ISOC2 (isochorismatase domain containing 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: ISOC2 (isochorismatase domain containing 2) Sus scrofa
Analyze
Symbol: ISOC2
Name: isochorismatase domain containing 2
RGD ID: 14015180
Description: INVOLVED IN protein destabilization (inferred); ASSOCIATED WITH genetic disease (ortholog); osteoarthritis (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: isochorismatase domain-containing protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl659,602,104 - 59,609,640 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1659,602,100 - 59,609,659 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2654,537,532 - 54,542,844 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA)
nucleus  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:30032202  


Genomics

Comparative Map Data
ISOC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl659,602,104 - 59,609,640 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1659,602,100 - 59,609,659 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2654,537,532 - 54,542,844 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ISOC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381955,452,985 - 55,461,642 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1955,452,985 - 55,462,343 (-)EnsemblGRCh38hg38GRCh38
GRCh371955,964,352 - 55,973,009 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361960,656,168 - 60,664,824 (-)NCBINCBI36Build 36hg18NCBI36
Build 341960,656,167 - 60,664,824NCBI
Celera1953,004,437 - 53,013,142 (-)NCBICelera
Cytogenetic Map19q13.42NCBI
HuRef1952,278,467 - 52,287,157 (-)NCBIHuRef
CHM1_11955,958,477 - 55,967,154 (-)NCBICHM1_1
T2T-CHM13v2.01958,548,867 - 58,557,801 (-)NCBIT2T-CHM13v2.0
Isoc2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3974,880,052 - 4,898,716 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl74,880,152 - 4,899,972 (+)EnsemblGRCm39 Ensembl
GRCm3874,877,053 - 4,895,717 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl74,877,153 - 4,896,973 (+)EnsemblGRCm38mm10GRCm38
MGSCv3774,828,655 - 4,847,319 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3674,480,225 - 4,498,487 (+)NCBIMGSCv36mm8
Celera74,618,950 - 4,637,275 (+)NCBICelera
Cytogenetic Map7A1NCBI
cM Map72.82NCBI
Isoc2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8178,001,735 - 78,022,565 (+)NCBIGRCr8
mRatBN7.2168,972,960 - 68,993,760 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl168,972,960 - 68,993,757 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx174,318,029 - 74,338,796 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0182,882,342 - 82,903,107 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0176,031,095 - 76,051,863 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0172,524,569 - 72,545,331 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl172,524,569 - 72,545,329 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0175,991,119 - 76,011,825 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4167,689,184 - 67,710,260 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1167,767,294 - 67,788,370 (+)NCBI
Celera168,130,600 - 68,151,250 (-)NCBICelera
Cytogenetic Map1q12NCBI
Isoc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955567829,300 - 835,505 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955567829,799 - 835,322 (+)NCBIChiLan1.0ChiLan1.0
ISOC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22061,592,558 - 61,602,213 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11963,321,124 - 63,330,684 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01952,496,880 - 52,507,073 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11961,185,417 - 61,196,482 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1961,185,417 - 61,196,482 (-)Ensemblpanpan1.1panPan2
ISOC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11102,246,881 - 102,253,726 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1102,247,010 - 102,253,733 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1102,303,585 - 102,310,431 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01102,900,055 - 102,906,903 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1102,900,171 - 102,906,907 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11102,537,262 - 102,544,106 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01102,249,372 - 102,256,225 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01103,012,602 - 103,019,448 (+)NCBIUU_Cfam_GSD_1.0
Isoc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244093491,873,059 - 1,877,900 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936886681,643 - 684,281 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936886681,325 - 686,142 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ISOC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1648,049,571 - 48,059,174 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl648,049,495 - 48,058,387 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045697,981 - 707,568 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Isoc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248321,894,339 - 1,896,851 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248321,891,506 - 1,896,751 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ISOC2
56 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2 2 1 1 2 1 1
Low 10 2 1 4 1 20 1 2 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000003653   ⟹   ENSSSCP00000003568
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl659,602,104 - 59,609,640 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000083690   ⟹   ENSSSCP00000062429
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl659,602,106 - 59,609,603 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000086766   ⟹   ENSSSCP00000069509
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl659,602,108 - 59,609,594 (-)Ensembl
RefSeq Acc Id: XM_021095040   ⟹   XP_020950699
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1659,602,100 - 59,609,659 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021095041   ⟹   XP_020950700
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1659,602,105 - 59,609,659 (-)NCBI
Sequence:
RefSeq Acc Id: XR_002344817
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1659,602,380 - 59,609,659 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020950699   ⟸   XM_021095040
- Peptide Label: isoform X1
- UniProtKB: A0A4X1UAV9 (UniProtKB/TrEMBL),   F1RMR5 (UniProtKB/TrEMBL),   A0A4X1UBD6 (UniProtKB/TrEMBL),   A0A8D1CRN9 (UniProtKB/TrEMBL),   A0A8D1LTZ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020950700   ⟸   XM_021095041
- Peptide Label: isoform X2
- UniProtKB: A0A4X1UDH4 (UniProtKB/TrEMBL),   A0A5G2QX42 (UniProtKB/TrEMBL),   A0A8D0MEJ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000062429   ⟸   ENSSSCT00000083690
RefSeq Acc Id: ENSSSCP00000003568   ⟸   ENSSSCT00000003653
RefSeq Acc Id: ENSSSCP00000069509   ⟸   ENSSSCT00000086766
Protein Domains
Isochorismatase-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000003289 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005011325 UniProtKB/TrEMBL
  ENSSSCG00015004505 UniProtKB/TrEMBL
  ENSSSCG00025055182 UniProtKB/TrEMBL
  ENSSSCG00030055985 UniProtKB/TrEMBL
  ENSSSCG00035029007 UniProtKB/TrEMBL
  ENSSSCG00040017573 UniProtKB/TrEMBL
  ENSSSCG00045010230 UniProtKB/TrEMBL
  ENSSSCG00050024191 UniProtKB/TrEMBL
  ENSSSCG00055030316 UniProtKB/TrEMBL
  ENSSSCG00060014249 UniProtKB/TrEMBL
  ENSSSCG00065011618 UniProtKB/TrEMBL
  ENSSSCG00070016326 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000003653 ENTREZGENE
  ENSSSCT00000003653.5 UniProtKB/TrEMBL
  ENSSSCT00000083690.2 UniProtKB/TrEMBL
  ENSSSCT00000086766 ENTREZGENE
  ENSSSCT00000086766.1 UniProtKB/TrEMBL
  ENSSSCT00005017674.1 UniProtKB/TrEMBL
  ENSSSCT00005017736.1 UniProtKB/TrEMBL
  ENSSSCT00005017746.1 UniProtKB/TrEMBL
  ENSSSCT00015006014.1 UniProtKB/TrEMBL
  ENSSSCT00015006019.1 UniProtKB/TrEMBL
  ENSSSCT00015006021.1 UniProtKB/TrEMBL
  ENSSSCT00025075547.1 UniProtKB/TrEMBL
  ENSSSCT00025075673.1 UniProtKB/TrEMBL
  ENSSSCT00025075794.1 UniProtKB/TrEMBL
  ENSSSCT00030078017.1 UniProtKB/TrEMBL
  ENSSSCT00030078052.1 UniProtKB/TrEMBL
  ENSSSCT00030078079.1 UniProtKB/TrEMBL
  ENSSSCT00030078103.1 UniProtKB/TrEMBL
  ENSSSCT00035038379.1 UniProtKB/TrEMBL
  ENSSSCT00035038389.1 UniProtKB/TrEMBL
  ENSSSCT00035038395.1 UniProtKB/TrEMBL
  ENSSSCT00040023731.1 UniProtKB/TrEMBL
  ENSSSCT00040023754.1 UniProtKB/TrEMBL
  ENSSSCT00040023791.1 UniProtKB/TrEMBL
  ENSSSCT00045017383.1 UniProtKB/TrEMBL
  ENSSSCT00045017437.1 UniProtKB/TrEMBL
  ENSSSCT00045017471.1 UniProtKB/TrEMBL
  ENSSSCT00050032615.1 UniProtKB/TrEMBL
  ENSSSCT00050032620.1 UniProtKB/TrEMBL
  ENSSSCT00050032634.1 UniProtKB/TrEMBL
  ENSSSCT00055060328.1 UniProtKB/TrEMBL
  ENSSSCT00055060371.1 UniProtKB/TrEMBL
  ENSSSCT00055060392.1 UniProtKB/TrEMBL
  ENSSSCT00055060398.1 UniProtKB/TrEMBL
  ENSSSCT00060018823.1 UniProtKB/TrEMBL
  ENSSSCT00060018828.1 UniProtKB/TrEMBL
  ENSSSCT00060018833.1 UniProtKB/TrEMBL
  ENSSSCT00060018834.1 UniProtKB/TrEMBL
  ENSSSCT00065015454.1 UniProtKB/TrEMBL
  ENSSSCT00065015465.1 UniProtKB/TrEMBL
  ENSSSCT00065015469.1 UniProtKB/TrEMBL
  ENSSSCT00070032360.1 UniProtKB/TrEMBL
  ENSSSCT00070032455.1 UniProtKB/TrEMBL
  ENSSSCT00070032610.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.850 UniProtKB/TrEMBL
InterPro Isochorismatase-like UniProtKB/TrEMBL
  Isochorismatase-like_sf UniProtKB/TrEMBL
NCBI Gene ISOC2 ENTREZGENE
PANTHER HYDROLASE UniProtKB/TrEMBL
  ISOCHORISMATASE DOMAIN-CONTAINING PROTEIN 2 UniProtKB/TrEMBL
Pfam Isochorismatase UniProtKB/TrEMBL
Superfamily-SCOP SSF52499 UniProtKB/TrEMBL
UniProt A0A4X1UAV9 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1UBD6 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1UDH4 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2QW66_PIG UniProtKB/TrEMBL
  A0A5G2QX42 ENTREZGENE
  A0A8D0MEJ1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1CRN9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1LTZ6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1UEQ4_PIG UniProtKB/TrEMBL
  F1RMR5 ENTREZGENE
UniProt Secondary A0A5G2QX42 UniProtKB/TrEMBL
  F1RMR5 UniProtKB/TrEMBL
VGNC ID VGNC:89228 ENTREZGENE