RPS6KA1 (ribosomal protein S6 kinase A1) - Rat Genome Database

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Gene: RPS6KA1 (ribosomal protein S6 kinase A1) Sus scrofa
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Symbol: RPS6KA1
Name: ribosomal protein S6 kinase A1
RGD ID: 14001092
Description: ENCODES a protein that exhibits kinase activity (ortholog); transcription factor binding (ortholog); INVOLVED IN hepatocyte proliferation (ortholog); negative regulation of apoptotic process (ortholog); positive regulation of transcription, DNA-templated (ortholog); PARTICIPATES IN adenosine signaling pathway; fibroblast growth factor signaling pathway; mTOR signaling pathway; ASSOCIATED WITH fetal alcohol spectrum disorder (ortholog); Sezary's disease (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog); spindle (ortholog); INTERACTS WITH anthra[1,9-cd]pyrazol-6(2H)-one; ivermectin; sodium arsenite
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ribosomal protein S6 kinase alpha-1; ribosomal protein S6 kinase, 90kDa, polypeptide 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl683,905,076 - 83,950,984 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1683,905,124 - 83,947,189 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2677,443,084 - 77,480,448 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:17145712  


Genomics

Comparative Map Data
RPS6KA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl683,905,076 - 83,950,984 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1683,905,124 - 83,947,189 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2677,443,084 - 77,480,448 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RPS6KA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl126,529,761 - 26,575,030 (+)EnsemblGRCh38hg38GRCh38
GRCh38126,529,761 - 26,575,028 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37126,856,252 - 26,901,516 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36126,728,836 - 26,774,107 (+)NCBINCBI36hg18NCBI36
Build 34126,540,390 - 26,585,662NCBI
Celera125,253,435 - 25,298,712 (+)NCBI
Cytogenetic Map1p36.11NCBI
HuRef125,110,498 - 25,155,787 (+)NCBIHuRef
CHM1_1126,969,231 - 27,014,507 (+)NCBICHM1_1
Rps6ka1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394133,574,601 - 133,615,466 (-)NCBIGRCm39mm39
GRCm39 Ensembl4133,574,601 - 133,615,108 (-)Ensembl
GRCm384133,847,290 - 133,887,797 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4133,847,290 - 133,887,797 (-)EnsemblGRCm38mm10GRCm38
MGSCv374133,403,205 - 133,443,714 (-)NCBIGRCm37mm9NCBIm37
MGSCv364133,119,370 - 133,159,860 (-)NCBImm8
Celera4132,018,889 - 132,060,783 (-)NCBICelera
Cytogenetic Map4D2.3NCBI
Rps6ka1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25146,079,018 - 146,118,272 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl5146,079,021 - 146,118,272 (-)Ensembl
Rnor_6.05152,078,217 - 152,122,684 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5152,078,220 - 152,122,684 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05155,760,609 - 155,805,563 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45151,274,666 - 151,288,007 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15151,284,704 - 151,298,043 (+)NCBI
Celera5144,500,101 - 144,539,235 (-)NCBICelera
Cytogenetic Map5q36NCBI
Rps6ka1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554525,904,762 - 5,939,091 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554525,905,561 - 5,938,096 (+)NCBIChiLan1.0ChiLan1.0
RPS6KA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1126,856,061 - 26,900,532 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl126,856,057 - 26,900,532 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0125,792,428 - 25,837,950 (+)NCBIMhudiblu_PPA_v0panPan3
RPS6KA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1273,497,128 - 73,533,853 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl273,497,473 - 73,534,378 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha270,074,045 - 70,110,763 (-)NCBI
ROS_Cfam_1.0274,060,131 - 74,097,008 (-)NCBI
UMICH_Zoey_3.1270,884,942 - 70,921,656 (-)NCBI
UNSW_CanFamBas_1.0271,890,665 - 71,927,571 (-)NCBI
UU_Cfam_GSD_1.0272,894,123 - 72,930,845 (-)NCBI
Rps6ka1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505845,171,987 - 45,205,720 (+)NCBI
SpeTri2.0NW_00493647410,996,867 - 11,030,504 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RPS6KA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120106,180,708 - 106,226,636 (-)NCBI
ChlSab1.1 Ensembl20106,180,418 - 106,226,552 (-)Ensembl
Vero_WHO_p1.0NW_02366603310,197,449 - 10,243,985 (+)NCBI
Rps6ka1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476410,527,012 - 10,566,625 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 8 2 5 2 1 3
Low 2 2 3 2 21 2 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000003952   ⟹   ENSSSCP00000003861
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl683,905,077 - 83,947,185 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000042826   ⟹   ENSSSCP00000033010
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl683,905,076 - 83,947,185 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000044862   ⟹   ENSSSCP00000055482
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl683,917,861 - 83,947,181 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000045657   ⟹   ENSSSCP00000043988
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl683,905,120 - 83,947,151 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000089337   ⟹   ENSSSCP00000068175
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl683,919,937 - 83,950,984 (+)Ensembl
RefSeq Acc Id: NM_001243214   ⟹   NP_001230143
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1683,905,124 - 83,947,189 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021093347   ⟹   XP_020949006
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1683,917,157 - 83,947,189 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021093348   ⟹   XP_020949007
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1683,919,820 - 83,947,189 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001230143 (Get FASTA)   NCBI Sequence Viewer  
  XP_020949006 (Get FASTA)   NCBI Sequence Viewer  
  XP_020949007 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001230143   ⟸   NM_001243214
- Sequence:
RefSeq Acc Id: XP_020949006   ⟸   XM_021093347
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020949007   ⟸   XM_021093348
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSSSCP00000055482   ⟸   ENSSSCT00000044862
RefSeq Acc Id: ENSSSCP00000068175   ⟸   ENSSSCT00000089337
RefSeq Acc Id: ENSSSCP00000043988   ⟸   ENSSSCT00000045657
RefSeq Acc Id: ENSSSCP00000033010   ⟸   ENSSSCT00000042826
RefSeq Acc Id: ENSSSCP00000003861   ⟸   ENSSSCT00000003952

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000003558 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070022299 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000003861 UniProtKB/TrEMBL
  ENSSSCP00000033010 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000043988 UniProtKB/TrEMBL
  ENSSSCP00000055482 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000068175 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070042082 UniProtKB/TrEMBL
  ENSSSCP00070042126 UniProtKB/TrEMBL
  ENSSSCP00070042171 UniProtKB/TrEMBL
  ENSSSCP00070042299 UniProtKB/TrEMBL
  ENSSSCP00070042318 UniProtKB/TrEMBL
  ENSSSCP00070042342 UniProtKB/TrEMBL
  ENSSSCP00070042386 UniProtKB/TrEMBL
  ENSSSCP00070042435 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000003952 UniProtKB/TrEMBL
  ENSSSCT00000042826 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000044862 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000045657 UniProtKB/TrEMBL
  ENSSSCT00000089337 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070049829 UniProtKB/TrEMBL
  ENSSSCT00070049877 UniProtKB/TrEMBL
  ENSSSCT00070049927 UniProtKB/TrEMBL
  ENSSSCT00070050070 UniProtKB/TrEMBL
  ENSSSCT00070050092 UniProtKB/TrEMBL
  ENSSSCT00070050120 UniProtKB/TrEMBL
  ENSSSCT00070050167 UniProtKB/TrEMBL
  ENSSSCT00070050220 UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Pkinase_C UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ribosomal_S6_kinase_II UniProtKB/TrEMBL
  RSK_N UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene RPS6KA1 ENTREZGENE
Pfam Pkinase UniProtKB/TrEMBL
  Pkinase_C UniProtKB/TrEMBL
PIRSF Ribsml_S6_kin_2 UniProtKB/TrEMBL
PROSITE AGC_KINASE_CTER UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TK_X UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A286ZNG1_PIG UniProtKB/TrEMBL
  A0A287AJ05_PIG UniProtKB/TrEMBL
  A0A287BHE2_PIG UniProtKB/TrEMBL
  A0A4X1VFJ0_PIG UniProtKB/TrEMBL
  A0A4X1VFN0_PIG UniProtKB/TrEMBL
  A0A4X1VG05_PIG UniProtKB/TrEMBL
  A0A4X1VGD5_PIG UniProtKB/TrEMBL
  A0A4X1VJT1_PIG UniProtKB/TrEMBL
  A0A4X1VKK2_PIG UniProtKB/TrEMBL
  A0A4X1VKP0_PIG UniProtKB/TrEMBL
  A0A4X1VMW9_PIG UniProtKB/TrEMBL
  A0A5G2QVK7_PIG UniProtKB/TrEMBL
  F1STS3_PIG UniProtKB/TrEMBL
VGNC ID VGNC:92440 ENTREZGENE