ARF6 (ADP ribosylation factor 6) - Rat Genome Database

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Gene: ARF6 (ADP ribosylation factor 6) Sus scrofa
Analyze
Symbol: ARF6
Name: ADP ribosylation factor 6
RGD ID: 13948387
Description: ENCODES a protein that exhibits G protein activity (ortholog); GDP binding (ortholog); GTP binding (ortholog); INVOLVED IN cellular response to nerve growth factor stimulus (ortholog); erythrocyte apoptotic process (ortholog); establishment of epithelial cell polarity (ortholog); PARTICIPATES IN E-cadherin signaling pathway; phosphatidylinositol 3-kinase class I signaling pathway; ASSOCIATED WITH Brain-Lung-Thyroid Syndrome (ortholog); FOUND IN cleavage furrow (ortholog); cytosol (ortholog); early endosome (ortholog); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ADP-ribosylation factor 6
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1179,713,299 - 179,717,841 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11179,697,582 - 179,717,299 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21200,071,305 - 200,075,268 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell differentiation  (IEA)
cellular response to nerve growth factor stimulus  (ISO)
cortical actin cytoskeleton organization  (IEA)
endocytic recycling  (IEA)
erythrocyte apoptotic process  (IEA,ISO)
establishment of epithelial cell polarity  (IEA,ISO)
hepatocyte apoptotic process  (IEA,ISO)
intracellular protein transport  (IBA)
liver development  (IEA,ISO)
maintenance of postsynaptic density structure  (ISO)
negative regulation of dendrite development  (ISO)
negative regulation of protein localization to cell surface  (IEA)
nervous system development  (IEA)
positive regulation of actin filament polymerization  (IEA)
positive regulation of focal adhesion disassembly  (IEA)
positive regulation of keratinocyte migration  (IEA)
positive regulation of mitotic cytokinetic process  (IEA)
positive regulation of neuron projection development  (IEA)
positive regulation of protein localization to plasma membrane  (IEA)
positive regulation of protein secretion  (IEA)
protein localization to cell surface  (IEA)
protein localization to cleavage furrow  (IEA)
protein localization to endosome  (IBA,IEA,ISS)
protein localization to plasma membrane  (IEA)
protein transport  (IEA)
regulation of dendritic spine development  (IBA,IEA,ISS)
regulation of filopodium assembly  (IEA)
regulation of neuron projection development  (IEA,ISO)
regulation of presynapse assembly  (ISO)
regulation of Rac protein signal transduction  (IEA)
ruffle assembly  (IEA)
synaptic vesicle endocytosis  (ISO)
vesicle-mediated transport  (IBA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:20662810   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ARF6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1179,713,299 - 179,717,841 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11179,697,582 - 179,717,299 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21200,071,305 - 200,075,268 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ARF6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381449,893,082 - 49,897,054 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1449,893,079 - 49,897,054 (+)EnsemblGRCh38hg38GRCh38
GRCh371450,359,800 - 50,363,772 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361449,429,486 - 49,433,522 (+)NCBINCBI36Build 36hg18NCBI36
Build 341449,429,588 - 49,431,484NCBI
Celera1430,226,871 - 30,230,907 (+)NCBICelera
Cytogenetic Map14q21.3NCBI
HuRef1430,484,292 - 30,488,326 (+)NCBIHuRef
CHM1_11450,297,978 - 50,302,011 (+)NCBICHM1_1
T2T-CHM13v2.01444,098,298 - 44,102,268 (+)NCBIT2T-CHM13v2.0
Arf6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391269,418,924 - 69,422,754 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1269,418,924 - 69,420,557 (+)EnsemblGRCm39 Ensembl
GRCm381269,372,150 - 69,375,980 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1269,372,150 - 69,373,783 (+)EnsemblGRCm38mm10GRCm38
MGSCv371270,473,137 - 70,476,967 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361270,290,793 - 70,292,388 (+)NCBIMGSCv36mm8
Celera1270,470,421 - 70,474,282 (+)NCBICelera
Cytogenetic Map12C2NCBI
cM Map1228.81NCBI
Arf6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8693,589,777 - 93,590,925 (+)NCBIGRCr8
mRatBN7.2687,853,742 - 87,854,890 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl687,840,142 - 87,874,114 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx688,252,904 - 88,254,050 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0688,552,333 - 88,553,479 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0687,992,090 - 87,993,236 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0691,697,109 - 91,698,257 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl691,697,109 - 91,698,255 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06101,149,908 - 101,152,127 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4691,337,496 - 91,338,644 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1691,340,951 - 91,342,098 (+)NCBI
Celera686,351,473 - 86,352,621 (+)NCBICelera
Cytogenetic Map6q24NCBI
Arf6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540912,817,496 - 12,818,023 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540912,814,814 - 12,818,142 (-)NCBIChiLan1.0ChiLan1.0
ARF6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21551,028,155 - 51,033,366 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11450,244,617 - 50,249,869 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01430,482,191 - 30,486,741 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11448,788,586 - 48,792,641 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1448,789,329 - 48,789,856 (+)Ensemblpanpan1.1panPan2
ARF6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1826,445,407 - 26,449,430 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl826,445,647 - 26,525,530 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha826,199,039 - 26,203,086 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0826,622,998 - 26,627,047 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl826,623,051 - 26,703,339 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1826,278,479 - 26,282,519 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0826,351,547 - 26,355,590 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0826,669,436 - 26,673,480 (+)NCBIUU_Cfam_GSD_1.0
Arf6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864058,503,422 - 58,507,422 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936583181,490 - 185,471 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936583181,490 - 185,466 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARF6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12426,948,794 - 26,952,803 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2426,949,388 - 26,950,074 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605315,277,536 - 15,281,551 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arf6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473118,882,690 - 18,883,217 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473118,880,065 - 18,883,456 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ARF6
335 total Variants

Sequence


Ensembl Acc Id: ENSSSCT00000005528   ⟹   ENSSSCP00000005391
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1179,713,563 - 179,715,629 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000058177   ⟹   ENSSSCP00000058854
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1179,713,401 - 179,717,841 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000074052   ⟹   ENSSSCP00000064421
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1179,713,299 - 179,715,048 (+)Ensembl
RefSeq Acc Id: NM_001078677   ⟹   NP_001072145
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11179,714,037 - 179,714,564 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005659939   ⟹   XP_005659996
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11179,713,166 - 179,717,299 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021084333   ⟹   XP_020939992
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11179,697,582 - 179,717,299 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001072145 (Get FASTA)   NCBI Sequence Viewer  
  XP_005659996 (Get FASTA)   NCBI Sequence Viewer  
  XP_020939992 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABJ09398 (Get FASTA)   NCBI Sequence Viewer  
  ACI15389 (Get FASTA)   NCBI Sequence Viewer  
  ACM17704 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000005391
  ENSSSCP00000005391.4
  ENSSSCP00000058854
  ENSSSCP00000058854.1
  ENSSSCP00000064421.1
  ENSSSCP00005020040.1
  ENSSSCP00005020061.1
  ENSSSCP00015014421.1
  ENSSSCP00015014438.1
  ENSSSCP00015014456.1
  ENSSSCP00025047388.1
  ENSSSCP00025047400.1
  ENSSSCP00025047408.1
  ENSSSCP00030043491.1
  ENSSSCP00030043503.1
  ENSSSCP00030043509.1
  ENSSSCP00035009549.1
  ENSSSCP00035009551.1
  ENSSSCP00035009552.1
  ENSSSCP00040036622.1
  ENSSSCP00040036638.1
  ENSSSCP00040036659.1
  ENSSSCP00045010256.1
  ENSSSCP00045010272.1
  ENSSSCP00045010290.1
  ENSSSCP00050042385.1
  ENSSSCP00050042389.1
  ENSSSCP00050042391.1
  ENSSSCP00050042396.1
  ENSSSCP00055017020.1
  ENSSSCP00055017025.1
  ENSSSCP00055017047.1
  ENSSSCP00055017057.1
  ENSSSCP00060004061.1
  ENSSSCP00060004063.1
  ENSSSCP00060004065.1
  ENSSSCP00065036291.1
  ENSSSCP00065036298.1
  ENSSSCP00065036304.1
  ENSSSCP00065036311.1
  ENSSSCP00070001514.1
  ENSSSCP00070001520.1
  ENSSSCP00070001526.1
  ENSSSCP00070001532.1
GenBank Protein Q007T5 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_020939992   ⟸   XM_021084333
- Peptide Label: isoform X1
- UniProtKB: Q007T5 (UniProtKB/Swiss-Prot),   C4MQ03 (UniProtKB/TrEMBL),   B9V4F1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005659996   ⟸   XM_005659939
- Peptide Label: isoform X1
- UniProtKB: Q007T5 (UniProtKB/Swiss-Prot),   C4MQ03 (UniProtKB/TrEMBL),   B9V4F1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001072145   ⟸   NM_001078677
- UniProtKB: Q007T5 (UniProtKB/Swiss-Prot),   C4MQ03 (UniProtKB/TrEMBL),   B9V4F1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000005391   ⟸   ENSSSCT00000005528
Ensembl Acc Id: ENSSSCP00000064421   ⟸   ENSSSCT00000074052
Ensembl Acc Id: ENSSSCP00000058854   ⟸   ENSSSCT00000058177


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000005012 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSSSCG00005020845 UniProtKB/Swiss-Prot
  ENSSSCG00015027240 UniProtKB/Swiss-Prot
  ENSSSCG00025076444 UniProtKB/Swiss-Prot
  ENSSSCG00030067449 UniProtKB/Swiss-Prot
  ENSSSCG00035019495 UniProtKB/Swiss-Prot
  ENSSSCG00040061728 UniProtKB/Swiss-Prot
  ENSSSCG00045008747 UniProtKB/Swiss-Prot
  ENSSSCG00050071942 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00055010938 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00060008590 UniProtKB/Swiss-Prot
  ENSSSCG00065060772 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00070000951 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000005528 ENTREZGENE
  ENSSSCT00000005528.5 UniProtKB/Swiss-Prot
  ENSSSCT00000058177 ENTREZGENE
  ENSSSCT00000058177.3 UniProtKB/Swiss-Prot
  ENSSSCT00000074052.2 UniProtKB/Swiss-Prot
  ENSSSCT00005032868.1 UniProtKB/Swiss-Prot
  ENSSSCT00005032906.1 UniProtKB/Swiss-Prot
  ENSSSCT00015036207.1 UniProtKB/Swiss-Prot
  ENSSSCT00015036246.1 UniProtKB/Swiss-Prot
  ENSSSCT00015036282.1 UniProtKB/Swiss-Prot
  ENSSSCT00025105859.1 UniProtKB/Swiss-Prot
  ENSSSCT00025105874.1 UniProtKB/Swiss-Prot
  ENSSSCT00025105884.1 UniProtKB/Swiss-Prot
  ENSSSCT00030094340.1 UniProtKB/Swiss-Prot
  ENSSSCT00030094368.1 UniProtKB/Swiss-Prot
  ENSSSCT00030094386.1 UniProtKB/Swiss-Prot
  ENSSSCT00035025265.1 UniProtKB/Swiss-Prot
  ENSSSCT00035025273.1 UniProtKB/Swiss-Prot
  ENSSSCT00035025274.1 UniProtKB/Swiss-Prot
  ENSSSCT00040084027.1 UniProtKB/Swiss-Prot
  ENSSSCT00040084060.1 UniProtKB/Swiss-Prot
  ENSSSCT00040084096.1 UniProtKB/Swiss-Prot
  ENSSSCT00045014781.1 UniProtKB/Swiss-Prot
  ENSSSCT00045014803.1 UniProtKB/Swiss-Prot
  ENSSSCT00045014827.1 UniProtKB/Swiss-Prot
  ENSSSCT00050098190.1 UniProtKB/Swiss-Prot
  ENSSSCT00050098196.1 UniProtKB/Swiss-Prot
  ENSSSCT00050098202.1 UniProtKB/Swiss-Prot
  ENSSSCT00050098207.1 UniProtKB/TrEMBL
  ENSSSCT00055021481.1 UniProtKB/TrEMBL
  ENSSSCT00055021488.1 UniProtKB/Swiss-Prot
  ENSSSCT00055021515.1 UniProtKB/Swiss-Prot
  ENSSSCT00055021529.1 UniProtKB/Swiss-Prot
  ENSSSCT00060010997.1 UniProtKB/Swiss-Prot
  ENSSSCT00060011000.1 UniProtKB/Swiss-Prot
  ENSSSCT00060011003.1 UniProtKB/Swiss-Prot
  ENSSSCT00065083259.1 UniProtKB/TrEMBL
  ENSSSCT00065083268.1 UniProtKB/Swiss-Prot
  ENSSSCT00065083279.1 UniProtKB/Swiss-Prot
  ENSSSCT00065083291.1 UniProtKB/Swiss-Prot
  ENSSSCT00070001820.1 UniProtKB/TrEMBL
  ENSSSCT00070001826.1 UniProtKB/Swiss-Prot
  ENSSSCT00070001832.1 UniProtKB/Swiss-Prot
  ENSSSCT00070001838.1 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Arf6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase_ARF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase_ARF/SAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:780425 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene ARF6 ENTREZGENE
PANTHER ADP-RIBOSYLATION FACTOR 6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11711 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Arf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS SAR1GTPBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ARF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAB UniProtKB/TrEMBL
SMART ARF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A4X1SI58_PIG UniProtKB/TrEMBL
  ARF6_PIG UniProtKB/Swiss-Prot
  B9V4F1 ENTREZGENE, UniProtKB/TrEMBL
  C4MQ03 ENTREZGENE, UniProtKB/TrEMBL
  Q007T5 ENTREZGENE
VGNC ID VGNC:85448 ENTREZGENE