OAZ3 (ornithine decarboxylase antizyme 3) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: OAZ3 (ornithine decarboxylase antizyme 3) Sus scrofa
Analyze
Symbol: OAZ3
Name: ornithine decarboxylase antizyme 3
RGD ID: 13911727
Description: The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 3, the third member of the antizyme family. Like antizymes 1 and 2, antizyme 3 inhibits ODC activity and polyamine uptake, however, it does not stimulate ODC degradation. Also, while antizymes 1 and 2 have broad tissue distribution, expression of antizyme 3 is restricted to haploid germ cells in testis, suggesting a distinct role for this antizyme in spermiogenesis. Antizyme 3 gene knockout studies in mice showed that homozygous mutant male mice were infertile, and indicated the likely role of this antizyme in the formation of a rigid connection between the sperm head and tail during spermatogenesis. Alternatively spliced transcript variants encoding different isoforms, including one resulting from the use of non-AUG (CUG) translation initiation codon, have been found for this gene. [provided by RefSeq, Aug 2014]
Type: protein-coding
RefSeq Status: REVIEWED
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl497,439,993 - 97,448,493 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1497,439,993 - 97,448,493 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24106,463,000 - 106,471,500 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO)
nucleoplasm  (IEA)
nucleus  (IBA,ISO)
sperm flagellum  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:10781034   PMID:17332016  


Genomics

Comparative Map Data
OAZ3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl497,439,993 - 97,448,493 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1497,439,993 - 97,448,493 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24106,463,000 - 106,471,500 (-)NCBISscrofa10.2Sscrofa10.2susScr3
OAZ3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1151,762,899 - 151,771,334 (+)EnsemblGRCh38hg38GRCh38
GRCh381151,762,969 - 151,771,330 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371151,735,445 - 151,743,806 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361150,005,755 - 150,010,429 (+)NCBINCBI36hg18NCBI36
Build 341148,552,203 - 148,556,878NCBI
Celera1124,850,058 - 124,858,481 (+)NCBI
Cytogenetic Map1q21.3NCBI
HuRef1123,112,255 - 123,120,706 (+)NCBIHuRef
CHM1_11153,130,577 - 153,138,934 (+)NCBICHM1_1
Oaz3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39394,340,694 - 94,343,958 (-)NCBIGRCm39mm39
GRCm39 Ensembl394,339,721 - 94,351,222 (-)Ensembl
GRCm38394,433,387 - 94,436,651 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl394,432,414 - 94,443,915 (-)EnsemblGRCm38mm10GRCm38
MGSCv37394,237,088 - 94,240,538 (-)NCBIGRCm37mm9NCBIm37
MGSCv36394,518,794 - 94,522,020 (-)NCBImm8
Celera395,877,993 - 95,881,443 (-)NCBICelera
Cytogenetic Map3F2.1NCBI
Oaz3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22182,073,212 - 182,076,147 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl2182,073,215 - 182,082,399 (-)Ensembl
Rnor_6.02195,675,925 - 195,678,859 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2195,676,048 - 195,678,848 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02215,154,619 - 215,157,553 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42189,408,566 - 189,411,500 (-)NCBIRGSC3.4rn4RGSC3.4
Celera2174,623,440 - 174,626,374 (-)NCBICelera
Cytogenetic Map2q34NCBI
Oaz3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955589654,088 - 658,003 (-)NCBIChiLan1.0ChiLan1.0
OAZ3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11130,765,003 - 130,773,974 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1130,765,290 - 130,773,859 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01127,121,375 - 127,129,940 (+)NCBIMhudiblu_PPA_v0panPan3
OAZ3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11760,789,541 - 60,792,954 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1760,786,963 - 60,792,954 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1760,230,905 - 60,234,318 (+)NCBI
ROS_Cfam_1.01761,806,097 - 61,809,510 (+)NCBI
UMICH_Zoey_3.11760,632,865 - 60,636,278 (+)NCBI
UNSW_CanFamBas_1.01760,719,198 - 60,722,609 (+)NCBI
UU_Cfam_GSD_1.01761,448,108 - 61,451,521 (+)NCBI
Oaz3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505822,932,990 - 22,935,704 (+)NCBI
SpeTri2.0NW_0049365801,963,372 - 1,966,086 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OAZ3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12011,916,163 - 11,922,770 (-)NCBI
Vero_WHO_p1.0NW_02366603811,486,262 - 11,492,728 (-)NCBI
Oaz3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477219,438,742 - 19,445,293 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system nervous system renal system reproductive system respiratory system
High
Medium
Low 3 1 3 2 23 1 1
Below cutoff 6 2 1 1 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000029296   ⟹   ENSSSCP00000027453
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl497,441,322 - 97,443,952 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000045777   ⟹   ENSSSCP00000049681
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl497,439,993 - 97,448,493 (-)Ensembl
RefSeq Acc Id: NM_001122996   ⟹   NP_001116468
RefSeq Status: REVIEWED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1497,439,993 - 97,443,923 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001301406   ⟹   NP_001288335
RefSeq Status: REVIEWED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1497,439,993 - 97,448,493 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001116468 (Get FASTA)   NCBI Sequence Viewer  
  NP_001288335 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ACB41770 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001288335   ⟸   NM_001301406
- Peptide Label: isoform 2
- UniProtKB: B2CR17 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001116468   ⟸   NM_001122996
- Peptide Label: isoform 1
- Sequence:
RefSeq Acc Id: ENSSSCP00000027453   ⟸   ENSSSCT00000029296
RefSeq Acc Id: ENSSSCP00000049681   ⟸   ENSSSCT00000045777


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000027091 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000027453 UniProtKB/TrEMBL
  ENSSSCP00000049681 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000029296 UniProtKB/TrEMBL
  ENSSSCT00000045777 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 3.40.630.60 UniProtKB/TrEMBL
InterPro Acyl_CoA_acyltransferase UniProtKB/TrEMBL
  ODC-AZ_3 UniProtKB/TrEMBL
  ODC_AZ UniProtKB/TrEMBL
  ODC_AZ_sf UniProtKB/TrEMBL
NCBI Gene OAZ3 ENTREZGENE
PANTHER PTHR10279 UniProtKB/TrEMBL
  PTHR10279:SF9 UniProtKB/TrEMBL
Pfam ODC_AZ UniProtKB/TrEMBL
PROSITE ODC_AZ UniProtKB/TrEMBL
Superfamily-SCOP SSF55729 UniProtKB/TrEMBL
UniProt A0A287B0J7_PIG UniProtKB/TrEMBL
  B2CR17 ENTREZGENE
  I3LTK6_PIG UniProtKB/TrEMBL
UniProt Secondary B2CR17 UniProtKB/TrEMBL
VGNC ID VGNC:91010 ENTREZGENE