CMAH (cytidine monophospho-N-acetylneuraminic acid hydroxylase) - Rat Genome Database

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Gene: CMAH (cytidine monophospho-N-acetylneuraminic acid hydroxylase) Sus scrofa
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Symbol: CMAH
Name: cytidine monophospho-N-acetylneuraminic acid hydroxylase (Ensembl:cytidine monophosphate-N-acetylneuraminic acid hydroxylase)
RGD ID: 13958677
Description: ENCODES a protein that exhibits 2 iron, 2 sulfur cluster binding (inferred); CMP-N-acetylneuraminate monooxygenase activity (inferred); iron-sulfur cluster binding (inferred); INVOLVED IN CMP-N-acetylneuraminate metabolic process (ortholog); regulation of Wnt signaling pathway (ortholog); ASSOCIATED WITH multiple sclerosis (ortholog); FOUND IN cytoskeleton (ortholog); membrane (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CMP-N-acetylneuraminate monooxygenase; CMP-N-acetylneuraminic acid hydroxylase; CMP-Neu5Ac hydroxylase; CMP-NeuAc hydroxylase; cytidine monophosphate-N-acetylneuraminic acid hydroxylase
RGD Orthologs
Human
Mouse
Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl719,870,966 - 19,955,759 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1719,879,367 - 19,917,761 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2721,032,289 - 21,070,741 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA)
cytoskeleton  (ISO)
membrane  (ISO)
nucleus  (ISO)

Molecular Function

References
Additional References at PubMed
PMID:8647250   PMID:20047559   PMID:22564646   PMID:24033743   PMID:26906939   PMID:27100221   PMID:28114170   PMID:31591751  


Genomics

Comparative Map Data
CMAH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl719,870,966 - 19,955,759 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1719,879,367 - 19,917,761 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2721,032,289 - 21,070,741 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CMAHP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38625,081,067 - 25,138,392 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl625,061,626 - 25,452,263 (-)EnsemblGRCh38hg38GRCh38
GRCh37625,081,295 - 25,138,620 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36625,189,274 - 25,246,030 (-)NCBINCBI36Build 36hg18NCBI36
Build 34625,189,521 - 25,246,011NCBI
Celera626,308,566 - 26,365,922 (-)NCBICelera
Cytogenetic Map6p22.3NCBI
HuRef625,024,347 - 25,081,700 (-)NCBIHuRef
CHM1_1625,083,540 - 25,140,873 (-)NCBICHM1_1
T2T-CHM13v2.0624,946,777 - 25,004,128 (-)NCBIT2T-CHM13v2.0
Cmah
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391324,511,387 - 24,661,272 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1324,511,387 - 24,661,360 (+)EnsemblGRCm39 Ensembl
GRCm381324,327,404 - 24,477,289 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1324,327,404 - 24,477,377 (+)EnsemblGRCm38mm10GRCm38
MGSCv371324,419,289 - 24,569,154 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361324,422,587 - 24,478,476 (+)NCBIMGSCv36mm8
Celera1324,557,924 - 24,708,037 (+)NCBICelera
Cytogenetic Map13A3.1NCBI
Cmahp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21740,557,161 - 40,642,350 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1740,583,667 - 40,642,275 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1740,651,566 - 40,713,392 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01742,255,609 - 42,317,444 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01740,538,784 - 40,596,352 (-)NCBIRnor_WKY
Rnor_6.01742,567,472 - 42,640,221 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1742,583,945 - 42,640,221 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01744,449,934 - 44,506,535 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41747,672,292 - 47,715,697 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11747,675,138 - 47,718,538 (-)NCBI
Celera1740,219,952 - 40,277,207 (-)NCBICelera
Cytogenetic Map17p11NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 8 2 5 1 1
Low 2 2 3 2 22 2 2 2
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000001195   ⟹   ENSSSCP00000001169
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl719,874,132 - 19,955,759 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000075719   ⟹   ENSSSCP00000060314
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl719,870,966 - 19,918,025 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000089016   ⟹   ENSSSCP00000074125
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl719,882,495 - 20,002,956 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000090931   ⟹   ENSSSCP00000063404
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl719,880,134 - 19,918,093 (-)Ensembl
RefSeq Acc Id: NM_001113015   ⟹   NP_001106486
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1719,879,367 - 19,917,761 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001106486   ⟸   NM_001113015
- UniProtKB: A8WAC5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000001169   ⟸   ENSSSCT00000001195
RefSeq Acc Id: ENSSSCP00000074125   ⟸   ENSSSCT00000089016
RefSeq Acc Id: ENSSSCP00000063404   ⟸   ENSSSCT00000090931
RefSeq Acc Id: ENSSSCP00000060314   ⟸   ENSSSCT00000075719
Protein Domains
Rieske


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000001099 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000001169.2 UniProtKB/TrEMBL
  ENSSSCP00000060314 ENTREZGENE
  ENSSSCP00000060314.1 UniProtKB/TrEMBL
  ENSSSCP00000063404.1 UniProtKB/TrEMBL
  ENSSSCP00000074125.1 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000001195.4 UniProtKB/TrEMBL
  ENSSSCT00000075719 ENTREZGENE
  ENSSSCT00000075719.1 UniProtKB/TrEMBL
  ENSSSCT00000089016.1 UniProtKB/TrEMBL
  ENSSSCT00000090931.1 UniProtKB/TrEMBL
Gene3D-CATH 2.102.10.10 UniProtKB/TrEMBL
  3.60.15.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CMP-Neu5Ac_hydroxylase_Rieske UniProtKB/TrEMBL
  Cnh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RibonucZ/Hydroxyglut_hydro UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rieske_2Fe-2S UniProtKB/TrEMBL
  Rieske_2Fe-2S_sf UniProtKB/TrEMBL
KEGG Report ssc:396918 UniProtKB/TrEMBL
NCBI Gene CMAH ENTREZGENE
PANTHER PTHR46522 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Rieske UniProtKB/TrEMBL
PROSITE RIESKE UniProtKB/TrEMBL
Superfamily-SCOP SSF50022 UniProtKB/TrEMBL
  SSF56281 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A480JKF8_PIG UniProtKB/TrEMBL
  A0A5G2Q829_PIG UniProtKB/TrEMBL
  A0A5G2QGI1_PIG UniProtKB/TrEMBL
  A8WAC5 ENTREZGENE, UniProtKB/TrEMBL
  CMAH_PIG UniProtKB/Swiss-Prot
  F1RUD5_PIG UniProtKB/TrEMBL
  O19074 ENTREZGENE
VGNC ID VGNC:109137 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-03-28 CMAH  cytidine monophospho-N-acetylneuraminic acid hydroxylase  CMAH  cytidine monophosphate-N-acetylneuraminic acid hydroxylase  Symbol and/or name change 19259463 PROVISIONAL