11217,366,493 - 217,441,643 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21243,230,452 - 243,270,312 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase B activity  (ISO)
adult behavior  (IEA)
amino acid transport  (IEA)
behavioral fear response  (IEA)
blood vessel morphogenesis  (IEA)
brain development  (IEA)
cellular response to ammonium ion  (IEA)
cellular response to bisphenol A  (IEA)
cellular response to cocaine  (IEA)
cellular response to mercury ion  (IEA)
cellular response to oxidative stress  (IEA)
chloride transmembrane transport  (IEA)
conditioned place preference  (IEA)
cysteine transmembrane transport  (IEA)
cysteine transport  (IEA)
cytokine-mediated signaling pathway  (IEA)
D-aspartate import across plasma membrane  (IEA)
D-aspartate transmembrane transport  (IEA)
dopamine metabolic process  (IEA)
establishment of protein localization  (IEA)
G protein-coupled dopamine receptor signaling pathway  (IEA)
gene expression  (IEA)
glutamate receptor signaling pathway  (IEA)
glutathione biosynthetic process  (IEA)
glutathione metabolic process  (IEA,ISO)
grooming behavior  (IEA)
heart contraction  (IEA)
intracellular glutamate homeostasis  (IEA)
intracellular zinc ion homeostasis  (IEA,ISO)
L-aspartate import across plasma membrane  (IEA)
L-aspartate transmembrane transport  (IEA)
L-glutamate import  (IEA)
L-glutamate import across plasma membrane  (IEA)
L-glutamate transmembrane transport  (IBA,IEA,ISO)
learning or memory  (IEA)
locomotory behavior  (IEA)
long-term synaptic potentiation  (IEA,ISO)
maintenance of blood-brain barrier  (IEA)
memory  (IEA)
motor behavior  (IEA)
motor neuron apoptotic process  (IEA)
negative regulation of neuron apoptotic process  (IEA)
neurogenesis  (IEA)
neuron apoptotic process  (IEA)
neurotransmitter receptor transport to plasma membrane  (IEA)
peptidyl-serine phosphorylation  (ISO)
positive regulation of heart rate  (IEA)
postsynaptic modulation of chemical synaptic transmission  (IEA)
regulation of heart rate  (IEA)
regulation of protein phosphorylation  (ISO)
regulation of protein targeting to membrane  (IEA)
response to amphetamine  (IEA)
response to anesthetic  (IEA,ISO)
response to axon injury  (IEA,ISO)
response to decreased oxygen levels  (IEA,ISO)
response to morphine  (IEA)
response to xenobiotic stimulus  (IEA)
retina development in camera-type eye  (IEA)
retina layer formation  (IEA,ISO)
righting reflex  (IEA)
superoxide metabolic process  (IEA)
synapse organization  (IEA)
zinc ion transmembrane transport  (IEA)

References
Additional References at PubMed
PMID:14681463   PMID:15044176   PMID:23271124   PMID:26338884   PMID:30032202  


Genomics

Comparative Map Data
SLC1A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1217,366,499 - 217,441,674 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11217,366,493 - 217,441,643 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21243,230,452 - 243,270,312 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC1A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3894,490,468 - 4,587,469 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl94,490,468 - 4,587,469 (+)EnsemblGRCh38hg38GRCh38
GRCh3794,490,468 - 4,587,469 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3694,480,444 - 4,577,469 (+)NCBINCBI36Build 36hg18NCBI36
Build 3494,480,439 - 4,577,258NCBI
Celera94,412,118 - 4,509,171 (+)NCBICelera
Cytogenetic Map9p24.2NCBI
HuRef94,445,524 - 4,542,606 (+)NCBIHuRef
CHM1_194,490,396 - 4,587,442 (+)NCBICHM1_1
T2T-CHM13v2.094,494,107 - 4,591,140 (+)NCBIT2T-CHM13v2.0
Slc1a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391928,812,535 - 28,891,360 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1928,812,449 - 28,891,360 (+)EnsemblGRCm39 Ensembl
GRCm381928,835,135 - 28,913,960 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1928,835,049 - 28,913,960 (+)EnsemblGRCm38mm10GRCm38
MGSCv371928,909,656 - 28,988,450 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361928,901,163 - 28,979,957 (+)NCBIMGSCv36mm8
Celera1929,610,074 - 29,689,176 (+)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1923.5NCBI
Slc1a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81235,963,455 - 236,043,572 (+)NCBIGRCr8
mRatBN7.21226,549,932 - 226,631,925 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1226,549,842 - 226,630,402 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1234,954,243 - 235,033,486 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01241,883,904 - 241,963,149 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01234,707,753 - 234,788,324 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01246,955,017 - 247,035,159 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1246,954,980 - 247,037,056 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01254,195,480 - 254,274,919 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41232,469,746 - 232,549,584 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11232,633,737 - 232,715,504 (+)NCBI
Celera1223,704,163 - 223,782,895 (+)NCBICelera
Cytogenetic Map1q52NCBI
Slc1a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554348,790,685 - 8,879,757 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554348,790,685 - 8,879,757 (+)NCBIChiLan1.0ChiLan1.0
SLC1A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v211119,970,573 - 120,068,724 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan19119,977,375 - 120,074,653 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v094,323,124 - 4,420,193 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.194,511,491 - 4,608,337 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl94,511,491 - 4,608,337 (+)Ensemblpanpan1.1panPan2
SLC1A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1192,898,274 - 92,978,260 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl192,898,274 - 92,978,260 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha193,370,688 - 93,450,612 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0193,451,994 - 93,532,207 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl193,451,891 - 93,532,204 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1193,083,822 - 93,163,810 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0192,807,174 - 92,887,351 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0193,572,134 - 93,652,376 (+)NCBIUU_Cfam_GSD_1.0
Slc1a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947140,482,449 - 140,559,751 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936503613,223 - 690,721 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936503613,250 - 690,555 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC1A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11274,949,560 - 75,041,455 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1274,949,028 - 75,041,369 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603863,278,537 - 63,371,858 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc1a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247369,246,262 - 9,325,485 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247369,246,348 - 9,325,671 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SLC1A1
1133 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 4 23 3 3 10 9 23 2 5 1

Sequence


Ensembl Acc Id: ENSSSCT00000005755   ⟹   ENSSSCP00000005613
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1217,366,499 - 217,441,674 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000072841   ⟹   ENSSSCP00000064729
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1217,366,499 - 217,441,674 (-)Ensembl
RefSeq Acc Id: NM_001164649   ⟹   NP_001158121
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11217,366,493 - 217,441,643 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001158121   ⟸   NM_001164649
- UniProtKB: F1SK41 (UniProtKB/TrEMBL),   A0A4X1W8W1 (UniProtKB/TrEMBL),   C8CAX4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000005613   ⟸   ENSSSCT00000005755
Ensembl Acc Id: ENSSSCP00000064729   ⟸   ENSSSCT00000072841


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000005222 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015066794 UniProtKB/TrEMBL
  ENSSSCG00025040158 UniProtKB/TrEMBL
  ENSSSCG00030053253 UniProtKB/TrEMBL
  ENSSSCG00035004751 UniProtKB/TrEMBL
  ENSSSCG00040013107 UniProtKB/TrEMBL
  ENSSSCG00045017899 UniProtKB/TrEMBL
  ENSSSCG00055002360 UniProtKB/TrEMBL
  ENSSSCG00060056025 UniProtKB/TrEMBL
  ENSSSCG00065050752 UniProtKB/TrEMBL
  ENSSSCG00070029360 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000005755 ENTREZGENE
  ENSSSCT00000005755.4 UniProtKB/TrEMBL
  ENSSSCT00000072841.1 UniProtKB/TrEMBL
  ENSSSCT00015089603.1 UniProtKB/TrEMBL
  ENSSSCT00015089667.1 UniProtKB/TrEMBL
  ENSSSCT00025054645.1 UniProtKB/TrEMBL
  ENSSSCT00025054815.1 UniProtKB/TrEMBL
  ENSSSCT00030074331.1 UniProtKB/TrEMBL
  ENSSSCT00030074351.1 UniProtKB/TrEMBL
  ENSSSCT00035005992.1 UniProtKB/TrEMBL
  ENSSSCT00035005995.1 UniProtKB/TrEMBL
  ENSSSCT00040017471.1 UniProtKB/TrEMBL
  ENSSSCT00040017493.1 UniProtKB/TrEMBL
  ENSSSCT00045030495.1 UniProtKB/TrEMBL
  ENSSSCT00045030600.1 UniProtKB/TrEMBL
  ENSSSCT00055004482.1 UniProtKB/TrEMBL
  ENSSSCT00055004488.1 UniProtKB/TrEMBL
  ENSSSCT00060076349.1 UniProtKB/TrEMBL
  ENSSSCT00060076357.1 UniProtKB/TrEMBL
  ENSSSCT00065069522.1 UniProtKB/TrEMBL
  ENSSSCT00065069524.1 UniProtKB/TrEMBL
  ENSSSCT00070058962.1 UniProtKB/TrEMBL
  ENSSSCT00070058966.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.3860.10 UniProtKB/TrEMBL
InterPro DAACS UniProtKB/TrEMBL
  Na-dicarboxylate_symporter UniProtKB/TrEMBL
  Na-dicarboxylate_symporter_CS UniProtKB/TrEMBL
  Na:dicarbo_symporter_sf UniProtKB/TrEMBL
KEGG Report ssc:397003 UniProtKB/TrEMBL
NCBI Gene SLC1A1 ENTREZGENE
PANTHER EXCITATORY AMINO ACID TRANSPORTER 3 UniProtKB/TrEMBL
  SODIUM/DICARBOXYLATE SYMPORTER-RELATED UniProtKB/TrEMBL
Pfam SDF UniProtKB/TrEMBL
PRINTS EDTRNSPORT UniProtKB/TrEMBL
PROSITE NA_DICARBOXYL_SYMP_1 UniProtKB/TrEMBL
  NA_DICARBOXYL_SYMP_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF118215 UniProtKB/TrEMBL
UniProt A0A4X1W7M7_PIG UniProtKB/TrEMBL
  A0A4X1W8W1 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2R2G4_PIG UniProtKB/TrEMBL
  C8CAX4 ENTREZGENE, UniProtKB/TrEMBL
  F1SK41 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:92963 ENTREZGENE