CDK8 (cyclin dependent kinase 8) - Rat Genome Database

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Gene: CDK8 (cyclin dependent kinase 8) Sus scrofa
Analyze
Symbol: CDK8
Name: cyclin dependent kinase 8
RGD ID: 14019797
Description: ENCODES a protein that exhibits protein kinase activity (ortholog); ubiquitin protein ligase activity (ortholog); INVOLVED IN negative regulation of triglyceride metabolic process (ortholog); protein ubiquitination (ortholog); PARTICIPATES IN RNA polymerase II transcription pathway; ASSOCIATED WITH congenital diaphragmatic hernia (ortholog); congenital heart disease (ortholog); Diaphragmatic Hernia (ortholog); FOUND IN nucleus (ortholog); protein-containing complex (ortholog); ubiquitin ligase complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: cyclin-dependent kinase 8
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl114,054,209 - 4,181,093 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1114,054,442 - 4,161,501 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2113,493,422 - 3,545,124 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:17145712  


Genomics

Comparative Map Data
CDK8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl114,054,209 - 4,181,093 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1114,054,442 - 4,161,501 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2113,493,422 - 3,545,124 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CDK8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1326,254,104 - 26,405,238 (+)EnsemblGRCh38hg38GRCh38
GRCh381326,254,125 - 26,405,238 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371326,828,266 - 26,979,375 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361325,726,756 - 25,876,569 (+)NCBINCBI36hg18NCBI36
Build 341325,726,755 - 25,876,569NCBI
Celera137,896,857 - 8,046,682 (+)NCBI
Cytogenetic Map13q12.13NCBI
HuRef137,646,374 - 7,796,038 (+)NCBIHuRef
CHM1_11326,796,796 - 26,946,621 (+)NCBICHM1_1
Cdk8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395146,167,432 - 146,239,684 (+)NCBIGRCm39mm39
GRCm39 Ensembl5146,168,040 - 146,239,684 (+)Ensembl
GRCm385146,230,795 - 146,302,874 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5146,231,230 - 146,302,874 (+)EnsemblGRCm38mm10GRCm38
MGSCv375147,043,251 - 147,114,450 (+)NCBIGRCm37mm9NCBIm37
MGSCv365146,535,913 - 146,607,053 (+)NCBImm8
Celera5144,210,649 - 144,281,842 (+)NCBICelera
Cytogenetic Map5G3NCBI
Cdk8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2128,737,198 - 8,805,026 (-)NCBImRatBN7.2
Rnor_6.01210,496,273 - 10,561,335 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01212,597,402 - 12,663,842 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4129,215,964 - 9,254,015 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1210,565,691 - 10,631,673 (-)NCBICelera
Cytogenetic Map12p11NCBI
Cdk8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554975,781,237 - 5,908,374 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554975,781,237 - 5,908,072 (+)NCBIChiLan1.0ChiLan1.0
CDK8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11325,895,353 - 26,046,120 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1325,895,705 - 26,046,120 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0137,546,922 - 7,698,079 (+)NCBIMhudiblu_PPA_v0panPan3
CDK8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12513,043,949 - 13,179,752 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2513,045,343 - 13,179,656 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2513,114,192 - 13,250,035 (-)NCBI
ROS_Cfam_1.02513,179,325 - 13,315,182 (-)NCBI
UMICH_Zoey_3.12513,063,086 - 13,198,906 (-)NCBI
UNSW_CanFamBas_1.02513,055,645 - 13,191,566 (-)NCBI
UU_Cfam_GSD_1.02513,106,469 - 13,242,317 (-)NCBI
Cdk8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945114,926,309 - 115,028,565 (+)NCBI
SpeTri2.0NW_00493694891,578 - 236,051 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDK8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.135,505,532 - 5,652,527 (+)NCBI
ChlSab1.1 Ensembl35,505,625 - 5,651,366 (+)Ensembl
Vero_WHO_p1.0NW_02366605738,774,603 - 38,922,173 (-)NCBI
Cdk8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477612,114,277 - 12,324,481 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1 3 1 6 2 1
Low 9 4 4 2 17 2 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000010186   ⟹   ENSSSCP00000009920
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl114,054,209 - 4,181,093 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000029736   ⟹   ENSSSCP00000024405
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl114,054,441 - 4,161,501 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000059226   ⟹   ENSSSCP00000044905
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl114,054,441 - 4,161,501 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000090671   ⟹   ENSSSCP00000063190
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl114,054,209 - 4,158,464 (+)Ensembl
RefSeq Acc Id: XM_021065497   ⟹   XP_020921156
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1114,054,442 - 4,161,501 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021065498   ⟹   XP_020921157
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1114,054,442 - 4,161,501 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021065499   ⟹   XP_020921158
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1114,054,442 - 4,161,501 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021065500   ⟹   XP_020921159
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1114,054,442 - 4,161,501 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021065501   ⟹   XP_020921160
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1114,054,542 - 4,161,501 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_020921156   ⟸   XM_021065497
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020921157   ⟸   XM_021065498
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_020921158   ⟸   XM_021065499
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_020921159   ⟸   XM_021065500
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_020921160   ⟸   XM_021065501
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: ENSSSCP00000024405   ⟸   ENSSSCT00000029736
RefSeq Acc Id: ENSSSCP00000009920   ⟸   ENSSSCT00000010186
RefSeq Acc Id: ENSSSCP00000063190   ⟸   ENSSSCT00000090671
RefSeq Acc Id: ENSSSCP00000044905   ⟸   ENSSSCT00000059226
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000009298 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070010450 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000009920 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000024405 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000044905 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000063190 UniProtKB/TrEMBL
  ENSSSCP00070016892 UniProtKB/TrEMBL
  ENSSSCP00070016899 UniProtKB/TrEMBL
  ENSSSCP00070016907 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000010186 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000029736 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000059226 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000090671 UniProtKB/TrEMBL
  ENSSSCT00070020328 UniProtKB/TrEMBL
  ENSSSCT00070020334 UniProtKB/TrEMBL
  ENSSSCT00070020343 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene CDK8 ENTREZGENE
Pfam Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A287ALK4_PIG UniProtKB/TrEMBL
  A0A4X1TJE6_PIG UniProtKB/TrEMBL
  A0A4X1TNT4_PIG UniProtKB/TrEMBL
  A0A4X1TNY6_PIG UniProtKB/TrEMBL
  A0A5G2QH83_PIG UniProtKB/TrEMBL
  F1RTK4_PIG UniProtKB/TrEMBL
  I3LJZ2_PIG UniProtKB/TrEMBL
VGNC ID VGNC:86507 ENTREZGENE