AMD1 (adenosylmethionine decarboxylase 1) - Rat Genome Database

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Gene: AMD1 (adenosylmethionine decarboxylase 1) Sus scrofa
Analyze
Symbol: AMD1
Name: adenosylmethionine decarboxylase 1
RGD ID: 13936115
Description: ENCODES a protein that exhibits adenosylmethionine decarboxylase activity (ortholog); identical protein binding (ortholog); putrescine binding (ortholog); INVOLVED IN polyamine metabolic process (ortholog); S-adenosylmethionine metabolic process (ortholog); spermidine biosynthetic process (ortholog); PARTICIPATES IN glycine N-methyltransferase deficiency pathway; homocystinuria pathway; hypermethioninemia pathway; ASSOCIATED WITH developmental and epileptic encephalopathy 87 (ortholog); genetic disease (ortholog); lung non-small cell carcinoma (ortholog); FOUND IN cytosol (inferred); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: S-adenosylmethionine decarboxylase proenzyme
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl176,839,731 - 76,863,738 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1176,839,448 - 76,863,745 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2186,399,564 - 86,423,858 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IBA,IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
AMD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl176,839,731 - 76,863,738 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1176,839,448 - 76,863,745 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2186,399,564 - 86,423,858 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AMD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386110,814,617 - 110,895,713 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6110,874,770 - 110,898,879 (+)EnsemblGRCh38hg38GRCh38
GRCh376111,135,820 - 111,216,916 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366111,302,680 - 111,323,606 (+)NCBINCBI36Build 36hg18NCBI36
Build 346111,302,680 - 111,323,599NCBI
Celera6111,942,595 - 111,963,525 (+)NCBICelera
Cytogenetic Map6q21NCBI
HuRef6108,767,311 - 108,788,282 (+)NCBIHuRef
CHM1_16111,459,114 - 111,480,041 (+)NCBICHM1_1
T2T-CHM13v2.06111,993,221 - 112,074,322 (+)NCBIT2T-CHM13v2.0
Amd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391040,163,454 - 40,178,184 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1040,163,454 - 40,178,184 (-)EnsemblGRCm39 Ensembl
GRCm381040,287,458 - 40,302,188 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1040,287,458 - 40,302,188 (-)EnsemblGRCm38mm10GRCm38
MGSCv371040,007,265 - 40,021,992 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361039,976,874 - 39,991,588 (-)NCBIMGSCv36mm8
Celera1036,613,234 - 36,615,716 (-)NCBICelera
Cytogenetic Map10B1NCBI
cM Map1021.85NCBI
Amd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82045,250,289 - 45,324,939 (-)NCBIGRCr8
mRatBN7.22043,695,783 - 43,711,476 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2043,697,237 - 43,711,476 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2045,444,766 - 45,460,459 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02045,103,953 - 45,119,647 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02045,848,695 - 45,864,247 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02045,384,000 - 45,399,694 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2045,384,000 - 45,399,694 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02047,103,749 - 47,119,386 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42044,452,475 - 44,468,111 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12044,475,485 - 44,491,122 (-)NCBI
Celera2044,399,688 - 44,415,381 (-)NCBICelera
Cytogenetic Map20q12NCBI
Amd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541135,541,517 - 35,563,209 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541135,541,517 - 35,563,209 (+)NCBIChiLan1.0ChiLan1.0
AMD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25130,884,293 - 130,905,305 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16128,770,354 - 128,794,437 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06108,678,741 - 108,699,695 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16112,761,072 - 112,782,074 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6112,761,072 - 112,782,074 (+)Ensemblpanpan1.1panPan2
AMD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11267,432,871 - 67,453,791 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1267,448,141 - 67,451,696 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1267,251,123 - 67,272,026 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01268,311,059 - 68,331,965 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1268,311,069 - 68,334,115 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11267,662,003 - 67,682,902 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01267,507,932 - 67,528,835 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01267,786,118 - 67,807,019 (+)NCBIUU_Cfam_GSD_1.0
Amd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946102,381,927 - 102,400,701 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365646,656,746 - 6,673,462 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365646,656,789 - 6,675,564 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AMD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11362,977,659 - 62,999,150 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604035,281,244 - 35,302,558 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Amd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249161,837,242 - 1,854,883 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249161,837,258 - 1,855,450 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in AMD1
392 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 4 3 5 2 23 2 3 3
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000004855   ⟹   ENSSSCP00000004741
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl176,839,734 - 76,862,072 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000089341   ⟹   ENSSSCP00000072370
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl176,840,058 - 76,863,722 (+)Ensembl
RefSeq Acc Id: XM_003121345   ⟹   XP_003121393
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1176,839,448 - 76,863,745 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_003121393   ⟸   XM_003121345
- UniProtKB: A0A4X1VBX0 (UniProtKB/TrEMBL),   A0A480PUC7 (UniProtKB/TrEMBL),   A0A8D1VQ72 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000072370   ⟸   ENSSSCT00000089341
RefSeq Acc Id: ENSSSCP00000004741   ⟸   ENSSSCT00000004855


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000004392 Ensembl, UniProtKB/TrEMBL
  ENSSSCG00015042199 UniProtKB/TrEMBL
  ENSSSCG00025075199 UniProtKB/TrEMBL
  ENSSSCG00030018151 UniProtKB/TrEMBL
  ENSSSCG00035018240 UniProtKB/TrEMBL
  ENSSSCG00040009847 UniProtKB/TrEMBL
  ENSSSCG00045007874 UniProtKB/TrEMBL
  ENSSSCG00050020895 UniProtKB/TrEMBL
  ENSSSCG00055023443 UniProtKB/TrEMBL
  ENSSSCG00060046568 UniProtKB/TrEMBL
  ENSSSCG00065039076 UniProtKB/TrEMBL
  ENSSSCG00070022825 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000004855.5 UniProtKB/TrEMBL
  ENSSSCT00000089341.2 UniProtKB/TrEMBL
  ENSSSCT00015056577.1 UniProtKB/TrEMBL
  ENSSSCT00015056667.1 UniProtKB/TrEMBL
  ENSSSCT00025103703.1 UniProtKB/TrEMBL
  ENSSSCT00025103748.1 UniProtKB/TrEMBL
  ENSSSCT00030025124.1 UniProtKB/TrEMBL
  ENSSSCT00035023552.1 UniProtKB/TrEMBL
  ENSSSCT00035023559.1 UniProtKB/TrEMBL
  ENSSSCT00035023560.1 UniProtKB/TrEMBL
  ENSSSCT00040012798.1 UniProtKB/TrEMBL
  ENSSSCT00045013236.1 UniProtKB/TrEMBL
  ENSSSCT00045013281.1 UniProtKB/TrEMBL
  ENSSSCT00050028208.1 UniProtKB/TrEMBL
  ENSSSCT00055046188.1 UniProtKB/TrEMBL
  ENSSSCT00055046296.1 UniProtKB/TrEMBL
  ENSSSCT00060063224.1 UniProtKB/TrEMBL
  ENSSSCT00060063229.1 UniProtKB/TrEMBL
  ENSSSCT00065053408.1 UniProtKB/TrEMBL
  ENSSSCT00065053410.1 UniProtKB/TrEMBL
  ENSSSCT00070045412.1 UniProtKB/TrEMBL
  ENSSSCT00070045414.1 UniProtKB/TrEMBL
Gene3D-CATH S-adenosylmethionine decarboxylase UniProtKB/TrEMBL
  S-adenosylmethionine decarboxylase UniProtKB/TrEMBL
InterPro AdoMetDC-like UniProtKB/TrEMBL
  S-AdoMet_decarboxylase UniProtKB/TrEMBL
  S-AdoMet_deCO2ase_core UniProtKB/TrEMBL
  S-AdoMet_deCO2ase_CS UniProtKB/TrEMBL
KEGG Report ssc:100155925 UniProtKB/TrEMBL
NCBI Gene AMD1 ENTREZGENE
PANTHER PTHR11570 UniProtKB/TrEMBL
  S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME UniProtKB/TrEMBL
Pfam SAM_decarbox UniProtKB/TrEMBL
PIRSF S-AdenosylMet_decarboxylase UniProtKB/TrEMBL
PROSITE ADOMETDC UniProtKB/TrEMBL
Superfamily-SCOP SSF56276 UniProtKB/TrEMBL
UniProt A0A480PUC7 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1V642_PIG UniProtKB/TrEMBL
  A0A4X1VBX0 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2RK32_PIG UniProtKB/TrEMBL
  A0A8D0Z1P2_PIG UniProtKB/TrEMBL
  A0A8D0Z278_PIG UniProtKB/TrEMBL
  A0A8D1DCL9_PIG UniProtKB/TrEMBL
  A0A8D1VQ72 ENTREZGENE, UniProtKB/TrEMBL
  F1RT08_PIG UniProtKB/TrEMBL
VGNC ID VGNC:103024 ENTREZGENE