HIKESHI (heat shock protein nuclear import factor hikeshi)

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Gene: HIKESHI (heat shock protein nuclear import factor hikeshi) Sus scrofa

Analyze

Symbol:

HIKESHI

Name:

heat shock protein nuclear import factor hikeshi

RGD ID:

13918898

Description:

INVOLVED IN Golgi organization (ortholog); lung development (ortholog); protein transport (ortholog); ASSOCIATED WITH Disease Progression (ortholog); exudative vitreoretinopathy 1 (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nuclear body (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Also known as:

Hikeshi, heat shock protein nuclear import factor; protein Hikeshi

RGD Orthologs

Human

Mouse

Rat

Chinchilla

Bonobo

Dog

Squirrel

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	20,181,235 - 20,280,211 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	20,181,187 - 20,224,116 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	22,356,187 - 22,360,193 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Disease Progression (ISO)

exudative vitreoretinopathy 1 (ISO)

genetic disease (ISO)

hypomyelinating leukodystrophy 13 (ISO)

melanoma (ISO)

Stomach Neoplasms (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to heat (IEA)

Golgi organization (IEA,ISO)

lung development (IEA,ISO)

protein import into nucleus (IBA)

protein transport (ISO)

Cellular Component

cytoplasm (ISO)

cytosol (IBA,ISO)

nuclear body (ISO)

nuclear speck (IEA)

nucleoplasm (ISO)

nucleus (IBA,ISO)

Molecular Function

Hsp70 protein binding (IBA)

nuclear import signal receptor activity (IBA)

protein binding (ISO)

References

Additional References at PubMed

PMID:14681463	PMID:15679890

Genomics

Comparative Map Data

HIKESHI
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	20,181,235 - 20,280,211 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	20,181,187 - 20,224,116 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	22,356,187 - 22,360,193 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HIKESHI
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	11	86,302,211 - 86,345,943 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	11	86,302,229 - 86,345,943 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	11	86,013,282 - 86,056,985 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	85,690,936 - 85,734,633 (+)	NCBI	NCBI36		hg18	NCBI36
Celera	11	83,323,908 - 83,367,617 (+)	NCBI
Cytogenetic Map	11	q14.2	NCBI
HuRef	11	82,301,646 - 82,345,552 (+)	NCBI		HuRef
CHM1_1	11	85,899,013 - 85,942,745 (+)	NCBI		CHM1_1

Hikeshi
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	89,567,893 - 89,590,446 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	7	89,566,737 - 89,590,412 (-)	Ensembl
GRCm38	7	89,918,685 - 89,941,223 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	89,917,529 - 89,941,204 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	97,067,199 - 97,089,695 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	7	89,793,881 - 89,816,377 (-)	NCBI			mm8
Celera	7	87,236,722 - 87,262,240 (-)	NCBI		Celera
Cytogenetic Map	7	D3	NCBI
cM Map	7	50.4	NCBI

Hikeshi
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	1	143,825,922 - 143,849,374 (-)	NCBI
Rnor_6.0 Ensembl	1	154,142,836 - 154,170,409 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	1	154,147,098 - 154,170,429 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	1	160,451,592 - 160,474,918 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	146,522,014 - 146,545,388 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	1	146,600,420 - 146,623,794 (-)	NCBI
Celera	1	142,066,378 - 142,089,750 (-)	NCBI		Celera
Cytogenetic Map	1	q32	NCBI

Hikeshi
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955414	6,628,216 - 6,656,633 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955414	6,632,434 - 6,656,633 (-)	NCBI	ChiLan1.0	ChiLan1.0

HIKESHI
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	11	84,961,298 - 85,004,740 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	84,961,298 - 85,004,740 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	11	81,353,756 - 81,397,167 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

HIKESHI
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	21	13,210,362 - 13,249,565 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	21	13,210,356 - 13,249,595 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Hikeshi
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936498	14,110,382 - 14,138,095 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HIKESHI
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	77,559,538 - 77,612,738 (+)	NCBI
ChlSab1.1 Ensembl	1	77,559,548 - 77,612,434 (+)	Ensembl

Hikeshi
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624845	3,650,180 - 3,676,805 (-)	NCBI

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	hemolymphoid system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system
High
Medium	10	4	3	5	2	21	2	3	3
Low						2
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013979233	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000070	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK234383	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK235088	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK235125	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK235711	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY609409	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CU914737	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FP565467	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GFLN01013060	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSSSCT00000031507 ⟹ ENSSSCP00000025601

RefSeq Status:

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	9	20,181,235 - 20,280,211 (+)	Ensembl

RefSeq Acc Id:

ENSSSCT00000052414 ⟹ ENSSSCP00000036251

RefSeq Status:

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	9	20,185,123 - 20,280,211 (+)	Ensembl

RefSeq Acc Id:

XM_013979233 ⟹ XP_013834687

RefSeq Status:

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	9	20,181,187 - 20,224,116 (+)	NCBI

Sequence:

show sequence

CCGGAAGTACTTGTCGCTAGAGAGGCGCTCTGGTTAGGAGGGGAGGTCAGAGGTCGCGGGGGTA
GAAGGCGTTCCTGCCGCTGGCCTAGTCGTTATGTAGTGGAGGGGTAGGCGCCCTCCTCCATGTT
CTGGAAGGTTCTTGGTCTCGACTAGGGCAGAAGCCCCAGGACTTCTAGTCCCCGGCTTCGGGTC
CCTGCCGGCTGAGCGGAGCCGCCGCCGCCATGTTTGGCTGCTTGGTGGCGGGGAGGCTGGTGCA
AACAGCTGCACAGCAAGTGGCAGAGGATAAATTTGTTTTTGACTTGCCCGATTATGAAAATATC
AACCATGTTGTGGTTTTTATGCTGGGAACAATCCCATTTCCTGAGGGAATGGGAGGATCTGTCT
ACTTTTCCTATCCTGATTCAAATGGAATGCCAGTATGGCAGCTCCTAGGATTTGTCACGAATGG
GAAACCAAGTGCCATCTTCAAAATTTCAGGTCTTAAATCTGGTGAAGGAAGCCAACACCCTTTT
GGAGCCATGAATATTGTCCAAACTCCGTCTGTTGCTCAGATTGGAATTTCAGTGGAATTACTGG
ACAGTCTGGCTCAGCAGACTCCTGTAGGTAATGCTGCTGTATCATCAGTTGACTCATTCACTCA
GTTCACACAAAAGATGTTGGACAACTTCTACAATTTTGCTTCATCATTTGCTGTCTCTCAGGCC
CAGATGACACCAAGTCCATCTGAAATGTTCATCCCAGCAAATGTGGTTCTGAAATGGTATGAAA
ACTTTCAAAGACGACTAGCACAGAACCCTCTCTTTTGGAAAACATAATTTGAATAAAATAATTT
TTAATGGATTCTGAAATTTGTCATGTTTTGAAGATAATGACTGTTTAAAAGCATGAAGTCAAAA
GGATCATGAAGCTAAGTTTAAAAACTGCTTTAGTAACTATGAAGCTTAATTGAAATCTTTATAA
AAAATTAAAAACATTGAAAAATGAAAATATGTTCATCATTAATGACTTTTTTCCCTTAAGCTTA
AAATACTCAGAGACAAAACATTTTGTTTTGGCTATGATTCGTTTTTTACTTAAAAATAAAGCAT
ATTTACAGTAGTGTGCCAGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_013834687	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	XP_013834687 ⟸ XM_013979233
- UniProtKB:	I3LNC7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MFGCLVAGRLVQTAAQQVAEDKFVFDLPDYENINHVVVFMLGTIPFPEGMGGSVYFSYPDSNGM PVWQLLGFVTNGKPSAIFKISGLKSGEGSQHPFGAMNIVQTPSVAQIGISVELLDSLAQQTPVG NAAVSSVDSFTQFTQKMLDNFYNFASSFAVSQAQMTPSPSEMFIPANVVLKWYENFQRRLAQNP LFWKT hide sequence

RefSeq Acc Id:

ENSSSCP00000025601 ⟸ ENSSSCT00000031507

RefSeq Acc Id:

ENSSSCP00000036251 ⟸ ENSSSCT00000052414

Protein Domains

DUF775

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000021210	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00070014146	UniProtKB/TrEMBL
Ensembl Protein	ENSSSCP00000025601	ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCP00000036251	UniProtKB/TrEMBL
	ENSSSCP00070023071	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000031507	ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCT00000052414	UniProtKB/TrEMBL
	ENSSSCT00070027719	UniProtKB/TrEMBL
InterPro	DUF775	UniProtKB/TrEMBL
	OPI10	UniProtKB/TrEMBL
KEGG Report	ssc:100739665	UniProtKB/TrEMBL
NCBI Gene	HIKESHI	ENTREZGENE
PANTHER	PTHR12925	UniProtKB/TrEMBL
Pfam	DUF775	UniProtKB/TrEMBL
UniProt	A0A286ZX84_PIG	UniProtKB/TrEMBL
	A0A4X1U4W7_PIG	UniProtKB/TrEMBL
	I3LNC7	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:88883	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-04-16	HIKESHI	heat shock protein nuclear import factor hikeshi		Hikeshi, heat shock protein nuclear import factor	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM