PDE4A (phosphodiesterase 4A) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: PDE4A (phosphodiesterase 4A) Sus scrofa
Analyze
Symbol: PDE4A
Name: phosphodiesterase 4A
RGD ID: 13920372
Description: ENCODES a protein that exhibits 3',5'-cyclic-AMP phosphodiesterase activity (inferred); 3',5'-cyclic-nucleotide phosphodiesterase activity (inferred); cAMP binding (inferred); INVOLVED IN cellular response to xenobiotic stimulus (ortholog); modulation of chemical synaptic transmission (ortholog); regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); PARTICIPATES IN protein kinase A (PKA) signaling pathway; ASSOCIATED WITH autistic disorder (ortholog); brucellosis (ortholog); visual epilepsy (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); membrane (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: cAMP-specific 3',5'-cyclic phosphodiesterase 4A; cyclic AMP-specific phosphodiesterase SSPDE4A1A; phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl269,225,395 - 69,267,971 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1269,225,403 - 69,268,327 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2269,575,206 - 69,621,539 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:9677330   PMID:10393044   PMID:11306681   PMID:15305063  


Genomics

Comparative Map Data
PDE4A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl269,225,395 - 69,267,971 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1269,225,403 - 69,268,327 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2269,575,206 - 69,621,539 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PDE4A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1910,416,773 - 10,469,630 (+)EnsemblGRCh38hg38GRCh38
GRCh381910,416,773 - 10,469,631 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371910,527,449 - 10,580,307 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,424,637 - 10,441,306 (+)NCBINCBI36hg18NCBI36
Build 341910,424,636 - 10,441,306NCBI
Celera1910,426,030 - 10,475,005 (+)NCBI
Cytogenetic Map19p13.2NCBI
HuRef1910,107,514 - 10,160,337 (+)NCBIHuRef
CHM1_11910,528,205 - 10,581,112 (+)NCBICHM1_1
Pde4a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39921,076,998 - 21,124,544 (+)NCBIGRCm39mm39
GRCm39 Ensembl921,077,010 - 21,124,544 (+)Ensembl
GRCm38921,165,700 - 21,213,248 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl921,165,714 - 21,213,248 (+)EnsemblGRCm38mm10GRCm38
MGSCv37920,970,158 - 21,017,692 (+)NCBIGRCm37mm9NCBIm37
MGSCv36920,916,193 - 20,962,012 (+)NCBImm8
Celera918,434,443 - 18,481,980 (+)NCBICelera
Cytogenetic Map9A3NCBI
cM Map97.73NCBI
Pde4a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2819,706,649 - 19,751,937 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl819,703,290 - 19,751,961 (+)Ensembl
Rnor_6.0822,189,533 - 22,234,036 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl822,189,600 - 22,233,748 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0822,245,707 - 22,289,417 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4820,192,677 - 20,241,557 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1820,192,676 - 20,241,557 (+)NCBI
Celera821,100,973 - 21,145,549 (+)NCBICelera
Cytogenetic Map8q13NCBI
Pde4a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554951,663,011 - 1,691,810 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554951,659,499 - 1,693,609 (+)NCBIChiLan1.0ChiLan1.0
PDE4A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11910,635,827 - 10,683,940 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1910,632,273 - 10,681,944 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0199,956,019 - 10,020,538 (+)NCBIMhudiblu_PPA_v0panPan3
PDE4A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12050,672,012 - 50,723,318 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2050,672,363 - 50,811,160 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2050,543,839 - 50,590,408 (-)NCBI
ROS_Cfam_1.02051,194,942 - 51,241,814 (-)NCBI
UMICH_Zoey_3.12050,401,492 - 50,448,153 (-)NCBI
UNSW_CanFamBas_1.02050,829,833 - 50,877,183 (-)NCBI
UU_Cfam_GSD_1.02051,070,685 - 51,117,859 (-)NCBI
Pde4a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118209,585,776 - 209,632,221 (-)NCBI
SpeTri2.0NW_004936659742,969 - 770,473 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDE4A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.169,455,471 - 9,503,809 (+)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607410,496,519 - 10,547,679 (-)NCBIVero_WHO_p1.0
Pde4a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248282,540,121 - 2,574,706 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1
Low 8 4 3 5 2 22 2 2 3
Below cutoff 2 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000014898   ⟹   ENSSSCP00000014497
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl269,254,436 - 69,266,728 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000014899   ⟹   ENSSSCP00000014498
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl269,257,891 - 69,267,971 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000051363   ⟹   ENSSSCP00000049699
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl269,236,992 - 69,266,728 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000054156   ⟹   ENSSSCP00000043919
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl269,225,395 - 69,266,728 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000064874   ⟹   ENSSSCP00000043736
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl269,235,619 - 69,266,728 (+)Ensembl
RefSeq Acc Id: NM_001123159   ⟹   NP_001116631
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1269,254,819 - 69,267,971 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005654820   ⟹   XP_005654877
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1269,225,403 - 69,268,327 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005654822   ⟹   XP_005654879
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1269,239,548 - 69,268,327 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005654824   ⟹   XP_005654881
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1269,236,971 - 69,268,327 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013987406   ⟹   XP_013842860
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1269,235,539 - 69,268,327 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021080483   ⟹   XP_020936142
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1269,235,612 - 69,268,327 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_005654877   ⟸   XM_005654820
- Peptide Label: isoform X1
- UniProtKB: A0A287AJ56 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013842860   ⟸   XM_013987406
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_020936142   ⟸   XM_021080483
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_005654881   ⟸   XM_005654824
- Peptide Label: isoform X3
- UniProtKB: A0A287AZW9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005654879   ⟸   XM_005654822
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: NP_001116631   ⟸   NM_001123159
- UniProtKB: Q684M5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000043736   ⟸   ENSSSCT00000064874
RefSeq Acc Id: ENSSSCP00000043919   ⟸   ENSSSCT00000054156
RefSeq Acc Id: ENSSSCP00000049699   ⟸   ENSSSCT00000051363
RefSeq Acc Id: ENSSSCP00000014497   ⟸   ENSSSCT00000014898
RefSeq Acc Id: ENSSSCP00000014498   ⟸   ENSSSCT00000014899
Protein Domains
PDE4_UCR   PDEase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000013642 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070022645 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000014497 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000014498 UniProtKB/TrEMBL
  ENSSSCP00000043736 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000043919 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000049699 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070037899 UniProtKB/TrEMBL
  ENSSSCP00070037906 UniProtKB/TrEMBL
  ENSSSCP00070037911 UniProtKB/TrEMBL
  ENSSSCP00070037996 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000014898 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000014899 UniProtKB/TrEMBL
  ENSSSCT00000051363 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000054156 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000064874 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070044993 UniProtKB/TrEMBL
  ENSSSCT00070045000 UniProtKB/TrEMBL
  ENSSSCT00070045005 UniProtKB/TrEMBL
  ENSSSCT00070045097 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1300.10 UniProtKB/TrEMBL
InterPro HD/PDEase_dom UniProtKB/TrEMBL
  PDE4_UCR UniProtKB/TrEMBL
  PDEase UniProtKB/TrEMBL
  PDEase_catalytic_dom UniProtKB/TrEMBL
  PDEase_catalytic_dom_sf UniProtKB/TrEMBL
  PDEase_CS UniProtKB/TrEMBL
KEGG Report ssc:396825 UniProtKB/TrEMBL
NCBI Gene PDE4A ENTREZGENE
Pfam PDE4_UCR UniProtKB/TrEMBL
  PDEase_I UniProtKB/TrEMBL
PRINTS PDIESTERASE1 UniProtKB/TrEMBL
PROSITE PDEASE_I_1 UniProtKB/TrEMBL
  PDEASE_I_2 UniProtKB/TrEMBL
SMART HDc UniProtKB/TrEMBL
UniProt A0A287AIL5_PIG UniProtKB/TrEMBL
  A0A287AJ56 ENTREZGENE, UniProtKB/TrEMBL
  A0A287AZW9 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1V8C9_PIG UniProtKB/TrEMBL
  A0A4X1VAS7_PIG UniProtKB/TrEMBL
  A0A4X1VAT4_PIG UniProtKB/TrEMBL
  A0A4X1VB41_PIG UniProtKB/TrEMBL
  F1S583_PIG UniProtKB/TrEMBL
  F6Q4N0_PIG UniProtKB/TrEMBL
  O77823_PIG UniProtKB/TrEMBL
  Q000W9_PIG UniProtKB/TrEMBL
  Q684M5 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:91254 ENTREZGENE