LRRC57 (leucine rich repeat containing 57)

Gene: LRRC57 (leucine rich repeat containing 57) Sus scrofa

Analyze

Symbol:

LRRC57

Name:

leucine rich repeat containing 57

RGD ID:

13963937

Description:

ASSOCIATED WITH Bloom syndrome (ortholog); colorectal cancer (ortholog); genetic disease (ortholog)

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

leucine-rich repeat-containing protein 57

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	128,839,204 - 128,847,431 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	128,839,137 - 128,845,749 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	143,731,688 - 143,738,556 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Bloom syndrome (ISO)

colorectal cancer (ISO)

genetic disease (ISO)

References

Additional References at PubMed

PMID:14681463	PMID:15679890	PMID:22301074

Genomics

Comparative Map Data

LRRC57
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	128,839,204 - 128,847,431 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	128,839,137 - 128,845,749 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	143,731,688 - 143,738,556 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LRRC57
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	42,528,327 - 42,548,793 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	42,537,820 - 42,548,802 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	42,830,027 - 42,840,991 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	40,622,014 - 40,628,292 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	15	19,602,426 - 19,608,708 (-)	NCBI		Celera
Cytogenetic Map	15	q15.2	NCBI
HuRef	15	19,682,473 - 19,688,755 (-)	NCBI		HuRef
CHM1_1	15	42,953,162 - 42,959,444 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	15	40,334,371 - 40,354,843 (-)	NCBI		T2T-CHM13v2.0

Lrrc57
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	120,434,719 - 120,439,989 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	120,434,719 - 120,440,001 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	120,604,238 - 120,609,508 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	120,604,238 - 120,609,520 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	120,429,974 - 120,435,244 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	120,295,679 - 120,300,715 (-)	NCBI		MGSCv36	mm8
Celera	2	121,757,029 - 121,762,300 (-)	NCBI		Celera
Cytogenetic Map	2	E5	NCBI
cM Map	2	60.37	NCBI

Lrrc57
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	127,998,535 - 128,007,004 (-)	NCBI		GRCr8
mRatBN7.2	3	107,544,786 - 107,553,256 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	107,547,405 - 107,553,256 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	111,222,226 - 111,228,070 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	119,817,799 - 119,823,643 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	117,478,192 - 117,484,036 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	112,365,936 - 112,371,787 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	112,365,938 - 112,385,528 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0 Ensembl	3	112,370,057 - 112,371,664 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	118,912,832 - 118,918,683 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	107,365,961 - 107,371,816 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	107,262,390 - 107,268,061 (-)	NCBI
Celera	3	106,454,979 - 106,460,831 (-)	NCBI		Celera
Cytogenetic Map	3	q35	NCBI

Lrrc57
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955416	9,230,362 - 9,237,799 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955416	9,230,362 - 9,237,799 (-)	NCBI	ChiLan1.0	ChiLan1.0

LRRC57
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	31,788,619 - 31,799,619 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	35,945,583 - 35,956,606 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	21,499,139 - 21,510,154 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	39,659,381 - 39,666,068 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	39,659,387 - 39,666,068 (-)	Ensembl	panpan1.1		panPan2

LRRC57
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	30	9,497,328 - 9,502,235 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	30	9,554,594 - 9,559,683 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	30	9,632,152 - 9,637,242 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	30	9,632,159 - 9,637,170 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	30	9,551,416 - 9,556,506 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	30	9,657,980 - 9,663,060 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	30	9,790,695 - 9,795,782 (-)	NCBI		UU_Cfam_GSD_1.0

Lrrc57
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	87,974,785 - 87,978,759 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936471	5,820,579 - 5,827,084 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936471	5,822,165 - 5,826,894 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LRRC57
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	40,427,588 - 40,434,108 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	40,427,887 - 40,432,553 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	100,578,130 - 100,584,784 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Lrrc57
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624804	9,648,956 - 9,656,754 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624804	9,648,956 - 9,656,464 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in LRRC57
101 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	hemolymphoid system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system
High
Medium	2			2		2			2
Low	8	4	3	3	2	21	2	3	1
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001244811	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK235771	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY609484	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CU929677	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GFLN01115832	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSSCT00000005219 ⟹ ENSSSCP00000005093

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	1	128,839,204 - 128,847,431 (+)	Ensembl

RefSeq Acc Id:

NM_001244811 ⟹ NP_001231740

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	1	128,839,137 - 128,845,749 (+)	NCBI

Sequence:

show sequence

CTTTCTCCACCCAGCCGGCTGTGAGCTGAGGGGTAGGAGGCGAGTTCCGGGATTCCGGATCCTC
CCTAGGCTCCTAGCGGCGGCTGGTTTCGGAAGAGCTGCAAAATCGGCAGGGCCTGGTGTTCTGC
TCTTTCTTCCCAGCCACTCTTGGGCTGGCCCCCAAGATCCAGGGATCCGCAGGAGGGACCTGAG
CAGTGGCGCTAGGATGGGAAACAGTGCCCTCCGTGCTCATGTGGAAACCGCGCAGAAAACTGGT
GTCTTTCAGCTTAAGGATCGTGGGCTGACCGAGTTCCCCTCAGAGTTGCAGAAGCTGACAAGCA
ATCTCAGGACCATCGACTTGTCCAGCAACAAGATCGAGAGTCTACCGCCTATGATTATAGGGAA
GTTCACTCTACTGAAGAGCCTCTCCTTGAACAACAACAGACTGACTGTTCTTCCTGATGAGTTA
TGCCATCTGAAAAAGCTAGAGACACTAAGTCTAAACAACAATCACTTAAGAGAGCTGCCATCTA
CTTTTGGGCAACTGTCTGCCCTGAAGACCCTGAGCATCTCTGGGAACCAGCTGCGAGCACTACC
ACCCCAGCTTTGTAGCCTACGGCACCTGGATGTAGTGGATCTCTCCAAGAACCAGATTCGGAGC
ATACCTGACATAGTAGGGGAGCTGCAGGTCATCGAACTCAACCTCAACCAGAACCAGATATCTC
AGATTTCAGTGAAGATATCTTGCTGTCCTCGCCTTAAAGTTCTCCGTCTGGAGGAGAACTGCCT
TGAGCTCAGTATGCTCCCACAGAGCATTCTCAGTGATTCCCAGATCTGTCTGCTTGCTGTGGAA
GGCAACCTTTTTGAAATAAAAAAACTTCGAGAATTAGAAGGCTATGACAAGTACATGGAGAGGT
TCACGGCCACCAAGAAGAAGTTTGCGTGATGTTCTCCAGGAACATGGGAACCTTAAAGGACACT
GGTTGGAACCTTTTGCAATCTGGCAGAATCAGAGGTTCCTGCTGTCAAGGATGTCTGCAGTAAG
GAGATAACCCTCCAGGAGGTTATGTTTCACTCTGATCGTTTTCCTTCCCAGGGCTTATCTCAAA
TAAGCTAAAAGGAATCAAGAGACAGGAAGAGTCCTCCATTTTAAGTCATGGATAGGGCAAAGGA
CAATGTTCATCTTCAAAACCATCATTAGTTTGGCTTTAAGAAACCCAGTAGCTAGTTGCTATTT
ATACAGTGAGAGGATGCTGCCTGGTACCAGAATAGCTTCACACAACAGCTTGAAATTTCATGTG
TTTCCTATGTGCAAGCTTTCATAAAGTCAGATGCCATTCCACTTCTGTGTTAACATTTTATATT
TTTATGAAATTCAAATAATTTGTGAGAGGCTGCTATGGTTAAAGAATTTAAGATTCCAGTCCAT
CAATTCAATTGCAATGTTTATACTTGGAATTTAGGATGTATGTAAACACATGACTCTTTTGATT
AAAAGTGTACTTTGTAGAGAAGCAACAACACAACACTAAGAGATGTTCCCCAAGGCTGCAGTAG
CAAATTTTTTACTATTGCAGGTGCCTTATTGATAGAGGGCTCTGAAGAGCTAAAACTATATATG
CAAAACTTGTAAGATACAAGGGTTTTAATAATCAAGATTTTCCTGAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001231740	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00000005093
	ENSSSCP00000005093.2
	ENSSSCP00005028780.1
	ENSSSCP00015034896.1
	ENSSSCP00025020780.1
	ENSSSCP00030040010.1
	ENSSSCP00035012966.1
	ENSSSCP00040014045.1
	ENSSSCP00045007195.1
	ENSSSCP00050030685.1
	ENSSSCP00055046487.1
	ENSSSCP00060044925.1
	ENSSSCP00065030417.1
	ENSSSCP00070035358.1

RefSeq Acc Id:

NP_001231740 ⟸ NM_001244811

- UniProtKB:

F1SI25 (UniProtKB/TrEMBL), A0A4X1V3Q6 (UniProtKB/TrEMBL), A0A8D1WUH8 (UniProtKB/TrEMBL), A0A8D1K737 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGNSALRAHVETAQKTGVFQLKDRGLTEFPSELQKLTSNLRTIDLSSNKIESLPPMIIGKFTLL
KSLSLNNNRLTVLPDELCHLKKLETLSLNNNHLRELPSTFGQLSALKTLSISGNQLRALPPQLC
SLRHLDVVDLSKNQIRSIPDIVGELQVIELNLNQNQISQISVKISCCPRLKVLRLEENCLELSM
LPQSILSDSQICLLAVEGNLFEIKKLRELEGYDKYMERFTATKKKFA

hide sequence

RefSeq Acc Id:

ENSSSCP00000005093 ⟸ ENSSSCT00000005219

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000004726	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00005029426	UniProtKB/TrEMBL
	ENSSSCG00015064119	UniProtKB/TrEMBL
	ENSSSCG00025035561	UniProtKB/TrEMBL
	ENSSSCG00030062038	UniProtKB/TrEMBL
	ENSSSCG00035024985	UniProtKB/TrEMBL
	ENSSSCG00040025566	UniProtKB/TrEMBL
	ENSSSCG00045006361	UniProtKB/TrEMBL
	ENSSSCG00050052415	UniProtKB/TrEMBL
	ENSSSCG00055029286	UniProtKB/TrEMBL
	ENSSSCG00060075194	UniProtKB/TrEMBL
	ENSSSCG00065050991	UniProtKB/TrEMBL
	ENSSSCG00070021179	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000005219	ENTREZGENE
	ENSSSCT00000005219.5	UniProtKB/TrEMBL
	ENSSSCT00005046804.1	UniProtKB/TrEMBL
	ENSSSCT00015085823.1	UniProtKB/TrEMBL
	ENSSSCT00025048494.1	UniProtKB/TrEMBL
	ENSSSCT00030086740.1	UniProtKB/TrEMBL
	ENSSSCT00035032877.1	UniProtKB/TrEMBL
	ENSSSCT00040034092.1	UniProtKB/TrEMBL
	ENSSSCT00045010561.1	UniProtKB/TrEMBL
	ENSSSCT00050071378.1	UniProtKB/TrEMBL
	ENSSSCT00055058116.1	UniProtKB/TrEMBL
	ENSSSCT00060103029.1	UniProtKB/TrEMBL
	ENSSSCT00065069831.1	UniProtKB/TrEMBL
	ENSSSCT00070042081.1	UniProtKB/TrEMBL
Gene3D-CATH	3.80.10.10	UniProtKB/TrEMBL
InterPro	Leu-rich_rpt	UniProtKB/TrEMBL
	Leu-rich_rpt_4	UniProtKB/TrEMBL
	Leu-rich_rpt_typical-subtyp	UniProtKB/TrEMBL
	LRR_dom_sf	UniProtKB/TrEMBL
KEGG Report	ssc:100513451	UniProtKB/TrEMBL
NCBI Gene	LRRC57	ENTREZGENE
PANTHER	PTHR48051	UniProtKB/TrEMBL
	ZGC:77287	UniProtKB/TrEMBL
Pfam	LRR_4	UniProtKB/TrEMBL
	LRR_8	UniProtKB/TrEMBL
PRINTS	LEURICHRPT	UniProtKB/TrEMBL
PROSITE	LRR	UniProtKB/TrEMBL
SMART	LRR_BAC	UniProtKB/TrEMBL
	LRR_TYP	UniProtKB/TrEMBL
Superfamily-SCOP	L domain-like	UniProtKB/TrEMBL
UniProt	A0A4X1V3Q6	ENTREZGENE
	A0A8D1K737	ENTREZGENE, UniProtKB/TrEMBL
	A0A8D1WUH8	ENTREZGENE, UniProtKB/TrEMBL
	F1SI25	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	A0A4X1V3Q6	UniProtKB/TrEMBL
VGNC ID	VGNC:103119	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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