PIP4K2A (phosphatidylinositol-5-phosphate 4-kinase type 2 alpha) - Rat Genome Database
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Gene: PIP4K2A (phosphatidylinositol-5-phosphate 4-kinase type 2 alpha) Sus scrofa
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Symbol: PIP4K2A
Name: phosphatidylinositol-5-phosphate 4-kinase type 2 alpha
RGD ID: 14008977
Description: ENCODES a protein that exhibits 1-phosphatidylinositol-4-phosphate 5-kinase activity (ortholog); protein homodimerization activity (ortholog); INVOLVED IN 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process (ortholog); autophagosome-lysosome fusion (ortholog); megakaryocyte development (ortholog); PARTICIPATES IN phosphoinositide metabolic pathway; ASSOCIATED WITH melanoma (ortholog); FOUND IN lysosome (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha; diphosphoinositide kinase 2-alpha; phosphatidylinositol 5-phosphate 4-kinase type II alpha; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha; phosphatidylinositol-4-phosphate-5-kinase; PI(5)P 4-kinase type II alpha; PIP4KII-alpha; ptdIns(5)P-4-kinase isoform 2-alpha
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1052,223,425 - 52,408,922 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11052,224,367 - 52,408,928 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21057,880,198 - 58,064,685 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
melanoma  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:12226715   PMID:14681463   PMID:17145712   PMID:17407547  


Genomics

Comparative Map Data
PIP4K2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1052,223,425 - 52,408,922 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11052,224,367 - 52,408,928 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21057,880,198 - 58,064,685 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PIP4K2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1022,534,854 - 22,714,578 (-)EnsemblGRCh38hg38GRCh38
GRCh381022,534,854 - 22,714,578 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371022,823,783 - 23,003,507 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361022,863,772 - 23,043,509 (-)NCBINCBI36hg18NCBI36
Build 341022,865,828 - 23,043,490NCBI
Celera1022,511,468 - 22,691,158 (-)NCBI
Cytogenetic Map10p12.2NCBI
HuRef1022,484,658 - 22,664,398 (-)NCBIHuRef
CHM1_11022,824,227 - 23,003,964 (-)NCBICHM1_1
Pip4k2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39218,847,066 - 19,003,101 (-)NCBIGRCm39mm39
GRCm39 Ensembl218,847,066 - 19,002,937 (-)Ensembl
GRCm38218,842,255 - 18,998,291 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl218,842,255 - 18,998,126 (-)EnsemblGRCm38mm10GRCm38
MGSCv37218,763,883 - 18,919,748 (-)NCBIGRCm37mm9NCBIm37
MGSCv36218,760,014 - 18,915,870 (-)NCBImm8
Celera218,734,163 - 18,892,750 (-)NCBICelera
Cytogenetic Map2A3NCBI
Pip4k2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21781,496,669 - 81,668,180 (-)NCBI
Rnor_6.01785,533,056 - 85,748,843 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01787,260,013 - 87,284,895 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01787,360,739 - 87,463,987 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41792,950,531 - 93,111,944 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11792,963,045 - 93,122,777NCBI
Celera1780,777,213 - 80,940,203 (-)NCBICelera
Cytogenetic Map17q12.3NCBI
Pip4k2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554296,336,355 - 6,399,672 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554296,231,135 - 6,399,672 (+)NCBIChiLan1.0ChiLan1.0
PIP4K2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11023,066,771 - 23,141,230 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01022,691,355 - 22,870,628 (-)NCBIMhudiblu_PPA_v0panPan3
PIP4K2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl210,463,010 - 10,640,327 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1210,464,019 - 10,642,365 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Pip4k2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365205,383,737 - 5,540,176 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIP4K2A
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1922,306,307 - 22,482,074 (-)NCBI
ChlSab1.1 Ensembl922,306,312 - 22,481,954 (-)Ensembl
Pip4k2a
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247965,963,005 - 6,113,081 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 2 5 20 3 3
Low 2 3 2 3 2
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001195781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013980256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013980257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002336109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002336110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002336111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AEMK02000074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK236956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK237654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK239452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK390658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW354834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP159408 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX917527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ019726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU463173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB786847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EW419242 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EW428145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FD636809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FS668037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GFLN01088893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U96135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSSCT00000012125   ⟹   ENSSSCP00000011817
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1052,223,425 - 52,408,922 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000012126   ⟹   ENSSSCP00000011818
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1052,224,398 - 52,408,273 (+)Ensembl
RefSeq Acc Id: NM_001195781   ⟹   NP_001182710
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11052,224,533 - 52,408,928 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013980256   ⟹   XP_013835710
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11052,291,868 - 52,408,928 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013980257   ⟹   XP_013835711
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11052,224,367 - 52,408,928 (+)NCBI
Sequence:
RefSeq Acc Id: XR_002336109
RefSeq Status:
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11052,224,367 - 52,408,928 (+)NCBI
Sequence:
RefSeq Acc Id: XR_002336110
RefSeq Status:
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11052,224,367 - 52,408,928 (+)NCBI
Sequence:
RefSeq Acc Id: XR_002336111
RefSeq Status:
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11052,341,205 - 52,408,928 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001182710 (Get FASTA)   NCBI Sequence Viewer  
  XP_013835710 (Get FASTA)   NCBI Sequence Viewer  
  XP_013835711 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB53645 (Get FASTA)   NCBI Sequence Viewer  
  O13010 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_013835711   ⟸   XM_013980257
- Peptide Label: isoform X2
- UniProtKB: F1RVI4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001182710   ⟸   NM_001195781
- UniProtKB: O13010 (UniProtKB/Swiss-Prot),   F1RVI6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013835710   ⟸   XM_013980256
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSSSCP00000011817   ⟸   ENSSSCT00000012125
RefSeq Acc Id: ENSSSCP00000011818   ⟸   ENSSSCT00000012126
Protein Domains
PIPK


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000011079 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070012177 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000011817 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000011818 UniProtKB/TrEMBL
  ENSSSCP00070019694 UniProtKB/TrEMBL
  ENSSSCP00070019704 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000012125 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000012126 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070023818 UniProtKB/TrEMBL
  ENSSSCT00070023831 UniProtKB/TrEMBL
Gene3D-CATH 3.30.800.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.810.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro PInositol-4-P-5-kinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PInositol-4-P-5-kinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PInositol-4-P-5-kinase_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PInositol-4-P-5-kinase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:100520446 UniProtKB/Swiss-Prot
NCBI Gene PIP4K2A ENTREZGENE
PANTHER PTHR23086 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PIP5K UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PIPK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PIPKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A4X1TW84_PIG UniProtKB/TrEMBL
  A0A4X1TWC4_PIG UniProtKB/TrEMBL
  F1RVI4 ENTREZGENE, UniProtKB/TrEMBL
  F1RVI6 ENTREZGENE, UniProtKB/TrEMBL
  O13010 ENTREZGENE, UniProtKB/Swiss-Prot
VGNC ID VGNC:96485 ENTREZGENE