TTK (TTK protein kinase) - Rat Genome Database

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Gene: TTK (TTK protein kinase) Sus scrofa
Analyze
Symbol: TTK
Name: TTK protein kinase
RGD ID: 14007559
Description: ENCODES a protein that exhibits ATP binding (inferred); identical protein binding (inferred); kinetochore binding (inferred); INVOLVED IN female meiosis chromosome segregation (ortholog); meiotic spindle assembly checkpoint signaling (ortholog); peptidyl-serine phosphorylation (ortholog); ASSOCIATED WITH COVID-19 (ortholog); hepatocellular carcinoma (ortholog); Pancreatic Neoplasms (ortholog); FOUND IN cytoplasm (inferred); kinetochore (inferred)
Type: protein-coding
RefSeq Status: MODEL
Also known as: dual specificity protein kinase TTK
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl186,076,583 - 86,125,718 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1186,076,576 - 86,125,334 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2196,781,685 - 96,828,277 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
kinetochore  (IBA,IEA)
nucleus  (IBA)
spindle  (IBA)

Molecular Function

References
Additional References at PubMed
PMID:14681463  


Genomics

Comparative Map Data
TTK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl186,076,583 - 86,125,718 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1186,076,576 - 86,125,334 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2196,781,685 - 96,828,277 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TTK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl680,003,887 - 80,042,527 (+)EnsemblGRCh38hg38GRCh38
GRCh38680,004,147 - 80,042,651 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37680,714,366 - 80,752,244 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36680,771,078 - 80,808,958 (+)NCBINCBI36hg18NCBI36
Build 34680,771,077 - 80,808,956NCBI
Celera681,132,293 - 81,170,226 (+)NCBI
Cytogenetic Map6q14.1NCBI
HuRef677,937,044 - 77,974,979 (+)NCBIHuRef
CHM1_1680,811,776 - 80,849,705 (+)NCBICHM1_1
Ttk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39983,716,704 - 83,754,443 (+)NCBIGRCm39mm39
GRCm39 Ensembl983,716,742 - 83,754,442 (+)Ensembl
GRCm38983,834,651 - 83,872,390 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl983,834,689 - 83,872,389 (+)EnsemblGRCm38mm10GRCm38
MGSCv37983,728,296 - 83,765,997 (+)NCBIGRCm37mm9NCBIm37
MGSCv36983,631,459 - 83,669,102 (+)NCBImm8
Celera980,934,680 - 80,972,688 (+)NCBICelera
Cytogenetic Map9E2NCBI
Ttk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2884,754,329 - 84,792,653 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl884,754,315 - 84,792,651 (+)Ensembl
Rnor_6.0891,368,065 - 91,405,995 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl891,368,111 - 91,405,993 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0890,886,724 - 90,924,327 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4888,906,665 - 88,944,613 (+)NCBIRGSC3.4rn4RGSC3.4
Celera884,402,963 - 84,441,218 (+)NCBICelera
Cytogenetic Map8q31NCBI
Ttk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555027,824,194 - 7,866,879 (+)NCBIChiLan1.0ChiLan1.0
TTK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1681,158,143 - 81,196,478 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl681,158,143 - 81,196,478 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0677,887,382 - 77,925,737 (+)NCBIMhudiblu_PPA_v0panPan3
TTK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11240,915,733 - 40,959,423 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1240,915,439 - 40,957,279 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1240,787,409 - 40,829,802 (+)NCBI
ROS_Cfam_1.01241,678,975 - 41,721,444 (+)NCBI
UMICH_Zoey_3.11240,992,362 - 41,034,814 (+)NCBI
UNSW_CanFamBas_1.01240,969,244 - 41,011,626 (+)NCBI
UU_Cfam_GSD_1.01241,120,015 - 41,162,453 (+)NCBI
Ttk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494676,256,203 - 76,303,738 (+)NCBI
SpeTri2.0NW_00493651010,176,968 - 10,213,483 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TTK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1134,738,849 - 4,779,563 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl134,738,959 - 4,780,627 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666040180,959,238 - 181,026,938 (+)NCBIVero_WHO_p1.0
Ttk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248196,631,697 - 6,682,181 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 10 2 1 5 5 2 3
Below cutoff 2 2 2 18 2 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000004933   ⟹   ENSSSCP00000004816
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl186,076,583 - 86,125,291 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000037594   ⟹   ENSSSCP00000033728
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl186,076,583 - 86,125,199 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000081646   ⟹   ENSSSCP00000061387
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl186,077,301 - 86,125,202 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000084805   ⟹   ENSSSCP00000068925
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl186,077,299 - 86,125,718 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000090650   ⟹   ENSSSCP00000069910
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl186,121,045 - 86,124,068 (-)Ensembl
RefSeq Acc Id: XM_021092051   ⟹   XP_020947710
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1186,076,576 - 86,125,265 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021092055   ⟹   XP_020947714
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1186,076,576 - 86,125,237 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021092059   ⟹   XP_020947718
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1186,076,576 - 86,125,237 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021092069   ⟹   XP_020947728
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1186,076,576 - 86,125,334 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021092077   ⟹   XP_020947736
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1186,076,576 - 86,125,237 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_020947728   ⟸   XM_021092069
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020947710   ⟸   XM_021092051
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020947714   ⟸   XM_021092055
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020947736   ⟸   XM_021092077
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_020947718   ⟸   XM_021092059
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSSSCP00000069910   ⟸   ENSSSCT00000090650
RefSeq Acc Id: ENSSSCP00000068925   ⟸   ENSSSCT00000084805
RefSeq Acc Id: ENSSSCP00000033728   ⟸   ENSSSCT00000037594
RefSeq Acc Id: ENSSSCP00000061387   ⟸   ENSSSCT00000081646
RefSeq Acc Id: ENSSSCP00000004816   ⟸   ENSSSCT00000004933
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000004466 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070021279 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000004816 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000033728 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000061387 UniProtKB/TrEMBL
  ENSSSCP00000068925 UniProtKB/TrEMBL
  ENSSSCP00000069910 UniProtKB/TrEMBL
  ENSSSCP00070035606 UniProtKB/TrEMBL
  ENSSSCP00070035608 UniProtKB/TrEMBL
  ENSSSCP00070035611 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000004933 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000037594 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000081646 UniProtKB/TrEMBL
  ENSSSCT00000084805 UniProtKB/TrEMBL
  ENSSSCT00000090650 UniProtKB/TrEMBL
  ENSSSCT00070042352 UniProtKB/TrEMBL
  ENSSSCT00070042354 UniProtKB/TrEMBL
  ENSSSCT00070042357 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.10 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kin_Mps1_fam UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  TPR-like_helical_dom_sf UniProtKB/TrEMBL
NCBI Gene TTK ENTREZGENE
PANTHER PTHR22974:SF21 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF48452 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A286ZQJ7_PIG UniProtKB/TrEMBL
  A0A4X1UZ17_PIG UniProtKB/TrEMBL
  A0A4X1V396_PIG UniProtKB/TrEMBL
  A0A4X1V4B2_PIG UniProtKB/TrEMBL
  A0A5G2QAH1_PIG UniProtKB/TrEMBL
  A0A5G2QVM7_PIG UniProtKB/TrEMBL
  A0A5G2R0J7_PIG UniProtKB/TrEMBL
  F1RQL2_PIG UniProtKB/TrEMBL
VGNC ID VGNC:94565 ENTREZGENE