PLA2G2E (phospholipase A2 group IIE)

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Gene: PLA2G2E (phospholipase A2 group IIE) Sus scrofa

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Symbol:

PLA2G2E

Name:

phospholipase A2 group IIE

RGD ID:

13923436

Description:

ENCODES a protein that exhibits calcium ion binding (inferred); calcium-dependent phospholipase A2 activity (inferred); calcium-independent phospholipase A2 activity (inferred); INVOLVED IN low-density lipoprotein particle remodeling (ortholog); ASSOCIATED WITH 3-hydroxy-3-methylglutaryl-CoA lyase deficiency (ortholog); chromosome 1p36 deletion syndrome (ortholog); congenital disorder of glycosylation Ir (ortholog); FOUND IN extracellular region (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

group IIE secretory phospholipase A2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	78,278,284 - 78,282,377 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	78,278,080 - 78,282,253 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

3-hydroxy-3-methylglutaryl-CoA lyase deficiency (ISO)

chromosome 1p36 deletion syndrome (ISO)

congenital disorder of glycosylation Ir (ISO)

hyperprolinemia type 2 (ISO)

Parkinson's disease 6 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

arachidonate secretion (IEA)

lipid catabolic process (IEA)

lipid metabolic process (IEA)

low-density lipoprotein particle remodeling (IEA,ISO)

phosphatidylcholine metabolic process (IBA,IEA)

phosphatidylglycerol metabolic process (IBA,IEA)

phospholipid metabolic process (IEA)

Cellular Component

extracellular region (IEA)

Molecular Function

calcium ion binding (IBA,IEA)

calcium-dependent phospholipase A2 activity (IBA,IEA)

calcium-independent phospholipase A2 activity (IEA)

hydrolase activity (IEA)

metal ion binding (IEA)

phospholipase A2 activity (IEA)

phospholipid binding (IBA)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

PLA2G2E
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	78,278,284 - 78,282,377 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	78,278,080 - 78,282,253 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

PLA2G2E
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	19,920,009 - 19,923,617 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	19,920,009 - 19,923,617 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	20,246,502 - 20,250,110 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	20,119,387 - 20,122,697 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	19,992,105 - 19,995,416	NCBI
Celera	1	18,573,636 - 18,576,946 (-)	NCBI		Celera
Cytogenetic Map	1	p36.13	NCBI
HuRef	1	18,492,424 - 18,495,734 (-)	NCBI		HuRef
CHM1_1	1	20,356,341 - 20,359,651 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	19,743,391 - 19,746,999 (-)	NCBI		T2T-CHM13v2.0

Pla2g2e
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	138,605,253 - 138,610,125 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	138,605,253 - 138,610,128 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	138,877,911 - 138,882,817 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	138,877,942 - 138,882,817 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	138,433,857 - 138,438,729 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	138,150,018 - 138,154,890 (+)	NCBI		MGSCv36	mm8
Celera	4	140,664,246 - 140,669,119 (+)	NCBI		Celera
Cytogenetic Map	4	D3	NCBI
cM Map	4	70.57	NCBI

Pla2g2e
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	156,404,639 - 156,410,421 (+)	NCBI		GRCr8
mRatBN7.2	5	151,121,363 - 151,127,147 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	151,121,439 - 151,126,821 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	153,818,819 - 153,824,204 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	155,593,127 - 155,598,512 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	155,575,036 - 155,580,421 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	157,327,657 - 157,333,039 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	157,327,657 - 157,333,039 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	161,068,641 - 161,074,026 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	157,699,794 - 157,705,176 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	157,694,981 - 157,715,203 (+)	NCBI
Celera	5	149,507,214 - 149,512,594 (+)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

Pla2g2e
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955452	520,361 - 525,846 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955452	522,314 - 526,095 (-)	NCBI	ChiLan1.0	ChiLan1.0

PLA2G2E
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	207,195,771 - 207,202,322 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	206,312,620 - 206,316,256 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	18,874,301 - 18,878,218 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	19,918,391 - 19,921,639 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	19,918,391 - 19,921,639 (-)	Ensembl	panpan1.1		panPan2

PLA2G2E
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	78,834,820 - 78,838,058 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	78,831,309 - 78,841,821 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	75,348,378 - 75,351,277 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	79,401,692 - 79,404,574 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	79,401,692 - 79,405,786 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	76,220,563 - 76,223,447 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	77,227,501 - 77,230,383 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	78,298,456 - 78,301,338 (+)	NCBI		UU_Cfam_GSD_1.0

PLA2G2E
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	112,632,404 - 112,636,571 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	112,632,759 - 112,635,992 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	3,543,895 - 3,548,096 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pla2g2e
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624764	4,985,688 - 4,988,818 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624764	4,984,021 - 4,989,315 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in PLA2G2E
60 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	nervous system	reproductive system
2	1	2	1

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_021095473	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000045	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSSCT00000042230 ⟹ ENSSSCP00000048306

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	6	78,278,284 - 78,282,377 (-)	Ensembl

RefSeq Acc Id:

XM_021095473 ⟹ XP_020951132

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	6	78,278,080 - 78,282,253 (-)	NCBI

Sequence:

show sequence

CCTCTGCTCACCTCCCCTCCCCCCAGGATGAAGCCTCCCCCTCTTTTGACCTTACTTTGCCTCC
TGGTGGCCCTGGCTGGCGGGAACCTGGTTCAGTTTGGGGTGATGATTGAGAGGATGACGGGGAA
GCCTGCACTGCAGTACAATGACTATGGCTGCTACTGTGGCGTCGGCGGCGCCCACTGGCCAGTG
GACCAGACAGACTGGTGCTGCCATGCCCATGACTGCTGCTATGGGCGTCTGGAGAAGCTGGGCT
GTGAGCCCAAACTGGAAAAGTATCTTTTCTCTGCCAGCAGGCGCAATATCGTCTGTGCCGGCAG
AACCAGCTGCCAGCGACAAACCTGCGAGTGTGACAAGAGGGCTGCGCTCTGCTTTCGCCGCCAC
CTGGGCACCTACAACCGTAAATACGCCCATTATCCGGACAAGCTGTGCACAGGACCCACCCCGC
CCTGCTAAGTCTGTGTTCCCCCGCCTCCCTCCCGCCCCCACCCTCCAGCTGCTGACCTCAGGAA
CACTGTCACAAAGGCCCTCCCTCTGGAAAACTCCTTTGCTGCAAACCCACTCCTCCTTCCCACA
CTCGGGCCTGGACCCTCGTGGGCCTCCCCAGGCCACACCTCCCCCAGAAAGACCTGTGCCTGGG
GGCCTTTCAGTACCCAGAAGACTCTGTAACCCGCCCCTGGGACCTCAGTTCCCTCTTCTGAATA
TATGAATAATGTCTTCCCACAATTCGAATACGGATCCTCGGATTCATTGTAGGGGTTTAATTAG
TCTACAGTTTCATTCATGCCTTGGTTTCTGAGCACCACTGTGTGCCAGCGTGCTAAGCACTGGG
ACACAGCGTGGGTCTGACATGGGTGGCCCCCCACCTGCAATTGCAACACTGCCCTTTCAGTTTC
CTATTCTCATAAGTTTTTGTGACTCTTTTTCTAACATTATACAATCTTTTCCAAGACAATAATG
GCAATCTCTAGAAGATATGTTTCTGGCCCGATGGTGTAATGTGAGAAGCACACAAAATACCAGC
CCCAAAATATTGTCCCCACTATGTCACCAGACTCCAAATCCCTCCCATCAGAAGACTGGCTGAG
AGTGAAAAGAAACTCTCGAGTCAACTTATTCCAGTCCCTCCTGTGACCGATGGGGGCCTGGCGG
TCAGAGAGGGAAGTTCTACCTGAAGGCGTGTCCTCACGCCCAAGCCAGGGTGCCTCCATTTTTT
CATGCATCAGCCACCTACACTCTGCCCCTCTGGTTACCATCTTGCGCCAGCCCAGAGGACCCAG
GGAAGTCAGCTATGAGATGCCTGGGCCAGGTCAGGCTCCTGATACGGGGAGGGAAGAGGAAAGA
TTTCAACATCCAACATCCTGGG

hide sequence

Protein Sequences


Protein RefSeqs	XP_020951132	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00000048306
	ENSSSCP00000048306.1
	ENSSSCP00015003464.1
	ENSSSCP00025011333.1
	ENSSSCP00030018786.1
	ENSSSCP00035033792.1
	ENSSSCP00040039115.1
	ENSSSCP00045019159.1
	ENSSSCP00050048520.1
	ENSSSCP00055009586.1
	ENSSSCP00060023143.1
	ENSSSCP00065025283.1
	ENSSSCP00070049311.1

RefSeq Acc Id:	XP_020951132 ⟸ XM_021095473
- UniProtKB:	A0A287AW04 (UniProtKB/TrEMBL), A0A8D1KXK5 (UniProtKB/TrEMBL), A0A4X1W4B6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKPPPLLTLLCLLVALAGGNLVQFGVMIERMTGKPALQYNDYGCYCGVGGAHWPVDQTDWCCHA HDCCYGRLEKLGCEPKLEKYLFSASRRNIVCAGRTSCQRQTCECDKRAALCFRRHLGTYNRKYA HYPDKLCTGPTPPC hide sequence

Ensembl Acc Id:

ENSSSCP00000048306 ⟸ ENSSSCT00000042230

Protein Domains

Phospholipase A2

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000033887	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00015006469	UniProtKB/TrEMBL
	ENSSSCG00025019714	UniProtKB/TrEMBL
	ENSSSCG00030029721	UniProtKB/TrEMBL
	ENSSSCG00035060782	UniProtKB/TrEMBL
	ENSSSCG00040065197	UniProtKB/TrEMBL
	ENSSSCG00045016271	UniProtKB/TrEMBL
	ENSSSCG00050078987	UniProtKB/TrEMBL
	ENSSSCG00055006262	UniProtKB/TrEMBL
	ENSSSCG00060040099	UniProtKB/TrEMBL
	ENSSSCG00065042644	UniProtKB/TrEMBL
	ENSSSCG00070028920	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000042230	ENTREZGENE
	ENSSSCT00000042230.3	UniProtKB/TrEMBL
	ENSSSCT00015008583.1	UniProtKB/TrEMBL
	ENSSSCT00025026749.1	UniProtKB/TrEMBL
	ENSSSCT00030041290.1	UniProtKB/TrEMBL
	ENSSSCT00035081617.1	UniProtKB/TrEMBL
	ENSSSCT00040088992.1	UniProtKB/TrEMBL
	ENSSSCT00045027692.1	UniProtKB/TrEMBL
	ENSSSCT00050109033.1	UniProtKB/TrEMBL
	ENSSSCT00055012135.1	UniProtKB/TrEMBL
	ENSSSCT00060054285.1	UniProtKB/TrEMBL
	ENSSSCT00065058310.1	UniProtKB/TrEMBL
	ENSSSCT00070057994.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.90.10	UniProtKB/TrEMBL
InterPro	PLipase_A2	UniProtKB/TrEMBL
	PLipase_A2_dom	UniProtKB/TrEMBL
	PLipase_A2_dom_sf	UniProtKB/TrEMBL
	PLipase_A2_His_AS	UniProtKB/TrEMBL
NCBI Gene	PLA2G2E	ENTREZGENE
PANTHER	GROUP IIE SECRETORY PHOSPHOLIPASE A2	UniProtKB/TrEMBL
	PTHR11716	UniProtKB/TrEMBL
Pfam	Phospholip_A2_1	UniProtKB/TrEMBL
PRINTS	PHPHLIPASEA2	UniProtKB/TrEMBL
PROSITE	PA2_HIS	UniProtKB/TrEMBL
SMART	PA2c	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48619	UniProtKB/TrEMBL
UniProt	A0A287AW04	ENTREZGENE, UniProtKB/TrEMBL
	A0A4X1W4B6	ENTREZGENE, UniProtKB/TrEMBL
	A0A8D1KXK5	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:91492	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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