CRKL (CRK like proto-oncogene, adaptor protein) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: CRKL (CRK like proto-oncogene, adaptor protein) Sus scrofa
Analyze
Symbol: CRKL
Name: CRK like proto-oncogene, adaptor protein (Ensembl:CRK like proto-onco, adaptor protein)
RGD ID: 13922006
Description: ENCODES a protein that exhibits identical protein binding (inferred); phosphotyrosine residue binding (inferred); receptor tyrosine kinase binding (inferred); INVOLVED IN acetylcholine receptor signaling pathway (ortholog); animal organ morphogenesis (ortholog); anterior/posterior pattern specification (ortholog); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; erythropoietin signaling pathway; insulin-like growth factor signaling pathway; ASSOCIATED WITH autistic disorder (ortholog); Breast Neoplasms (ortholog); chromosome 22q11.2 deletion syndrome, distal (ortholog); FOUND IN extrinsic component of postsynaptic membrane (ortholog); neuromuscular junction (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: crk-like protein; v-crk avian sarcoma virus CT10 oncogene-like
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1450,528,955 - 50,558,662 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11450,528,950 - 50,558,664 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21453,977,699 - 54,007,396 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acetylcholine receptor signaling pathway  (IEA,ISO)
animal organ morphogenesis  (IEA,ISO)
anterior/posterior pattern specification  (IEA,ISO)
B cell apoptotic process  (IEA,ISO)
blood vessel development  (IEA,ISO)
cell chemotaxis  (IEA,ISO)
cell migration  (IEA)
cellular response to interleukin-7  (IEA,ISO)
cellular response to transforming growth factor beta stimulus  (IEA)
cellular response to xenobiotic stimulus  (IEA,ISO)
cerebellar neuron development  (IEA,ISO)
cerebral cortex development  (IEA,ISO)
chordate pharynx development  (IEA,ISO)
cranial skeletal system development  (IEA,ISO)
dendrite development  (IEA,ISO)
endothelin receptor signaling pathway  (IEA,ISO)
enzyme-linked receptor protein signaling pathway  (IEA)
establishment of cell polarity  (IEA,ISO)
fibroblast growth factor receptor signaling pathway  (IEA,ISO)
heart development  (IEA,ISO)
helper T cell diapedesis  (IEA,ISO)
hippocampus development  (IEA,ISO)
lipid metabolic process  (IEA,ISO)
male gonad development  (IEA,ISO)
negative regulation of gene expression  (IEA)
negative regulation of protein phosphorylation  (IEA)
neuron migration  (IEA,ISO)
outflow tract morphogenesis  (IEA,ISO)
parathyroid gland development  (IEA,ISO)
pattern specification process  (IEA,ISO)
positive regulation of cell population proliferation  (IEA)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO)
positive regulation of glial cell migration  (IEA)
positive regulation of MAPK cascade  (IEA,ISO)
positive regulation of protein phosphorylation  (IEA)
positive regulation of Rac protein signal transduction  (IEA)
positive regulation of skeletal muscle acetylcholine-gated channel clustering  (IEA)
positive regulation of substrate adhesion-dependent cell spreading  (IEA)
postsynaptic specialization assembly  (IEA)
reelin-mediated signaling pathway  (IEA,ISO)
regulation of cell adhesion mediated by integrin  (IEA,ISO)
regulation of cell growth  (IEA,ISO)
regulation of cell motility  (IEA)
regulation of dendrite development  (IEA,ISO)
regulation of gene expression  (IEA,ISO)
regulation of intracellular signal transduction  (IEA)
regulation of leukocyte migration  (IEA,ISO)
regulation of skeletal muscle acetylcholine-gated channel clustering  (IEA,ISO)
regulation of T cell migration  (IEA,ISO)
response to fibroblast growth factor  (IEA,ISO)
retinoic acid receptor signaling pathway  (IEA,ISO)
signal transduction  (IEA)
single fertilization  (IEA,ISO)
spermatogenesis  (IEA,ISO)
T cell receptor signaling pathway  (IEA,ISO)
thymus development  (IEA,ISO)
urogenital system development  (IEA,ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CRKL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1450,528,955 - 50,558,662 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11450,528,950 - 50,558,664 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21453,977,699 - 54,007,396 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CRKL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382220,917,407 - 20,953,747 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2220,917,407 - 20,953,747 (+)EnsemblGRCh38hg38GRCh38
GRCh372221,271,695 - 21,308,035 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362219,601,714 - 19,637,890 (+)NCBINCBI36Build 36hg18NCBI36
Build 342219,596,267 - 19,632,443NCBI
Celera224,763,059 - 4,799,374 (+)NCBICelera
Cytogenetic Map22q11.21ENTREZGENE
HuRef224,539,711 - 4,576,600 (+)NCBIHuRef
CHM1_12221,271,912 - 21,308,243 (+)NCBICHM1_1
T2T-CHM13v2.02221,326,128 - 21,362,450 (+)NCBIT2T-CHM13v2.0
Crkl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391617,269,849 - 17,305,304 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1617,269,851 - 17,305,298 (+)EnsemblGRCm39 Ensembl
GRCm381617,451,985 - 17,487,440 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1617,451,987 - 17,487,434 (+)EnsemblGRCm38mm10GRCm38
MGSCv371617,452,080 - 17,486,348 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361617,365,550 - 17,399,818 (+)NCBIMGSCv36mm8
Celera1618,025,071 - 18,059,338 (+)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1610.82NCBI
Crkl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81197,033,033 - 97,067,457 (-)NCBIGRCr8
mRatBN7.21183,528,788 - 83,563,214 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1183,526,530 - 83,563,238 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1192,256,298 - 92,290,727 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01184,917,451 - 84,951,879 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01183,971,055 - 84,005,485 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01187,338,606 - 87,356,644 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1187,778,312 - 87,815,043 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01190,397,653 - 90,408,448 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,520,244 - 85,554,667 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11185,560,841 - 85,595,264 (-)NCBI
Celera1182,297,248 - 82,331,672 (-)NCBICelera
Cytogenetic Map11q23NCBI
Crkl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544219,358,081 - 19,388,815 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544219,358,202 - 19,388,552 (-)NCBIChiLan1.0ChiLan1.0
CRKL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22330,622,858 - 30,660,228 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12233,172,806 - 33,209,143 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0223,141,147 - 3,177,448 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12219,632,359 - 19,668,858 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2219,632,359 - 19,668,858 (+)Ensemblpanpan1.1panPan2
CRKL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12630,542,276 - 30,582,479 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2630,545,311 - 30,581,964 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2630,499,506 - 30,540,212 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02631,950,077 - 31,990,503 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2631,950,075 - 31,990,495 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12629,995,836 - 30,036,268 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02629,619,771 - 29,660,610 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02630,708,885 - 30,749,836 (-)NCBIUU_Cfam_GSD_1.0
Crkl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118140,267,911 - 140,306,379 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366192,447,614 - 2,479,805 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366192,447,686 - 2,479,589 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC103222955
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1194,855,633 - 4,889,674 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl194,855,611 - 4,890,302 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660852,080,371 - 2,099,812 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Crkl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624945734,532 - 767,168 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624945734,532 - 767,184 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CRKL
417 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 2 3 5 2 21 2 3 3
Low 2 2
Below cutoff

Sequence


RefSeq Acc Id: ENSSSCT00000011056   ⟹   ENSSSCP00000010768
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1450,528,955 - 50,558,662 (+)Ensembl
RefSeq Acc Id: XM_003132994   ⟹   XP_003133042
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11450,528,950 - 50,558,664 (+)NCBI
Sequence:
RefSeq Acc Id: XP_003133042   ⟸   XM_003132994
- UniProtKB: F1RKX9 (UniProtKB/TrEMBL),   A0A4X1UYQ0 (UniProtKB/TrEMBL),   A0A0B8RTT8 (UniProtKB/TrEMBL),   A0A8D0TEI8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000010768   ⟸   ENSSSCT00000011056
Protein Domains
SH2   SH3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000010095 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005027371 UniProtKB/TrEMBL
  ENSSSCG00015013582 UniProtKB/TrEMBL
  ENSSSCG00025073695 UniProtKB/TrEMBL
  ENSSSCG00030073856 UniProtKB/TrEMBL
  ENSSSCG00035063148 UniProtKB/TrEMBL
  ENSSSCG00040073254 UniProtKB/TrEMBL
  ENSSSCG00045010829 UniProtKB/TrEMBL
  ENSSSCG00050048874 UniProtKB/TrEMBL
  ENSSSCG00055027589 UniProtKB/TrEMBL
  ENSSSCG00060023258 UniProtKB/TrEMBL
  ENSSSCG00065051892 UniProtKB/TrEMBL
  ENSSSCG00070020171 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000011056 ENTREZGENE
  ENSSSCT00000011056.5 UniProtKB/TrEMBL
  ENSSSCT00005043388.1 UniProtKB/TrEMBL
  ENSSSCT00015018029.1 UniProtKB/TrEMBL
  ENSSSCT00025101448.1 UniProtKB/TrEMBL
  ENSSSCT00030103466.1 UniProtKB/TrEMBL
  ENSSSCT00035084899.1 UniProtKB/TrEMBL
  ENSSSCT00040101008.1 UniProtKB/TrEMBL
  ENSSSCT00045018405.1 UniProtKB/TrEMBL
  ENSSSCT00050066523.1 UniProtKB/TrEMBL
  ENSSSCT00055054573.1 UniProtKB/TrEMBL
  ENSSSCT00060031543.1 UniProtKB/TrEMBL
  ENSSSCT00065071056.1 UniProtKB/TrEMBL
  ENSSSCT00070040017.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro CRK_SH3_N UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
KEGG Report ssc:100525363 UniProtKB/TrEMBL
NCBI Gene CRKL ENTREZGENE
PANTHER CRK-LIKE PROTEIN UniProtKB/TrEMBL
  SH2-SH3 ADAPTOR PROTEIN-RELATED UniProtKB/TrEMBL
Pfam SH2 UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
  SH3_2 UniProtKB/TrEMBL
PRINTS SH2DOMAIN UniProtKB/TrEMBL
  SH3DOMAIN UniProtKB/TrEMBL
PROSITE SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt A0A0B8RTT8 ENTREZGENE
  A0A4X1UYQ0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0TEI8 ENTREZGENE, UniProtKB/TrEMBL
  F1RKX9 ENTREZGENE
UniProt Secondary F1RKX9 UniProtKB/TrEMBL
VGNC ID VGNC:86997 ENTREZGENE