ATP1B1 (ATPase Na+/K+ transporting subunit beta 1) - Rat Genome Database

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Gene: ATP1B1 (ATPase Na+/K+ transporting subunit beta 1) Sus scrofa
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Symbol: ATP1B1
Name: ATPase Na+/K+ transporting subunit beta 1
RGD ID: 13957452
Description: ENCODES a protein that exhibits ATPase activator activity; ATPase binding; protein-macromolecule adaptor activity; INVOLVED IN cellular potassium ion homeostasis; cellular sodium ion homeostasis; membrane repolarization; PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; ASSOCIATED WITH 1q24 Deletion Syndrome (ortholog); acute myeloid leukemia (ortholog); Cardiac Arrhythmias (ortholog); FOUND IN sodium:potassium-exchanging ATPase complex; apical plasma membrane (ortholog); basolateral plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: ATPase, Na+/K+ transporting, beta 1 polypeptide; Na+, K+-ATPase beta-subunit; sodium/potassium-dependent ATPase subunit beta-1; sodium/potassium-transporting ATPase subunit beta-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl481,911,558 - 81,997,714 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1481,912,543 - 81,937,015 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2489,530,583 - 89,550,423 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap4q1.3-q2.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway  (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
alfentanil pharmacodynamics pathway  (ISO)
amiloride pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
bendroflumethiazide pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bumetanide pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
chlorothiazide pharmacodynamics pathway  (ISO)
chlorthalidone pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
cystinuria pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
eplerenone pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
etacrynic acid pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
furosemide pharmacodynamics pathway  (ISO)
Hartnup disease pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrochlorothiazide pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydroflumethiazide pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
iminoglycinuria pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
lactose degradation pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
lysinuric protein intolerance pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
metolazone pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
spironolactone pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
torasemide pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)
trehalose degradation pathway  (ISO)
triamterene pharmacodynamics pathway  (ISO)
trichlormethiazide pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:2423371   PMID:2436627   PMID:3036581   PMID:8381768   PMID:9250869   PMID:14681463   PMID:15679890   PMID:18052210   PMID:18075585   PMID:19542013   PMID:19726667   PMID:20501797  
PMID:21182963   PMID:24089211  


Genomics

Comparative Map Data
ATP1B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl481,911,558 - 81,997,714 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1481,912,543 - 81,937,015 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2489,530,583 - 89,550,423 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap4q1.3-q2.1NCBI
ATP1B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1169,105,697 - 169,132,722 (+)EnsemblGRCh38hg38GRCh38
GRCh381169,106,690 - 169,132,719 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371169,075,928 - 169,101,957 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361167,342,571 - 167,368,584 (+)NCBINCBI36hg18NCBI36
Build 341165,807,604 - 165,833,618NCBI
Celera1142,186,000 - 142,212,016 (+)NCBI
Cytogenetic Map1q24.2NCBI
HuRef1140,321,997 - 140,348,078 (+)NCBIHuRef
CHM1_11170,498,009 - 170,524,021 (+)NCBICHM1_1
Atp1b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391164,264,668 - 164,285,924 (-)NCBIGRCm39mm39
GRCm39 Ensembl1164,264,678 - 164,285,924 (-)Ensembl
GRCm381164,437,099 - 164,458,355 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1164,437,109 - 164,458,355 (-)EnsemblGRCm38mm10GRCm38
MGSCv371166,367,398 - 166,388,486 (-)NCBIGRCm37mm9NCBIm37
MGSCv361166,273,942 - 166,295,030 (-)NCBImm8
Celera1166,878,624 - 166,899,734 (-)NCBICelera
Cytogenetic Map1H2.2NCBI
cM Map171.75NCBI
Atp1b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21376,786,580 - 76,807,096 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1376,786,578 - 76,807,459 (-)Ensembl
Rnor_6.01382,737,161 - 82,757,681 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1382,737,159 - 82,758,004 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01387,621,447 - 87,641,967 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41380,214,056 - 80,234,576 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11380,228,241 - 80,249,087 (-)NCBI
Celera1376,517,954 - 76,538,475 (-)NCBICelera
RH 3.4 Map13485.8RGD
Cytogenetic Map13q23NCBI
Atp1b1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554628,073,679 - 8,094,880 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554628,072,519 - 8,095,311 (-)NCBIChiLan1.0ChiLan1.0
ATP1B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11148,314,700 - 148,343,205 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1148,314,793 - 148,342,050 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01144,592,667 - 144,621,052 (+)NCBIMhudiblu_PPA_v0panPan3
ATP1B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1729,464,132 - 29,487,124 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl729,464,132 - 29,487,947 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha728,995,904 - 29,019,080 (-)NCBI
ROS_Cfam_1.0729,266,289 - 29,289,513 (-)NCBI
UMICH_Zoey_3.1729,114,027 - 29,137,166 (-)NCBI
UNSW_CanFamBas_1.0729,155,842 - 29,179,013 (-)NCBI
UU_Cfam_GSD_1.0729,386,814 - 29,410,001 (-)NCBI
Atp1b1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934499,591,400 - 99,613,578 (-)NCBI
SpeTri2.0NW_00493648117,438,146 - 17,460,329 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATP1B1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12559,898,745 - 59,925,166 (-)NCBI
ChlSab1.1 Ensembl2559,895,341 - 59,925,522 (-)Ensembl
Vero_WHO_p1.0NW_02366605561,575,309 - 61,602,086 (-)NCBI
Atp1b1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248267,058,046 - 7,076,919 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 8 2 3 1 2 23 2 3 3
Low 2 2 4
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000006901   ⟹   ENSSSCP00000006713
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl481,911,558 - 81,997,714 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000045595   ⟹   ENSSSCP00000043160
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl481,911,566 - 81,937,025 (-)Ensembl
RefSeq Acc Id: NM_001001542   ⟹   NP_001001542
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1481,912,543 - 81,937,015 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001001542 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA31001 (Get FASTA)   NCBI Sequence Viewer  
  CAA27575 (Get FASTA)   NCBI Sequence Viewer  
  CAA28301 (Get FASTA)   NCBI Sequence Viewer  
  CAB92954 (Get FASTA)   NCBI Sequence Viewer  
  P05027 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001001542   ⟸   NM_001001542
- UniProtKB: P05027 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSSSCP00000006713   ⟸   ENSSSCT00000006901
RefSeq Acc Id: ENSSSCP00000043160   ⟸   ENSSSCT00000045595


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000006296 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00025052482 UniProtKB/Swiss-Prot
  ENSSSCG00035064350 UniProtKB/Swiss-Prot
  ENSSSCG00045038671 UniProtKB/Swiss-Prot
  ENSSSCG00055010846 UniProtKB/Swiss-Prot
  ENSSSCG00070021088 UniProtKB/Swiss-Prot
Ensembl Protein ENSSSCP00000006713 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSSSCP00000043160 UniProtKB/TrEMBL
  ENSSSCP00025031098 UniProtKB/Swiss-Prot
  ENSSSCP00035036104 UniProtKB/Swiss-Prot
  ENSSSCP00045047697 UniProtKB/Swiss-Prot
  ENSSSCP00055016922 UniProtKB/Swiss-Prot
  ENSSSCP00070035369 UniProtKB/Swiss-Prot
  ENSSSCP00070035513 UniProtKB/Swiss-Prot
  ENSSSCP00070035557 UniProtKB/Swiss-Prot
Ensembl Transcript ENSSSCT00000006901 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSSSCT00000045595 UniProtKB/TrEMBL
  ENSSSCT00025071802 UniProtKB/Swiss-Prot
  ENSSSCT00035086630 UniProtKB/Swiss-Prot
  ENSSSCT00045067159 UniProtKB/Swiss-Prot
  ENSSSCT00055021364 UniProtKB/Swiss-Prot
  ENSSSCT00070042092 UniProtKB/Swiss-Prot
  ENSSSCT00070042253 UniProtKB/Swiss-Prot
  ENSSSCT00070042300 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.1660 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Na/K_ATPase_sub_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Na/K_ATPase_sub_beta_chordates UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Na/K_ATPase_sub_beta_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:396898 UniProtKB/Swiss-Prot
NCBI Gene ATP1B1 ENTREZGENE
PANTHER PTHR11523 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11523:SF10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Na_K-ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ATPASE_NA_K_BETA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPASE_NA_K_BETA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs Na_K_ATPase_bet UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A5S6HMA0_PIG UniProtKB/TrEMBL
  AT1B1_PIG UniProtKB/Swiss-Prot, ENTREZGENE
  Q9N0I6_PIG UniProtKB/TrEMBL
VGNC ID VGNC:85642 ENTREZGENE