HES4 (hes family bHLH transcription factor 4) - Rat Genome Database

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Gene: HES4 (hes family bHLH transcription factor 4) Sus scrofa
Analyze
Symbol: HES4
Name: hes family bHLH transcription factor 4
RGD ID: 14010317
Description: ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); protein dimerization activity (inferred); INVOLVED IN anterior/posterior pattern specification (inferred); regulation of DNA-templated transcription (inferred); regulation of neurogenesis (inferred); ASSOCIATED WITH chromosome 1p36 deletion syndrome (ortholog); Ehlers-Danlos syndrome spondylodysplastic type 2 (ortholog); genetic disease (ortholog); FOUND IN nucleus (inferred); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: transcription factor HES-4
RGD Orthologs
Human
Bonobo
Dog
Squirrel
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl663,351,602 - 63,356,466 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1663,351,593 - 63,356,690 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2657,945,481 - 57,947,004 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IBA,IEA)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
HES4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl663,351,602 - 63,356,466 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1663,351,593 - 63,356,690 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2657,945,481 - 57,947,004 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HES4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381998,964 - 1,000,097 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1998,962 - 1,000,172 (-)EnsemblGRCh38hg38GRCh38
GRCh371934,344 - 935,477 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361924,207 - 925,333 (-)NCBINCBI36Build 36hg18NCBI36
Build 341974,411 - 975,537NCBI
Celera11,654,697 - 1,655,907 (+)NCBICelera
Cytogenetic Map1p36.33NCBI
HuRef1205,850 - 207,060 (-)NCBIHuRef
CHM1_11921,200 - 922,410 (-)NCBICHM1_1
T2T-CHM13v2.01429,119 - 430,252 (-)NCBIT2T-CHM13v2.0
HES4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21227,270,295 - 227,271,341 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11225,966,912 - 225,967,958 (+)NCBINHGRI_mPanPan1
HES4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1556,221,509 - 56,226,938 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl556,225,497 - 56,226,772 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha556,299,569 - 56,304,879 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0556,425,073 - 56,430,382 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl556,426,788 - 56,430,438 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1556,416,121 - 56,421,431 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0556,308,024 - 56,313,332 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0556,698,073 - 56,703,383 (-)NCBIUU_Cfam_GSD_1.0
Hes4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505827,401,708 - 27,414,167 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049367372,054,879 - 2,056,126 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HES4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120130,433,355 - 130,438,589 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20130,435,291 - 130,436,213 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605435,060,767 - 35,065,995 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in HES4
62 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1
Low 9 4 3 4 2 23 2 2 1
Below cutoff 1 1 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000060433   ⟹   ENSSSCP00000046780
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl663,351,602 - 63,356,466 (-)Ensembl
RefSeq Acc Id: XM_003481929   ⟹   XP_003481977
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1663,351,593 - 63,356,690 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_003481977   ⟸   XM_003481929
- UniProtKB: A0A287AS85 (UniProtKB/TrEMBL),   A0A8D1BYK8 (UniProtKB/TrEMBL),   A0A8D1AT65 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000046780   ⟸   ENSSSCT00000060433
Protein Domains
bHLH   Orange


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000035420 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025069744 UniProtKB/TrEMBL
  ENSSSCG00030009264 UniProtKB/TrEMBL
  ENSSSCG00035062351 UniProtKB/TrEMBL
  ENSSSCG00040004909 UniProtKB/TrEMBL
  ENSSSCG00045039159 UniProtKB/TrEMBL
  ENSSSCG00050023098 UniProtKB/TrEMBL
  ENSSSCG00055014858 UniProtKB/TrEMBL
  ENSSSCG00060042688 UniProtKB/TrEMBL
  ENSSSCG00065072535 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000060433 ENTREZGENE
  ENSSSCT00000060433.2 UniProtKB/TrEMBL
  ENSSSCT00025095786.1 UniProtKB/TrEMBL
  ENSSSCT00030012645.1 UniProtKB/TrEMBL
  ENSSSCT00035083799.1 UniProtKB/TrEMBL
  ENSSSCT00040006525.1 UniProtKB/TrEMBL
  ENSSSCT00045068084.1 UniProtKB/TrEMBL
  ENSSSCT00050031173.1 UniProtKB/TrEMBL
  ENSSSCT00055029263.1 UniProtKB/TrEMBL
  ENSSSCT00060057878.1 UniProtKB/TrEMBL
  ENSSSCT00065099698.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/TrEMBL
  6.10.250.980 UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/TrEMBL
  Orange_dom UniProtKB/TrEMBL
KEGG Report ssc:100739264 UniProtKB/TrEMBL
NCBI Gene HES4 ENTREZGENE
PANTHER BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED UniProtKB/TrEMBL
  TRANSCRIPTION FACTOR HES-4 UniProtKB/TrEMBL
Pfam Hairy_orange UniProtKB/TrEMBL
  HLH UniProtKB/TrEMBL
PROSITE BHLH UniProtKB/TrEMBL
  ORANGE UniProtKB/TrEMBL
SMART HLH UniProtKB/TrEMBL
  ORANGE UniProtKB/TrEMBL
Superfamily-SCOP Orange domain-like UniProtKB/TrEMBL
  SSF47459 UniProtKB/TrEMBL
UniProt A0A287AS85 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1AT65 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1BYK8 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:88857 ENTREZGENE