MS4A8 (membrane spanning 4-domains A8)

Gene: MS4A8 (membrane spanning 4-domains A8) Sus scrofa

Analyze

Symbol:

MS4A8

Name:

membrane spanning 4-domains A8

RGD ID:

13938935

Description:

ASSOCIATED WITH genetic disease (ortholog); intellectual disability (ortholog); leukocyte adhesion deficiency 3 (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

LOC110259710; membrane-spanning 4-domains subfamily A member 8-like; membrane-spanning 4-domains subfamily A member 8B; MS4A8B

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	10,989,969 - 11,007,621 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	10,989,947 - 11,007,621 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

intellectual disability (ISO)

leukocyte adhesion deficiency 3 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell surface receptor signaling pathway (IBA)

Cellular Component

membrane (IEA)

plasma membrane (IBA,IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

MS4A8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	10,989,969 - 11,007,621 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	10,989,947 - 11,007,621 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

MS4A8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	60,699,612 - 60,715,807 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	60,699,585 - 60,715,807 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	60,467,085 - 60,483,280 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	60,223,623 - 60,239,860 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	60,223,622 - 60,239,858	NCBI
Celera	11	57,831,254 - 57,847,490 (+)	NCBI		Celera
Cytogenetic Map	11	q12.2	NCBI
HuRef	11	56,813,422 - 56,829,655 (+)	NCBI		HuRef
CHM1_1	11	60,333,125 - 60,349,358 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	60,650,773 - 60,666,970 (+)	NCBI		T2T-CHM13v2.0

Ms4a8a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	11,044,835 - 11,058,467 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	11,044,835 - 11,058,466 (-)	Ensembl		GRCm39 Ensembl
GRCm38	19	11,067,471 - 11,081,103 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	11,067,471 - 11,081,102 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	19	11,141,961 - 11,155,593 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	19	11,134,516 - 11,148,073 (-)	NCBI		MGSCv36	mm8
Celera	19	11,758,959 - 11,772,928 (-)	NCBI		Celera
Cytogenetic Map	19	A	NCBI
cM Map	19	7.62	NCBI

Ms4a8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	217,155,557 - 217,169,151 (-)	NCBI		GRCr8
mRatBN7.2	1	207,730,665 - 207,744,260 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	207,730,665 - 207,744,324 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	216,105,502 - 216,119,101 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	223,165,601 - 223,179,274 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	215,859,903 - 215,873,498 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	227,136,154 - 227,149,748 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	227,136,154 - 227,149,748 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	234,203,005 - 234,216,599 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	213,583,486 - 213,597,080 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	213,741,912 - 213,785,366 (-)	NCBI
Celera	1	205,215,300 - 205,228,872 (-)	NCBI		Celera
Cytogenetic Map	1	q43	NCBI

MS4A8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	61,871,137 - 61,887,198 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	62,915,230 - 62,931,252 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	55,965,123 - 55,981,042 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	59,406,395 - 59,422,277 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	59,406,395 - 59,422,277 (+)	Ensembl	panpan1.1		panPan2

LOC102153191
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	21	50,497,486 - 50,504,173 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	21	49,936,895 - 49,944,920 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	21	51,668,967 - 51,677,011 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	21	50,716,461 - 50,724,482 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	21	50,815,733 - 50,821,947 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	21	51,438,692 - 51,446,753 (-)	NCBI		UU_Cfam_GSD_1.0

Ms4a8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	12,146,900 - 12,157,540 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936581	2,261,090 - 2,271,213 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936581	2,260,960 - 2,270,127 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MS4A8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	13,125,146 - 13,140,500 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	13,123,461 - 13,140,309 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	110,480,437 - 110,495,367 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Variants

Variants in MS4A8
368 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	hemolymphoid system	nervous system	respiratory system
High
Medium
Low	5	1
Below cutoff	2	1	2	1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_021085457	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GFLN01115433	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KX147102	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KX192172	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSSCT00000033243 ⟹ ENSSSCP00000028362

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	2	10,989,969 - 11,007,621 (-)	Ensembl

RefSeq Acc Id:

XM_021085457 ⟹ XP_020941116

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	2	10,989,947 - 11,007,621 (-)	NCBI

Sequence:

show sequence

TTCTGCGCACAGATACCATTAAACTCTTGCCCAACTGAATTACAGTAAAGTGGCTCCATGGCCA
AAACAGGAAGCAAATATGGGTGGGGGCACTGAGCCCTACGCCACTAGTCACCAAGCTTGCACCT
AGGAGAAAAGTGAAGTGACCTTTGGATATTTCTAAGCCTGTCCCTCAACAGAACCCAGGGCCAT
CATCCTCTAGGGAAAACAAGTTGCCTACAGCAAAAACTGAGAACAGAGAAGCAAGGGAGACTTA
GCTGCTGGCAGAACAAAACATCATGAATCCAATGAATACGGCAGGCCCCGCGCCCAACTCCGTG
TTTGTGGTGACATCCCCGGATGGGTACACTGTGTTGCCGTCCGGCATGACCCAGGTGTATCCAA
GCTACCAGCCCCAAGCATTTGTGGGTCAACCACCTGCCCAGGGAACCCTGAAAGAAGGCAAAGC
CTTAGGGGCCGTCCAGATCCTGATCGGCCTGTTTTACTTGGGCCTTGCCTCTATCATGGGGACA
GTCTTGGCGAGAGGATATCTGGCGATCTCATTCAATGGAGGCTTTCCCTTCTGGGCGGGCATCT
GGTTTATCGTTTCAGGATCCCTCTCAGTGACTGCAGAAAAACAGCCAAGATCTTCCTGCCTGCT
GAACAGCAGCTTGGGTTTCAACATCCTCAGTGCCATCTACTCTCTGGTTGGAATCTGTCTCTTC
ACAGCAGAATTAGTGATCGCTCCCTCCTTCCTCTGGACCGACCATCATTCCCCTCCATTCTGGA
ACGTGATCACAGGAATAGCGATATCTAGCGTGTTTCTCATCTTCTGCCTCCTGGAATTCTGCAT
CGCATGTGCATGTGCCCACTTTGGCTGCCAGCTGGTCTGCTACAAACCCAAAACTGTGGGCATG
GTTATCCCAAACATCTATGTGGCAAACCCAGTGGTCAACCCAGAACCAGAGAATACGCCACCGG
ATTATTCCAACATCCAGGGCGACAAATAAACGAAGCCAAATGTTCTAGAAACATTTTTCACGGG
GACGGAAAGAGGACCTCCCCTTGCTGGGCTTCTGAAACAAGATGCTGTCTTCTCTGATCACCTT
TAAAAAACGTCTGTCCAAGCACATGCGTCCTGAACTTCATTCCATTCAACCTGGGAGATCATGC
TGTGCTCTGAGGGTTTGGGATGGAAATGCTGTAAAAATTTGGTTGTGATGATTGTTGTACACCT
ATAAATGTAATAAAATCCATTAAGTAATTAAAAATAAATAAACAAATAAGTAAATAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_020941116	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	APU50821	(Get FASTA)	NCBI Sequence Viewer
	APX42105	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00000028362
	ENSSSCP00000028362.2
	ENSSSCP00005042043.1
	ENSSSCP00015020898.1
	ENSSSCP00025025861.1
	ENSSSCP00035036251.1
	ENSSSCP00045034061.1
	ENSSSCP00070043012.1

RefSeq Acc Id:	XP_020941116 ⟸ XM_021085457
- UniProtKB:	A0A8D0TMH9 (UniProtKB/TrEMBL), K7GKI5 (UniProtKB/TrEMBL), A0A1L7H7K3 (UniProtKB/TrEMBL), A0A4X1VHW5 (UniProtKB/TrEMBL), A0A8D1ARL8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MNPMNTAGPAPNSVFVVTSPDGYTVLPSGMTQVYPSYQPQAFVGQPPAQGTLKEGKALGAVQIL IGLFYLGLASIMGTVLARGYLAISFNGGFPFWAGIWFIVSGSLSVTAEKQPRSSCLLNSSLGFN ILSAIYSLVGICLFTAELVIAPSFLWTDHHSPPFWNVITGIAISSVFLIFCLLEFCIACACAHF GCQLVCYKPKTVGMVIPNIYVANPVVNPEPENTPPDYSNIQGDK hide sequence

RefSeq Acc Id:

ENSSSCP00000028362 ⟸ ENSSSCT00000033243

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000030879	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00005042200	UniProtKB/TrEMBL
	ENSSSCG00015039247	UniProtKB/TrEMBL
	ENSSSCG00025044884	UniProtKB/TrEMBL
	ENSSSCG00035064604	UniProtKB/TrEMBL
	ENSSSCG00045028709	UniProtKB/TrEMBL
	ENSSSCG00070025455	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000033243	ENTREZGENE
	ENSSSCT00000033243.2	UniProtKB/TrEMBL
	ENSSSCT00005067665.1	UniProtKB/TrEMBL
	ENSSSCT00015052254.1	UniProtKB/TrEMBL
	ENSSSCT00025060928.1	UniProtKB/TrEMBL
	ENSSSCT00035086948.1	UniProtKB/TrEMBL
	ENSSSCT00045048962.1	UniProtKB/TrEMBL
	ENSSSCT00070050880.1	UniProtKB/TrEMBL
InterPro	CD20-like	UniProtKB/TrEMBL
	MS4A	UniProtKB/TrEMBL
NCBI Gene	LOC110259710	ENTREZGENE
PANTHER	MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 8	UniProtKB/TrEMBL
	PTHR23320	UniProtKB/TrEMBL
Pfam	CD20	UniProtKB/TrEMBL
UniProt	A0A1L7H7K3	ENTREZGENE, UniProtKB/TrEMBL
	A0A4X1VHW5	ENTREZGENE, UniProtKB/TrEMBL
	A0A8D0TMH9	ENTREZGENE
	A0A8D1ARL8	ENTREZGENE, UniProtKB/TrEMBL
	K7GKI5	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	A0A8D0TMH9	UniProtKB/TrEMBL
VGNC ID	VGNC:108755	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2022-02-21	MS4A8	membrane spanning 4-domains A8	LOC110259710	membrane-spanning 4-domains subfamily A member 8-like	Symbol and/or name change	19259463	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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