LRRC8A (leucine rich repeat containing 8 VRAC subunit A) - Rat Genome Database
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Gene: LRRC8A (leucine rich repeat containing 8 VRAC subunit A) Sus scrofa
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Symbol: LRRC8A
Name: leucine rich repeat containing 8 VRAC subunit A
RGD ID: 13968422
Description: ENCODES a protein that exhibits anion channel activity (ortholog); volume-sensitive anion channel activity (ortholog); INVOLVED IN anion transmembrane transport (ortholog); anion transport (ortholog); aspartate transmembrane transport (ortholog); ASSOCIATED WITH agammaglobulinemia (ortholog); agammaglobulinemia 5 (ortholog); FOUND IN cell surface (ortholog); integral component of plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: leucine rich repeat containing 8 family member A; volume-regulated anion channel subunit LRRC8A
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1269,209,671 - 269,238,526 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11269,209,660 - 269,238,529 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21303,258,058 - 303,270,700 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References
Additional References at PubMed
PMID:14681463   PMID:17145712  


Genomics

Comparative Map Data
LRRC8A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1269,209,671 - 269,238,526 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11269,209,660 - 269,238,529 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21303,258,058 - 303,270,700 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LRRC8A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl9128,882,112 - 128,918,039 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl9128,882,133 - 128,918,039 (+)EnsemblGRCh38hg38GRCh38
GRCh389128,882,133 - 128,918,042 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh379131,644,412 - 131,680,318 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369130,684,268 - 130,720,136 (+)NCBINCBI36hg18NCBI36
Celera9102,296,285 - 102,332,152 (+)NCBI
Cytogenetic Map9q34.11NCBI
HuRef9101,252,498 - 101,288,005 (+)NCBIHuRef
CHM1_19131,795,371 - 131,831,304 (+)NCBICHM1_1
Lrrc8a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39230,127,781 - 30,153,802 (+)NCBIGRCm39mm39
GRCm39 Ensembl230,127,727 - 30,153,802 (+)Ensembl
GRCm38230,237,769 - 30,263,790 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl230,237,715 - 30,263,790 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl230,240,567 - 30,282,148 (+)EnsemblGRCm38mm10GRCm38
MGSCv37230,093,289 - 30,119,310 (+)NCBIGRCm37mm9NCBIm37
MGSCv36230,059,778 - 30,085,799 (+)NCBImm8
Celera229,942,159 - 29,968,181 (+)NCBICelera
Cytogenetic Map2BNCBI
Lrrc8a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2313,509,577 - 13,537,174 (+)NCBI
Rnor_6.0 Ensembl38,802,852 - 8,828,533 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.038,801,544 - 8,829,506 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0314,155,802 - 14,182,455 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.439,280,625 - 9,306,317 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.139,280,924 - 9,306,606 (+)NCBI
Celera38,277,157 - 8,302,778 (+)NCBICelera
Cytogenetic Map3p12NCBI
Lrrc8a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555701,271,131 - 1,295,773 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555701,270,710 - 1,295,658 (+)NCBIChiLan1.0ChiLan1.0
LRRC8A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19128,670,292 - 128,705,466 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9128,670,292 - 128,705,466 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v09100,003,969 - 100,039,859 (+)NCBIMhudiblu_PPA_v0panPan3
LRRC8A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl954,734,505 - 54,756,780 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1954,732,847 - 54,760,077 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Lrrc8a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493648716,360,672 - 16,387,860 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRRC8A
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1129,237,706 - 9,272,637 (-)NCBI
ChlSab1.1 Ensembl129,234,738 - 9,272,565 (-)Ensembl
Lrrc8a
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247606,122,626 - 6,148,033 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1
Low 10 4 3 5 2 22 2 3 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000006227   ⟹   ENSSSCP00000006068
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1269,209,692 - 269,238,523 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000064548   ⟹   ENSSSCP00000035469
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1269,209,671 - 269,238,526 (+)Ensembl
RefSeq Acc Id: XM_001928850   ⟹   XP_001928885
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11269,209,660 - 269,238,529 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005660498   ⟹   XP_005660555
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11269,210,041 - 269,238,529 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005660499   ⟹   XP_005660556
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11269,212,995 - 269,238,529 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013993913   ⟹   XP_013849367
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11269,209,666 - 269,238,529 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_001928885 (Get FASTA)   NCBI Sequence Viewer  
  XP_005660555 (Get FASTA)   NCBI Sequence Viewer  
  XP_005660556 (Get FASTA)   NCBI Sequence Viewer  
  XP_013849367 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_001928885   ⟸   XM_001928850
- UniProtKB: F1RR61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013849367   ⟸   XM_013993913
- UniProtKB: F1RR61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005660555   ⟸   XM_005660498
- UniProtKB: F1RR61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005660556   ⟸   XM_005660499
- UniProtKB: F1RR61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000035469   ⟸   ENSSSCT00000064548
RefSeq Acc Id: ENSSSCP00000006068   ⟸   ENSSSCT00000006227
Protein Domains
Pannexin_like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000005664 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070010598 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000006068 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000035469 UniProtKB/TrEMBL
  ENSSSCP00070017054 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000006227 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000064548 UniProtKB/TrEMBL
  ENSSSCT00070020565 UniProtKB/TrEMBL
Gene3D-CATH 3.80.10.10 UniProtKB/TrEMBL
InterPro Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
  LRRC8_Pannexin-like UniProtKB/TrEMBL
KEGG Report ssc:100157556 UniProtKB/TrEMBL
NCBI Gene LRRC8A ENTREZGENE
Pfam LRR_8 UniProtKB/TrEMBL
  Pannexin_like UniProtKB/TrEMBL
PROSITE LRR UniProtKB/TrEMBL
SMART LRR_TYP UniProtKB/TrEMBL
UniProt A0A286ZVF2_PIG UniProtKB/TrEMBL
  A0A4X1TJT1_PIG UniProtKB/TrEMBL
  F1RR61 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:98085 ENTREZGENE