CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase) - Rat Genome Database
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Gene: CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase) Sus scrofa
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Symbol: CAD
Name: carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
RGD ID: 14019515
Description: ENCODES a protein that exhibits aspartate carbamoyltransferase activity (ortholog); carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity (ortholog); dihydroorotase activity (ortholog); INVOLVED IN 'de novo' pyrimidine nucleobase biosynthetic process (ortholog); animal organ regeneration (ortholog); cellular response to drug (ortholog); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; beta-ureidopropionase deficiency pathway; Canavan disease pathway; ASSOCIATED WITH Acute Erythroblastic Leukemia (ortholog); beta thalassemia (ortholog); congenital hypoplastic anemia (ortholog); FOUND IN cell projection (ortholog); cytosol (ortholog); neuronal cell body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOW QUALITY PROTEIN: CAD protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3111,887,020 - 111,914,495 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13111,887,017 - 111,914,511 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

Genomics

Comparative Map Data
CAD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3111,887,020 - 111,914,495 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13111,887,017 - 111,914,511 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CAD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl227,217,369 - 27,243,943 (+)EnsemblGRCh38hg38GRCh38
GRCh38227,217,369 - 27,243,943 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37227,440,237 - 27,466,811 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh37227,440,258 - 27,466,660 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36227,293,762 - 27,320,158 (+)NCBINCBI36hg18NCBI36
Build 34227,351,908 - 27,378,305NCBI
Celera227,286,585 - 27,312,981 (+)NCBI
Cytogenetic Map2p23.3NCBI
HuRef227,181,964 - 27,208,360 (+)NCBIHuRef
CHM1_1227,370,163 - 27,396,565 (+)NCBICHM1_1
Cad
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39531,211,964 - 31,235,823 (+)NCBIGRCm39mm39
GRCm38531,054,620 - 31,078,479 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl531,054,780 - 31,078,479 (+)EnsemblGRCm38mm10GRCm38
MGSCv37531,357,184 - 31,380,852 (+)NCBIGRCm37mm9NCBIm37
MGSCv36531,331,392 - 31,355,060 (+)NCBImm8
Celera528,526,834 - 28,551,927 (+)NCBICelera
Cytogenetic Map5B1NCBI
Cad
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2625,292,133 - 25,315,176 (-)NCBI
Rnor_6.0 Ensembl626,657,780 - 26,680,284 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0626,657,507 - 26,680,459 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0636,472,498 - 36,495,450 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4625,272,416 - 25,296,266 (-)NCBIRGSC3.4rn4RGSC3.4
Celera624,783,039 - 24,805,943 (-)NCBICelera
Cytogenetic Map6q14NCBI
Cad
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554699,203,434 - 9,227,865 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554699,203,433 - 9,227,526 (+)NCBIChiLan1.0ChiLan1.0
CAD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A27,306,488 - 27,332,804 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A27,306,527 - 27,332,804 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A27,218,699 - 27,245,156 (+)NCBIMhudiblu_PPA_v0panPan3
CAD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1721,197,826 - 21,221,635 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11721,198,839 - 21,221,897 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Cad
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364935,308,268 - 5,332,934 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CAD
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11480,371,154 - 80,399,193 (-)NCBI
ChlSab1.1 Ensembl1480,371,096 - 80,398,914 (-)Ensembl
Cad
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247389,318,213 - 9,340,765 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 10 3 3 5 2 23 2 3 3
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000024601   ⟹   ENSSSCP00000025052
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl3111,887,020 - 111,914,495 (-)Ensembl
RefSeq Acc Id: XM_021087696   ⟹   XP_020943355
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.13111,887,017 - 111,914,511 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020943355 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020943355   ⟸   XM_021087696
- Sequence:
RefSeq Acc Id: ENSSSCP00000025052   ⟸   ENSSSCT00000024601

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000028978 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070011138 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000025052 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070018178 UniProtKB/TrEMBL
  ENSSSCP00070018214 UniProtKB/TrEMBL
  ENSSSCP00070018252 UniProtKB/TrEMBL
  ENSSSCP00070018262 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000024601 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070021944 UniProtKB/TrEMBL
  ENSSSCT00070021992 UniProtKB/TrEMBL
  ENSSSCT00070022038 UniProtKB/TrEMBL
  ENSSSCT00070022048 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1030.10 UniProtKB/TrEMBL
  3.30.1490.20 UniProtKB/TrEMBL
  3.40.50.1370 UniProtKB/TrEMBL
  3.40.50.1380 UniProtKB/TrEMBL
  3.40.50.880 UniProtKB/TrEMBL
  3.50.30.20 UniProtKB/TrEMBL
InterPro Amidohydro-rel UniProtKB/TrEMBL
  Asp/Orn_carbamoyltranf_P-bd UniProtKB/TrEMBL
  Asp/Orn_carbamoylTrfase UniProtKB/TrEMBL
  Asp/Orn_carbamoylTrfase_sf UniProtKB/TrEMBL
  Asp_carbamoyltransf UniProtKB/TrEMBL
  Asp_carbamoyltransf_Asp/Orn-bd UniProtKB/TrEMBL
  ATP-grasp UniProtKB/TrEMBL
  ATP_grasp_subdomain_1 UniProtKB/TrEMBL
  CarbamoylP_synth_lsu UniProtKB/TrEMBL
  CarbamoylP_synth_lsu_oligo UniProtKB/TrEMBL
  CarbamoylP_synth_lsu_oligo_sf UniProtKB/TrEMBL
  CarbamoylP_synth_ssu UniProtKB/TrEMBL
  CarbamoylP_synth_ssu_N UniProtKB/TrEMBL
  CarbP_synth_ssu_N_sf UniProtKB/TrEMBL
  CbamoylP_synth_lsu-like_ATP-bd UniProtKB/TrEMBL
  CbamoylP_synth_lsu_CPSase_dom UniProtKB/TrEMBL
  Class_I_gatase-like UniProtKB/TrEMBL
  CPSase_GATase1 UniProtKB/TrEMBL
  Dihydroorotase_CS UniProtKB/TrEMBL
  GATASE UniProtKB/TrEMBL
  Metal-dep_hydrolase_composite UniProtKB/TrEMBL
  Metal_Hydrolase UniProtKB/TrEMBL
  MGS-like_dom UniProtKB/TrEMBL
  MGS-like_dom_sf UniProtKB/TrEMBL
  PreATP-grasp_dom_sf UniProtKB/TrEMBL
NCBI Gene CAD ENTREZGENE
Pfam Amidohydro_1 UniProtKB/TrEMBL
  CPSase_L_D2 UniProtKB/TrEMBL
  CPSase_L_D3 UniProtKB/TrEMBL
  CPSase_sm_chain UniProtKB/TrEMBL
  GATase UniProtKB/TrEMBL
  MGS UniProtKB/TrEMBL
  OTCace UniProtKB/TrEMBL
  OTCace_N UniProtKB/TrEMBL
PRINTS AOTCASE UniProtKB/TrEMBL
  CPSASE UniProtKB/TrEMBL
PROSITE ATP_GRASP UniProtKB/TrEMBL
  CARBAMOYLTRANSFERASE UniProtKB/TrEMBL
  CPSASE_1 UniProtKB/TrEMBL
  CPSASE_2 UniProtKB/TrEMBL
  DIHYDROOROTASE_1 UniProtKB/TrEMBL
  DIHYDROOROTASE_2 UniProtKB/TrEMBL
  GATASE_TYPE_1 UniProtKB/TrEMBL
  MGS UniProtKB/TrEMBL
SMART CPSase_L_D3 UniProtKB/TrEMBL
  CPSase_sm_chain UniProtKB/TrEMBL
  MGS UniProtKB/TrEMBL
Superfamily-SCOP SSF48108 UniProtKB/TrEMBL
  SSF51338 UniProtKB/TrEMBL
  SSF51556 UniProtKB/TrEMBL
  SSF52021 UniProtKB/TrEMBL
  SSF52317 UniProtKB/TrEMBL
  SSF52335 UniProtKB/TrEMBL
  SSF52440 UniProtKB/TrEMBL
  SSF53671 UniProtKB/TrEMBL
TIGRFAMs asp_carb_tr UniProtKB/TrEMBL
  CPSaseII_lrg UniProtKB/TrEMBL
  CPSaseIIsmall UniProtKB/TrEMBL
UniProt A0A4X1TMN9_PIG UniProtKB/TrEMBL
  A0A4X1TMT2_PIG UniProtKB/TrEMBL
  A0A4X1TSE2_PIG UniProtKB/TrEMBL
  A0A4X1TSF1_PIG UniProtKB/TrEMBL
  I3LLT2_PIG UniProtKB/TrEMBL
VGNC ID VGNC:97042 ENTREZGENE