DOCK1 (dedicator of cytokinesis 1) - Rat Genome Database

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Gene: DOCK1 (dedicator of cytokinesis 1) Sus scrofa
Analyze
Symbol: DOCK1
Name: dedicator of cytokinesis 1
RGD ID: 13956250
Description: ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (ortholog); INVOLVED IN cell migration (ortholog); hematopoietic progenitor cell differentiation (ortholog); positive regulation of epithelial cell migration (ortholog); ASSOCIATED WITH COVID-19 (ortholog); DiGeorge syndrome (ortholog); distal 10q deletion syndrome (ortholog); FOUND IN guanyl-nucleotide exchange factor complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: dedicator of cytokinesis protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14136,257,807 - 136,741,882 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114136,199,747 - 136,745,488 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214148,261,860 - 148,289,427 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
DOCK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14136,257,807 - 136,741,882 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114136,199,747 - 136,745,488 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214148,261,860 - 148,289,427 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DOCK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810126,905,428 - 127,452,516 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10126,905,409 - 127,452,517 (+)EnsemblGRCh38hg38GRCh38
GRCh3710128,593,997 - 129,250,780 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610128,658,955 - 129,140,770 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410128,658,954 - 129,140,769NCBI
Celera10122,439,168 - 122,921,173 (+)NCBICelera
Cytogenetic Map10q26.2NCBI
HuRef10122,340,788 - 122,823,487 (+)NCBIHuRef
CHM1_110129,050,827 - 129,533,068 (+)NCBICHM1_1
T2T-CHM13v2.010127,789,114 - 128,347,493 (+)NCBIT2T-CHM13v2.0
Dock1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397134,272,416 - 134,775,376 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7134,272,383 - 134,775,368 (+)EnsemblGRCm39 Ensembl
GRCm387134,670,687 - 135,173,647 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7134,670,654 - 135,173,639 (+)EnsemblGRCm38mm10GRCm38
MGSCv377141,862,370 - 142,365,330 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367134,509,030 - 135,011,990 (+)NCBIMGSCv36mm8
Celera7134,477,959 - 134,991,792 (+)NCBICelera
Cytogenetic Map7F3NCBI
cM Map779.14NCBI
Dock1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81198,897,021 - 199,413,636 (+)NCBIGRCr8
mRatBN7.21189,467,143 - 189,983,777 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1189,467,143 - 189,983,768 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1197,826,434 - 198,344,503 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01204,994,807 - 205,504,092 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01197,668,299 - 198,177,593 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01206,900,617 - 207,414,852 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1206,900,617 - 207,414,843 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01213,838,803 - 214,349,261 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41194,172,914 - 194,795,629 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1187,188,438 - 187,700,806 (+)NCBICelera
Cytogenetic Map1q41NCBI
Dock1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554774,725,039 - 5,243,866 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554774,725,780 - 5,243,812 (+)NCBIChiLan1.0ChiLan1.0
DOCK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28138,770,611 - 139,332,095 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110138,780,105 - 139,337,446 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010123,485,345 - 124,041,337 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110127,744,782 - 128,289,981 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10127,803,236 - 128,288,897 (+)Ensemblpanpan1.1panPan2
DOCK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12835,862,267 - 36,397,666 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2835,861,523 - 36,396,883 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2835,960,163 - 36,453,573 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02836,536,271 - 37,030,199 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2836,536,316 - 37,030,230 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12836,012,508 - 36,505,888 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02836,009,501 - 36,504,114 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02836,265,344 - 36,759,122 (+)NCBIUU_Cfam_GSD_1.0
Dock1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721310,451,230 - 10,887,747 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648614,692,532 - 15,092,307 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648614,583,042 - 15,092,164 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DOCK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19119,519,230 - 120,064,767 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604880,885,791 - 81,444,814 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dock1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473719,574,948 - 20,105,265 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473719,575,012 - 20,105,406 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in DOCK1
19406 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 8 1 1 7 2 3 1
Low 2 3 3 4 2 16 2
Below cutoff

Sequence


RefSeq Acc Id: ENSSSCT00000050919   ⟹   ENSSSCP00000038012
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl14136,257,807 - 136,741,882 (+)Ensembl
RefSeq Acc Id: XM_021072613   ⟹   XP_020928272
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.114136,199,747 - 136,745,488 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020928272 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000038012
  ENSSSCP00000038012.2
GenBank Protein JAA53710 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_020928272   ⟸   XM_021072613
- UniProtKB: A0A480QSR6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000038012   ⟸   ENSSSCT00000050919
Protein Domains
C2 DOCK-type   DOCKER   SH3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000035045 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000050919 ENTREZGENE
  ENSSSCT00000050919.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.350 UniProtKB/TrEMBL
  1.20.58.740 UniProtKB/TrEMBL
  1.25.40.410 UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  DHR-1_domain UniProtKB/TrEMBL
  DHR-2 UniProtKB/TrEMBL
  DOCK UniProtKB/TrEMBL
  DOCK1_5_SH3 UniProtKB/TrEMBL
  DOCK1_C2 UniProtKB/TrEMBL
  DOCK_C_lobe_A UniProtKB/TrEMBL
  DOCK_C_lobe_C UniProtKB/TrEMBL
  DOCK_N UniProtKB/TrEMBL
  DOCK_N_sub1 UniProtKB/TrEMBL
  DOCKER_Lobe_A UniProtKB/TrEMBL
  DOCKER_Lobe_B UniProtKB/TrEMBL
  DOCKER_Lobe_C UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
NCBI Gene DOCK1 ENTREZGENE
PANTHER DEDICATOR OF CYTOKINESIS PROTEIN 1 UniProtKB/TrEMBL
  PTHR45653 UniProtKB/TrEMBL
Pfam DHR-2 UniProtKB/TrEMBL
  DHR-2_Lobe_B UniProtKB/TrEMBL
  DHR-2_Lobe_C UniProtKB/TrEMBL
  DOCK-C2 UniProtKB/TrEMBL
  DOCK_N UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
PROSITE DHR_1 UniProtKB/TrEMBL
  DHR_2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART SH3 UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/TrEMBL
  SSF50044 UniProtKB/TrEMBL
UniProt A0A287A2N5_PIG UniProtKB/TrEMBL
  A0A480QSR6 ENTREZGENE, UniProtKB/TrEMBL
  K9IVS2_PIG UniProtKB/TrEMBL
VGNC ID VGNC:87390 ENTREZGENE