MOCS3 (molybdenum cofactor synthesis 3) - Rat Genome Database

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Gene: MOCS3 (molybdenum cofactor synthesis 3) Sus scrofa
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Symbol: MOCS3
Name: molybdenum cofactor synthesis 3
RGD ID: 13939256
Description: ENCODES a protein that exhibits molybdopterin-synthase sulfurtransferase activity (ortholog); nucleotidyltransferase activity (ortholog); sulfurtransferase activity (ortholog); INVOLVED IN Mo-molybdopterin cofactor biosynthetic process (ortholog); tRNA thio-modification (ortholog); tRNA wobble uridine modification (ortholog); PARTICIPATES IN molybdenum cofactor biosynthetic pathway; ASSOCIATED WITH congenital disorder of glycosylation Ie (ortholog); genetic disease (ortholog); Hydrops Fetalis (ortholog); FOUND IN cytosol (ortholog); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: adenylyltransferase and sulfurtransferase MOCS3; Molybdenum cofactor synthesis protein 3; UBA4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1752,377,348 - 52,380,260 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11752,377,343 - 52,379,711 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21758,817,392 - 58,819,760 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MOCS3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1752,377,348 - 52,380,260 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11752,377,343 - 52,379,711 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21758,817,392 - 58,819,760 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MOCS3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382050,958,818 - 50,963,929 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2050,958,818 - 50,963,929 (+)EnsemblGRCh38hg38GRCh38
GRCh372049,575,355 - 49,580,466 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362049,008,770 - 49,011,227 (+)NCBINCBI36Build 36hg18NCBI36
Build 342049,008,769 - 49,011,227NCBI
Celera2046,279,623 - 46,282,080 (+)NCBICelera
Cytogenetic Map20q13.13NCBI
HuRef2046,323,922 - 46,326,971 (+)NCBIHuRef
CHM1_12049,480,642 - 49,483,691 (+)NCBICHM1_1
T2T-CHM13v2.02052,729,421 - 52,734,532 (+)NCBIT2T-CHM13v2.0
Mocs3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392168,072,542 - 168,074,223 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2168,072,542 - 168,074,514 (+)EnsemblGRCm39 Ensembl
GRCm382168,230,622 - 168,232,303 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2168,230,622 - 168,232,594 (+)EnsemblGRCm38mm10GRCm38
MGSCv372168,056,122 - 168,057,803 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362167,921,827 - 167,923,801 (+)NCBIMGSCv36mm8
Celera2174,174,727 - 174,176,408 (+)NCBICelera
Cytogenetic Map2H3NCBI
cM Map288.5NCBI
Mocs3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83177,358,639 - 177,360,599 (+)NCBIGRCr8
mRatBN7.23156,939,763 - 156,941,723 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3156,939,809 - 156,941,890 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3160,734,559 - 160,736,519 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03169,233,657 - 169,235,617 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03166,975,357 - 166,977,317 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03164,986,421 - 164,988,381 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3164,986,421 - 164,988,369 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03171,125,683 - 171,127,643 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43159,393,645 - 159,395,605 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13159,299,677 - 159,301,073 (+)NCBI
Celera3155,513,119 - 155,515,079 (+)NCBICelera
Cytogenetic Map3q42NCBI
Mocs3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554457,470,888 - 7,472,267 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554457,470,030 - 7,472,323 (-)NCBIChiLan1.0ChiLan1.0
MOCS3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22156,710,029 - 56,712,278 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12056,703,146 - 56,705,872 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02047,305,561 - 47,310,809 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12048,432,496 - 48,435,534 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2048,432,519 - 48,433,901 (+)Ensemblpanpan1.1panPan2
MOCS3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12437,268,781 - 37,271,581 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2437,268,808 - 37,270,304 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2436,510,770 - 36,513,446 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02437,978,399 - 37,981,075 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2437,978,427 - 37,979,923 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12437,213,898 - 37,216,575 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02437,347,791 - 37,350,464 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02437,892,834 - 37,895,510 (+)NCBIUU_Cfam_GSD_1.0
Mocs3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640188,376,546 - 188,378,551 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365143,830,627 - 3,832,009 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365143,830,189 - 3,832,194 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MOCS3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1213,011,922 - 13,014,409 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl213,012,821 - 13,014,203 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605061,442,062 - 61,447,320 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mocs3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247904,796,765 - 4,798,153 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247904,793,371 - 4,798,156 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MOCS3
45 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 10 4 3 5 2 23 2 3 3
Below cutoff

Sequence


RefSeq Acc Id: ENSSSCT00000008181   ⟹   ENSSSCP00000007964
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1752,377,348 - 52,380,260 (+)Ensembl
RefSeq Acc Id: NM_001101819   ⟹   NP_001095289
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11752,377,343 - 52,379,711 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001095289   ⟸   NM_001101819
- UniProtKB: A5GFZ6 (UniProtKB/Swiss-Prot),   A0A4X1UHD0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000007964   ⟸   ENSSSCT00000008181
Protein Domains
Rhodanese


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000007475 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSSSCG00005026569 UniProtKB/Swiss-Prot
  ENSSSCG00015000484 UniProtKB/Swiss-Prot
  ENSSSCG00025055407 UniProtKB/Swiss-Prot
  ENSSSCG00030000701 UniProtKB/Swiss-Prot
  ENSSSCG00035032535 UniProtKB/Swiss-Prot
  ENSSSCG00040040925 UniProtKB/Swiss-Prot
  ENSSSCG00045026435 UniProtKB/Swiss-Prot
  ENSSSCG00050058821 UniProtKB/Swiss-Prot
  ENSSSCG00055027385 UniProtKB/Swiss-Prot
  ENSSSCG00060027198 UniProtKB/Swiss-Prot
  ENSSSCG00065069118 UniProtKB/Swiss-Prot
  ENSSSCG00070017819 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000008181 ENTREZGENE
  ENSSSCT00000008181.3 UniProtKB/Swiss-Prot
  ENSSSCT00005041996.1 UniProtKB/Swiss-Prot
  ENSSSCT00015000540.1 UniProtKB/Swiss-Prot
  ENSSSCT00025075782.1 UniProtKB/Swiss-Prot
  ENSSSCT00030000934.1 UniProtKB/Swiss-Prot
  ENSSSCT00035043090.1 UniProtKB/Swiss-Prot
  ENSSSCT00040054693.1 UniProtKB/Swiss-Prot
  ENSSSCT00045044975.1 UniProtKB/Swiss-Prot
  ENSSSCT00050080146.1 UniProtKB/Swiss-Prot
  ENSSSCT00055054141.1 UniProtKB/Swiss-Prot
  ENSSSCT00060036825.1 UniProtKB/Swiss-Prot
  ENSSSCT00065094878.1 UniProtKB/Swiss-Prot
  ENSSSCT00070035154.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro MOCS3/Uba4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodanese-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodanese-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ThiF/MoeB/HesA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ThiF_NAD_FAD-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiquitin-activating_enz UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:100124378 UniProtKB/Swiss-Prot
NCBI Gene MOCS3 ENTREZGENE
PANTHER ADENYLYLTRANSFERASE AND SULFURTRANSFERASE MOCS3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10953 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Rhodanese UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ThiF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE RHODANESE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RHOD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF69572 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A4X1UHD0 ENTREZGENE, UniProtKB/TrEMBL
  A5GFZ6 ENTREZGENE, UniProtKB/Swiss-Prot
VGNC ID VGNC:103989 ENTREZGENE