YWHAH (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta) - Rat Genome Database

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Gene: YWHAH (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta) Sus scrofa
Analyze
Symbol: YWHAH
Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
RGD ID: 14017677
Description: ENCODES a protein that exhibits actin binding (inferred); enzyme binding (inferred); identical protein binding (inferred); INVOLVED IN intracellular protein transport (ortholog); negative regulation of dendrite morphogenesis (ortholog); substantia nigra development (ortholog); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; mTOR signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH cardiomyopathy (ortholog); Experimental Diabetes Mellitus (ortholog); genetic disease (ortholog); FOUND IN cerebellar granule cell to Purkinje cell synapse (ortholog); glutamatergic synapse (ortholog); presynapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 14-3-3 protein eta; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1448,544,173 - 48,556,490 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11448,544,031 - 48,556,496 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21451,861,302 - 51,873,780 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:14681463   PMID:30032202  


Genomics

Comparative Map Data
YWHAH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1448,544,173 - 48,556,490 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11448,544,031 - 48,556,496 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21451,861,302 - 51,873,780 (+)NCBISscrofa10.2Sscrofa10.2susScr3
YWHAH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382231,944,535 - 31,957,603 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2231,944,522 - 31,957,603 (+)EnsemblGRCh38hg38GRCh38
GRCh372232,340,521 - 32,353,590 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362230,670,479 - 30,683,590 (+)NCBINCBI36Build 36hg18NCBI36
Build 342230,665,082 - 30,678,143NCBI
Celera2216,140,927 - 16,154,032 (+)NCBICelera
Cytogenetic Map22q12.3NCBI
HuRef2215,296,794 - 15,309,903 (+)NCBIHuRef
CHM1_12232,299,883 - 32,312,993 (+)NCBICHM1_1
T2T-CHM13v2.02232,408,656 - 32,421,713 (+)NCBIT2T-CHM13v2.0
Ywhah
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39533,176,160 - 33,185,310 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl533,176,160 - 33,185,310 (+)EnsemblGRCm39 Ensembl
GRCm38533,018,816 - 33,027,966 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl533,018,816 - 33,027,966 (+)EnsemblGRCm38mm10GRCm38
MGSCv37533,361,465 - 33,370,615 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36533,329,757 - 33,344,823 (+)NCBIMGSCv36mm8
Celera530,495,248 - 30,504,397 (+)NCBICelera
Cytogenetic Map5B1NCBI
cM Map517.42NCBI
Ywhah
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81481,920,819 - 81,930,202 (-)NCBIGRCr8
mRatBN7.21477,696,332 - 77,705,715 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1477,696,333 - 77,705,741 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1482,138,138 - 82,147,522 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01483,378,671 - 83,388,056 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01479,823,989 - 79,833,373 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01483,053,041 - 83,062,424 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1483,053,041 - 83,062,424 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01483,739,009 - 83,748,391 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41483,448,395 - 83,457,778 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11483,454,749 - 83,464,132 (-)NCBI
Celera1476,611,913 - 76,621,296 (-)NCBICelera
Cytogenetic Map14q21NCBI
Ywhah
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554556,045,919 - 6,057,729 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554556,045,919 - 6,057,729 (+)NCBIChiLan1.0ChiLan1.0
YWHAH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22341,896,667 - 41,909,802 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12244,597,258 - 44,610,288 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02212,966,653 - 12,979,695 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12230,814,699 - 30,832,613 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2230,819,821 - 30,831,804 (+)Ensemblpanpan1.1panPan2
YWHAH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12624,785,374 - 24,796,603 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2624,785,368 - 24,795,778 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2624,653,699 - 24,664,927 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02625,171,660 - 25,183,107 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2625,170,742 - 25,183,121 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12624,870,912 - 24,882,134 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02625,132,984 - 25,144,210 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02625,195,163 - 25,206,388 (+)NCBIUU_Cfam_GSD_1.0
Ywhah
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118118,339,882 - 118,351,331 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367551,597,445 - 1,609,003 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367551,597,487 - 1,608,915 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
YWHAH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11914,825,963 - 14,839,668 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1914,826,135 - 14,840,325 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045111,267,273 - 111,281,244 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ywhah
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247478,350,474 - 8,363,576 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247478,350,552 - 8,362,610 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in YWHAH
215 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 4 3 5 23 2 3
Low 2 2 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000010992   ⟹   ENSSSCP00000010705
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1448,544,173 - 48,556,490 (+)Ensembl
RefSeq Acc Id: XM_001928076   ⟹   XP_001928111
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11448,544,031 - 48,556,496 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_001928111   ⟸   XM_001928076
- UniProtKB: F2Z4Y1 (UniProtKB/TrEMBL),   A0A4X1V4V6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000010705   ⟸   ENSSSCT00000010992
Protein Domains
14-3-3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000010035 Ensembl, UniProtKB/TrEMBL
  ENSSSCG00015061237 UniProtKB/TrEMBL
  ENSSSCG00025075438 UniProtKB/TrEMBL
  ENSSSCG00030020373 UniProtKB/TrEMBL
  ENSSSCG00035022335 UniProtKB/TrEMBL
  ENSSSCG00040005932 UniProtKB/TrEMBL
  ENSSSCG00045001468 UniProtKB/TrEMBL
  ENSSSCG00050073395 UniProtKB/TrEMBL
  ENSSSCG00055010679 UniProtKB/TrEMBL
  ENSSSCG00060075929 UniProtKB/TrEMBL
  ENSSSCG00065059244 UniProtKB/TrEMBL
  ENSSSCG00070021891 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000010992.5 UniProtKB/TrEMBL
  ENSSSCT00015081848.1 UniProtKB/TrEMBL
  ENSSSCT00025104064.1 UniProtKB/TrEMBL
  ENSSSCT00030028176.1 UniProtKB/TrEMBL
  ENSSSCT00035029147.1 UniProtKB/TrEMBL
  ENSSSCT00040007835.1 UniProtKB/TrEMBL
  ENSSSCT00045002338.1 UniProtKB/TrEMBL
  ENSSSCT00050100324.1 UniProtKB/TrEMBL
  ENSSSCT00055020983.1 UniProtKB/TrEMBL
  ENSSSCT00055020997.1 UniProtKB/TrEMBL
  ENSSSCT00060104075.1 UniProtKB/TrEMBL
  ENSSSCT00065081079.1 UniProtKB/TrEMBL
  ENSSSCT00070043505.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.190.20 UniProtKB/TrEMBL
InterPro 14-3-3 UniProtKB/TrEMBL
  14-3-3_CS UniProtKB/TrEMBL
  14-3-3_dom_sf UniProtKB/TrEMBL
  14-3-3_domain UniProtKB/TrEMBL
KEGG Report ssc:100155504 UniProtKB/TrEMBL
NCBI Gene YWHAH ENTREZGENE
PANTHER 14-3-3 PROTEIN ETA UniProtKB/TrEMBL
  PTHR18860 UniProtKB/TrEMBL
Pfam 14-3-3 UniProtKB/TrEMBL
PIRSF 14-3-3 UniProtKB/TrEMBL
PRINTS 1433ZETA UniProtKB/TrEMBL
PROSITE 1433_1 UniProtKB/TrEMBL
  1433_2 UniProtKB/TrEMBL
SMART 14_3_3 UniProtKB/TrEMBL
Superfamily-SCOP SSF48445 UniProtKB/TrEMBL
UniProt A0A4X1V4V6 ENTREZGENE, UniProtKB/TrEMBL
  F2Z4Y1 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:95045 ENTREZGENE