TMEM14A (transmembrane protein 14A) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: TMEM14A (transmembrane protein 14A) Sus scrofa
Analyze
Symbol: TMEM14A
Name: transmembrane protein 14A
RGD ID: 13984749
Description: INVOLVED IN negative regulation of apoptotic process (ortholog); negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway (ortholog); ASSOCIATED WITH genetic disease (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog); mitochondrial membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl746,509,777 - 46,517,732 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1746,509,724 - 46,517,735 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27134,211,575 - 134,218,991 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:15679890   PMID:17145712   PMID:30032202  


Genomics

Comparative Map Data
TMEM14A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl746,509,777 - 46,517,732 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1746,509,724 - 46,517,735 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27134,211,575 - 134,218,991 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TMEM14A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38652,671,113 - 52,686,588 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl652,671,113 - 52,686,588 (+)EnsemblGRCh38hg38GRCh38
GRCh37652,535,911 - 52,551,386 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36652,643,843 - 52,659,345 (+)NCBINCBI36Build 36hg18NCBI36
Build 34652,643,863 - 52,659,342NCBI
Celera654,196,977 - 54,212,463 (+)NCBICelera
Cytogenetic Map6p12.2NCBI
HuRef652,367,119 - 52,382,535 (+)NCBIHuRef
CHM1_1652,538,093 - 52,553,590 (+)NCBICHM1_1
T2T-CHM13v2.0652,509,853 - 52,525,372 (+)NCBIT2T-CHM13v2.0
Tmem14a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39121,236,609 - 21,300,391 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl121,288,799 - 21,300,391 (+)EnsemblGRCm39 Ensembl
GRCm38121,166,436 - 21,230,167 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl121,218,575 - 21,230,167 (+)EnsemblGRCm38mm10GRCm38
MGSCv37121,208,712 - 21,220,248 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36121,203,813 - 21,215,315 (+)NCBIMGSCv36mm8
Celera121,087,828 - 21,099,400 (+)NCBICelera
Cytogenetic Map1A4NCBI
cM Map16.5NCBI
Tmem14a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8931,137,011 - 31,148,794 (+)NCBIGRCr8
mRatBN7.2923,640,594 - 23,652,379 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl923,640,594 - 23,652,379 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl923,733,039 - 23,734,463 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx932,131,886 - 32,145,560 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0937,252,577 - 37,266,255 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0935,567,818 - 35,581,496 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0927,333,956 - 27,345,612 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl927,333,956 - 27,351,295 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl927,343,853 - 27,345,070 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0926,187,241 - 26,198,598 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4919,986,826 - 19,999,299 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1919,984,156 - 19,996,628 (+)NCBI
Celera921,214,591 - 21,228,190 (+)NCBICelera
Cytogenetic Map9q13NCBI
Tmem14a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554115,373,251 - 5,379,767 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554115,372,713 - 5,380,033 (-)NCBIChiLan1.0ChiLan1.0
TMEM14A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2567,135,737 - 67,157,973 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1663,018,973 - 63,034,401 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0652,226,416 - 52,241,846 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1653,492,943 - 53,508,340 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl653,492,943 - 53,508,340 (+)Ensemblpanpan1.1panPan2
TMEM14A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11220,303,724 - 20,318,336 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1220,198,868 - 20,213,473 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01220,801,318 - 20,815,838 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11220,307,098 - 20,321,683 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01220,410,701 - 20,425,306 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01220,549,342 - 20,563,953 (+)NCBIUU_Cfam_GSD_1.0
Tmem14a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494655,761,976 - 55,780,517 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364768,180,141 - 8,185,884 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364768,179,949 - 8,198,204 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM14A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11719,819,918 - 19,835,919 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1719,820,458 - 19,829,781 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604452,574,544 - 52,590,827 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmem14a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248553,388,847 - 3,394,990 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248553,388,292 - 3,411,943 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TMEM14A
184 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2 10 1
Low 10 4 1 5 2 13 2 2 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000002909   ⟹   ENSSSCP00000002830
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl746,509,777 - 46,517,732 (+)Ensembl
RefSeq Acc Id: XM_003128796   ⟹   XP_003128844
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1746,509,747 - 46,517,733 (+)NCBI
Sequence:
RefSeq Acc Id: XM_003482329   ⟹   XP_003482377
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1746,510,094 - 46,517,733 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005666469   ⟹   XP_005666526
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1746,509,724 - 46,517,735 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013978452   ⟹   XP_013833906
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1746,509,761 - 46,517,735 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_005666526   ⟸   XM_005666469
- UniProtKB: P56984 (UniProtKB/Swiss-Prot),   A0A480JHW3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003128844   ⟸   XM_003128796
- UniProtKB: P56984 (UniProtKB/Swiss-Prot),   A0A480JHW3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013833906   ⟸   XM_013978452
- UniProtKB: P56984 (UniProtKB/Swiss-Prot),   A0A480JHW3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003482377   ⟸   XM_003482329
- UniProtKB: P56984 (UniProtKB/Swiss-Prot),   A0A480JHW3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000002830   ⟸   ENSSSCT00000002909


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000002622 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSSSCG00005018506 UniProtKB/Swiss-Prot
  ENSSSCG00015055381 UniProtKB/Swiss-Prot
  ENSSSCG00025049444 UniProtKB/Swiss-Prot
  ENSSSCG00030049402 UniProtKB/Swiss-Prot
  ENSSSCG00035065416 UniProtKB/Swiss-Prot
  ENSSSCG00040005339 UniProtKB/Swiss-Prot
  ENSSSCG00045003203 UniProtKB/Swiss-Prot
  ENSSSCG00050001339 UniProtKB/Swiss-Prot
  ENSSSCG00055013247 UniProtKB/Swiss-Prot
  ENSSSCG00060010005 UniProtKB/Swiss-Prot
  ENSSSCG00065033455 UniProtKB/Swiss-Prot
  ENSSSCG00070009067 UniProtKB/Swiss-Prot
Ensembl Transcript ENSSSCT00000002909 ENTREZGENE
  ENSSSCT00000002909.4 UniProtKB/Swiss-Prot
  ENSSSCT00005029139.1 UniProtKB/Swiss-Prot
  ENSSSCT00005029151.1 UniProtKB/Swiss-Prot
  ENSSSCT00015073756.1 UniProtKB/Swiss-Prot
  ENSSSCT00025067316.1 UniProtKB/Swiss-Prot
  ENSSSCT00030068883.1 UniProtKB/Swiss-Prot
  ENSSSCT00035088107.1 UniProtKB/Swiss-Prot
  ENSSSCT00040007054.1 UniProtKB/Swiss-Prot
  ENSSSCT00045005175.1 UniProtKB/Swiss-Prot
  ENSSSCT00050001590.1 UniProtKB/Swiss-Prot
  ENSSSCT00055026043.1 UniProtKB/Swiss-Prot
  ENSSSCT00060012938.1 UniProtKB/Swiss-Prot
  ENSSSCT00065045455.1 UniProtKB/Swiss-Prot
  ENSSSCT00070017587.1 UniProtKB/Swiss-Prot
  ENSSSCT00070017596.1 UniProtKB/Swiss-Prot
  ENSSSCT00070017603.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.10.1740 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.250.1330 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro TMEM14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TMEM14_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:100512176 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene TMEM14A ENTREZGENE
PANTHER PTHR12668 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSMEMBRANE PROTEIN 14A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Tmemb_14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A480JHW3 ENTREZGENE, UniProtKB/TrEMBL
  P56984 ENTREZGENE, UniProtKB/Swiss-Prot
VGNC ID VGNC:94094 ENTREZGENE