FSTL4 (follistatin like 4) - Rat Genome Database

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Gene: FSTL4 (follistatin like 4) Sus scrofa
Analyze
Symbol: FSTL4
Name: follistatin like 4
RGD ID: 13932998
Description: ENCODES a protein that exhibits brain-derived neurotrophic factor binding (inferred); calcium ion binding (inferred); INVOLVED IN negative regulation of axon extension (ortholog); negative regulation of brain-derived neurotrophic factor receptor signaling pathway (ortholog); negative regulation of collateral sprouting (ortholog); ASSOCIATED WITH Hereditary Neoplastic Syndromes (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN extracellular region (inferred); secretory granule (inferred)
Type: protein-coding
RefSeq Status: MODEL
Also known as: follistatin-related protein 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2135,488,545 - 136,096,788 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12135,486,885 - 136,096,939 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22141,008,905 - 141,041,306 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:17145712  


Genomics

Comparative Map Data
FSTL4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2135,488,545 - 136,096,788 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12135,486,885 - 136,096,939 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22141,008,905 - 141,041,306 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FSTL4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl5133,196,455 - 133,612,541 (-)EnsemblGRCh38hg38GRCh38
GRCh385133,194,827 - 133,842,066 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375132,532,147 - 132,948,232 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365132,560,051 - 132,976,122 (-)NCBINCBI36hg18NCBI36
Celera5128,660,188 - 129,071,771 (-)NCBI
Cytogenetic Map5q31.1NCBI
HuRef5127,723,604 - 128,135,825 (-)NCBIHuRef
CHM1_15131,965,487 - 132,380,818 (-)NCBICHM1_1
Fstl4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391152,655,320 - 53,083,277 (+)NCBIGRCm39mm39
GRCm39 Ensembl1152,655,461 - 53,079,365 (+)Ensembl
GRCm381152,764,489 - 53,192,450 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1152,764,634 - 53,188,538 (+)EnsemblGRCm38mm10GRCm38
MGSCv371152,578,208 - 53,000,849 (+)NCBIGRCm37mm9NCBIm37
MGSCv361152,608,129 - 53,030,770 (+)NCBImm8
Celera1157,342,639 - 57,767,017 (+)NCBICelera
Cytogenetic Map11B1.3NCBI
Fstl4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21036,911,228 - 37,338,665 (+)NCBI
Rnor_6.0 Ensembl1038,104,558 - 38,532,196 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01038,104,344 - 38,532,216 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01037,877,767 - 38,314,006 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41038,190,597 - 38,635,242 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11038,196,029 - 38,642,071 (+)NCBI
Celera1036,261,450 - 36,687,189 (+)NCBICelera
Cytogenetic Map10q22NCBI
Fstl4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554084,522,031 - 4,898,690 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554084,521,922 - 4,898,697 (-)NCBIChiLan1.0ChiLan1.0
FSTL4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15134,764,310 - 135,171,980 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5134,766,944 - 135,163,711 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05128,606,171 - 129,016,734 (-)NCBIMhudiblu_PPA_v0panPan3
FSTL4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11121,453,982 - 21,850,969 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1121,458,678 - 21,856,547 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1120,263,099 - 20,590,135 (-)NCBI
ROS_Cfam_1.01122,253,158 - 22,646,541 (-)NCBI
UMICH_Zoey_3.11120,959,653 - 21,352,662 (-)NCBI
UNSW_CanFamBas_1.01120,817,666 - 21,210,744 (-)NCBI
UU_Cfam_GSD_1.01121,460,502 - 21,853,816 (-)NCBI
Fstl4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213114,780,303 - 114,998,812 (+)NCBI
SpeTri2.0NW_0049366471,783,065 - 1,997,203 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FSTL4
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12336,005,475 - 36,423,806 (-)NCBI
ChlSab1.1 Ensembl2336,011,179 - 36,217,708 (-)Ensembl
Fstl4
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473338,339,826 - 38,952,595 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system hemolymphoid system nervous system renal system reproductive system
High
Medium
Low 3 23 1
Below cutoff 6 2 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000015616   ⟹   ENSSSCP00000015204
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl2135,488,545 - 136,096,788 (-)Ensembl
RefSeq Acc Id: XM_021084752   ⟹   XP_020940411
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.12135,486,885 - 135,920,595 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021084753   ⟹   XP_020940412
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.12135,486,885 - 136,096,939 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020940411 (Get FASTA)   NCBI Sequence Viewer  
  XP_020940412 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020940412   ⟸   XM_021084753
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_020940411   ⟸   XM_021084752
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSSSCP00000015204   ⟸   ENSSSCT00000015616
Protein Domains
EF-hand   Ig-like   Kazal-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000014293 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000015204 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000015616 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/TrEMBL
InterPro EF-hand-dom_pair UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
  Kazal_dom UniProtKB/TrEMBL
  Kazal_dom_sf UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
NCBI Gene FSTL4 ENTREZGENE
Pfam EF-hand_5 UniProtKB/TrEMBL
  Kazal_2 UniProtKB/TrEMBL
PROSITE EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
  IG_LIKE UniProtKB/TrEMBL
  KAZAL_2 UniProtKB/TrEMBL
SMART IGc2 UniProtKB/TrEMBL
  KAZAL UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF100895 UniProtKB/TrEMBL
  SSF47473 UniProtKB/TrEMBL
  SSF48726 UniProtKB/TrEMBL
UniProt F1RI14_PIG UniProtKB/TrEMBL
VGNC ID VGNC:88256 ENTREZGENE