ARHGAP21 (Rho GTPase activating protein 21) - Rat Genome Database

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Gene: ARHGAP21 (Rho GTPase activating protein 21) Sus scrofa
Analyze
Symbol: ARHGAP21
Name: Rho GTPase activating protein 21
RGD ID: 13954309
Description: ENCODES a protein that exhibits GTPase activator activity (inferred); INVOLVED IN regulation of endocytosis (ortholog); ASSOCIATED WITH genetic disease (ortholog); FOUND IN actin cytoskeleton (inferred); anchoring junction (inferred); cell junction (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: rho GTPase-activating protein 21
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1050,638,719 - 50,669,497 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11050,541,582 - 50,680,156 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21055,994,406 - 56,132,994 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ARHGAP21
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1050,638,719 - 50,669,497 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11050,541,582 - 50,680,156 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21055,994,406 - 56,132,994 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ARHGAP21
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381024,583,614 - 24,723,887 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1024,583,609 - 24,723,887 (-)EnsemblGRCh38hg38GRCh38
GRCh371024,872,543 - 25,012,816 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361024,912,549 - 25,052,550 (-)NCBINCBI36Build 36hg18NCBI36
Build 341024,912,550 - 25,052,550NCBI
Celera1024,564,446 - 24,712,895 (-)NCBICelera
Cytogenetic Map10p12.1NCBI
HuRef1024,534,090 - 24,673,492 (-)NCBIHuRef
CHM1_11024,872,464 - 25,013,653 (-)NCBICHM1_1
T2T-CHM13v2.01024,602,382 - 24,742,515 (-)NCBIT2T-CHM13v2.0
Arhgap21
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39220,852,746 - 20,973,761 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl220,852,730 - 20,973,692 (-)EnsemblGRCm39 Ensembl
GRCm38220,847,919 - 20,968,691 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl220,847,919 - 20,968,881 (-)EnsemblGRCm38mm10GRCm38
MGSCv37220,769,546 - 20,889,348 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36220,765,673 - 20,886,635 (-)NCBIMGSCv36mm8
Celera220,722,855 - 20,850,910 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map214.6NCBI
Arhgap21
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81788,256,961 - 88,380,478 (-)NCBIGRCr8
mRatBN7.21783,348,673 - 83,472,202 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1783,348,673 - 83,472,444 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1786,828,401 - 86,951,837 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01790,663,807 - 90,787,236 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01784,680,722 - 84,804,160 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01787,725,978 - 87,797,436 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1787,725,867 - 87,826,421 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01789,415,087 - 89,486,545 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41794,817,558 - 94,941,088 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11794,828,397 - 94,951,968 (-)NCBI
Celera1782,609,823 - 82,732,937 (-)NCBICelera
Cytogenetic Map17q12.3NCBI
Arhgap21
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554294,424,425 - 4,559,596 (+)NCBIChiLan1.0ChiLan1.0
ARHGAP21
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2837,285,685 - 37,420,926 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11037,291,011 - 37,428,169 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01024,761,427 - 24,898,572 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11025,131,262 - 25,267,188 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1025,132,054 - 25,266,378 (-)Ensemblpanpan1.1panPan2
ARHGAP21
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.128,740,760 - 8,877,399 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl28,740,119 - 8,877,016 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha27,492,699 - 7,570,795 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.026,941,316 - 7,076,212 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl26,941,307 - 7,075,970 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.126,367,333 - 6,445,123 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.026,386,800 - 6,529,731 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.026,612,602 - 6,694,835 (+)NCBIUU_Cfam_GSD_1.0
Arhgap21
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934424,183,514 - 24,257,210 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936484349,466 - 483,523 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936484348,671 - 393,993 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGAP21
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1924,325,648 - 24,459,006 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl924,326,454 - 24,406,743 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605130,261,895 - 30,397,345 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arhgap21
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247964,201,438 - 4,321,507 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247964,201,335 - 4,321,307 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ARHGAP21
5144 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 9 1 3 3 1 23 2 2
Low 1 3 2 1 2 1 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000028075   ⟹   ENSSSCP00000022198
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1050,638,719 - 50,669,497 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000029464   ⟹   ENSSSCP00000027534
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1050,540,556 - 50,680,151 (+)Ensembl
RefSeq Acc Id: XM_021064916   ⟹   XP_020920575
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11050,541,582 - 50,680,156 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020920575   ⟸   XM_021064916
- UniProtKB: A0A4X1TU98 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000027534   ⟸   ENSSSCT00000029464
RefSeq Acc Id: ENSSSCP00000022198   ⟸   ENSSSCT00000028075
Protein Domains
PDZ   PH   Rho-GAP


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000011074 Ensembl, UniProtKB/TrEMBL
  ENSSSCG00015055637 UniProtKB/TrEMBL
  ENSSSCG00030062401 UniProtKB/TrEMBL
  ENSSSCG00035076567 UniProtKB/TrEMBL
  ENSSSCG00040024747 UniProtKB/TrEMBL
  ENSSSCG00045001390 UniProtKB/TrEMBL
  ENSSSCG00055020258 UniProtKB/TrEMBL
  ENSSSCG00070012776 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000028075.4 UniProtKB/TrEMBL
  ENSSSCT00015074782.1 UniProtKB/TrEMBL
  ENSSSCT00015075010.1 UniProtKB/TrEMBL
  ENSSSCT00030087293.1 UniProtKB/TrEMBL
  ENSSSCT00030087303.1 UniProtKB/TrEMBL
  ENSSSCT00030087351.1 UniProtKB/TrEMBL
  ENSSSCT00030087373.1 UniProtKB/TrEMBL
  ENSSSCT00035104150.1 UniProtKB/TrEMBL
  ENSSSCT00035104185.1 UniProtKB/TrEMBL
  ENSSSCT00035104203.1 UniProtKB/TrEMBL
  ENSSSCT00040033045.1 UniProtKB/TrEMBL
  ENSSSCT00040033103.1 UniProtKB/TrEMBL
  ENSSSCT00040033240.1 UniProtKB/TrEMBL
  ENSSSCT00040033327.1 UniProtKB/TrEMBL
  ENSSSCT00040033575.1 UniProtKB/TrEMBL
  ENSSSCT00045002235.1 UniProtKB/TrEMBL
  ENSSSCT00045002290.1 UniProtKB/TrEMBL
  ENSSSCT00045002367.1 UniProtKB/TrEMBL
  ENSSSCT00055039715.1 UniProtKB/TrEMBL
  ENSSSCT00055039939.1 UniProtKB/TrEMBL
  ENSSSCT00055040318.1 UniProtKB/TrEMBL
  ENSSSCT00055040527.1 UniProtKB/TrEMBL
  ENSSSCT00070025133.1 UniProtKB/TrEMBL
  ENSSSCT00070025142.1 UniProtKB/TrEMBL
  ENSSSCT00070025162.1 UniProtKB/TrEMBL
  ENSSSCT00070025181.1 UniProtKB/TrEMBL
  ENSSSCT00070025202.1 UniProtKB/TrEMBL
  ENSSSCT00070025261.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.555.10 UniProtKB/TrEMBL
  1.20.5.220 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  2.30.42.10 UniProtKB/TrEMBL
InterPro PDZ UniProtKB/TrEMBL
  PDZ_6 UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/TrEMBL
  RhoGAP_dom UniProtKB/TrEMBL
NCBI Gene ARHGAP21 ENTREZGENE
PANTHER PDZ DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  RHO GTPASE-ACTIVATING PROTEIN 21 UniProtKB/TrEMBL
Pfam PDZ_6 UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
  RhoGAP UniProtKB/TrEMBL
PROSITE PDZ UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
  RHOGAP UniProtKB/TrEMBL
SMART PDZ UniProtKB/TrEMBL
  RhoGAP UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF48350 UniProtKB/TrEMBL
  SSF50156 UniProtKB/TrEMBL
UniProt A0A4X1TU98 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1TUB1_PIG UniProtKB/TrEMBL
  A0A4X1TWN9_PIG UniProtKB/TrEMBL
  A0A4X1TZ50_PIG UniProtKB/TrEMBL
  A0A4X1TZR2_PIG UniProtKB/TrEMBL
  A0A8D0XPW1_PIG UniProtKB/TrEMBL
  A0A8D0XTS1_PIG UniProtKB/TrEMBL
  A0A8D0XUQ9_PIG UniProtKB/TrEMBL
  A0A8D0XVD1_PIG UniProtKB/TrEMBL
  A0A8D1BDQ0_PIG UniProtKB/TrEMBL
  A0A8D1BJJ0_PIG UniProtKB/TrEMBL
  A0A8D1DWR7_PIG UniProtKB/TrEMBL
  A0A8D1DWX0_PIG UniProtKB/TrEMBL
  A0A8D1DYV9_PIG UniProtKB/TrEMBL
  A0A8D1DZM6_PIG UniProtKB/TrEMBL
  A0A8D1DZR0_PIG UniProtKB/TrEMBL
  A0A8D1G9Y9_PIG UniProtKB/TrEMBL
  A0A8D1GCX6_PIG UniProtKB/TrEMBL
  I3LDR4_PIG UniProtKB/TrEMBL
VGNC ID VGNC:96018 ENTREZGENE