LRRC8E (leucine rich repeat containing 8 VRAC subunit E) - Rat Genome Database
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Gene: LRRC8E (leucine rich repeat containing 8 VRAC subunit E) Sus scrofa
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Symbol: LRRC8E
Name: leucine rich repeat containing 8 VRAC subunit E
RGD ID: 13918135
Description: ENCODES a protein that exhibits volume-sensitive anion channel activity (ortholog); INVOLVED IN anion transmembrane transport (ortholog); ASSOCIATED WITH familial hemophagocytic lymphohistiocytosis 5 (ortholog); long QT syndrome (ortholog); FOUND IN cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: leucine rich repeat containing 8 family member E; volume-regulated anion channel subunit LRRC8E
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl271,309,402 - 71,329,422 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1271,309,404 - 71,318,225 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2271,710,888 - 71,718,616 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

Genomics

Comparative Map Data
LRRC8E
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl271,309,402 - 71,329,422 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1271,309,404 - 71,318,225 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2271,710,888 - 71,718,616 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LRRC8E
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl197,888,505 - 7,902,021 (+)EnsemblGRCh38hg38GRCh38
GRCh38197,888,510 - 7,902,016 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37197,953,390 - 7,966,908 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh37197,953,395 - 7,966,901 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36197,859,390 - 7,872,907 (+)NCBINCBI36hg18NCBI36
Celera197,824,591 - 7,838,110 (+)NCBI
Cytogenetic Map19p13.2NCBI
HuRef197,623,841 - 7,637,152 (+)NCBIHuRef
CHM1_1197,952,868 - 7,966,380 (+)NCBICHM1_1
Lrrc8e
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3984,274,269 - 4,287,470 (+)NCBIGRCm39mm39
GRCm3884,224,268 - 4,237,470 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl84,226,827 - 4,237,470 (+)EnsemblGRCm38mm10GRCm38
MGSCv3784,226,827 - 4,237,470 (+)NCBIGRCm37mm9NCBIm37
MGSCv3684,226,827 - 4,236,898 (+)NCBImm8
Celera84,416,312 - 4,438,059 (+)NCBICelera
Cytogenetic Map8A1.1NCBI
Lrrc8e
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2122,578,240 - 2,589,407 (+)NCBI
Rnor_6.0 Ensembl122,557,275 - 2,568,382 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0122,557,267 - 2,568,416 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0124,710,039 - 4,721,300 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4121,554,464 - 1,566,012 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1121,554,997 - 1,566,044 (-)NCBI
Celera124,393,851 - 4,404,933 (+)NCBICelera
Cytogenetic Map12p12NCBI
Lrrc8e
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555631,362,266 - 1,370,226 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555631,362,266 - 1,370,221 (-)NCBIChiLan1.0ChiLan1.0
LRRC8E
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1198,041,185 - 8,055,684 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl198,041,185 - 8,055,684 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0197,189,490 - 7,203,310 (+)NCBIMhudiblu_PPA_v0panPan3
LRRC8E
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2052,588,973 - 52,593,214 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12052,585,636 - 52,593,207 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Lrrc8e
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365884,873,412 - 4,880,574 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRRC8E
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.167,337,918 - 7,351,914 (+)NCBI
ChlSab1.1 Ensembl67,346,243 - 7,351,855 (+)Ensembl
Lrrc8e
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624828859,419 - 868,595 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system hemolymphoid system nervous system renal system reproductive system respiratory system
High
Medium
Low 1 3 1
Below cutoff 8 3 3 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000014838   ⟹   ENSSSCP00000014437
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl271,309,402 - 71,329,422 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000053292   ⟹   ENSSSCP00000037480
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl271,309,402 - 71,314,701 (-)Ensembl
RefSeq Acc Id: XM_003123182   ⟹   XP_003123230
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1271,310,497 - 71,318,225 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005661262   ⟹   XP_005661319
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1271,309,404 - 71,316,655 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013994699   ⟹   XP_013850153
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1271,310,497 - 71,314,098 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021083893   ⟹   XP_020939552
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1271,310,497 - 71,316,655 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003123230 (Get FASTA)   NCBI Sequence Viewer  
  XP_005661319 (Get FASTA)   NCBI Sequence Viewer  
  XP_013850153 (Get FASTA)   NCBI Sequence Viewer  
  XP_020939552 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005661319   ⟸   XM_005661262
- Peptide Label: isoform X1
- UniProtKB: A0A287A0M3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003123230   ⟸   XM_003123182
- Peptide Label: isoform X1
- UniProtKB: A0A287A0M3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020939552   ⟸   XM_021083893
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013850153   ⟸   XM_013994699
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSSSCP00000037480   ⟸   ENSSSCT00000053292
RefSeq Acc Id: ENSSSCP00000014437   ⟸   ENSSSCT00000014838
Protein Domains
Pannexin_like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000013586 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070025557 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000014437 UniProtKB/TrEMBL
  ENSSSCP00000037480 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070043216 UniProtKB/TrEMBL
  ENSSSCP00070043217 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000014838 UniProtKB/TrEMBL
  ENSSSCT00000053292 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070051098 UniProtKB/TrEMBL
  ENSSSCT00070051099 UniProtKB/TrEMBL
Gene3D-CATH 3.80.10.10 UniProtKB/TrEMBL
InterPro Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
  LRRC8_Pannexin-like UniProtKB/TrEMBL
KEGG Report ssc:100517078 UniProtKB/TrEMBL
NCBI Gene LRRC8E ENTREZGENE
Pfam LRR_8 UniProtKB/TrEMBL
  Pannexin_like UniProtKB/TrEMBL
PROSITE LRR UniProtKB/TrEMBL
SMART LRR_TYP UniProtKB/TrEMBL
UniProt A0A287A0M3 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1VIE5_PIG UniProtKB/TrEMBL
  A0A4X1VNY2_PIG UniProtKB/TrEMBL
  F1SA81_PIG UniProtKB/TrEMBL
VGNC ID VGNC:98089 ENTREZGENE