ALDH1A2 (aldehyde dehydrogenase 1 family member A2) - Rat Genome Database

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Gene: ALDH1A2 (aldehyde dehydrogenase 1 family member A2) Sus scrofa
Analyze
Symbol: ALDH1A2
Name: aldehyde dehydrogenase 1 family member A2
RGD ID: 13960675
Description: ENCODES a protein that exhibits retinal binding (ortholog); retinal dehydrogenase activity (ortholog); INVOLVED IN 9-cis-retinoic acid biosynthetic process (ortholog); anterior/posterior pattern specification (ortholog); blood vessel development (ortholog); PARTICIPATES IN retinoic acid metabolic pathway; retinol metabolic pathway; vitamin A deficiency pathway; ASSOCIATED WITH Bloom syndrome (ortholog); colorectal cancer (ortholog); Coronary Occlusion (ortholog); FOUND IN cytosol (ortholog); perinuclear region of cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: retinal dehydrogenase 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1113,932,739 - 114,037,046 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11113,932,722 - 114,037,059 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21126,038,541 - 126,105,080 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
9-cis-retinoic acid biosynthetic process  (IEA,ISO)
anterior/posterior pattern specification  (IEA,ISO)
blood vessel development  (IEA,ISO)
camera-type eye development  (IEA,ISO)
cardiac muscle tissue development  (IEA,ISO)
cell population proliferation  (IEA,ISO)
cellular response to retinoic acid  (IEA)
determination of bilateral symmetry  (IEA,ISO)
embryonic camera-type eye development  (IEA,ISO)
embryonic digestive tract development  (IEA,ISO)
embryonic forelimb morphogenesis  (IEA,ISO)
embryonic limb morphogenesis  (IEA,ISO)
face development  (IEA,ISO)
forebrain development  (IEA,ISO)
heart morphogenesis  (IEA,ISO)
hindbrain development  (IEA,ISO)
kidney development  (ISO)
liver development  (ISO)
lung development  (IEA,ISO)
midgut development  (ISO)
morphogenesis of embryonic epithelium  (IEA,ISO)
negative regulation of cell population proliferation  (IEA)
neural crest cell development  (IEA,ISO)
neural tube development  (IEA)
neuron differentiation  (IEA,ISO)
pancreas development  (IEA,ISO)
pituitary gland development  (ISO)
positive regulation of apoptotic process  (IEA,ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
protein homotetramerization  (IEA)
proximal/distal pattern formation  (IEA,ISO)
regulation of endothelial cell proliferation  (IEA)
regulation of vascular endothelial cell proliferation  (IEA,ISO)
response to cytokine  (IEA)
response to estradiol  (ISO)
response to vitamin A  (ISO)
retinal metabolic process  (IEA,ISO)
retinoic acid biosynthetic process  (IEA,ISO)
retinoic acid metabolic process  (IEA,ISO)
retinoic acid receptor signaling pathway  (IEA,ISO)
retinoic acid receptor signaling pathway involved in somitogenesis  (IEA,ISO)
ureter maturation  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:17145712  


Genomics

Comparative Map Data
ALDH1A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1113,932,739 - 114,037,046 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11113,932,722 - 114,037,059 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21126,038,541 - 126,105,080 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ALDH1A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381557,953,429 - 58,065,711 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1557,953,424 - 58,497,866 (-)EnsemblGRCh38hg38GRCh38
GRCh371558,245,627 - 58,357,909 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361556,032,919 - 56,145,198 (-)NCBINCBI36Build 36hg18NCBI36
Build 341556,032,918 - 56,093,527NCBI
Celera1535,135,291 - 35,247,470 (-)NCBICelera
Cytogenetic Map15q21.3NCBI
HuRef1535,068,702 - 35,181,099 (-)NCBIHuRef
CHM1_11558,363,582 - 58,476,117 (-)NCBICHM1_1
T2T-CHM13v2.01555,755,851 - 55,868,018 (-)NCBIT2T-CHM13v2.0
Aldh1a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39971,123,071 - 71,203,525 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl971,123,071 - 71,203,525 (+)EnsemblGRCm39 Ensembl
GRCm38971,215,789 - 71,296,243 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl971,215,789 - 71,296,243 (+)EnsemblGRCm38mm10GRCm38
MGSCv37971,063,596 - 71,144,050 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36971,014,409 - 71,094,803 (+)NCBIMGSCv36mm8
Celera968,414,967 - 68,495,534 (+)NCBICelera
Cytogenetic Map9DNCBI
cM Map939.85NCBI
Aldh1a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2871,877,850 - 71,957,107 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl871,877,850 - 71,957,107 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx877,412,501 - 77,491,856 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0875,685,476 - 75,764,833 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0873,522,516 - 73,601,878 (+)NCBIRnor_WKY
Rnor_6.0877,640,234 - 77,719,488 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl877,640,222 - 77,719,489 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0875,363,285 - 75,442,554 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4875,692,099 - 75,771,159 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1875,711,165 - 75,790,204 (+)NCBI
Celera869,779,737 - 69,858,993 (-)NCBICelera
Cytogenetic Map8q24NCBI
Aldh1a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545016,406,436 - 16,453,180 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545016,406,578 - 16,453,048 (+)NCBIChiLan1.0ChiLan1.0
ALDH1A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11555,237,101 - 55,349,851 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1555,237,101 - 55,557,168 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01536,925,443 - 37,038,288 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ALDH1A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13023,074,432 - 23,170,374 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3023,074,432 - 23,340,030 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3023,045,955 - 23,141,851 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03023,233,206 - 23,329,111 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3023,233,206 - 23,498,331 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13023,164,758 - 23,260,609 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03023,250,334 - 23,346,246 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03023,392,036 - 23,488,058 (-)NCBIUU_Cfam_GSD_1.0
Aldh1a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640101,327,905 - 101,415,451 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647119,175,992 - 19,263,335 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493647119,175,997 - 19,263,335 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALDH1A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12625,439,159 - 25,557,199 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2625,439,360 - 25,557,202 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048115,756,952 - 115,875,731 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aldh1a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478113,756,390 - 13,845,479 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478113,756,469 - 13,845,253 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 3 3 2
Low 9 4 3 9 2 1 2
Below cutoff 1 1 2 6 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000024465   ⟹   ENSSSCP00000027099
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1113,972,578 - 114,037,046 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000027950   ⟹   ENSSSCP00000024476
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1113,932,739 - 114,037,046 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000070862   ⟹   ENSSSCP00000072501
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1113,932,739 - 114,037,046 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000072756   ⟹   ENSSSCP00000074195
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1113,932,739 - 114,031,591 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000106626   ⟹   ENSSSCP00000078186
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1113,932,739 - 114,029,120 (+)Ensembl
RefSeq Acc Id: XM_021094598   ⟹   XP_020950257
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11113,932,739 - 114,037,059 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021094606   ⟹   XP_020950265
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11113,932,722 - 114,037,059 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021094609   ⟹   XP_020950268
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11113,933,068 - 114,037,059 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020950257 (Get FASTA)   NCBI Sequence Viewer  
  XP_020950265 (Get FASTA)   NCBI Sequence Viewer  
  XP_020950268 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020950265   ⟸   XM_021094606
- Peptide Label: isoform X1
- UniProtKB: A0A8D1KXY2 (UniProtKB/TrEMBL),   I3LK62 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020950257   ⟸   XM_021094598
- Peptide Label: isoform X1
- UniProtKB: A0A8D1KXY2 (UniProtKB/TrEMBL),   I3LK62 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020950268   ⟸   XM_021094609
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSSSCP00000027099   ⟸   ENSSSCT00000024465
RefSeq Acc Id: ENSSSCP00000072501   ⟸   ENSSSCT00000070862
RefSeq Acc Id: ENSSSCP00000024476   ⟸   ENSSSCT00000027950
RefSeq Acc Id: ENSSSCP00000074195   ⟸   ENSSSCT00000072756
RefSeq Acc Id: ENSSSCP00000078186   ⟸   ENSSSCT00000106626
Protein Domains
Aldedh


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000025578 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005032497 UniProtKB/TrEMBL
  ENSSSCG00015016728 UniProtKB/TrEMBL
  ENSSSCG00025024131 UniProtKB/TrEMBL
  ENSSSCG00030043092 UniProtKB/TrEMBL
  ENSSSCG00035063213 UniProtKB/TrEMBL
  ENSSSCG00040033606 UniProtKB/TrEMBL
  ENSSSCG00045018004 UniProtKB/TrEMBL
  ENSSSCG00050007038 UniProtKB/TrEMBL
  ENSSSCG00055009804 UniProtKB/TrEMBL
  ENSSSCG00060064029 UniProtKB/TrEMBL
  ENSSSCG00070010025 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000024476 ENTREZGENE
  ENSSSCP00000024476.2 UniProtKB/TrEMBL
  ENSSSCP00000027099 ENTREZGENE
  ENSSSCP00000027099.3 UniProtKB/TrEMBL
  ENSSSCP00000072501.1 UniProtKB/TrEMBL
  ENSSSCP00000074195.1 UniProtKB/TrEMBL
  ENSSSCP00005032340.1 UniProtKB/TrEMBL
  ENSSSCP00005032383.1 UniProtKB/TrEMBL
  ENSSSCP00005032397.1 UniProtKB/TrEMBL
  ENSSSCP00015008845.1 UniProtKB/TrEMBL
  ENSSSCP00015008862.1 UniProtKB/TrEMBL
  ENSSSCP00025013755.1 UniProtKB/TrEMBL
  ENSSSCP00025013795.1 UniProtKB/TrEMBL
  ENSSSCP00025013848.1 UniProtKB/TrEMBL
  ENSSSCP00030027563.1 UniProtKB/TrEMBL
  ENSSSCP00030027581.1 UniProtKB/TrEMBL
  ENSSSCP00035035373.1 UniProtKB/TrEMBL
  ENSSSCP00035035376.1 UniProtKB/TrEMBL
  ENSSSCP00035035378.1 UniProtKB/TrEMBL
  ENSSSCP00040019110.1 UniProtKB/TrEMBL
  ENSSSCP00040019112.1 UniProtKB/TrEMBL
  ENSSSCP00045021413.1 UniProtKB/TrEMBL
  ENSSSCP00045021478.1 UniProtKB/TrEMBL
  ENSSSCP00050004157.1 UniProtKB/TrEMBL
  ENSSSCP00050004160.1 UniProtKB/TrEMBL
  ENSSSCP00055015330.1 UniProtKB/TrEMBL
  ENSSSCP00055015379.1 UniProtKB/TrEMBL
  ENSSSCP00055015425.1 UniProtKB/TrEMBL
  ENSSSCP00060037927.1 UniProtKB/TrEMBL
  ENSSSCP00060037936.1 UniProtKB/TrEMBL
  ENSSSCP00070016253.1 UniProtKB/TrEMBL
  ENSSSCP00070016262.1 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000024465 ENTREZGENE
  ENSSSCT00000024465.3 UniProtKB/TrEMBL
  ENSSSCT00000027950 ENTREZGENE
  ENSSSCT00000027950.2 UniProtKB/TrEMBL
  ENSSSCT00000070862.1 UniProtKB/TrEMBL
  ENSSSCT00000072756.1 UniProtKB/TrEMBL
  ENSSSCT00005052322.1 UniProtKB/TrEMBL
  ENSSSCT00005052413.1 UniProtKB/TrEMBL
  ENSSSCT00005052445.1 UniProtKB/TrEMBL
  ENSSSCT00015022692.1 UniProtKB/TrEMBL
  ENSSSCT00015022763.1 UniProtKB/TrEMBL
  ENSSSCT00025032955.1 UniProtKB/TrEMBL
  ENSSSCT00025033086.1 UniProtKB/TrEMBL
  ENSSSCT00025033229.1 UniProtKB/TrEMBL
  ENSSSCT00030060203.1 UniProtKB/TrEMBL
  ENSSSCT00030060243.1 UniProtKB/TrEMBL
  ENSSSCT00035085016.1 UniProtKB/TrEMBL
  ENSSSCT00035085023.1 UniProtKB/TrEMBL
  ENSSSCT00035085025.1 UniProtKB/TrEMBL
  ENSSSCT00040045537.1 UniProtKB/TrEMBL
  ENSSSCT00040045547.1 UniProtKB/TrEMBL
  ENSSSCT00045030879.1 UniProtKB/TrEMBL
  ENSSSCT00045030963.1 UniProtKB/TrEMBL
  ENSSSCT00050009665.1 UniProtKB/TrEMBL
  ENSSSCT00050009669.1 UniProtKB/TrEMBL
  ENSSSCT00055019438.1 UniProtKB/TrEMBL
  ENSSSCT00055019500.1 UniProtKB/TrEMBL
  ENSSSCT00055019555.1 UniProtKB/TrEMBL
  ENSSSCT00060087586.1 UniProtKB/TrEMBL
  ENSSSCT00060087613.1 UniProtKB/TrEMBL
  ENSSSCT00070019535.1 UniProtKB/TrEMBL
  ENSSSCT00070019547.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.309.10 UniProtKB/TrEMBL
  3.40.605.10 UniProtKB/TrEMBL
InterPro Ald_DH/histidinol_DH UniProtKB/TrEMBL
  Ald_DH_C UniProtKB/TrEMBL
  Ald_DH_CS_CYS UniProtKB/TrEMBL
  Ald_DH_CS_GLU UniProtKB/TrEMBL
  Ald_DH_N UniProtKB/TrEMBL
  Aldehyde_DH_dom UniProtKB/TrEMBL
NCBI Gene ALDH1A2 ENTREZGENE
Pfam Aldedh UniProtKB/TrEMBL
PROSITE ALDEHYDE_DEHYDR_CYS UniProtKB/TrEMBL
  ALDEHYDE_DEHYDR_GLU UniProtKB/TrEMBL
Superfamily-SCOP SSF53720 UniProtKB/TrEMBL
UniProt A0A4X1THV6_PIG UniProtKB/TrEMBL
  A0A4X1TM35_PIG UniProtKB/TrEMBL
  A0A5G2R5I9_PIG UniProtKB/TrEMBL
  A0A5G2RN58_PIG UniProtKB/TrEMBL
  A0A8D0K431_PIG UniProtKB/TrEMBL
  A0A8D0LSL7_PIG UniProtKB/TrEMBL
  A0A8D0RA05_PIG UniProtKB/TrEMBL
  A0A8D1JQB7_PIG UniProtKB/TrEMBL
  A0A8D1KXY2 ENTREZGENE, UniProtKB/TrEMBL
  I3LK62 ENTREZGENE, UniProtKB/TrEMBL
  I3LSK6_PIG UniProtKB/TrEMBL
VGNC ID VGNC:97878 ENTREZGENE