CDKL3 (cyclin dependent kinase like 3) - Rat Genome Database

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Gene: CDKL3 (cyclin dependent kinase like 3) Sus scrofa
Analyze
Symbol: CDKL3
Name: cyclin dependent kinase like 3
RGD ID: 13996197
Description: ENCODES a protein that exhibits ATP binding (inferred); protein kinase activity (inferred); protein serine/threonine kinase activity (inferred); INVOLVED IN dendrite extension (ortholog); negative regulation of axon extension (ortholog); positive regulation of dendrite morphogenesis (ortholog); ASSOCIATED WITH familial adenomatous polyposis 1 (ortholog); genetic disease (ortholog); Hereditary Neoplastic Syndromes (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cyclin-dependent kinase-like 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2136,590,682 - 136,648,485 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12136,585,248 - 136,648,515 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22142,212,422 - 142,223,609 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
nucleus  (IBA,IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CDKL3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2136,590,682 - 136,648,485 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12136,585,248 - 136,648,515 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22142,212,422 - 142,223,609 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CDKL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385134,283,345 - 134,371,624 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5134,286,350 - 134,371,047 (-)EnsemblGRCh38hg38GRCh38
GRCh375133,634,115 - 133,706,734 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365133,671,591 - 133,730,113 (-)NCBINCBI36Build 36hg18NCBI36
Build 345133,671,590 - 133,730,113NCBI
Celera5129,757,884 - 129,826,544 (-)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5128,818,996 - 128,887,557 (-)NCBIHuRef
CHM1_15133,066,750 - 133,135,396 (-)NCBICHM1_1
T2T-CHM13v2.05134,806,646 - 134,895,410 (-)NCBIT2T-CHM13v2.0
Cdkl3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391151,891,694 - 51,980,605 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1151,895,048 - 51,980,611 (+)EnsemblGRCm39 Ensembl
GRCm381152,000,842 - 52,089,778 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1152,004,221 - 52,089,784 (+)EnsemblGRCm38mm10GRCm38
MGSCv371151,817,723 - 51,898,169 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361151,847,745 - 51,881,588 (+)NCBIMGSCv36mm8
Celera1156,572,516 - 56,652,949 (+)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.85NCBI
Cdkl3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81036,755,413 - 36,850,197 (+)NCBIGRCr8
mRatBN7.21036,263,212 - 36,349,268 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1036,266,977 - 36,349,268 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1040,961,446 - 40,985,530 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01040,451,416 - 40,475,500 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01035,955,138 - 35,979,222 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01037,458,397 - 37,510,345 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1037,458,452 - 37,493,491 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01037,227,962 - 37,315,393 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41037,527,865 - 37,552,851 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1035,621,986 - 35,646,386 (+)NCBICelera
Cytogenetic Map10q22NCBI
Cdkl3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554085,471,700 - 5,552,572 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554085,466,943 - 5,552,572 (-)NCBIChiLan1.0ChiLan1.0
CDKL3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24129,534,851 - 129,669,652 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15127,674,413 - 127,809,214 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05129,701,972 - 129,774,627 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15135,852,296 - 135,925,175 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5135,852,530 - 135,921,269 (-)Ensemblpanpan1.1panPan2
CDKL3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11122,416,098 - 22,524,629 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1122,432,720 - 22,522,050 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1121,161,600 - 21,270,215 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01123,216,801 - 23,326,006 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1123,217,296 - 23,323,427 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11121,916,781 - 22,025,627 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01121,781,996 - 21,891,142 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01122,424,396 - 22,533,353 (-)NCBIUU_Cfam_GSD_1.0
Cdkl3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213113,911,281 - 113,960,296 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936647914,141 - 963,055 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936647914,057 - 961,953 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDKL3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12337,039,133 - 37,176,406 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2337,107,949 - 37,175,449 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603440,752,879 - 40,830,473 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdkl3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473337,910,890 - 37,968,821 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CDKL3
2135 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 2 1 3 4 2 17 2 2 1
Below cutoff 8 3 1 6 1 2

Sequence


RefSeq Acc Id: ENSSSCT00000015625   ⟹   ENSSSCP00000015212
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl2136,590,682 - 136,648,485 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000074517   ⟹   ENSSSCP00000061057
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl2136,590,920 - 136,648,485 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000082061   ⟹   ENSSSCP00000061683
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl2136,584,826 - 136,648,714 (-)Ensembl
RefSeq Acc Id: XM_021084762   ⟹   XP_020940421
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.12136,585,250 - 136,648,515 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021084763   ⟹   XP_020940422
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.12136,585,248 - 136,648,437 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021084764   ⟹   XP_020940423
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.12136,585,248 - 136,648,508 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021084765   ⟹   XP_020940424
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.12136,585,251 - 136,648,515 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021084766   ⟹   XP_020940425
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.12136,587,525 - 136,648,515 (-)NCBI
Sequence:
RefSeq Acc Id: XP_020940423   ⟸   XM_021084764
- Peptide Label: isoform X1
- UniProtKB: A0A4X1UZQ5 (UniProtKB/TrEMBL),   A0A8D1DJC5 (UniProtKB/TrEMBL),   A0A8D1AEL8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020940422   ⟸   XM_021084763
- Peptide Label: isoform X1
- UniProtKB: A0A4X1UZQ5 (UniProtKB/TrEMBL),   A0A8D1DJC5 (UniProtKB/TrEMBL),   A0A8D1AEL8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020940421   ⟸   XM_021084762
- Peptide Label: isoform X1
- UniProtKB: A0A4X1UZQ5 (UniProtKB/TrEMBL),   A0A8D1DJC5 (UniProtKB/TrEMBL),   A0A8D1AEL8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020940424   ⟸   XM_021084765
- Peptide Label: isoform X2
- UniProtKB: A0A5G2QS86 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020940425   ⟸   XM_021084766
- Peptide Label: isoform X3
- UniProtKB: A0A8D0S8S8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000015212   ⟸   ENSSSCT00000015625
RefSeq Acc Id: ENSSSCP00000061057   ⟸   ENSSSCT00000074517
RefSeq Acc Id: ENSSSCP00000061683   ⟸   ENSSSCT00000082061
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000014302 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005028712 UniProtKB/TrEMBL
  ENSSSCG00025048895 UniProtKB/TrEMBL
  ENSSSCG00035052733 UniProtKB/TrEMBL
  ENSSSCG00040013636 UniProtKB/TrEMBL
  ENSSSCG00070020522 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000015625.5 UniProtKB/TrEMBL
  ENSSSCT00000074517 ENTREZGENE
  ENSSSCT00000074517.2 UniProtKB/TrEMBL
  ENSSSCT00005045496.1 UniProtKB/TrEMBL
  ENSSSCT00025066565.1 UniProtKB/TrEMBL
  ENSSSCT00035070299.1 UniProtKB/TrEMBL
  ENSSSCT00040018164.1 UniProtKB/TrEMBL
  ENSSSCT00070040792.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene CDKL3 ENTREZGENE
PANTHER CELL DIVISION PROTEIN KINASE UniProtKB/TrEMBL
  CYCLIN-DEPENDENT KINASE-LIKE 3 UniProtKB/TrEMBL
  MITOGEN-ACTIVATED PROTEIN KINASE UniProtKB/TrEMBL
  OS02G0492300 PROTEIN UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A4X1UZQ5 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2QS86 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0S8S8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1AEL8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1DJC5 ENTREZGENE, UniProtKB/TrEMBL
  F1RHD0_PIG UniProtKB/TrEMBL
VGNC ID VGNC:86512 ENTREZGENE