TBC1D22A (TBC1 domain family member 22A) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: TBC1D22A (TBC1 domain family member 22A) Sus scrofa
Analyze
Symbol: TBC1D22A
Name: TBC1 domain family member 22A
RGD ID: 14013168
Description: ENCODES a protein that exhibits 14-3-3 protein binding (inferred); GTPase activator activity (inferred); protein homodimerization activity (inferred); INVOLVED IN regulation of cilium assembly (ortholog); ASSOCIATED WITH genetic disease (ortholog); intellectual disability (ortholog); Phelan-McDermid syndrome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl52,528,921 - 2,787,304 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.152,528,920 - 2,787,313 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.25126,533 - 312,712 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:30032202  


Genomics

Comparative Map Data
TBC1D22A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl52,528,921 - 2,787,304 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.152,528,920 - 2,787,313 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.25126,533 - 312,712 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TBC1D22A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382246,762,650 - 47,175,699 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2246,762,617 - 47,175,699 (+)EnsemblGRCh38hg38GRCh38
GRCh372247,158,547 - 47,571,342 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362245,537,213 - 45,948,390 (+)NCBINCBI36Build 36hg18NCBI36
Celera2231,074,220 - 31,486,114 (+)NCBICelera
Cytogenetic Map22q13.31NCBI
HuRef2230,103,503 - 30,516,056 (+)NCBIHuRef
CHM1_12247,117,886 - 47,530,004 (+)NCBICHM1_1
T2T-CHM13v2.02247,250,621 - 47,665,617 (+)NCBIT2T-CHM13v2.0
Tbc1d22a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391586,095,502 - 86,382,704 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1586,098,660 - 86,382,704 (+)EnsemblGRCm39 Ensembl
GRCm381586,214,411 - 86,498,503 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1586,214,459 - 86,498,503 (+)EnsemblGRCm38mm10GRCm38
MGSCv371586,044,889 - 86,328,933 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361586,042,225 - 86,326,269 (+)NCBIMGSCv36mm8
Celera1588,356,819 - 88,637,955 (+)NCBICelera
Cytogenetic Map15E2NCBI
cM Map1540.56NCBI
Tbc1d22a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87119,172,284 - 119,457,271 (+)NCBIGRCr8
mRatBN7.27117,292,481 - 117,577,473 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7117,292,631 - 117,577,483 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7119,044,006 - 119,331,705 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07121,269,640 - 121,557,332 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07121,239,221 - 121,526,927 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07127,081,769 - 127,227,601 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7127,081,978 - 127,223,231 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07126,792,288 - 126,930,133 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.17124,240,095 - 124,527,412 (+)NCBI
Celera7113,582,538 - 114,076,520 (+)NCBICelera
Cytogenetic Map7q34NCBI
Tbc1d22a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541330,709,724 - 31,026,238 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541330,710,432 - 31,025,784 (+)NCBIChiLan1.0ChiLan1.0
TBC1D22A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22356,605,984 - 57,025,743 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12259,297,405 - 59,716,769 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02226,934,409 - 27,353,029 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12245,830,747 - 46,241,738 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2245,830,747 - 46,241,738 (+)Ensemblpanpan1.1panPan2
TBC1D22A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11019,196,866 - 19,532,103 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1019,070,467 - 19,532,062 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1019,119,926 - 19,454,053 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01019,933,410 - 20,267,704 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1019,933,339 - 20,267,651 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11019,651,625 - 19,985,731 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01019,964,022 - 20,298,045 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01020,145,684 - 20,479,843 (-)NCBIUU_Cfam_GSD_1.0
Tbc1d22a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049452,963,792 - 3,272,058 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366292,966,507 - 3,272,030 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366292,965,289 - 3,272,028 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TBC1D22A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11929,260,995 - 29,681,768 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1929,261,018 - 29,684,409 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604595,780,108 - 96,253,332 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tbc1d22a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247522,903,130 - 3,273,535 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247522,816,547 - 3,272,693 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TBC1D22A
13480 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 6 2 1 5 3 2 3 3
Low 4 2 2 2 20
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000001044   ⟹   ENSSSCP00000001022
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl52,528,921 - 2,787,304 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000079994   ⟹   ENSSSCP00000071147
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl52,528,921 - 2,787,149 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000083688   ⟹   ENSSSCP00000060649
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl52,528,921 - 2,787,304 (-)Ensembl
RefSeq Acc Id: XM_021091361   ⟹   XP_020947020
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.152,528,920 - 2,787,313 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020947020   ⟸   XM_021091361
- UniProtKB: F1RYI5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000001022   ⟸   ENSSSCT00000001044
RefSeq Acc Id: ENSSSCP00000060649   ⟸   ENSSSCT00000083688
RefSeq Acc Id: ENSSSCP00000071147   ⟸   ENSSSCT00000079994
Protein Domains
Rab-GAP TBC


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000000955 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015014361 UniProtKB/TrEMBL
  ENSSSCG00025039818 UniProtKB/TrEMBL
  ENSSSCG00030061574 UniProtKB/TrEMBL
  ENSSSCG00035041284 UniProtKB/TrEMBL
  ENSSSCG00045020106 UniProtKB/TrEMBL
  ENSSSCG00050038956 UniProtKB/TrEMBL
  ENSSSCG00055020824 UniProtKB/TrEMBL
  ENSSSCG00060016807 UniProtKB/TrEMBL
  ENSSSCG00065063075 UniProtKB/TrEMBL
  ENSSSCG00070029030 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000001044 ENTREZGENE
  ENSSSCT00000001044.4 UniProtKB/TrEMBL
  ENSSSCT00000079994.1 UniProtKB/TrEMBL
  ENSSSCT00000083688.1 UniProtKB/TrEMBL
  ENSSSCT00015019268.1 UniProtKB/TrEMBL
  ENSSSCT00015019288.1 UniProtKB/TrEMBL
  ENSSSCT00015019352.1 UniProtKB/TrEMBL
  ENSSSCT00025054099.1 UniProtKB/TrEMBL
  ENSSSCT00025054305.1 UniProtKB/TrEMBL
  ENSSSCT00025054599.1 UniProtKB/TrEMBL
  ENSSSCT00030086211.1 UniProtKB/TrEMBL
  ENSSSCT00030086267.1 UniProtKB/TrEMBL
  ENSSSCT00030086319.1 UniProtKB/TrEMBL
  ENSSSCT00030086367.1 UniProtKB/TrEMBL
  ENSSSCT00030086401.1 UniProtKB/TrEMBL
  ENSSSCT00030086437.1 UniProtKB/TrEMBL
  ENSSSCT00030086511.1 UniProtKB/TrEMBL
  ENSSSCT00035054849.1 UniProtKB/TrEMBL
  ENSSSCT00035054870.1 UniProtKB/TrEMBL
  ENSSSCT00045034621.1 UniProtKB/TrEMBL
  ENSSSCT00045034806.1 UniProtKB/TrEMBL
  ENSSSCT00045034908.1 UniProtKB/TrEMBL
  ENSSSCT00045035066.1 UniProtKB/TrEMBL
  ENSSSCT00045035157.1 UniProtKB/TrEMBL
  ENSSSCT00045035241.1 UniProtKB/TrEMBL
  ENSSSCT00045035349.1 UniProtKB/TrEMBL
  ENSSSCT00050052539.1 UniProtKB/TrEMBL
  ENSSSCT00050052546.1 UniProtKB/TrEMBL
  ENSSSCT00050052569.1 UniProtKB/TrEMBL
  ENSSSCT00055040816.1 UniProtKB/TrEMBL
  ENSSSCT00055041022.1 UniProtKB/TrEMBL
  ENSSSCT00060022453.1 UniProtKB/TrEMBL
  ENSSSCT00060022461.1 UniProtKB/TrEMBL
  ENSSSCT00060022465.1 UniProtKB/TrEMBL
  ENSSSCT00060022470.1 UniProtKB/TrEMBL
  ENSSSCT00060022471.1 UniProtKB/TrEMBL
  ENSSSCT00060022479.1 UniProtKB/TrEMBL
  ENSSSCT00060022484.1 UniProtKB/TrEMBL
  ENSSSCT00065086518.1 UniProtKB/TrEMBL
  ENSSSCT00065086535.1 UniProtKB/TrEMBL
  ENSSSCT00070058221.1 UniProtKB/TrEMBL
  ENSSSCT00070058285.1 UniProtKB/TrEMBL
  ENSSSCT00070058287.1 UniProtKB/TrEMBL
  ENSSSCT00070058289.1 UniProtKB/TrEMBL
Gene3D-CATH putative rabgap domain of human tbc1 domain family member 14 like domains UniProtKB/TrEMBL
  Ypt/Rab-GAP domain of gyp1p, domain 3 UniProtKB/TrEMBL
InterPro Rab-GTPase-TBC_dom UniProtKB/TrEMBL
  Rab-GTPase_TBC_sf UniProtKB/TrEMBL
NCBI Gene TBC1D22A ENTREZGENE
PANTHER TBC1 DOMAIN FAMILY MEMBER 22A UniProtKB/TrEMBL
  TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN UniProtKB/TrEMBL
Pfam RabGAP-TBC UniProtKB/TrEMBL
PROSITE TBC_RABGAP UniProtKB/TrEMBL
SMART TBC UniProtKB/TrEMBL
Superfamily-SCOP SSF47923 UniProtKB/TrEMBL
UniProt A0A4X1W079_PIG UniProtKB/TrEMBL
  A0A4X1W698_PIG UniProtKB/TrEMBL
  A0A4X1W786_PIG UniProtKB/TrEMBL
  A0A4X1W7E5_PIG UniProtKB/TrEMBL
  A0A5G2QQU2_PIG UniProtKB/TrEMBL
  A0A5G2RI37_PIG UniProtKB/TrEMBL
  A0A8D0XTL0_PIG UniProtKB/TrEMBL
  A0A8D1CEW0_PIG UniProtKB/TrEMBL
  A0A8D1I338_PIG UniProtKB/TrEMBL
  A0A8D1MG09_PIG UniProtKB/TrEMBL
  F1RYI5 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:93770 ENTREZGENE