TPK1 (thiamin pyrophosphokinase 1) - Rat Genome Database

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Gene: TPK1 (thiamin pyrophosphokinase 1) Sus scrofa
Analyze
Symbol: TPK1
Name: thiamin pyrophosphokinase 1
RGD ID: 13916489
Description: ENCODES a protein that exhibits ATP binding (inferred); identical protein binding (inferred); kinase activity (inferred); INVOLVED IN thiamine metabolic process (ortholog); PARTICIPATES IN thiamine metabolic pathway; ASSOCIATED WITH cortical dysplasia-focal epilepsy syndrome (ortholog); genetic disease (ortholog); Thiamine Metabolism Dysfunction Syndrome 5 (Episodic Encephalopathy Type) (ortholog); FOUND IN integral component of membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9112,931,795 - 113,305,178 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19112,931,370 - 113,305,178 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29124,255,226 - 124,629,455 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
TPK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9112,931,795 - 113,305,178 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19112,931,370 - 113,305,178 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29124,255,226 - 124,629,455 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TPK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl7144,451,941 - 144,836,395 (-)EnsemblGRCh38hg38GRCh38
GRCh387144,451,941 - 144,836,424 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh377144,149,034 - 144,533,146 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367143,779,967 - 144,164,079 (-)NCBINCBI36hg18NCBI36
Build 347143,586,690 - 143,970,781NCBI
Celera7138,823,074 - 139,207,017 (-)NCBI
Cytogenetic Map7q35NCBI
HuRef7138,228,218 - 138,611,054 (-)NCBIHuRef
CHM1_17144,157,512 - 144,541,732 (-)NCBICHM1_1
CRA_TCAGchr7v27143,487,292 - 143,871,298 (-)NCBI
Tpk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39643,316,510 - 43,644,726 (-)NCBIGRCm39mm39
GRCm39 Ensembl643,321,935 - 43,643,212 (-)Ensembl
GRCm38643,339,576 - 43,667,792 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl643,345,001 - 43,666,278 (-)EnsemblGRCm38mm10GRCm38
MGSCv37643,295,006 - 43,616,174 (-)NCBIGRCm37mm9NCBIm37
MGSCv36643,274,614 - 43,595,782 (-)NCBImm8
Celera643,288,958 - 43,609,819 (-)NCBICelera
Cytogenetic Map6B2.1NCBI
Tpk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2472,170,134 - 72,557,707 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl472,170,134 - 72,557,694 (-)Ensembl
Rnor_6.0472,792,252 - 73,174,179 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl472,792,252 - 73,174,179 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04137,495,338 - 137,661,388 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.04137,705,456 - 137,869,961 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4471,113,965 - 71,521,331 (-)NCBIRGSC3.4rn4RGSC3.4
Celera467,116,073 - 67,485,255 (-)NCBICelera
Cytogenetic Map4q24NCBI
Tpk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955491623,530 - 968,253 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955491621,941 - 968,570 (-)NCBIChiLan1.0ChiLan1.0
TPK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17148,653,898 - 149,036,602 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7148,654,445 - 149,036,342 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v07136,165,941 - 136,549,606 (-)NCBIMhudiblu_PPA_v0panPan3
TPK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1165,257,749 - 5,588,179 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl165,257,205 - 5,636,153 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha166,370,726 - 6,696,344 (+)NCBI
ROS_Cfam_1.0165,117,780 - 5,448,228 (+)NCBI
UMICH_Zoey_3.1165,053,899 - 5,379,513 (+)NCBI
UNSW_CanFamBas_1.0164,910,996 - 5,236,586 (+)NCBI
UU_Cfam_GSD_1.0164,981,542 - 5,307,335 (+)NCBI
Tpk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511811,116,997 - 11,488,862 (+)NCBI
SpeTri2.0NW_0049365271,450,918 - 1,786,431 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
Tpk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462480010,382,409 - 10,792,459 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 5 1 1 1 1
Low 5 4 2 5 1 22 1 3 3
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_003130287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005667774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005667775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013979874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013979876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021063590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021063591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021063592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021063593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021063594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021063596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021063597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021063598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AEMK02000070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK389839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU639480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GFLN01012652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSSCT00000016844   ⟹   ENSSSCP00000016393
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl9112,931,795 - 113,305,171 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000057925   ⟹   ENSSSCP00000051939
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl9113,010,491 - 113,305,175 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000058818   ⟹   ENSSSCP00000043433
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl9112,931,834 - 113,305,172 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000077863   ⟹   ENSSSCP00000063320
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl9112,931,818 - 113,305,173 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000082185   ⟹   ENSSSCP00000064143
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl9112,931,834 - 113,305,175 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000082440   ⟹   ENSSSCP00000073523
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl9112,961,711 - 113,305,178 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000088157   ⟹   ENSSSCP00000065159
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl9112,931,795 - 113,305,171 (+)Ensembl
RefSeq Acc Id: XM_003130287   ⟹   XP_003130335
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.19112,931,384 - 113,305,178 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005667774   ⟹   XP_005667831
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.19112,931,378 - 113,216,532 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005667775   ⟹   XP_005667832
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.19112,931,381 - 113,305,178 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013979874   ⟹   XP_013835328
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.19112,932,097 - 113,305,178 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013979876   ⟹   XP_013835330
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.19112,931,381 - 113,211,632 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021063590   ⟹   XP_020919249
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.19112,931,374 - 113,305,178 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021063591   ⟹   XP_020919250
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.19112,932,110 - 113,305,178 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021063592   ⟹   XP_020919251
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.19112,931,375 - 113,245,878 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021063593   ⟹   XP_020919252
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.19112,931,375 - 113,245,878 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021063594   ⟹   XP_020919253
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.19112,931,370 - 113,305,178 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021063596   ⟹   XP_020919255
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.19112,932,109 - 113,305,178 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021063597   ⟹   XP_020919256
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.19112,931,379 - 113,215,363 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021063598   ⟹   XP_020919257
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.19112,931,372 - 113,158,271 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_020919253   ⟸   XM_021063594
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_020919257   ⟸   XM_021063598
- Peptide Label: isoform X9
- Sequence:
RefSeq Acc Id: XP_020919249   ⟸   XM_021063590
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020919251   ⟸   XM_021063592
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_020919252   ⟸   XM_021063593
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_005667831   ⟸   XM_005667774
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_020919256   ⟸   XM_021063597
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_005667832   ⟸   XM_005667775
- Peptide Label: isoform X6
- UniProtKB: A0A287AHT7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013835330   ⟸   XM_013979876
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_003130335   ⟸   XM_003130287
- Peptide Label: isoform X2
- UniProtKB: F1SAD1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013835328   ⟸   XM_013979874
- Peptide Label: isoform X2
- UniProtKB: F1SAD1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020919255   ⟸   XM_021063596
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_020919250   ⟸   XM_021063591
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSSSCP00000065159   ⟸   ENSSSCT00000088157
RefSeq Acc Id: ENSSSCP00000043433   ⟸   ENSSSCT00000058818
RefSeq Acc Id: ENSSSCP00000016393   ⟸   ENSSSCT00000016844
RefSeq Acc Id: ENSSSCP00000063320   ⟸   ENSSSCT00000077863
RefSeq Acc Id: ENSSSCP00000064143   ⟸   ENSSSCT00000082185
RefSeq Acc Id: ENSSSCP00000073523   ⟸   ENSSSCT00000082440
RefSeq Acc Id: ENSSSCP00000051939   ⟸   ENSSSCT00000057925
Protein Domains
TPK_B1_binding   TPK_catalytic


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000015462 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070018453 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000016393 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000043433 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000051939 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000063320 UniProtKB/TrEMBL
  ENSSSCP00000064143 UniProtKB/TrEMBL
  ENSSSCP00000065159 UniProtKB/TrEMBL
  ENSSSCP00000073523 UniProtKB/TrEMBL
  ENSSSCP00070030515 UniProtKB/TrEMBL
  ENSSSCP00070030523 UniProtKB/TrEMBL
  ENSSSCP00070030525 UniProtKB/TrEMBL
  ENSSSCP00070030529 UniProtKB/TrEMBL
  ENSSSCP00070030530 UniProtKB/TrEMBL
  ENSSSCP00070030536 UniProtKB/TrEMBL
  ENSSSCP00070030545 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000016844 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000057925 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000058818 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000077863 UniProtKB/TrEMBL
  ENSSSCT00000082185 UniProtKB/TrEMBL
  ENSSSCT00000082440 UniProtKB/TrEMBL
  ENSSSCT00000088157 UniProtKB/TrEMBL
  ENSSSCT00070036496 UniProtKB/TrEMBL
  ENSSSCT00070036506 UniProtKB/TrEMBL
  ENSSSCT00070036508 UniProtKB/TrEMBL
  ENSSSCT00070036512 UniProtKB/TrEMBL
  ENSSSCT00070036513 UniProtKB/TrEMBL
  ENSSSCT00070036519 UniProtKB/TrEMBL
  ENSSSCT00070036529 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.10240 UniProtKB/TrEMBL
InterPro Thi_PPkinase UniProtKB/TrEMBL
  Thiamin_pyrophosphokinase_euk UniProtKB/TrEMBL
  Thiamin_PyroPKinase_B1-bd UniProtKB/TrEMBL
  TPK_B1-bd_sf UniProtKB/TrEMBL
  TPK_catalytic UniProtKB/TrEMBL
  TPK_catalytic_sf UniProtKB/TrEMBL
KEGG Report ssc:100524699 UniProtKB/TrEMBL
NCBI Gene TPK1 ENTREZGENE
Pfam TPK_B1_binding UniProtKB/TrEMBL
  TPK_catalytic UniProtKB/TrEMBL
PIRSF Thiamin_pyrophosphokinase UniProtKB/TrEMBL
SMART TPK_B1_binding UniProtKB/TrEMBL
Superfamily-SCOP SSF63862 UniProtKB/TrEMBL
  SSF63999 UniProtKB/TrEMBL
TIGRFAMs thi_PPkinase UniProtKB/TrEMBL
UniProt A0A287AHT7 ENTREZGENE, UniProtKB/TrEMBL
  A0A287B5Z9_PIG UniProtKB/TrEMBL
  A0A480PUY6_PIG UniProtKB/TrEMBL
  A0A4X1UKG9_PIG UniProtKB/TrEMBL
  A0A4X1UML3_PIG UniProtKB/TrEMBL
  A0A4X1UMM2_PIG UniProtKB/TrEMBL
  A0A4X1UMM6_PIG UniProtKB/TrEMBL
  A0A4X1UMP1_PIG UniProtKB/TrEMBL
  A0A4X1UPA0_PIG UniProtKB/TrEMBL
  A0A4X1UQR4_PIG UniProtKB/TrEMBL
  A0A5G2QH81_PIG UniProtKB/TrEMBL
  A0A5G2QHI6_PIG UniProtKB/TrEMBL
  A0A5G2R3N6_PIG UniProtKB/TrEMBL
  A0A5G2R8C6_PIG UniProtKB/TrEMBL
  F1SAD1 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:94337 ENTREZGENE