PRAG1 (PEAK1 related, kinase-activating pseudokinase 1) - Rat Genome Database

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Gene: PRAG1 (PEAK1 related, kinase-activating pseudokinase 1) Sus scrofa
Analyze
Symbol: PRAG1
Name: PEAK1 related, kinase-activating pseudokinase 1
RGD ID: 13922825
Description: ENCODES a protein that exhibits ATP binding (ortholog); identical protein binding (ortholog); INVOLVED IN cell migration (ortholog); negative regulation of neuron projection development (ortholog); positive regulation of Rho protein signal transduction (ortholog); ASSOCIATED WITH genetic disease (ortholog); FOUND IN cytoplasm (ortholog); focal adhesion (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: tyrosine-protein kinase SgK223
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.117745,039 - 793,409 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
focal adhesion  (ISO)
nucleus  (ISO)

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PRAG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.117745,039 - 793,409 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PRAG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3888,317,736 - 8,386,439 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl88,317,736 - 8,386,439 (-)EnsemblGRCh38hg38GRCh38
GRCh3788,175,258 - 8,243,949 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3688,212,668 - 8,276,667 (-)NCBINCBI36Build 36hg18NCBI36
Celera87,303,570 - 7,367,558 (-)NCBICelera
Cytogenetic Map8p23.1NCBI
HuRef87,099,920 - 7,163,897 (-)NCBIHuRef
CHM1_188,240,753 - 8,304,766 (-)NCBICHM1_1
T2T-CHM13v2.0811,357,159 - 11,425,856 (+)NCBIT2T-CHM13v2.0
Prag1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39836,562,015 - 36,614,939 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl836,561,982 - 36,614,941 (+)EnsemblGRCm39 Ensembl
GRCm38836,094,827 - 36,147,787 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl836,094,828 - 36,147,787 (+)EnsemblGRCm38mm10GRCm38
MGSCv37837,157,882 - 37,210,841 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36837,563,378 - 37,616,061 (+)NCBIMGSCv36mm8
Celera838,730,743 - 38,787,704 (+)NCBICelera
Cytogenetic Map8A4NCBI
cM Map822.78NCBI
Prag1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81662,791,249 - 62,844,532 (-)NCBIGRCr8
mRatBN7.21656,087,885 - 56,141,153 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1656,087,885 - 56,141,153 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1661,401,186 - 61,454,452 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01664,815,158 - 64,868,428 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01660,035,139 - 60,088,409 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01659,666,794 - 59,730,681 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1659,666,775 - 59,721,227 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01659,345,052 - 59,397,741 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41659,780,251 - 59,833,359 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11659,780,708 - 59,828,812 (-)NCBI
Celera1654,144,709 - 54,196,468 (-)NCBICelera
Cytogenetic Map16q12.2NCBI
Prag1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554634,394,718 - 4,446,696 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554634,397,246 - 4,446,696 (-)NCBIChiLan1.0ChiLan1.0
PRAG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2724,771,690 - 24,842,864 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18798,821 - 870,444 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0810,824,887 - 10,896,058 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PRAG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11636,058,527 - 36,103,933 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1636,053,967 - 36,103,764 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1636,509,721 - 36,568,184 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01638,083,633 - 38,142,148 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1638,096,813 - 38,142,148 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11636,183,300 - 36,241,596 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01636,745,966 - 36,804,272 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01636,865,728 - 36,924,087 (+)NCBIUU_Cfam_GSD_1.0
Prag1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494343,045,601 - 43,101,519 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365732,046,036 - 2,094,040 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365732,040,965 - 2,095,377 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRAG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1810,641,633 - 10,704,068 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl810,629,078 - 10,703,646 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605231,689,333 - 31,756,969 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prag1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248394,361,051 - 4,413,061 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248394,363,337 - 4,417,585 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PRAG1
1655 total Variants

Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_021077408   ⟹   XP_020933067
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.117745,039 - 793,409 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020933067 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00005017665.1
  ENSSSCP00025032564.1
  ENSSSCP00045011856.1
Reference Protein Sequences
RefSeq Acc Id: XP_020933067   ⟸   XM_021077408
- UniProtKB: A0A8D0SR71 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00005018386 UniProtKB/TrEMBL
  ENSSSCG00025054918 UniProtKB/TrEMBL
  ENSSSCG00045010159 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00005028953.1 UniProtKB/TrEMBL
  ENSSSCT00025075119.1 UniProtKB/TrEMBL
  ENSSSCT00045017193.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
NCBI Gene PRAG1 ENTREZGENE
PANTHER INACTIVE TYROSINE-PROTEIN KINASE PRAG1 UniProtKB/TrEMBL
  SERINE/THREONINE PROTEIN KINASE UniProtKB/TrEMBL
Pfam PK_Tyr_Ser-Thr UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A8D0LLK4_PIG UniProtKB/TrEMBL
  A0A8D0SR71 ENTREZGENE, UniProtKB/TrEMBL