MOCS3 (molybdenum cofactor synthesis 3) - Rat Genome Database

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Gene: MOCS3 (molybdenum cofactor synthesis 3) Sus scrofa
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Symbol: MOCS3
Name: molybdenum cofactor synthesis 3
RGD ID: 13939256
Description: ENCODES a protein that exhibits molybdopterin-synthase sulfurtransferase activity (ortholog); nucleotidyltransferase activity (ortholog); sulfurtransferase activity (ortholog); INVOLVED IN Mo-molybdopterin cofactor biosynthetic process (ortholog); tRNA thio-modification (ortholog); tRNA wobble uridine modification (ortholog); PARTICIPATES IN molybdenum cofactor biosynthetic pathway; ASSOCIATED WITH congenital disorder of glycosylation Ie (ortholog); Hydrops Fetalis (ortholog); FOUND IN cytosol (ortholog); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: adenylyltransferase and sulfurtransferase MOCS3; Molybdenum cofactor synthesis protein 3; UBA4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1752,377,348 - 52,380,260 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11752,377,343 - 52,379,711 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21758,817,392 - 58,819,760 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA)
cytosol  (IEA,ISS)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MOCS3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1752,377,348 - 52,380,260 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11752,377,343 - 52,379,711 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21758,817,392 - 58,819,760 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MOCS3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382050,958,818 - 50,963,929 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2050,958,818 - 50,963,929 (+)EnsemblGRCh38hg38GRCh38
GRCh372049,575,355 - 49,580,466 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362049,008,770 - 49,011,227 (+)NCBINCBI36Build 36hg18NCBI36
Build 342049,008,769 - 49,011,227NCBI
Celera2046,279,623 - 46,282,080 (+)NCBICelera
Cytogenetic Map20q13.13NCBI
HuRef2046,323,922 - 46,326,971 (+)NCBIHuRef
CHM1_12049,480,642 - 49,483,691 (+)NCBICHM1_1
T2T-CHM13v2.02052,729,421 - 52,734,532 (+)NCBIT2T-CHM13v2.0
Mocs3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392168,072,542 - 168,074,223 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2168,072,542 - 168,074,514 (+)EnsemblGRCm39 Ensembl
GRCm382168,230,622 - 168,232,303 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2168,230,622 - 168,232,594 (+)EnsemblGRCm38mm10GRCm38
MGSCv372168,056,122 - 168,057,803 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362167,921,827 - 167,923,801 (+)NCBIMGSCv36mm8
Celera2174,174,727 - 174,176,408 (+)NCBICelera
Cytogenetic Map2H3NCBI
cM Map288.5NCBI
Mocs3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83177,358,639 - 177,360,599 (+)NCBIGRCr8
mRatBN7.23156,939,763 - 156,941,723 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3156,939,809 - 156,941,890 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3160,734,559 - 160,736,519 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03169,233,657 - 169,235,617 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03166,975,357 - 166,977,317 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03164,986,421 - 164,988,381 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3164,986,421 - 164,988,369 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03171,125,683 - 171,127,643 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43159,393,645 - 159,395,605 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13159,299,677 - 159,301,073 (+)NCBI
Celera3155,513,119 - 155,515,079 (+)NCBICelera
Cytogenetic Map3q42NCBI
Mocs3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554457,470,888 - 7,472,267 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554457,470,030 - 7,472,323 (-)NCBIChiLan1.0ChiLan1.0
MOCS3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22156,710,029 - 56,712,278 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12056,703,146 - 56,705,872 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02047,305,561 - 47,310,809 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12048,432,496 - 48,435,534 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2048,432,519 - 48,433,901 (+)Ensemblpanpan1.1panPan2
MOCS3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12437,268,781 - 37,271,581 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2437,268,808 - 37,270,304 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2436,510,770 - 36,513,446 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02437,978,399 - 37,981,075 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2437,978,427 - 37,979,923 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12437,213,898 - 37,216,575 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02437,347,791 - 37,350,464 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02437,892,834 - 37,895,510 (+)NCBIUU_Cfam_GSD_1.0
Mocs3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640188,376,546 - 188,378,551 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365143,830,627 - 3,832,009 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365143,830,189 - 3,832,194 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MOCS3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1213,011,922 - 13,014,409 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl213,012,821 - 13,014,203 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605061,442,062 - 61,447,320 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mocs3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247904,796,765 - 4,798,153 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247904,793,371 - 4,798,156 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MOCS3
44 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000008181   ⟹   ENSSSCP00000007964
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1752,377,348 - 52,380,260 (+)Ensembl
RefSeq Acc Id: NM_001101819   ⟹   NP_001095289
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11752,377,343 - 52,379,711 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001095289   ⟸   NM_001101819
- UniProtKB: A5GFZ6 (UniProtKB/Swiss-Prot),   A0A4X1UHD0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000007964   ⟸   ENSSSCT00000008181
Protein Domains
Rhodanese


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000007475 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSSSCG00005026569 UniProtKB/Swiss-Prot
  ENSSSCG00015000484 UniProtKB/Swiss-Prot
  ENSSSCG00025055407 UniProtKB/Swiss-Prot
  ENSSSCG00030000701 UniProtKB/Swiss-Prot
  ENSSSCG00035032535 UniProtKB/Swiss-Prot
  ENSSSCG00040040925 UniProtKB/Swiss-Prot
  ENSSSCG00045026435 UniProtKB/Swiss-Prot
  ENSSSCG00050058821 UniProtKB/Swiss-Prot
  ENSSSCG00055027385 UniProtKB/Swiss-Prot
  ENSSSCG00060027198 UniProtKB/Swiss-Prot
  ENSSSCG00065069118 UniProtKB/Swiss-Prot
  ENSSSCG00070017819 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000008181 ENTREZGENE
  ENSSSCT00000008181.3 UniProtKB/Swiss-Prot
  ENSSSCT00005041996 UniProtKB/Swiss-Prot
  ENSSSCT00015000540.1 UniProtKB/Swiss-Prot
  ENSSSCT00025075782.1 UniProtKB/Swiss-Prot
  ENSSSCT00030000934.1 UniProtKB/Swiss-Prot
  ENSSSCT00035043090.1 UniProtKB/Swiss-Prot
  ENSSSCT00040054693.1 UniProtKB/Swiss-Prot
  ENSSSCT00045044975.1 UniProtKB/Swiss-Prot
  ENSSSCT00050080146.1 UniProtKB/Swiss-Prot
  ENSSSCT00055054141.1 UniProtKB/Swiss-Prot
  ENSSSCT00060036825.1 UniProtKB/Swiss-Prot
  ENSSSCT00065094878.1 UniProtKB/Swiss-Prot
  ENSSSCT00070035154.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro MOCS3/Uba4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodanese-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodanese-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ThiF/MoeB/HesA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ThiF_NAD_FAD-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiquitin-activating_enz UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:100124378 UniProtKB/Swiss-Prot
NCBI Gene MOCS3 ENTREZGENE
PANTHER ADENYLYLTRANSFERASE AND SULFURTRANSFERASE MOCS3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10953 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Rhodanese UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ThiF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE RHODANESE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RHOD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF69572 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A4X1UHD0 ENTREZGENE, UniProtKB/TrEMBL
  A5GFZ6 ENTREZGENE, UniProtKB/Swiss-Prot
VGNC ID VGNC:103989 ENTREZGENE