INPP5K (inositol polyphosphate-5-phosphatase K) - Rat Genome Database
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Gene: INPP5K (inositol polyphosphate-5-phosphatase K) Sus scrofa
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Symbol: INPP5K
Name: inositol polyphosphate-5-phosphatase K
RGD ID: 14016895
Description: ENCODES a protein that exhibits inositol bisphosphate phosphatase activity (ortholog); inositol trisphosphate phosphatase activity (ortholog); phosphatidylinositol phosphate 5-phosphatase activity (ortholog); INVOLVED IN cellular response to cAMP (ortholog); cellular response to hormone stimulus (ortholog); dephosphorylation (ortholog); ASSOCIATED WITH congenital muscular dystrophy with cataracts and intellectual disability (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulum (ortholog); membrane (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: inositol polyphosphate 5-phosphatase K; skeletal muscle- and kidney-enriched inositol phosphatase; SKIP
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1247,717,907 - 47,738,477 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11247,717,898 - 47,738,540 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21249,602,564 - 49,623,319 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to cAMP  (IEA,ISO)
cellular response to epidermal growth factor stimulus  (IEA)
cellular response to hormone stimulus  (ISO)
cellular response to insulin stimulus  (IEA)
cellular response to tumor necrosis factor  (IEA)
dephosphorylation  (ISO)
G protein-coupled receptor signaling pathway  (IEA,ISO)
glucose homeostasis  (IEA,ISO)
in utero embryonic development  (IEA,ISO)
inositol phosphate dephosphorylation  (IBA)
negative regulation by host of viral transcription  (IEA)
negative regulation of calcium ion transport  (IEA)
negative regulation of dephosphorylation  (IEA,ISO)
negative regulation of glucose transmembrane transport  (IEA)
negative regulation of glycogen (starch) synthase activity  (IEA,ISO)
negative regulation of glycogen biosynthetic process  (IBA,ISO)
negative regulation of insulin receptor signaling pathway  (IBA,ISO)
negative regulation of MAP kinase activity  (IEA)
negative regulation of peptidyl-serine phosphorylation  (IBA,ISO)
negative regulation of peptidyl-threonine phosphorylation  (IEA)
negative regulation of protein kinase activity  (ISO)
negative regulation of protein kinase B signaling  (IBA,ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of protein targeting to membrane  (IEA)
negative regulation of single stranded viral RNA replication via double stranded DNA intermediate  (IEA)
negative regulation of stress fiber assembly  (IEA)
negative regulation of transcription, DNA-templated  (IEA,ISO)
phosphatidylinositol dephosphorylation  (IBA,IEA)
positive regulation of renal water transport  (IEA,ISO)
positive regulation of transcription, DNA-templated  (IEA,ISO)
positive regulation of urine volume  (IEA,ISO)
protein localization to plasma membrane  (IEA,ISO)
regulation of glycogen biosynthetic process  (ISO)
response to insulin  (ISO)
ruffle assembly  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:20336382   PMID:22682687  


Genomics

Comparative Map Data
INPP5K
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1247,717,907 - 47,738,477 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11247,717,898 - 47,738,540 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21249,602,564 - 49,623,319 (-)NCBISscrofa10.2Sscrofa10.2susScr3
INPP5K
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl171,494,577 - 1,516,742 (-)EnsemblGRCh38hg38GRCh38
GRCh38171,494,575 - 1,516,735 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37171,397,869 - 1,420,182 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh37171,397,871 - 1,419,906 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36171,344,621 - 1,366,704 (-)NCBINCBI36hg18NCBI36
Celera171,413,368 - 1,435,621 (-)NCBI
Cytogenetic Map17p13.3NCBI
HuRef171,298,037 - 1,320,343 (-)NCBIHuRef
CHM1_1171,406,563 - 1,428,873 (-)NCBICHM1_1
Inpp5k
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391175,519,893 - 75,539,691 (+)NCBIGRCm39mm39
GRCm381175,629,067 - 75,648,865 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1175,630,988 - 75,648,871 (+)EnsemblGRCm38mm10GRCm38
MGSCv371175,444,522 - 75,462,367 (+)NCBIGRCm37mm9NCBIm37
MGSCv361175,447,215 - 75,465,060 (+)NCBImm8
Celera1183,140,156 - 83,157,894 (+)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1145.92NCBI
Inpp5k
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21060,474,262 - 60,495,813 (+)NCBI
Rnor_6.0 Ensembl1063,776,378 - 63,795,899 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01063,775,639 - 63,796,879 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01064,209,340 - 64,228,728 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41062,953,425 - 62,971,016 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11062,967,047 - 62,984,638 (+)NCBI
Celera1059,503,324 - 59,523,140 (+)NCBICelera
Cytogenetic Map10q24NCBI
Inpp5k
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554811,651,902 - 1,673,893 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554811,651,422 - 1,674,402 (+)NCBIChiLan1.0ChiLan1.0
INPP5K
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1171,377,310 - 1,399,373 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl171,377,312 - 1,399,373 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0171,477,511 - 1,499,765 (-)NCBIMhudiblu_PPA_v0panPan3
INPP5K
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl945,660,446 - 45,680,363 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1945,660,445 - 45,680,407 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Inpp5k
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365387,641,485 - 7,662,033 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
INPP5K
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1161,171,059 - 1,192,241 (-)NCBI
ChlSab1.1 Ensembl161,170,899 - 1,191,965 (-)Ensembl
Inpp5k
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247864,213,430 - 4,236,930 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1 1 1
Low 10 4 3 4 2 22 2 2 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000030204   ⟹   ENSSSCP00000024039
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1247,717,907 - 47,738,475 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000030655   ⟹   ENSSSCP00000025324
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1247,717,990 - 47,738,400 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000075492   ⟹   ENSSSCP00000069238
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1247,717,990 - 47,736,551 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000091212   ⟹   ENSSSCP00000070231
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1247,717,929 - 47,738,477 (-)Ensembl
RefSeq Acc Id: NM_001190292   ⟹   NP_001177221
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11247,719,157 - 47,738,346 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005657013   ⟹   XP_005657070
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11247,717,898 - 47,738,532 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013989998   ⟹   XP_013845452
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11247,717,898 - 47,736,468 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021066068   ⟹   XP_020921727
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11247,717,898 - 47,738,540 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001177221 (Get FASTA)   NCBI Sequence Viewer  
  XP_005657070 (Get FASTA)   NCBI Sequence Viewer  
  XP_013845452 (Get FASTA)   NCBI Sequence Viewer  
  XP_020921727 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ADE62527 (Get FASTA)   NCBI Sequence Viewer  
  ADE62528 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020921727   ⟸   XM_021066068
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005657070   ⟸   XM_005657013
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_013845452   ⟸   XM_013989998
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: NP_001177221   ⟸   NM_001190292
- UniProtKB: D7P0F2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000025324   ⟸   ENSSSCT00000030655
RefSeq Acc Id: ENSSSCP00000024039   ⟸   ENSSSCT00000030204
RefSeq Acc Id: ENSSSCP00000069238   ⟸   ENSSSCT00000075492
RefSeq Acc Id: ENSSSCP00000070231   ⟸   ENSSSCT00000091212
Protein Domains
IPPc


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000030707 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070014442 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000024039 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000025324 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000069238 UniProtKB/TrEMBL
  ENSSSCP00000070231 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070023665 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000030204 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000030655 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000075492 UniProtKB/TrEMBL
  ENSSSCT00000091212 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070028411 UniProtKB/TrEMBL
Gene3D-CATH 3.60.10.10 UniProtKB/TrEMBL
InterPro Endo/exonu/phosph_ase_sf UniProtKB/TrEMBL
  Endo/exonuclease/phosphatase UniProtKB/TrEMBL
  IPPc UniProtKB/TrEMBL
  SKICH UniProtKB/TrEMBL
KEGG Report ssc:100462756 UniProtKB/TrEMBL
NCBI Gene INPP5K ENTREZGENE
Pfam Exo_endo_phos UniProtKB/TrEMBL
  SKICH UniProtKB/TrEMBL
SMART IPPc UniProtKB/TrEMBL
Superfamily-SCOP SSF56219 UniProtKB/TrEMBL
UniProt A0A4X1U725_PIG UniProtKB/TrEMBL
  A0A5G2QYL7_PIG UniProtKB/TrEMBL
  A0A5G2QZB5_PIG UniProtKB/TrEMBL
  D7P0F2 ENTREZGENE, UniProtKB/TrEMBL
  I3LIY2_PIG UniProtKB/TrEMBL
  I3LMK3_PIG UniProtKB/TrEMBL
VGNC ID VGNC:89147 ENTREZGENE