CLCN5 (chloride voltage-gated channel 5) - Rat Genome Database
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Gene: CLCN5 (chloride voltage-gated channel 5) Sus scrofa
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Symbol: CLCN5
Name: chloride voltage-gated channel 5
RGD ID: 13972605
Description: ENCODES a protein that exhibits voltage-gated chloride channel activity (ortholog); INVOLVED IN chloride transport (ortholog); endocytosis (ortholog); ASSOCIATED WITH autistic disorder (ortholog); Bethlem Myopathy 1 (ortholog); Dent disease (ortholog); FOUND IN apical part of cell (ortholog); endosome (ortholog); Golgi apparatus (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: chloride channel protein 5; chloride transporter ClC-5; CLC-5; H(+)/Cl(-) exchange transporter 5; outwardly rectifying chloride channel
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX43,613,756 - 43,813,140 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X43,779,016 - 43,809,472 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X48,706,075 - 48,736,547 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:10978325  


Genomics

Comparative Map Data
CLCN5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX43,613,756 - 43,813,140 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X43,779,016 - 43,809,472 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X48,706,075 - 48,736,547 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CLCN5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX49,922,596 - 50,099,235 (+)EnsemblGRCh38hg38GRCh38
GRCh38X49,922,596 - 50,099,231 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X49,687,206 - 49,863,887 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X49,718,955 - 49,750,632 (+)NCBINCBI36hg18NCBI36
Build 34X49,537,191 - 49,560,557NCBI
CeleraX53,756,528 - 53,932,992 (+)NCBI
Cytogenetic MapXp11.23NCBI
HuRefX47,156,646 - 47,337,277 (+)NCBIHuRef
CHM1_1X49,766,989 - 49,943,526 (+)NCBICHM1_1
Clcn5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X7,020,049 - 7,185,597 (-)NCBIGRCm39mm39
GRCm39 EnsemblX7,020,049 - 7,185,597 (-)Ensembl
GRCm38X7,153,810 - 7,319,358 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX7,153,810 - 7,319,358 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X6,735,945 - 6,765,840 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X6,316,432 - 6,345,645 (-)NCBImm8
CeleraX4,285,826 - 4,305,500 (+)NCBICelera
Cytogenetic MapXA1.1NCBI
cM MapX3.21NCBI
Clcn5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X15,185,353 - 15,339,977 (+)NCBI
Rnor_6.0 EnsemblX16,050,780 - 16,196,789 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0X16,170,585 - 16,196,691 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X16,955,709 - 16,981,815 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X27,383,769 - 27,409,877 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X27,437,237 - 27,463,346 (+)NCBI
CeleraX15,387,005 - 15,413,019 (+)NCBICelera
RH 3.4 MapX169.21RGD
Cytogenetic MapXq12NCBI
Clcn5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555431,077,007 - 1,250,352 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555431,076,988 - 1,256,352 (+)NCBIChiLan1.0ChiLan1.0
CLCN5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X49,851,472 - 50,013,375 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX49,854,165 - 50,006,363 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X42,137,523 - 42,299,716 (+)NCBIMhudiblu_PPA_v0panPan3
CLCN5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 EnsemblX42,704,627 - 42,853,812 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1X42,705,789 - 42,860,701 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Clcn5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049367211,552,312 - 1,602,360 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CLCN5
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X46,772,176 - 46,934,886 (+)NCBI
ChlSab1.1 EnsemblX46,772,305 - 46,927,861 (+)Ensembl
Clcn5
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248931,390,417 - 1,581,457 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2
Low 10 2 3 5 2 23 3 3
Below cutoff 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000064514   ⟹   ENSSSCP00000042280
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 EnsemblX43,613,756 - 43,813,140 (+)Ensembl
RefSeq Acc Id: NM_214139   ⟹   NP_999304
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1X43,779,016 - 43,809,472 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_999304 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG29104 (Get FASTA)   NCBI Sequence Viewer  
  JAG69635 (Get FASTA)   NCBI Sequence Viewer  
  Q9GKE7 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_999304   ⟸   NM_214139
- UniProtKB: Q9GKE7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSSSCP00000042280   ⟸   ENSSSCT00000064514
Protein Domains
CBS


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000023026 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSSSCG00025072959 UniProtKB/Swiss-Prot
  ENSSSCG00030004195 UniProtKB/Swiss-Prot
  ENSSSCG00035056248 UniProtKB/Swiss-Prot
  ENSSSCG00045032335 UniProtKB/Swiss-Prot
  ENSSSCG00050079073 UniProtKB/Swiss-Prot
  ENSSSCG00055002299 UniProtKB/Swiss-Prot
  ENSSSCG00060026931 UniProtKB/Swiss-Prot
  ENSSSCG00070025014 UniProtKB/Swiss-Prot
Ensembl Protein ENSSSCP00000042280 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSSSCP00025044337 UniProtKB/Swiss-Prot
  ENSSSCP00030002301 UniProtKB/Swiss-Prot
  ENSSSCP00035030521 UniProtKB/Swiss-Prot
  ENSSSCP00045038497 UniProtKB/Swiss-Prot
  ENSSSCP00050048637 UniProtKB/Swiss-Prot
  ENSSSCP00055003367 UniProtKB/Swiss-Prot
  ENSSSCP00060015534 UniProtKB/Swiss-Prot
  ENSSSCP00070042232 UniProtKB/Swiss-Prot
  ENSSSCP00070042234 UniProtKB/Swiss-Prot
Ensembl Transcript ENSSSCT00000064514 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSSSCT00025100441 UniProtKB/Swiss-Prot
  ENSSSCT00030005600 UniProtKB/Swiss-Prot
  ENSSSCT00035075084 UniProtKB/Swiss-Prot
  ENSSSCT00045055218 UniProtKB/Swiss-Prot
  ENSSSCT00050109186 UniProtKB/Swiss-Prot
  ENSSSCT00055004384 UniProtKB/Swiss-Prot
  ENSSSCT00060036495 UniProtKB/Swiss-Prot
  ENSSSCT00070050001 UniProtKB/Swiss-Prot
  ENSSSCT00070050003 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.3080.10 UniProtKB/Swiss-Prot
InterPro CBS_dom UniProtKB/Swiss-Prot
  Cl-channel_core UniProtKB/Swiss-Prot
  Cl-channel_volt-gated UniProtKB/Swiss-Prot
  Cl_channel-5 UniProtKB/Swiss-Prot
KEGG Report ssc:397263 UniProtKB/Swiss-Prot
NCBI Gene CLCN5 ENTREZGENE
Pfam CBS UniProtKB/Swiss-Prot
  Voltage_CLC UniProtKB/Swiss-Prot
PRINTS CLCHANNEL UniProtKB/Swiss-Prot
  CLCHANNEL5 UniProtKB/Swiss-Prot
PROSITE CBS UniProtKB/Swiss-Prot
SMART CBS UniProtKB/Swiss-Prot
Superfamily-SCOP SSF81340 UniProtKB/Swiss-Prot
UniProt CLCN5_PIG UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A0A287BE85 UniProtKB/Swiss-Prot
VGNC ID VGNC:103925 ENTREZGENE