MCCC2 (methylcrotonyl-CoA carboxylase subunit 2) - Rat Genome Database

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Gene: MCCC2 (methylcrotonyl-CoA carboxylase subunit 2) Sus scrofa
Analyze
Symbol: MCCC2
Name: methylcrotonyl-CoA carboxylase subunit 2
RGD ID: 13971001
Description: ENCODES a protein that exhibits ligase activity (inferred); methylcrotonoyl-CoA carboxylase activity (inferred); INVOLVED IN coenzyme A metabolic process (ortholog); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; ASSOCIATED WITH 3-Methylcrotonyl-CoA carboxylase 2 deficiency (ortholog); 3-methylcrotonyl-CoA carboxylase deficiency (ortholog); autism spectrum disorder (ortholog); FOUND IN 3-methylcrotonyl-CoA carboxylase complex, mitochondrial (ortholog); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: methylcrotonoyl-CoA carboxylase 2; methylcrotonoyl-CoA carboxylase 2 (beta); methylcrotonoyl-CoA carboxylase beta chain, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1647,917,291 - 47,996,534 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11647,917,308 - 47,996,540 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21651,863,689 - 51,939,708 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:30032202  


Genomics

Comparative Map Data
MCCC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1647,917,291 - 47,996,534 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11647,917,308 - 47,996,540 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21651,863,689 - 51,939,708 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MCCC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38571,587,340 - 71,658,706 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl571,579,531 - 71,658,706 (+)EnsemblGRCh38hg38GRCh38
GRCh37570,883,167 - 70,954,533 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36570,918,910 - 70,988,981 (+)NCBINCBI36Build 36hg18NCBI36
Build 34570,918,909 - 70,988,981NCBI
Celera566,778,848 - 66,850,229 (+)NCBICelera
Cytogenetic Map5q13.2NCBI
HuRef566,088,903 - 66,160,527 (+)NCBIHuRef
CHM1_1570,315,816 - 70,387,189 (+)NCBICHM1_1
T2T-CHM13v2.0572,068,680 - 72,140,018 (+)NCBIT2T-CHM13v2.0
Mccc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913100,085,040 - 100,152,147 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13100,085,038 - 100,152,147 (-)EnsemblGRCm39 Ensembl
GRCm381399,948,532 - 100,015,639 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1399,948,530 - 100,015,639 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713100,718,487 - 100,785,594 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613101,048,783 - 101,115,886 (-)NCBIMGSCv36mm8
Celera13103,601,615 - 103,669,283 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1352.9NCBI
Mccc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8233,039,044 - 33,110,092 (-)NCBIGRCr8
mRatBN7.2231,304,927 - 31,375,978 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl231,304,932 - 31,375,972 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx238,383,154 - 38,454,061 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0236,477,507 - 36,548,413 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0231,270,308 - 31,341,430 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0230,175,017 - 30,246,028 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl230,175,018 - 30,246,010 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0249,333,901 - 49,404,647 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4230,961,607 - 31,032,883 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1230,881,976 - 30,953,252 (-)NCBI
Celera227,327,945 - 27,397,754 (-)NCBICelera
Cytogenetic Map2q12NCBI
Mccc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955575445,619 - 505,040 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955575445,627 - 503,891 (+)NCBIChiLan1.0ChiLan1.0
MCCC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2443,651,293 - 43,726,414 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1541,804,951 - 41,880,028 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0543,650,993 - 43,724,877 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1544,298,650 - 44,369,106 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl544,298,650 - 44,369,106 (-)Ensemblpanpan1.1panPan2
MCCC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1254,751,703 - 54,825,133 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl254,751,698 - 54,823,273 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha251,718,218 - 51,791,623 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0255,265,241 - 55,340,500 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl255,265,213 - 55,340,215 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1252,327,887 - 52,401,292 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0253,094,755 - 53,168,219 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0253,986,123 - 54,059,570 (+)NCBIUU_Cfam_GSD_1.0
Mccc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213186,028,772 - 186,100,599 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365494,755,546 - 4,830,242 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365494,760,073 - 4,830,190 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MCCC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1465,944,742 - 66,013,663 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl465,944,840 - 66,013,663 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604914,689,886 - 14,759,320 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mccc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624905645,715 - 712,364 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624905645,782 - 709,611 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MCCC2
2505 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1 1 20 2 2
Low 10 4 2 4 2 3 1 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000018480   ⟹   ENSSSCP00000017980
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1647,917,291 - 47,974,257 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000062419   ⟹   ENSSSCP00000052316
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1647,917,368 - 47,996,534 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000067179   ⟹   ENSSSCP00000067080
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1647,917,303 - 47,985,608 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000091683   ⟹   ENSSSCP00000078753
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1647,917,368 - 47,996,534 (+)Ensembl
RefSeq Acc Id: XM_005672531   ⟹   XP_005672588
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11647,917,308 - 47,996,540 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_005672588   ⟸   XM_005672531
- UniProtKB: A0A0B8S051 (UniProtKB/TrEMBL),   A0A8D1L482 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000052316   ⟸   ENSSSCT00000062419
RefSeq Acc Id: ENSSSCP00000067080   ⟸   ENSSSCT00000067179
RefSeq Acc Id: ENSSSCP00000017980   ⟸   ENSSSCT00000018480
RefSeq Acc Id: ENSSSCP00000078753   ⟸   ENSSSCT00000091683
Protein Domains
CoA carboxyltransferase C-terminal   CoA carboxyltransferase N-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000016971 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025040391 UniProtKB/TrEMBL
  ENSSSCG00045028031 UniProtKB/TrEMBL
  ENSSSCG00055023743 UniProtKB/TrEMBL
  ENSSSCG00070016633 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000018480.4 UniProtKB/TrEMBL
  ENSSSCT00000062419.3 UniProtKB/TrEMBL
  ENSSSCT00000067179.2 UniProtKB/TrEMBL
  ENSSSCT00000091683 ENTREZGENE
  ENSSSCT00000091683.1 UniProtKB/TrEMBL
  ENSSSCT00025054846.1 UniProtKB/TrEMBL
  ENSSSCT00025055230.1 UniProtKB/TrEMBL
  ENSSSCT00045047694.1 UniProtKB/TrEMBL
  ENSSSCT00045047820.1 UniProtKB/TrEMBL
  ENSSSCT00045048123.1 UniProtKB/TrEMBL
  ENSSSCT00045048289.1 UniProtKB/TrEMBL
  ENSSSCT00055046738.1 UniProtKB/TrEMBL
  ENSSSCT00055047071.1 UniProtKB/TrEMBL
  ENSSSCT00070032808.1 UniProtKB/TrEMBL
  ENSSSCT00070032818.1 UniProtKB/TrEMBL
  ENSSSCT00070032833.1 UniProtKB/TrEMBL
InterPro AcCoA_carboxyl UniProtKB/TrEMBL
  ClpP/crotonase-like_dom_sf UniProtKB/TrEMBL
  COA_CT_C UniProtKB/TrEMBL
  COA_CT_N UniProtKB/TrEMBL
  MCCB/AccD1-like UniProtKB/TrEMBL
NCBI Gene MCCC2 ENTREZGENE
PANTHER METHYLCROTONOYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL UniProtKB/TrEMBL
  PTHR22855 UniProtKB/TrEMBL
Pfam Carboxyl_trans UniProtKB/TrEMBL
PROSITE COA_CT_CTER UniProtKB/TrEMBL
  COA_CT_NTER UniProtKB/TrEMBL
Superfamily-SCOP SSF52096 UniProtKB/TrEMBL
UniProt A0A0B8S051 ENTREZGENE
  A0A287B773_PIG UniProtKB/TrEMBL
  A0A4X1UEA3_PIG UniProtKB/TrEMBL
  A0A4X1UGS7_PIG UniProtKB/TrEMBL
  A0A4X1UH87_PIG UniProtKB/TrEMBL
  A0A5G2QSH7_PIG UniProtKB/TrEMBL
  A0A8D0S4P4_PIG UniProtKB/TrEMBL
  A0A8D1IDG0_PIG UniProtKB/TrEMBL
  A0A8D1IHF5_PIG UniProtKB/TrEMBL
  A0A8D1L482 ENTREZGENE, UniProtKB/TrEMBL
  A0A8W4FIP3_PIG UniProtKB/TrEMBL
  F1SK15_PIG UniProtKB/TrEMBL
VGNC ID VGNC:90064 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-22 MCCC2  methylcrotonyl-CoA carboxylase subunit 2  MCCC2  methylcrotonoyl-CoA carboxylase 2  Symbol and/or name change 19259463 PROVISIONAL