SH3GL1 (SH3 domain containing GRB2 like 1, endophilin A2) - Rat Genome Database

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Gene: SH3GL1 (SH3 domain containing GRB2 like 1, endophilin A2) Sus scrofa
Analyze
Symbol: SH3GL1
Name: SH3 domain containing GRB2 like 1, endophilin A2
RGD ID: 13972134
Description: ENCODES a protein that exhibits beta-1 adrenergic receptor binding (ortholog); GTPase binding (ortholog); phosphatase binding (ortholog); INVOLVED IN modulation of excitatory postsynaptic potential (ortholog); positive regulation of synaptic vesicle endocytosis (ortholog); regulation of synaptic vesicle endocytosis (ortholog); PARTICIPATES IN clathrin-dependent synaptic vesicle endocytosis; ASSOCIATED WITH acute myeloid leukemia (ortholog); amenorrhea (ortholog); genetic disease (ortholog); FOUND IN hippocampal mossy fiber to CA3 synapse (ortholog); postsynaptic density, intracellular component (ortholog); presynapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: endophilin-A2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl274,414,466 - 74,445,447 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1274,414,453 - 74,445,450 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2274,907,406 - 74,938,402 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SH3GL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl274,414,466 - 74,445,447 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1274,414,453 - 74,445,450 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2274,907,406 - 74,938,402 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SH3GL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38194,360,370 - 4,400,547 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl194,360,370 - 4,400,547 (-)EnsemblGRCh38hg38GRCh38
GRCh37194,360,367 - 4,400,544 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36194,311,367 - 4,351,471 (-)NCBINCBI36Build 36hg18NCBI36
Build 34194,311,367 - 4,351,471NCBI
Celera194,298,613 - 4,338,694 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef194,122,883 - 4,162,918 (-)NCBIHuRef
CHM1_1194,360,010 - 4,400,159 (-)NCBICHM1_1
T2T-CHM13v2.0194,343,819 - 4,383,971 (-)NCBIT2T-CHM13v2.0
Sh3gl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391756,323,750 - 56,343,659 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1756,323,750 - 56,343,635 (-)EnsemblGRCm39 Ensembl
GRCm381756,016,750 - 56,036,659 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1756,016,750 - 56,036,635 (-)EnsemblGRCm38mm10GRCm38
MGSCv371756,156,173 - 56,175,999 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361755,610,043 - 55,629,869 (-)NCBIMGSCv36mm8
Celera1759,435,412 - 59,455,238 (-)NCBICelera
Cytogenetic Map17DNCBI
cM Map1729.11NCBI
Sh3gl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89929,459 - 956,922 (-)NCBIGRCr8
mRatBN7.29842,285 - 869,753 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl9842,288 - 869,716 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx91,293,680 - 1,316,867 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.096,640,221 - 6,663,407 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.095,598,716 - 5,621,903 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0911,031,847 - 11,055,285 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl911,031,841 - 11,055,285 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0910,018,274 - 10,040,574 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera97,637,327 - 7,660,492 (+)NCBICelera
Cytogenetic Map9q11NCBI
Sh3gl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554954,502,173 - 4,531,758 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554954,502,173 - 4,531,758 (+)NCBIChiLan1.0ChiLan1.0
SH3GL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2208,758,290 - 8,798,179 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1197,987,387 - 8,027,288 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0193,383,267 - 3,423,165 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1194,329,750 - 4,336,356 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl194,329,750 - 4,340,121 (-)Ensemblpanpan1.1panPan2
SH3GL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12055,279,622 - 55,311,579 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2055,279,621 - 55,311,536 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2055,007,793 - 55,039,737 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02055,938,684 - 55,970,631 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2055,938,677 - 55,980,136 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12054,999,266 - 55,031,183 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02055,480,162 - 55,512,107 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02055,678,880 - 55,710,790 (+)NCBIUU_Cfam_GSD_1.0
Sh3gl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118215,298,810 - 215,330,409 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365882,504,374 - 2,536,011 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365882,504,372 - 2,535,993 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SH3GL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.164,090,800 - 4,130,566 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl64,091,359 - 4,130,578 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660814,072,672 - 4,112,482 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sh3gl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248285,305,070 - 5,330,440 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248285,304,887 - 5,330,440 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SH3GL1
409 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 10 4 3 5 1 22 2 3 3
Below cutoff 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000014755   ⟹   ENSSSCP00000014357
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl274,414,466 - 74,445,447 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000041482   ⟹   ENSSSCP00000047284
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl274,414,481 - 74,449,433 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000099545   ⟹   ENSSSCP00000075455
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl274,439,949 - 74,445,447 (+)Ensembl
RefSeq Acc Id: XM_003123066   ⟹   XP_003123114
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1274,414,453 - 74,445,450 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005661329   ⟹   XP_005661386
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1274,414,458 - 74,445,450 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_003123114   ⟸   XM_003123066
- Peptide Label: isoform X2
- UniProtKB: A0A4X1VR96 (UniProtKB/TrEMBL),   A0A4X1VSN6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005661386   ⟸   XM_005661329
- Peptide Label: isoform X1
- UniProtKB: A0A4X1VSN6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000047284   ⟸   ENSSSCT00000041482
RefSeq Acc Id: ENSSSCP00000014357   ⟸   ENSSSCT00000014755
RefSeq Acc Id: ENSSSCP00000075455   ⟸   ENSSSCT00000099545
Protein Domains
BAR   SH3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000013508 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015041326 UniProtKB/TrEMBL
  ENSSSCG00030041737 UniProtKB/TrEMBL
  ENSSSCG00070026293 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000014755 ENTREZGENE
  ENSSSCT00000014755.5 UniProtKB/TrEMBL
  ENSSSCT00000099545.1 UniProtKB/TrEMBL
  ENSSSCT00015056858.1 UniProtKB/TrEMBL
  ENSSSCT00015057026.1 UniProtKB/TrEMBL
  ENSSSCT00030058253.1 UniProtKB/TrEMBL
  ENSSSCT00030058291.1 UniProtKB/TrEMBL
  ENSSSCT00070052691.1 UniProtKB/TrEMBL
  ENSSSCT00070052692.1 UniProtKB/TrEMBL
  ENSSSCT00070052693.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.60 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro AH/BAR_dom_sf UniProtKB/TrEMBL
  BAR_dom UniProtKB/TrEMBL
  Endophilin_A_SH3 UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
KEGG Report ssc:100523947 UniProtKB/TrEMBL
NCBI Gene SH3GL1 ENTREZGENE
PANTHER PTHR14167:SF63 UniProtKB/TrEMBL
  SH3 DOMAIN-CONTAINING UniProtKB/TrEMBL
Pfam BAR UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
PRINTS P67PHOX UniProtKB/TrEMBL
  SH3DOMAIN UniProtKB/TrEMBL
PROSITE BAR UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART BAR UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
Superfamily-SCOP SSF103657 UniProtKB/TrEMBL
  SSF50044 UniProtKB/TrEMBL
UniProt A0A4X1VM50_PIG UniProtKB/TrEMBL
  A0A4X1VR96 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1VSN6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8W4F870_PIG UniProtKB/TrEMBL
  F1S7L8_PIG UniProtKB/TrEMBL
VGNC ID VGNC:92823 ENTREZGENE