HCAR2 (hydroxycarboxylic acid receptor 2)

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Gene: HCAR2 (hydroxycarboxylic acid receptor 2) Sus scrofa

Analyze

Symbol:

HCAR2

Name:

hydroxycarboxylic acid receptor 2

RGD ID:

13978391

Description:

ENCODES a protein that exhibits G protein-coupled receptor activity (inferred); GTP binding (inferred); purinergic nucleotide receptor activity (inferred); INVOLVED IN negative regulation of lipid catabolic process (ortholog); neutrophil apoptotic process (ortholog); positive regulation of adiponectin secretion (ortholog); ASSOCIATED WITH Flushing (ortholog); genetic disease (ortholog); psoriasis (ortholog); FOUND IN cell junction (ortholog); plasma membrane (ortholog); INTERACTS WITH deoxynivalenol

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

GPR109A

RGD Orthologs

Human

Rat

Chinchilla

Bonobo

Dog

Squirrel

Alliance Genes

More Info

more info ...

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	14	30,117,014 - 30,119,293 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	31,807,258 - 31,807,879 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Flushing (ISO)

genetic disease (ISO)

psoriasis (ISO)

schizophrenia (ISO)

Skin Neoplasms (ISO)

squamous cell carcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

deoxynivalenol (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

G protein-coupled receptor signaling pathway (IBA,IEA)

negative regulation of lipid catabolic process (ISO)

neutrophil apoptotic process (ISO)

positive regulation of adiponectin secretion (ISO)

positive regulation of neutrophil apoptotic process (ISO)

purinergic nucleotide receptor signaling pathway (IEA)

signal transduction (IEA)

Cellular Component

cell junction (ISO)

membrane (IEA)

plasma membrane (IBA,ISO)

Molecular Function

G protein-coupled receptor activity (IEA)

GTP binding (IEA)

nicotinic acid receptor activity (IBA)

purinergic nucleotide receptor activity (IEA)

References

Additional References at PubMed

PMID:14681463	PMID:17145712	PMID:28715817

Genomics

Comparative Map Data

HCAR2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	14	30,117,014 - 30,119,293 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	31,807,258 - 31,807,879 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HCAR2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	122,701,293 - 122,703,357 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	12	122,701,293 - 122,703,357 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	123,185,840 - 123,187,904 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	121,751,793 - 121,753,857 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	121,710,720 - 121,712,784	NCBI
Celera	12	122,792,105 - 122,794,164 (-)	NCBI		Celera
Cytogenetic Map	12	q24.31	NCBI
HuRef	12	120,146,199 - 120,148,263 (-)	NCBI		HuRef
CHM1_1	12	123,154,148 - 123,156,212 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	122,696,704 - 122,698,768 (-)	NCBI		T2T-CHM13v2.0

Hcar2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	12	32,726,334 - 32,727,416 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	32,726,184 - 32,728,504 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	33,904,918 - 33,906,000 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	12	34,516,272 - 34,517,354 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	12	33,568,158 - 33,569,240 (+)	NCBI	Rnor_WKY
Rnor_6.0	12	38,160,464 - 38,161,546 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	38,160,464 - 38,161,546 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	40,029,980 - 40,031,062 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	33,863,876 - 33,864,958 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	12	33,727,263 - 33,728,346 (+)	NCBI
Celera	12	34,412,699 - 34,413,781 (+)	NCBI		Celera
Cytogenetic Map	12	q15	NCBI

Hcar2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955482	6,007,307 - 6,009,353 (+)	NCBI	ChiLan1.0	ChiLan1.0

HCAR2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	12	130,791,022 - 130,796,501 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	120,305,297 - 120,308,463 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	124,512,812 - 124,523,387 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

HCAR2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	6,748,415 - 6,750,509 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	6,909,373 - 6,911,477 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	6,997,607 - 6,999,707 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	6,997,738 - 6,998,829 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	6,929,608 - 6,931,708 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	7,023,319 - 7,025,423 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	6,976,781 - 6,978,885 (+)	NCBI		UU_Cfam_GSD_1.0

LOC101978400
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	157,577,983 - 157,580,165 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936558	1,899,313 - 1,901,409 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	hemolymphoid system	nervous system	renal system	reproductive system	respiratory system
High
Medium			2			1	2
Low	2	1	2	3	1	1	1
Below cutoff	5	2	1	8	1	1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_021072989	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000096	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK230929	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK237167	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK343672	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK390657	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK397813	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK399457	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CU468020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBZA01000276	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

XM_021072989 ⟹ XP_020928648

RefSeq Status:

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	14	30,117,014 - 30,119,293 (+)	NCBI

Sequence:

show sequence

CCTTGCTGGCTTTTTTTTTTTTTTAAGGCGATTTCGTAGTTTCCTGGTAACCATTCAGTCATCT
ATTTCAACACCCTGACATGACATAAAGGCGAGCACTGAACCACAGGTTCGCCACTCAGACCCAC
ACCTCTTTCTTTGAGCATTGGCTAGGTGAGGCGCTCCCAGAACCAGCTCAATTCAATCATGAAC
CCGTCCCACCAGCAGAATCATTTTCTGAAAATAGGCGACAAGAACTGCTGTGTGTTCCGGGATG
ACTTCATTGCCAAGGTGCTGCCGCCGGTGGTGGGGCTGGAGTTTGTGTTCGGGCTCCTGGGTAA
TGGCCTTGCTCTGTGGATTTTCTGCTTCCACCTCAAGTCTTGGAAATCCAGCCGGATTTTCCTG
TTCAACCTGGCCGTGGCTGACTTTCTCCTGATCATCTGCCTGCCATTCCTGACGGACAACTATG
TGAGGAAGTGGGACTGGAGATTTGGGGACATCCCCTGCCGAATAATGCTCTTCATGTTGGCCAT
GAACCGCCAGGGCAGCATCATCTTCCTCACAGTGGTGGCCGTGGACCGGTACTTCCGGGTGGTC
CATCCCCACCACGCTCTGAACAAGATCTCCAATCGCACAGCAGCCATCATCTCCTGCCTCCTGT
GGGGCCTCACAATTGGCCTGACGGTCCACCTCCTGAACAAAACGATGTTAATCAAGAAGCACGA
CTCATATTTGTGCAGTAGCTTCAGCATCTGCAATACCTTCCGCTGGCATGATGCCATGTTCCTC
CTGGAGTTCTTCCTGCCCCTGGGCATCATCCTGTTCTGCTCGGCCAGGATTGTCTGGAGCCTGC
GGCAGCGACAAATGGACCGGCATGTCAAGATCAAGAGGGCCATCAACTTCGTCATGGTGGTGGC
CATCGTCTTCATCATCTGCTTCCTGCCCAGCGTGGCCGTGCGCATCCGCATTTTCTGGCTTCTC
CGCACTGCTGGAACGGAGAACTGTGACATCTACCGCTCGGTGGACCTGGCGTTTTATATCACCC
TCAGCTTCACCTACATGAACAGTATGCTGGACCCTTTGGTGTATTACTTCTCCAGCCCATCTTT
CCCCAACTTCTTATCCACCTTGATCAACCGCTGCCTGCGGAGGAAGGTGCTGGAGGAGTCCAAC
AATAACCGCAGCACAAGCCTCGAGCTCACTGGGGAACCCAGCACCCACAGGAACGTTCCTGATA
CTTCAGTGGCCGATCCCAGGGAGCCGTTGAGCCCCTCTGACCTGACTCCAGCCTCTCATTAAAA
CAACCAAGCCAAGAAGGGAGATGGTCACCAAGGACCAGGATCTCTGGAGAAATGGTTTGGCTGG
TGCCCAGACTAACATCATTAGCCTTGGCCCGCGATTTCCCAGAACTTCCAGGTTCAAGAGAATC
AGATTTAGGGAATTGGTGTGGCAGCGTGGGCTGCCTGGTTGCCGAGTGTCTCCACAGGCATCTT
GTGGGGAATGGAGGATGAAGTTCCTAGGCGTCTGAAGCTTCTGATCAATCTTGGACCCTTGCAG
AACTGAAGATGGTCAAACTGTCCACTTTTCTGCTGCCGGAGAGTTGGAGCCCCAGAGACACCCC
TTGGCACCTGTGACTCACCAGCCTCTTTGCTTCACCTGTCTGAGACTTGGATGGTTCTCAGTTC
CTGGGCCGATGTCTCACTTGCCCGTGGGCTCCCGGTGGGATAAGGAAAGCTAAGTAATTGGAGG
GGAACTGTTGCTCCAGTAGGGAGCTCAGACATCATGAAACAAGCCAGTAGGTCACCTGGATTTC
AGGGGACCAATTCAGCTTCCAGCCAAGCTTTAGCAGAAACGGACTAGATGCACTAGCAGAGACG
CGCTTGCTTTGGTTAATCATCTGAGTTGCCAGTGGTGGTAAGAAGGGGCTTAGTCCCACTGAGG
AAAACAGTGTTGCTAAGGGAAAGGACATGGCATTTATGCTACAATCTGCCACTAATCGACACTA
ATTTTGAAGGTTGTGCAGTTCAAGAGACTTCAGGGAGGAGAGCAACTTCCCACCTCTGTTTGCT
TTTATCATTAAAAGGGAGATGATGCCTAAGGTTAGAGGCAGGGGGAAGATTCCTCCTGGCTCAT
TTGCTTGTGTTTCTGTACCTATAAGAAATCTACCACTTCAAGAAAGGGTGGGGGAAAAACTGTA
ATTGTAATGTATACTGTAAGGATAACCTGACCCCCTTGCTGTACAGTGGGAAAAAAAAAAAAAA
AAGAAATCTACCACTTCAATAAACTTTTGTGTGAGACACA

hide sequence

Protein Sequences


Protein RefSeqs	XP_020928648	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	JAG69492	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

XP_020928648 ⟸ XM_021072989

- UniProtKB:

A0A287AA85 (UniProtKB/TrEMBL), A0A4X1UES9 (UniProtKB/TrEMBL), A0A0B8RZI7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MNPSHQQNHFLKIGDKNCCVFRDDFIAKVLPPVVGLEFVFGLLGNGLALWIFCFHLKSWKSSRI
FLFNLAVADFLLIICLPFLTDNYVRKWDWRFGDIPCRIMLFMLAMNRQGSIIFLTVVAVDRYFR
VVHPHHALNKISNRTAAIISCLLWGLTIGLTVHLLNKTMLIKKHDSYLCSSFSICNTFRWHDAM
FLLEFFLPLGIILFCSARIVWSLRQRQMDRHVKIKRAINFVMVVAIVFIICFLPSVAVRIRIFW
LLRTAGTENCDIYRSVDLAFYITLSFTYMNSMLDPLVYYFSSPSFPNFLSTLINRCLRRKVLEE
SNNNRSTSLELTGEPSTHRNVPDTSVADPREPLSPSDLTPASH

hide sequence

Protein Domains

G-protein coupled receptors family 1 profile

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000037735	ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00015047294	UniProtKB/TrEMBL
	ENSSSCG00025008710	UniProtKB/TrEMBL
	ENSSSCG00030006509	UniProtKB/TrEMBL
	ENSSSCG00035046078	UniProtKB/TrEMBL
	ENSSSCG00040069246	UniProtKB/TrEMBL
	ENSSSCG00045038629	UniProtKB/TrEMBL
	ENSSSCG00050002467	UniProtKB/TrEMBL
	ENSSSCG00055003560	UniProtKB/TrEMBL
	ENSSSCG00060001835	UniProtKB/TrEMBL
	ENSSSCG00065041290	UniProtKB/TrEMBL
	ENSSSCG00070016378	UniProtKB/TrEMBL
Ensembl Protein	ENSSSCP00000040811	ENTREZGENE
	ENSSSCP00000040811.1	UniProtKB/TrEMBL
	ENSSSCP00015025267.1	UniProtKB/TrEMBL
	ENSSSCP00025004617.1	UniProtKB/TrEMBL
	ENSSSCP00030003743.1	UniProtKB/TrEMBL
	ENSSSCP00035024666.1	UniProtKB/TrEMBL
	ENSSSCP00040041859.1	UniProtKB/TrEMBL
	ENSSSCP00045047604.1	UniProtKB/TrEMBL
	ENSSSCP00050001015.1	UniProtKB/TrEMBL
	ENSSSCP00055005489.1	UniProtKB/TrEMBL
	ENSSSCP00060000713.1	UniProtKB/TrEMBL
	ENSSSCP00065024574.1	UniProtKB/TrEMBL
	ENSSSCP00070026901.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000065403	ENTREZGENE
	ENSSSCT00000065403.3	UniProtKB/TrEMBL
	ENSSSCT00015062991.1	UniProtKB/TrEMBL
	ENSSSCT00025011563.1	UniProtKB/TrEMBL
	ENSSSCT00030008724.1	UniProtKB/TrEMBL
	ENSSSCT00035061248.1	UniProtKB/TrEMBL
	ENSSSCT00040094725.1	UniProtKB/TrEMBL
	ENSSSCT00045067038.1	UniProtKB/TrEMBL
	ENSSSCT00050003084.1	UniProtKB/TrEMBL
	ENSSSCT00055006960.1	UniProtKB/TrEMBL
	ENSSSCT00060002240.1	UniProtKB/TrEMBL
	ENSSSCT00065056491.1	UniProtKB/TrEMBL
	ENSSSCT00070032238.1	UniProtKB/TrEMBL
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/TrEMBL
InterPro	GPCR_Rhodpsn	UniProtKB/TrEMBL
	GPCR_Rhodpsn_7TM	UniProtKB/TrEMBL
NCBI Gene	HCAR2	ENTREZGENE
PANTHER	HYDROXYCARBOXYLIC ACID RECEPTOR 2	UniProtKB/TrEMBL
	HYDROXYCARBOXYLIC ACID RECEPTOR 2	UniProtKB/TrEMBL
Pfam	7tm_1	UniProtKB/TrEMBL
PRINTS	GPCRRHODOPSN	UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F1_2	UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/TrEMBL
UniProt	A0A0B8RZI7	ENTREZGENE
	A0A287AA85	ENTREZGENE, UniProtKB/TrEMBL
	A0A4X1UES9	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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