BRK1 (BRICK1 subunit of SCAR/WAVE actin nucleating complex) - Rat Genome Database

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Gene: BRK1 (BRICK1 subunit of SCAR/WAVE actin nucleating complex) Sus scrofa
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Symbol: BRK1
Name: BRICK1 subunit of SCAR/WAVE actin nucleating complex
RGD ID: 13968115
Description: ENCODES a protein that exhibits small GTPase binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); cell motility (ortholog); in utero embryonic development (ortholog); PARTICIPATES IN platelet-derived growth factor signaling pathway; ASSOCIATED WITH Atrioventricular Septal Defect 2 (ortholog); familial erythrocytosis 2 (ortholog); Fanconi anemia (ortholog); FOUND IN cytoskeleton (inferred); lamellipodium (inferred)
Type: protein-coding
RefSeq Status: MODEL
Also known as: BRICK1, SCAR/WAVE actin nucleating complex subunit; protein BRICK1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1366,315,433 - 66,324,174 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11366,315,438 - 66,324,641 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21373,387,723 - 73,396,925 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463  


Genomics

Comparative Map Data
BRK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1366,315,433 - 66,324,174 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11366,315,438 - 66,324,641 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21373,387,723 - 73,396,925 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BRK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl310,115,675 - 10,127,190 (+)EnsemblGRCh38hg38GRCh38
GRCh38310,115,675 - 10,127,190 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37310,157,359 - 10,168,874 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36310,132,333 - 10,143,874 (+)NCBINCBI36hg18NCBI36
Build 34310,132,332 - 10,143,873NCBI
Celera310,093,000 - 10,104,540 (+)NCBI
Cytogenetic Map3p25.3NCBI
CHM1_1310,107,444 - 10,118,867 (+)NCBICHM1_1
Brk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396113,581,733 - 113,593,912 (+)NCBIGRCm39mm39
GRCm39 Ensembl6113,581,733 - 113,593,912 (+)Ensembl
GRCm386113,604,772 - 113,616,951 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6113,604,772 - 113,616,951 (+)EnsemblGRCm38mm10GRCm38
MGSCv376113,554,766 - 113,566,945 (+)NCBIGRCm37mm9NCBIm37
MGSCv366113,570,549 - 113,582,728 (+)NCBImm8
Celera6115,431,613 - 115,443,812 (+)NCBICelera
Cytogenetic Map6E3NCBI
Brk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24146,750,821 - 146,766,050 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl4146,750,821 - 146,768,856 (+)Ensembl
Rnor_6.04145,559,206 - 145,574,438 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4145,559,206 - 145,574,438 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04208,855,604 - 208,870,836 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44149,507,741 - 149,522,713 (+)NCBIRGSC3.4rn4RGSC3.4
Celera4135,305,443 - 135,320,375 (+)NCBICelera
Cytogenetic Map4q42NCBI
Brk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555611,545,576 - 1,554,618 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555611,545,921 - 1,554,423 (+)NCBIChiLan1.0ChiLan1.0
BRK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1310,403,896 - 10,415,545 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl310,403,896 - 10,415,545 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0310,051,054 - 10,062,364 (+)NCBIMhudiblu_PPA_v0panPan3
BRK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1208,220,109 - 8,231,337 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl208,221,575 - 8,231,258 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha208,254,060 - 8,265,072 (-)NCBI
ROS_Cfam_1.0208,249,396 - 8,260,618 (-)NCBI
UMICH_Zoey_3.1207,971,630 - 7,982,616 (-)NCBI
UNSW_CanFamBas_1.0208,317,028 - 8,328,249 (-)NCBI
UU_Cfam_GSD_1.0208,290,766 - 8,301,757 (-)NCBI
Brk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494215,753,956 - 15,761,145 (+)NCBI
SpeTri2.0NW_0049366023,147,773 - 3,155,739 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BRK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12246,157,063 - 46,169,833 (+)NCBI
Vero_WHO_p1.0NW_023666041120,376,713 - 120,389,511 (-)NCBI
Brk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247314,679,060 - 4,685,892 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 4 3 5 2 23 2 3 3
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000012657   ⟹   ENSSSCP00000012325
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1366,315,433 - 66,324,174 (+)Ensembl
RefSeq Acc Id: XM_003132361   ⟹   XP_003132409
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11366,315,438 - 66,324,641 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003132409 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003132409   ⟸   XM_003132361
- Sequence:
RefSeq Acc Id: ENSSSCP00000012325   ⟸   ENSSSCT00000012657


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000011565 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000012325 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000012657 ENTREZGENE, UniProtKB/TrEMBL
InterPro BRICK1 UniProtKB/TrEMBL
KEGG Report ssc:100522899 UniProtKB/TrEMBL
NCBI Gene BRK1 ENTREZGENE
PANTHER PTHR33668 UniProtKB/TrEMBL
UniProt F2Z5S6_PIG UniProtKB/TrEMBL
VGNC ID VGNC:85884 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-09-18 BRK1  BRICK1 subunit of SCAR/WAVE actin nucleating complex  BRK1  BRICK1, SCAR/WAVE actin nucleating complex subunit  Symbol and/or name change 5135510 APPROVED