BUB1B (BUB1 mitotic checkpoint serine/threonine kinase B) - Rat Genome Database

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Gene: BUB1B (BUB1 mitotic checkpoint serine/threonine kinase B) Sus scrofa
Analyze
Symbol: BUB1B
Name: BUB1 mitotic checkpoint serine/threonine kinase B
RGD ID: 13957389
Description: ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); protein kinase activity (inferred); INVOLVED IN metaphase/anaphase transition of mitotic cell cycle (ortholog); protein localization to chromosome, centromeric region (ortholog); ASSOCIATED WITH Aneuploidy (ortholog); Bloom syndrome (ortholog); cerebral palsy (ortholog); FOUND IN mitotic checkpoint complex (ortholog); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: mitotic checkpoint serine/threonine-protein kinase BUB1 beta
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1131,092,958 - 131,143,794 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11131,093,026 - 131,143,840 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21146,217,357 - 146,249,488 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
BUB1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1131,092,958 - 131,143,794 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11131,093,026 - 131,143,840 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21146,217,357 - 146,249,488 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BUB1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381540,161,069 - 40,221,123 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1540,161,023 - 40,221,123 (+)EnsemblGRCh38hg38GRCh38
GRCh371540,453,270 - 40,513,324 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361538,240,530 - 38,300,629 (+)NCBINCBI36Build 36hg18NCBI36
Build 341538,240,529 - 38,300,627NCBI
Celera1517,219,190 - 17,279,313 (+)NCBICelera
Cytogenetic Map15q15.1NCBI
HuRef1517,296,260 - 17,356,314 (+)NCBIHuRef
CHM1_11540,573,169 - 40,633,290 (+)NCBICHM1_1
T2T-CHM13v2.01537,967,956 - 38,028,008 (+)NCBIT2T-CHM13v2.0
Bub1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392118,428,684 - 118,472,073 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2118,428,692 - 118,472,072 (+)EnsemblGRCm39 Ensembl
GRCm382118,598,202 - 118,641,592 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2118,598,211 - 118,641,591 (+)EnsemblGRCm38mm10GRCm38
MGSCv372118,423,947 - 118,467,328 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362118,289,697 - 118,333,032 (+)NCBIMGSCv36mm8
Celera2119,745,153 - 119,796,040 (+)NCBICelera
Cytogenetic Map2E5NCBI
cM Map259.4NCBI
Bub1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83126,017,019 - 126,069,470 (+)NCBIGRCr8
mRatBN7.23105,563,089 - 105,615,547 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3105,563,138 - 105,615,547 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3109,236,836 - 109,289,246 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03117,832,398 - 117,884,807 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03115,492,765 - 115,545,173 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03110,367,949 - 110,420,471 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3110,367,939 - 110,420,458 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03116,912,599 - 116,965,060 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43105,063,018 - 105,116,145 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13104,974,011 - 104,978,578 (+)NCBI
Celera3104,480,144 - 104,532,190 (+)NCBICelera
Cytogenetic Map3q35NCBI
Bub1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554167,105,261 - 7,160,012 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554167,105,302 - 7,159,121 (+)NCBIChiLan1.0ChiLan1.0
BUB1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21629,395,286 - 29,455,478 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11533,546,708 - 33,606,921 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01519,095,383 - 19,155,557 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11537,350,826 - 37,410,661 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1537,350,826 - 37,410,648 (+)Ensemblpanpan1.1panPan2
BUB1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1307,361,982 - 7,410,162 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl307,322,912 - 7,438,052 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha307,416,730 - 7,464,873 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0307,490,487 - 7,538,685 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl307,490,458 - 7,538,459 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1307,412,929 - 7,461,263 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0307,519,268 - 7,567,181 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0307,647,445 - 7,695,793 (+)NCBIUU_Cfam_GSD_1.0
Bub1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864085,783,495 - 85,851,191 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364713,633,536 - 3,695,684 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364713,631,760 - 3,696,024 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BUB1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12642,769,955 - 42,855,353 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2642,792,830 - 42,855,306 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604898,101,756 - 98,168,849 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bub1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248047,492,799 - 7,533,408 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248047,477,046 - 7,533,322 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in BUB1B
875 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1 1 3 1
Low 9 1 3 2 11 3 2
Below cutoff 2 2 11 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000005281   ⟹   ENSSSCP00000005153
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1131,075,058 - 131,143,805 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000031444   ⟹   ENSSSCP00000022548
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1131,092,958 - 131,143,794 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000032164   ⟹   ENSSSCP00000022619
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1131,075,058 - 131,143,797 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000063679   ⟹   ENSSSCP00000058158
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1131,092,958 - 131,143,794 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000064597   ⟹   ENSSSCP00000034974
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1131,093,033 - 131,143,767 (-)Ensembl
RefSeq Acc Id: XM_021097818   ⟹   XP_020953477
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11131,093,026 - 131,143,840 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021097820   ⟹   XP_020953479
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11131,093,026 - 131,143,825 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021097824   ⟹   XP_020953483
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11131,093,026 - 131,143,825 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020953477   ⟸   XM_021097818
- Peptide Label: isoform X1
- UniProtKB: A0A4X1UTG2 (UniProtKB/TrEMBL),   I3LEQ9 (UniProtKB/TrEMBL),   A0A480QUU6 (UniProtKB/TrEMBL),   A0A481CD71 (UniProtKB/TrEMBL),   A0A8D0J2C4 (UniProtKB/TrEMBL),   A0A8D0UDB2 (UniProtKB/TrEMBL),   A0A8D1EE57 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020953483   ⟸   XM_021097824
- Peptide Label: isoform X3
- UniProtKB: A0A8D0J444 (UniProtKB/TrEMBL),   A0A8D0Q573 (UniProtKB/TrEMBL),   A0A8D1EE67 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020953479   ⟸   XM_021097820
- Peptide Label: isoform X2
- UniProtKB: A0A287BP09 (UniProtKB/TrEMBL),   A0A4X1UTH1 (UniProtKB/TrEMBL),   A0A8D0J444 (UniProtKB/TrEMBL),   A0A8D0Q573 (UniProtKB/TrEMBL),   A0A8D1EE67 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000022548   ⟸   ENSSSCT00000031444
RefSeq Acc Id: ENSSSCP00000005153   ⟸   ENSSSCT00000005281
RefSeq Acc Id: ENSSSCP00000022619   ⟸   ENSSSCT00000032164
RefSeq Acc Id: ENSSSCP00000034974   ⟸   ENSSSCT00000064597
RefSeq Acc Id: ENSSSCP00000058158   ⟸   ENSSSCT00000063679
Protein Domains
BUB1 N-terminal   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000004782 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005020133 UniProtKB/TrEMBL
  ENSSSCG00015077416 UniProtKB/TrEMBL
  ENSSSCG00025014217 UniProtKB/TrEMBL
  ENSSSCG00030030604 UniProtKB/TrEMBL
  ENSSSCG00035058616 UniProtKB/TrEMBL
  ENSSSCG00040034657 UniProtKB/TrEMBL
  ENSSSCG00045014664 UniProtKB/TrEMBL
  ENSSSCG00050060606 UniProtKB/TrEMBL
  ENSSSCG00055019340 UniProtKB/TrEMBL
  ENSSSCG00060004409 UniProtKB/TrEMBL
  ENSSSCG00065055194 UniProtKB/TrEMBL
  ENSSSCG00070019115 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000031444 ENTREZGENE
  ENSSSCT00000031444.4 UniProtKB/TrEMBL
  ENSSSCT00000063679 ENTREZGENE
  ENSSSCT00000063679.3 UniProtKB/TrEMBL
  ENSSSCT00005031684.1 UniProtKB/TrEMBL
  ENSSSCT00005031726.1 UniProtKB/TrEMBL
  ENSSSCT00005031771.1 UniProtKB/TrEMBL
  ENSSSCT00005031792.1 UniProtKB/TrEMBL
  ENSSSCT00015104622.1 UniProtKB/TrEMBL
  ENSSSCT00015104649.1 UniProtKB/TrEMBL
  ENSSSCT00025018943.1 UniProtKB/TrEMBL
  ENSSSCT00025019007.1 UniProtKB/TrEMBL
  ENSSSCT00025019061.1 UniProtKB/TrEMBL
  ENSSSCT00030042487.1 UniProtKB/TrEMBL
  ENSSSCT00030042526.1 UniProtKB/TrEMBL
  ENSSSCT00030042556.1 UniProtKB/TrEMBL
  ENSSSCT00030042585.1 UniProtKB/TrEMBL
  ENSSSCT00035078461.1 UniProtKB/TrEMBL
  ENSSSCT00035078474.1 UniProtKB/TrEMBL
  ENSSSCT00035078482.1 UniProtKB/TrEMBL
  ENSSSCT00035078486.1 UniProtKB/TrEMBL
  ENSSSCT00040046638.1 UniProtKB/TrEMBL
  ENSSSCT00040046666.1 UniProtKB/TrEMBL
  ENSSSCT00040046701.1 UniProtKB/TrEMBL
  ENSSSCT00040046729.1 UniProtKB/TrEMBL
  ENSSSCT00045024979.1 UniProtKB/TrEMBL
  ENSSSCT00045024992.1 UniProtKB/TrEMBL
  ENSSSCT00045025014.1 UniProtKB/TrEMBL
  ENSSSCT00050082560.1 UniProtKB/TrEMBL
  ENSSSCT00050082563.1 UniProtKB/TrEMBL
  ENSSSCT00050082565.1 UniProtKB/TrEMBL
  ENSSSCT00055037861.1 UniProtKB/TrEMBL
  ENSSSCT00055038038.1 UniProtKB/TrEMBL
  ENSSSCT00055038235.1 UniProtKB/TrEMBL
  ENSSSCT00055038397.1 UniProtKB/TrEMBL
  ENSSSCT00060005478.1 UniProtKB/TrEMBL
  ENSSSCT00060005482.1 UniProtKB/TrEMBL
  ENSSSCT00060005488.1 UniProtKB/TrEMBL
  ENSSSCT00065075583.1 UniProtKB/TrEMBL
  ENSSSCT00065075587.1 UniProtKB/TrEMBL
  ENSSSCT00065075606.1 UniProtKB/TrEMBL
  ENSSSCT00070037760.1 UniProtKB/TrEMBL
  ENSSSCT00070037777.1 UniProtKB/TrEMBL
  ENSSSCT00070037788.1 UniProtKB/TrEMBL
  ENSSSCT00070037804.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.430 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Bub1/Mad3 UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Mad3/Bub1_I UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
NCBI Gene BUB1B ENTREZGENE
PANTHER MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1 BETA UniProtKB/TrEMBL
  PTHR14030 UniProtKB/TrEMBL
Pfam Mad3_BUB1_I UniProtKB/TrEMBL
PROSITE BUB1_N UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
SMART Mad3_BUB1_I UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A287BP09 ENTREZGENE, UniProtKB/TrEMBL
  A0A480QUU6 ENTREZGENE, UniProtKB/TrEMBL
  A0A481CD71 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1US68_PIG UniProtKB/TrEMBL
  A0A4X1USP1_PIG UniProtKB/TrEMBL
  A0A4X1UTG2 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1UTH1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0IVX4_PIG UniProtKB/TrEMBL
  A0A8D0J164_PIG UniProtKB/TrEMBL
  A0A8D0J2C4 ENTREZGENE
  A0A8D0J444 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0Q573 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0UDB2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0WDF9_PIG UniProtKB/TrEMBL
  A0A8D0WED5_PIG UniProtKB/TrEMBL
  A0A8D0WGF4_PIG UniProtKB/TrEMBL
  A0A8D1AIQ4_PIG UniProtKB/TrEMBL
  A0A8D1C5B1_PIG UniProtKB/TrEMBL
  A0A8D1EBD0_PIG UniProtKB/TrEMBL
  A0A8D1EE57 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1EE67 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1EE79_PIG UniProtKB/TrEMBL
  A0A8D1HH63_PIG UniProtKB/TrEMBL
  I3LEQ9 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A8D0J2C4 UniProtKB/TrEMBL
VGNC ID VGNC:103039 ENTREZGENE