CWC25 (CWC25 spliceosome associated protein homolog)

Gene: CWC25 (CWC25 spliceosome associated protein homolog) Sus scrofa

Analyze

Symbol:

CWC25

Name:

CWC25 spliceosome associated protein homolog

RGD ID:

13971117

Description:

INVOLVED IN mRNA processing (inferred); mRNA splicing, via spliceosome (inferred); RNA splicing (inferred); ASSOCIATED WITH genetic disease (ortholog); FOUND IN nuclear speck (inferred); nucleus (inferred); spliceosomal complex (inferred)

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

pre-mRNA-splicing factor CWC25 homolog

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	23,298,065 - 23,316,238 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	23,298,050 - 23,315,445 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

mRNA processing (IEA)

mRNA splicing, via spliceosome (IBA,IEA)

RNA splicing (IEA)

Cellular Component

nuclear speck (IEA)

nucleus (IEA)

spliceosomal complex (IEA)

U2-type catalytic step 1 spliceosome (IEA)

U2-type spliceosomal complex (IBA,IEA)

Molecular Function

protein binding (ISO)

References

Additional References at PubMed

PMID:14681463	PMID:30032202

Genomics

Comparative Map Data

CWC25
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	23,298,065 - 23,316,238 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	23,298,050 - 23,315,445 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

CWC25
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	38,800,441 - 38,825,321 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	38,800,441 - 38,825,355 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	36,956,694 - 36,981,574 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	34,210,972 - 34,235,115 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	17	33,618,412 - 33,642,555 (-)	NCBI		Celera
Cytogenetic Map	17	q12	NCBI
HuRef	17	32,752,758 - 32,776,922 (-)	NCBI		HuRef
CHM1_1	17	37,191,993 - 37,216,912 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	17	39,663,526 - 39,688,404 (-)	NCBI		T2T-CHM13v2.0

Cwc25
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	97,636,296 - 97,657,439 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	97,636,307 - 97,657,382 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	97,745,470 - 97,766,613 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	97,745,481 - 97,766,556 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	97,606,784 - 97,627,927 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	97,561,705 - 97,582,646 (-)	NCBI		MGSCv36	mm8
Celera	11	107,395,235 - 107,416,163 (-)	NCBI		Celera
Cytogenetic Map	11	D	NCBI
cM Map	11	61.09	NCBI

Cwc25
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	83,232,052 - 83,256,722 (-)	NCBI		GRCr8
mRatBN7.2	10	82,735,698 - 82,760,373 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	82,736,995 - 82,760,354 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	87,683,936 - 87,708,652 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	87,182,022 - 87,206,740 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	82,574,601 - 82,599,319 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	85,684,898 - 85,709,568 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	85,684,898 - 85,709,568 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	85,475,897 - 85,499,557 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	86,491,167 - 86,515,834 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	86,507,374 - 86,537,704 (-)	NCBI
Celera	10	81,491,290 - 81,515,794 (-)	NCBI		Celera
Cytogenetic Map	10	q31	NCBI

Cwc25
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955451	13,868,845 - 13,884,267 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955451	13,867,570 - 13,884,433 (-)	NCBI	ChiLan1.0	ChiLan1.0

CWC25
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	26,122,697 - 26,147,986 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	28,006,272 - 28,031,553 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	18,446,107 - 18,471,059 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	18,719,907 - 18,745,213 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	18,719,907 - 18,745,213 (+)	Ensembl	panpan1.1		panPan2

CWC25
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	23,426,005 - 23,443,512 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	23,426,038 - 23,443,040 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	22,897,724 - 22,915,507 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	24,221,176 - 24,238,855 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	24,221,297 - 24,239,757 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	22,993,244 - 23,010,863 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	23,254,139 - 23,271,927 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	23,380,031 - 23,397,696 (+)	NCBI		UU_Cfam_GSD_1.0

Cwc25
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	22,848,443 - 22,871,673 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936490	14,202,679 - 14,226,704 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936490	14,201,851 - 14,226,724 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CWC25
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	67,357,118 - 67,389,809 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	67,357,125 - 67,391,550 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666077	38,358,971 - 38,387,272 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cwc25
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624795	3,890,848 - 3,905,960 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624795	3,891,607 - 3,907,160 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in CWC25
480 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	hemolymphoid system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system
High
Medium	1	1	1	4		2		2	1
Low	9	3	2	1	2	21	2	1	2
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001244652	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000080	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK235685	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK397237	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FS641046	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FS708165	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GFLN01108516	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSSCT00000027397 ⟹ ENSSSCP00000019372

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	12	23,298,103 - 23,315,518 (+)	Ensembl

RefSeq Acc Id:

ENSSSCT00000053706 ⟹ ENSSSCP00000032040

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	12	23,298,065 - 23,316,238 (+)	Ensembl

RefSeq Acc Id:

NM_001244652 ⟹ NP_001231581

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	12	23,298,050 - 23,315,445 (+)	NCBI

Sequence:

show sequence

TGATCCTGCGACGCCGTCGCCGCAATGGGACGCCCTCCCGGAAGTGGGCTCTGGATCGGGCAGT
GAAAGTGGTGTCCAGTTACCCCCGGGACCAGATCTGGGAAGTCGGAGCTGAACTGTTTCTTTAC
CTTTCTCCCATCCTTTCTGAATCTTCTAGGTCCGCCTAGTGAGGAAACGTCTCCGCCGTCATGG
GGGGCGGAGACCTGAATTTGAAGAAGAGCTGGCACCCGCAGACTCTCCGCAATGTGGAGAAAGT
GTGGAAGGCTGAGCAGAAGCATGAGGCCGAGCGGAAGAAGATTGAGGAGCTTCAGCGGGAACTG
CGGGAGGAGAGGGCTCGGGAGGAGATGCAGCGCTATGCGGAGGATGTCGGGGCTGTCAAGAAAA
AGGAAGAAAAATTGGACTGGATGTACCAGGGCCCCGGTGGGATGGTGAACCGTGATGAATACTT
ACTGGGGCGCCCCATTGACAAATACGTTTTTGAGAAGATGGAGGAGAAGGAGGCAGGCTGTTCC
TCTGAGACAGGACTCCTCCCAGGCTCTATCTTTGCCCCATCGGGTGCCAATTCCCTTCTTGACA
TGGCCAGCAAAATCCGGGAGGACCCACTCTTCATCATCAGGAAGAAAGAGGAGGAGAAAAAAAG
AGAGGTGTTGAATAATCCTGTGAAAATGAAGAAAATTAAAGAATTGTTGCAAATGAGTCTAGTA
AAAAAGGAGAAGAAGAAAAAGAAGGAGAAGAAAAAGAAGCACAAGAAACATAAGCACAGAGGCT
CAAGTAGCGATCGTTGCAGCAGCGAGGATGAGCGCGGCCGGGGGAGATCTCAAAAGAAGCTGGC
GAATTCTTCCCCTGTTTTGGCCAAAGTCCCTGGATATGGCTTACAGCTCAGGAACTCCGACCGG
AGCCAGGGACCGCGGGGTCCTCCGGCGGCTGAGCAGCGGGCAGGGCGTGGGTTGAAGAATTACT
CCAGGTCTAGAAGCTCCTCTCCCTCACCTCCGAGACACGCCAGCAAGAAGAGCACCAGAGAAGC
AGGGTCCCGGGACAGAAGGTCCCGGTCCCCGGGCAGAAGGTCCCGATCCCCCAGGCCAAGCAAA
CCGCACAACTCTAAGGTAAGCAGGAGAGACAGAGGCCGAACTAAGAGCCCATCACCTAAAAAAG
AGGTCTACCAAAGGCGGCATGCTCCAGGGTACACCAGAAAGCTCTCATCGGAGGAGCTGGAGCG
AAAACGGCAAGAGATGATGGAGAACGCCAAGTGGCGGGAGGCGGAGAGGCTCAACATCCTCAAG
AGACACGCCAAGGACGACGAGCGCGAGCAGAGGCTGCAGAAGCTGGACTCTCGGGATGGCAAGT
TCCTCCACCGCATGAAGCTAGAGAGCGCATCTACCTCCTCTCTGGAAGATCGGGTGAAGCGGAA
TATTTATTCCCTGCAGAGGACCTCAGTAGCTCTGGAGAAGAACTTTATGAAAAGATGAAAGCCA
TCGCCTGTCTTGCTGGTTTTCCTGAAGTTTTCAGGGAGGCTGCTGACCCCTTACAAATTCTCTT
TATAAGAGTTCAAATGGCTTCTTCCACAGATGTCAAACCACCACTGTTCAAAGTGACTGTCCCC
CGTGGATCGCAGAAACAGCCCATTTCTTTTGAGAACCCGTGTGACTTGCTCTATGGGACCCTCG
GTAACTTTTGCTGGGTGCAGAGCAGATTTTAACTTTTTTTTTTTTTTTTTTTTTTTTAGGGGAT
GGGCACTGGAGCATCTCGGGGTGAGCACTCATGTTGCTCTGGAAGCCTGCTCCCCATGGTCAGG
GTACTTTTTATTCCTCTTCCCTCCACCTGTGTGAACACCCCTATACTACCACCTCAGTATAGAC
CGGACCTTTTGGAAGCCTCTCTCCCCAAAGCCACTCAGGTAGAGCCCAGGGAGTGACAAAGAAT
CTGGAAGGGAAAACAATGCAAAAAAGCCCTGTAAATGAACTATTGAAGTATTTGGACTTTTTCT
CCAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001231581	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00000019372.2
	ENSSSCP00000032040
	ENSSSCP00000032040.1
	ENSSSCP00005020345.1
	ENSSSCP00015023511.1
	ENSSSCP00025027775.1
	ENSSSCP00030035317.1
	ENSSSCP00045031261.1
	ENSSSCP00055006718.1
	ENSSSCP00060032038.1
	ENSSSCP00070028961.1

RefSeq Acc Id:

NP_001231581 ⟸ NM_001244652

- UniProtKB:

A0A8D2BNM6 (UniProtKB/TrEMBL), A0A8D0XIK0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGGGDLNLKKSWHPQTLRNVEKVWKAEQKHEAERKKIEELQRELREERAREEMQRYAEDVGAVK
KKEEKLDWMYQGPGGMVNRDEYLLGRPIDKYVFEKMEEKEAGCSSETGLLPGSIFAPSGANSLL
DMASKIREDPLFIIRKKEEEKKREVLNNPVKMKKIKELLQMSLVKKEKKKKKEKKKKHKKHKHR
GSSSDRCSSEDERGRGRSQKKLANSSPVLAKVPGYGLQLRNSDRSQGPRGPPAAEQRAGRGLKN
YSRSRSSSPSPPRHASKKSTREAGSRDRRSRSPGRRSRSPRPSKPHNSKVSRRDRGRTKSPSPK
KEVYQRRHAPGYTRKLSSEELERKRQEMMENAKWREAERLNILKRHAKDDEREQRLQKLDSRDG
KFLHRMKLESASTSSLEDRVKRNIYSLQRTSVALEKNFMKR

hide sequence

RefSeq Acc Id:

ENSSSCP00000019372 ⟸ ENSSSCT00000027397

RefSeq Acc Id:

ENSSSCP00000032040 ⟸ ENSSSCT00000053706

Protein Domains

CBF1-interacting co-repressor CIR N-terminal

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000021478	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00005021145	UniProtKB/TrEMBL
	ENSSSCG00015044012	UniProtKB/TrEMBL
	ENSSSCG00025047921	UniProtKB/TrEMBL
	ENSSSCG00030055449	UniProtKB/TrEMBL
	ENSSSCG00045026492	UniProtKB/TrEMBL
	ENSSSCG00055004306	UniProtKB/TrEMBL
	ENSSSCG00060054578	UniProtKB/TrEMBL
	ENSSSCG00070017571	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000027397.4	UniProtKB/TrEMBL
	ENSSSCT00000053706	ENTREZGENE
	ENSSSCT00000053706.2	UniProtKB/TrEMBL
	ENSSSCT00005033376.1	UniProtKB/TrEMBL
	ENSSSCT00015058625.1	UniProtKB/TrEMBL
	ENSSSCT00025065149.1	UniProtKB/TrEMBL
	ENSSSCT00030077296.1	UniProtKB/TrEMBL
	ENSSSCT00045045077.1	UniProtKB/TrEMBL
	ENSSSCT00055008495.1	UniProtKB/TrEMBL
	ENSSSCT00060074294.1	UniProtKB/TrEMBL
	ENSSSCT00070034670.1	UniProtKB/TrEMBL
InterPro	CIR_N_dom	UniProtKB/TrEMBL
	CWC25	UniProtKB/TrEMBL
NCBI Gene	CWC25	ENTREZGENE
PANTHER	CELL CYCLE CONTROL PROTEIN CWF25	UniProtKB/TrEMBL
	PRE-MRNA-SPLICING FACTOR CWC25 HOMOLOG	UniProtKB/TrEMBL
Pfam	Cir_N	UniProtKB/TrEMBL
	CWC25	UniProtKB/TrEMBL
SMART	Cir_N	UniProtKB/TrEMBL
UniProt	A0A286ZKR9_PIG	UniProtKB/TrEMBL
	A0A4X1UG33_PIG	UniProtKB/TrEMBL
	A0A8D0XIK0	ENTREZGENE, UniProtKB/TrEMBL
	A0A8D2BNM6	ENTREZGENE, UniProtKB/TrEMBL
	I3L5S2_PIG	UniProtKB/TrEMBL
VGNC ID	VGNC:87096	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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