ADAM12 (ADAM metallopeptidase domain 12) - Rat Genome Database

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Gene: ADAM12 (ADAM metallopeptidase domain 12) Sus scrofa
Analyze
Symbol: ADAM12
Name: ADAM metallopeptidase domain 12
RGD ID: 13990380
Description: ENCODES a protein that exhibits SH3 domain binding (ortholog); INVOLVED IN positive regulation of angiogenesis (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; Notch signaling pathway; syndecan signaling pathway; ASSOCIATED WITH distal 10q deletion syndrome (ortholog); genetic disease (ortholog); osteoarthritis (ortholog); FOUND IN membrane (inferred); nucleoplasm (inferred); plasma membrane (inferred); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: disintegrin and metalloproteinase domain-containing protein 12
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14135,302,813 - 135,682,159 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114135,302,188 - 135,682,144 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214146,932,579 - 147,045,417 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
ADAM12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14135,302,813 - 135,682,159 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114135,302,188 - 135,682,144 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214146,932,579 - 147,045,417 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADAM12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810126,012,391 - 126,388,477 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10126,012,381 - 126,388,477 (-)EnsemblGRCh38hg38GRCh38
GRCh3710127,700,960 - 128,077,046 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610127,693,415 - 128,067,055 (-)NCBINCBI36Build 36hg18NCBI36
Build 3410127,719,903 - 128,067,014NCBI
Celera10121,478,343 - 121,851,743 (-)NCBICelera
Cytogenetic Map10q26.2NCBI
HuRef10121,392,073 - 121,764,737 (-)NCBIHuRef
CHM1_110127,984,707 - 128,358,883 (-)NCBICHM1_1
T2T-CHM13v2.010126,894,888 - 127,270,982 (-)NCBIT2T-CHM13v2.0
Adam12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397133,484,928 - 133,826,859 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7133,484,928 - 133,833,875 (-)EnsemblGRCm39 Ensembl
GRCm387133,883,199 - 134,225,097 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7133,883,199 - 134,232,146 (-)EnsemblGRCm38mm10GRCm38
MGSCv377141,074,882 - 141,416,780 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367133,722,315 - 134,063,440 (-)NCBIMGSCv36mm8
Celera7133,687,776 - 134,032,137 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map777.61NCBI
Adam12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81198,116,968 - 198,443,680 (-)NCBIGRCr8
mRatBN7.21188,686,984 - 189,014,206 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1188,686,989 - 189,020,667 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01205,951,840 - 206,286,294 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1205,956,342 - 206,282,575 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01212,899,587 - 213,227,846 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41193,384,457 - 193,650,892 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11193,533,921 - 193,999,142 (-)NCBI
Celera1186,424,760 - 186,758,584 (-)NCBICelera
Cytogenetic Map1q41NCBI
Adam12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554773,922,644 - 4,263,296 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554773,917,637 - 4,263,529 (-)NCBIChiLan1.0ChiLan1.0
ADAM12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28137,873,308 - 138,248,641 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110137,878,657 - 138,253,774 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010122,583,989 - 122,958,895 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110126,847,555 - 127,165,887 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10126,852,441 - 127,165,048 (-)Ensemblpanpan1.1panPan2
ADAM12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12835,154,899 - 35,484,852 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2835,158,126 - 35,485,573 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2835,213,245 - 35,542,024 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02835,712,857 - 36,042,749 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2835,717,643 - 36,042,829 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12835,266,353 - 35,595,299 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02835,256,524 - 35,591,575 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02835,517,721 - 35,847,105 (-)NCBIUU_Cfam_GSD_1.0
Adam12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721311,501,260 - 11,602,871 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648613,963,091 - 14,279,796 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648613,963,000 - 14,189,948 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAM12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19118,641,551 - 119,014,280 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9118,646,539 - 118,749,351 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604880,005,529 - 80,378,803 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adam12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473720,650,427 - 21,065,944 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473720,650,365 - 21,107,171 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ADAM12
17557 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 9 2 3 5 2 22 2 3 1
Below cutoff 1 2 1

Sequence


RefSeq Acc Id: ENSSSCT00000011758   ⟹   ENSSSCP00000011456
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl14135,302,813 - 135,682,159 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000042367   ⟹   ENSSSCP00000043168
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl14135,302,810 - 135,672,926 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000074893   ⟹   ENSSSCP00000073124
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl14135,302,814 - 135,680,389 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000081949   ⟹   ENSSSCP00000062895
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl14135,302,814 - 135,607,584 (-)Ensembl
RefSeq Acc Id: XM_021072591   ⟹   XP_020928250
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.114135,309,796 - 135,680,427 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021072592   ⟹   XP_020928251
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.114135,309,797 - 135,682,144 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021072593   ⟹   XP_020928252
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.114135,302,188 - 135,680,419 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021072594   ⟹   XP_020928253
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.114135,309,797 - 135,412,972 (-)NCBI
Sequence:
RefSeq Acc Id: XP_020928252   ⟸   XM_021072593
- Peptide Label: isoform X3
- UniProtKB: A0A480LRC7 (UniProtKB/TrEMBL),   A0A8D2A510 (UniProtKB/TrEMBL),   A0A480K8Z8 (UniProtKB/TrEMBL),   A0A8D0W629 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020928250   ⟸   XM_021072591
- Peptide Label: isoform X1
- UniProtKB: A0A480NGT8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020928251   ⟸   XM_021072592
- Peptide Label: isoform X2
- UniProtKB: A0A4X1VA06 (UniProtKB/TrEMBL),   F1SDM3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020928253   ⟸   XM_021072594
- Peptide Label: isoform X4
- UniProtKB: A0A8D1BGY2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000073124   ⟸   ENSSSCT00000074893
RefSeq Acc Id: ENSSSCP00000011456   ⟸   ENSSSCT00000011758
RefSeq Acc Id: ENSSSCP00000062895   ⟸   ENSSSCT00000081949
RefSeq Acc Id: ENSSSCP00000043168   ⟸   ENSSSCT00000042367
Protein Domains
Disintegrin   EGF-like   Peptidase M12B


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000010746 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005011288 UniProtKB/TrEMBL
  ENSSSCG00030024584 UniProtKB/TrEMBL
  ENSSSCG00035079900 UniProtKB/TrEMBL
  ENSSSCG00040011409 UniProtKB/TrEMBL
  ENSSSCG00045008047 UniProtKB/TrEMBL
  ENSSSCG00050046926 UniProtKB/TrEMBL
  ENSSSCG00055005469 UniProtKB/TrEMBL
  ENSSSCG00065074945 UniProtKB/TrEMBL
  ENSSSCG00070022728 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000011758.5 UniProtKB/TrEMBL
  ENSSSCT00000074893 ENTREZGENE
  ENSSSCT00000074893.2 UniProtKB/TrEMBL
  ENSSSCT00000081949.2 UniProtKB/TrEMBL
  ENSSSCT00005017724.1 UniProtKB/TrEMBL
  ENSSSCT00030034270.1 UniProtKB/TrEMBL
  ENSSSCT00030034274.1 UniProtKB/TrEMBL
  ENSSSCT00030034295.1 UniProtKB/TrEMBL
  ENSSSCT00030034305.1 UniProtKB/TrEMBL
  ENSSSCT00035109279.1 UniProtKB/TrEMBL
  ENSSSCT00040014932.1 UniProtKB/TrEMBL
  ENSSSCT00040014954.1 UniProtKB/TrEMBL
  ENSSSCT00040015036.1 UniProtKB/TrEMBL
  ENSSSCT00045013664.1 UniProtKB/TrEMBL
  ENSSSCT00045013751.1 UniProtKB/TrEMBL
  ENSSSCT00045013836.1 UniProtKB/TrEMBL
  ENSSSCT00050063891.1 UniProtKB/TrEMBL
  ENSSSCT00050063925.1 UniProtKB/TrEMBL
  ENSSSCT00050063930.1 UniProtKB/TrEMBL
  ENSSSCT00055010686.1 UniProtKB/TrEMBL
  ENSSSCT00055010755.1 UniProtKB/TrEMBL
  ENSSSCT00055010814.1 UniProtKB/TrEMBL
  ENSSSCT00065103369.1 UniProtKB/TrEMBL
  ENSSSCT00065103388.1 UniProtKB/TrEMBL
  ENSSSCT00065103401.1 UniProtKB/TrEMBL
  ENSSSCT00070045200.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.390.10 UniProtKB/TrEMBL
  4.10.70.10 UniProtKB/TrEMBL
InterPro ADAM_Cys-rich UniProtKB/TrEMBL
  Disintegrin_CS UniProtKB/TrEMBL
  Disintegrin_dom UniProtKB/TrEMBL
  Disintegrin_dom_sf UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/TrEMBL
  Peptidase_M12B_N UniProtKB/TrEMBL
  Reprolysin_adamalysin UniProtKB/TrEMBL
NCBI Gene ADAM12 ENTREZGENE
PANTHER ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN UniProtKB/TrEMBL
  DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 12 UniProtKB/TrEMBL
Pfam ADAM_CR UniProtKB/TrEMBL
  Disintegrin UniProtKB/TrEMBL
  Pep_M12B_propep UniProtKB/TrEMBL
  Reprolysin UniProtKB/TrEMBL
PRINTS DISINTEGRIN UniProtKB/TrEMBL
PROSITE ADAM_MEPRO UniProtKB/TrEMBL
  DISINTEGRIN_1 UniProtKB/TrEMBL
  DISINTEGRIN_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
SMART ACR UniProtKB/TrEMBL
  DISIN UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
  SSF57552 UniProtKB/TrEMBL
UniProt A0A480K8Z8 ENTREZGENE, UniProtKB/TrEMBL
  A0A480LRC7 ENTREZGENE, UniProtKB/TrEMBL
  A0A480NGT8 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1VA06 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2QFB9_PIG UniProtKB/TrEMBL
  A0A8D0ILQ1_PIG UniProtKB/TrEMBL
  A0A8D0W629 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0W6U6_PIG UniProtKB/TrEMBL
  A0A8D1BGY2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1K0W4_PIG UniProtKB/TrEMBL
  A0A8D2A2E4_PIG UniProtKB/TrEMBL
  A0A8D2A510 ENTREZGENE, UniProtKB/TrEMBL
  F1SDM3 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:85063 ENTREZGENE