F2RL2 (coagulation factor II thrombin receptor like 2) - Rat Genome Database

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Gene: F2RL2 (coagulation factor II thrombin receptor like 2) Sus scrofa
Analyze
Symbol: F2RL2
Name: coagulation factor II thrombin receptor like 2
RGD ID: 13971865
Description: ENCODES a protein that exhibits G protein-coupled receptor activity (inferred); proteinase-activated receptor activity (inferred); receptor ligand activity (inferred); INVOLVED IN blood coagulation (inferred); G protein-coupled receptor signaling pathway (inferred); ligand-gated ion channel signaling pathway (inferred); PARTICIPATES IN insulin signaling pathway; protease mediated signaling via protease-activated receptor 3; ASSOCIATED WITH genetic disease (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN apical plasma membrane (inferred); membrane (inferred); plasma membrane (inferred); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: proteinase-activated receptor 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl285,535,676 - 85,541,767 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1285,534,188 - 85,542,062 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2287,181,035 - 87,188,670 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
F2RL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl285,535,676 - 85,541,767 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1285,534,188 - 85,542,062 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2287,181,035 - 87,188,670 (+)NCBISscrofa10.2Sscrofa10.2susScr3
F2RL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38576,615,482 - 76,623,403 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl576,615,482 - 76,623,413 (-)EnsemblGRCh38hg38GRCh38
GRCh37575,911,307 - 75,919,228 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36575,947,063 - 75,954,996 (-)NCBINCBI36Build 36hg18NCBI36
Build 34575,947,063 - 75,954,996NCBI
Celera571,805,260 - 71,813,193 (-)NCBICelera
Cytogenetic Map5q13.3NCBI
HuRef571,119,015 - 71,126,968 (-)NCBIHuRef
CHM1_1575,344,295 - 75,352,247 (-)NCBICHM1_1
T2T-CHM13v2.0577,097,223 - 77,105,145 (-)NCBIT2T-CHM13v2.0
F2rl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391395,833,428 - 95,839,276 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1395,833,361 - 95,839,247 (+)EnsemblGRCm39 Ensembl
GRCm381395,696,920 - 95,702,768 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1395,696,853 - 95,702,739 (+)EnsemblGRCm38mm10GRCm38
MGSCv371396,466,875 - 96,472,723 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361396,797,656 - 96,803,438 (+)NCBIMGSCv36mm8
Celera1399,313,808 - 99,319,652 (+)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1350.38NCBI
F2rl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8228,706,766 - 28,711,808 (+)NCBIGRCr8
mRatBN7.2226,972,054 - 26,977,098 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl226,972,054 - 26,977,098 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx234,011,700 - 34,016,699 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0232,111,806 - 32,116,807 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0226,928,439 - 26,933,433 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0226,240,385 - 26,245,533 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl226,240,385 - 26,245,533 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0245,371,780 - 45,376,928 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4226,073,852 - 26,078,618 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1225,994,220 - 25,998,987 (+)NCBI
Celera223,033,959 - 23,038,978 (+)NCBICelera
Cytogenetic Map2q12NCBI
F2rl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542524,246,333 - 24,254,887 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542524,246,333 - 24,254,887 (+)NCBIChiLan1.0ChiLan1.0
F2RL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2438,681,399 - 38,689,370 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1536,835,029 - 36,842,961 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0538,680,372 - 38,688,509 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1539,297,424 - 39,305,370 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl539,297,424 - 39,305,370 (+)Ensemblpanpan1.1panPan2
F2RL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1329,967,278 - 29,974,316 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl329,967,312 - 29,972,872 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha331,206,044 - 31,213,084 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0329,891,456 - 29,898,496 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl329,891,199 - 29,898,494 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1329,822,502 - 29,829,542 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0329,802,374 - 29,809,212 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0330,172,976 - 30,180,016 (+)NCBIUU_Cfam_GSD_1.0
F2rl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213190,515,607 - 190,522,114 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936549337,024 - 342,948 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936549336,871 - 342,992 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
F2RL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1470,887,979 - 70,895,419 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl470,886,113 - 70,895,113 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604919,720,145 - 19,727,047 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
F2rl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248691,073,656 - 1,077,635 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248691,073,481 - 1,078,207 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in F2RL2
214 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 5 3 5 2 3 1
Low 5 1 3 23 2 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000050276   ⟹   ENSSSCP00000049904
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl285,535,676 - 85,541,767 (-)Ensembl
RefSeq Acc Id: XM_003123711   ⟹   XP_003123759
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1285,534,188 - 85,542,062 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_003123759   ⟸   XM_003123711
- UniProtKB: A0A4X1SV60 (UniProtKB/TrEMBL),   A0A480RZ72 (UniProtKB/TrEMBL),   A0A8D0X7K0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000049904   ⟸   ENSSSCT00000050276
Protein Domains
G-protein coupled receptors family 1 profile


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000037582 Ensembl, UniProtKB/TrEMBL
  ENSSSCG00015024933 UniProtKB/TrEMBL
  ENSSSCG00025012197 UniProtKB/TrEMBL
  ENSSSCG00030050715 UniProtKB/TrEMBL
  ENSSSCG00035036659 UniProtKB/TrEMBL
  ENSSSCG00040064304 UniProtKB/TrEMBL
  ENSSSCG00045000833 UniProtKB/TrEMBL
  ENSSSCG00050023979 UniProtKB/TrEMBL
  ENSSSCG00055004691 UniProtKB/TrEMBL
  ENSSSCG00060007368 UniProtKB/TrEMBL
  ENSSSCG00065077775 UniProtKB/TrEMBL
  ENSSSCG00070004460 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000050276.3 UniProtKB/TrEMBL
  ENSSSCT00015033060.1 UniProtKB/TrEMBL
  ENSSSCT00025016105.1 UniProtKB/TrEMBL
  ENSSSCT00030070678.1 UniProtKB/TrEMBL
  ENSSSCT00035048584.1 UniProtKB/TrEMBL
  ENSSSCT00040087776.1 UniProtKB/TrEMBL
  ENSSSCT00045001208.1 UniProtKB/TrEMBL
  ENSSSCT00050032310.1 UniProtKB/TrEMBL
  ENSSSCT00055009259.1 UniProtKB/TrEMBL
  ENSSSCT00060009391.1 UniProtKB/TrEMBL
  ENSSSCT00065107621.1 UniProtKB/TrEMBL
  ENSSSCT00070008419.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
  Prot_act_rcpt_3 UniProtKB/TrEMBL
  Protea_act_rcpt UniProtKB/TrEMBL
KEGG Report ssc:100519355 UniProtKB/TrEMBL
NCBI Gene F2RL2 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR UniProtKB/TrEMBL
  PROTEINASE-ACTIVATED RECEPTOR 3 UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  PROTEASEAR UniProtKB/TrEMBL
  PROTEASEAR3 UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A287B165_PIG UniProtKB/TrEMBL
  A0A480RZ72 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1SV60 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0X7K0 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:87862 ENTREZGENE