GNAZ (G protein subunit alpha z) - Rat Genome Database

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Gene: GNAZ (G protein subunit alpha z) Sus scrofa
Analyze
Symbol: GNAZ
Name: G protein subunit alpha z
RGD ID: 13943881
Description: ENCODES a protein that exhibits adenylate cyclase inhibitor activity (ortholog); G protein-coupled serotonin receptor binding (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); adenylate cyclase-modulating G protein-coupled receptor signaling pathway (ortholog); G protein-coupled serotonin receptor signaling pathway (ortholog); PARTICIPATES IN endothelin signaling pathway; Hedgehog signaling pathway; sphingosine 1-phosphate signaling pathway; ASSOCIATED WITH chromosome 22q11.2 deletion syndrome, distal (ortholog); DiGeorge syndrome (ortholog); genetic disease (ortholog); FOUND IN cell body (ortholog); dendrite (ortholog); plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: guanine nucleotide-binding protein G(z) subunit alpha
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1449,132,013 - 49,174,108 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11449,132,012 - 49,174,114 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21452,573,000 - 52,597,219 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
GNAZ
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1449,132,013 - 49,174,108 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11449,132,012 - 49,174,114 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21452,573,000 - 52,597,219 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GNAZ
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382223,070,519 - 23,125,032 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2223,070,519 - 23,125,032 (+)EnsemblGRCh38hg38GRCh38
GRCh372223,412,705 - 23,467,219 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362221,742,669 - 21,797,224 (+)NCBINCBI36Build 36hg18NCBI36
Build 342221,737,222 - 21,791,775NCBI
Celera227,227,239 - 7,281,792 (+)NCBICelera
Cytogenetic Map22q11.22-q11.23NCBI
HuRef226,380,502 - 6,434,961 (+)NCBIHuRef
CHM1_12223,424,953 - 23,479,508 (+)NCBICHM1_1
T2T-CHM13v2.02223,493,390 - 23,547,904 (+)NCBIT2T-CHM13v2.0
Gnaz
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391074,803,009 - 74,852,739 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1074,803,009 - 74,852,739 (+)EnsemblGRCm39 Ensembl
GRCm381074,967,177 - 75,016,907 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1074,967,177 - 75,016,907 (+)EnsemblGRCm38mm10GRCm38
MGSCv371074,429,976 - 74,478,622 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361074,410,947 - 74,459,593 (+)NCBIMGSCv36mm8
Celera1076,015,010 - 76,063,654 (+)NCBICelera
Cytogenetic Map10B5.3NCBI
cM Map1038.48NCBI
Gnaz
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82013,642,853 - 13,693,616 (-)NCBIGRCr8
mRatBN7.22013,643,473 - 13,694,240 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2013,644,640 - 13,669,907 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2014,351,133 - 14,376,399 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02013,711,964 - 13,737,230 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02014,184,561 - 14,209,827 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02014,593,072 - 14,644,020 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2014,593,819 - 14,620,019 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02016,776,281 - 16,801,749 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42014,148,003 - 14,174,136 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12014,147,070 - 14,198,741 (-)NCBI
Celera2015,127,777 - 15,153,073 (-)NCBICelera
Cytogenetic Map20p12NCBI
Gnaz
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554557,501,153 - 7,554,235 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554557,501,153 - 7,554,235 (+)NCBIChiLan1.0ChiLan1.0
GNAZ
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22332,902,100 - 32,956,731 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12235,125,858 - 35,180,490 (-)NCBINHGRI_mPanPan1
PanPan1.12221,694,068 - 21,748,459 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2221,719,169 - 21,746,851 (+)Ensemblpanpan1.1panPan2
GNAZ
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12627,780,598 - 27,811,688 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2627,781,704 - 27,810,188 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2626,858,045 - 26,887,668 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02629,186,052 - 29,215,701 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2629,163,807 - 29,215,697 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12627,269,346 - 27,298,991 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02626,887,024 - 26,916,646 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02627,876,069 - 27,905,727 (+)NCBIUU_Cfam_GSD_1.0
Gnaz
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118142,510,028 - 142,562,971 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936619191,091 - 244,235 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936619191,097 - 244,034 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GNAZ
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1192,758,097 - 2,812,306 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl192,757,819 - 2,788,076 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660854,314,170 - 4,368,661 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gnaz
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247479,425,775 - 9,480,162 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247479,425,720 - 9,479,571 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in GNAZ
463 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 20
Low 9 2 3 5 3 2 3 1
Below cutoff 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000011007   ⟹   ENSSSCP00000010719
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1449,132,013 - 49,174,108 (+)Ensembl
RefSeq Acc Id: XM_021072293   ⟹   XP_020927952
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11449,132,012 - 49,174,114 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021072294   ⟹   XP_020927953
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11449,132,016 - 49,174,114 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020927952   ⟸   XM_021072293
- Peptide Label: isoform X1
- UniProtKB: A0A4X1V5R9 (UniProtKB/TrEMBL),   F1RLT6 (UniProtKB/TrEMBL),   A0A8D0XF24 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020927953   ⟸   XM_021072294
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSSSCP00000010719   ⟸   ENSSSCT00000011007


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000010046 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005041520 UniProtKB/TrEMBL
  ENSSSCG00015026014 UniProtKB/TrEMBL
  ENSSSCG00025061255 UniProtKB/TrEMBL
  ENSSSCG00030052731 UniProtKB/TrEMBL
  ENSSSCG00035079044 UniProtKB/TrEMBL
  ENSSSCG00040053927 UniProtKB/TrEMBL
  ENSSSCG00045012772 UniProtKB/TrEMBL
  ENSSSCG00050027976 UniProtKB/TrEMBL
  ENSSSCG00055011589 UniProtKB/TrEMBL
  ENSSSCG00060074916 UniProtKB/TrEMBL
  ENSSSCG00065027393 UniProtKB/TrEMBL
  ENSSSCG00070021613 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000011007 ENTREZGENE
  ENSSSCT00000011007.5 UniProtKB/TrEMBL
  ENSSSCT00005066503.1 UniProtKB/TrEMBL
  ENSSSCT00005066512.1 UniProtKB/TrEMBL
  ENSSSCT00015034474.1 UniProtKB/TrEMBL
  ENSSSCT00025083873.1 UniProtKB/TrEMBL
  ENSSSCT00030073544.1 UniProtKB/TrEMBL
  ENSSSCT00035107972.1 UniProtKB/TrEMBL
  ENSSSCT00040072921.1 UniProtKB/TrEMBL
  ENSSSCT00045021753.1 UniProtKB/TrEMBL
  ENSSSCT00050037624.1 UniProtKB/TrEMBL
  ENSSSCT00055022678.1 UniProtKB/TrEMBL
  ENSSSCT00060102532.1 UniProtKB/TrEMBL
  ENSSSCT00065036893.1 UniProtKB/TrEMBL
  ENSSSCT00070042950.1 UniProtKB/TrEMBL
  ENSSSCT00070042954.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.400.10 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro Gprotein_alpha_I UniProtKB/TrEMBL
  Gprotein_alpha_su UniProtKB/TrEMBL
  GproteinA_insert UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene GNAZ ENTREZGENE
PANTHER GUANINE NUCLEOTIDE-BINDING PROTEIN G(Z) SUBUNIT ALPHA UniProtKB/TrEMBL
  PTHR10218 UniProtKB/TrEMBL
Pfam G-alpha UniProtKB/TrEMBL
PRINTS GPROTEINA UniProtKB/TrEMBL
  GPROTEINAI UniProtKB/TrEMBL
PROSITE G_ALPHA UniProtKB/TrEMBL
SMART G_alpha UniProtKB/TrEMBL
Superfamily-SCOP SSF47895 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A4X1V5R9 ENTREZGENE
  A0A8D0XF24 ENTREZGENE, UniProtKB/TrEMBL
  F1RLT6 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A4X1V5R9 UniProtKB/TrEMBL
VGNC ID VGNC:88528 ENTREZGENE