NNMT (nicotinamide N-methyltransferase) - Rat Genome Database

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Gene: NNMT (nicotinamide N-methyltransferase) Sus scrofa
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Symbol: NNMT
Name: nicotinamide N-methyltransferase
RGD ID: 13900845
Description: ENCODES a protein that exhibits nicotinamide N-methyltransferase activity (inferred); INVOLVED IN animal organ regeneration (ortholog); methylation (ortholog); positive regulation of gluconeogenesis (ortholog); PARTICIPATES IN homocysteine metabolic pathway; methionine cycle/metabolic pathway; niacin metabolic pathway; ASSOCIATED WITH hepatocellular carcinoma (ortholog); intellectual disability (ortholog); renal cell carcinoma (ortholog); FOUND IN cytosol (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl941,870,980 - 41,882,760 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1941,871,072 - 41,882,415 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2946,628,722 - 46,630,881 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IBA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463  


Genomics

Comparative Map Data
NNMT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl941,870,980 - 41,882,760 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1941,871,072 - 41,882,415 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2946,628,722 - 46,630,881 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NNMT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl11114,257,787 - 114,313,536 (+)EnsemblGRCh38hg38GRCh38
GRCh3811114,257,806 - 114,313,536 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711114,128,528 - 114,184,258 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611113,671,745 - 113,688,448 (+)NCBINCBI36hg18NCBI36
Build 3411113,672,381 - 113,688,448NCBI
Celera11111,319,440 - 111,336,148 (+)NCBI
Cytogenetic Map11q23.2NCBI
HuRef11110,095,320 - 110,112,028 (+)NCBIHuRef
CHM1_111114,050,619 - 114,067,325 (+)NCBICHM1_1
Nnmt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39948,449,300 - 48,518,955 (-)NCBIGRCm39mm39
GRCm39 Ensembl948,503,177 - 48,516,453 (-)Ensembl
GRCm38948,538,002 - 48,607,655 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl948,591,877 - 48,605,153 (-)EnsemblGRCm38mm10GRCm38
MGSCv37948,399,995 - 48,413,182 (-)NCBIGRCm37mm9NCBIm37
MGSCv36948,343,844 - 48,357,120 (-)NCBImm8
Celera945,886,739 - 45,899,895 (-)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map926.45NCBI
Nnmt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2848,928,663 - 48,947,734 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl848,933,598 - 48,946,655 (-)Ensembl
Rnor_6.0852,918,437 - 52,938,172 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl852,925,175 - 52,937,972 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0851,512,701 - 51,531,316 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4851,871,506 - 51,883,785 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1851,890,559 - 51,902,839 (-)NCBI
Celera848,493,115 - 48,505,360 (-)NCBICelera
Cytogenetic Map8q23NCBI
Nnmt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541215,892,906 - 15,916,166 (+)NCBIChiLan1.0ChiLan1.0
NNMT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.111113,016,613 - 113,029,581 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11113,016,613 - 113,029,581 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v011109,174,490 - 109,186,758 (+)NCBIMhudiblu_PPA_v0panPan3
NNMT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1519,026,514 - 19,044,154 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl519,026,556 - 19,044,016 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha518,951,887 - 18,969,497 (-)NCBI
ROS_Cfam_1.0519,047,373 - 19,066,042 (-)NCBI
UMICH_Zoey_3.1519,112,740 - 19,131,352 (-)NCBI
UNSW_CanFamBas_1.0519,013,803 - 19,032,413 (-)NCBI
UU_Cfam_GSD_1.0519,060,255 - 19,078,887 (-)NCBI
Nnmt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494796,354,163 - 96,372,216 (+)NCBI
SpeTri2.0NW_004936612333,421 - 351,202 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NNMT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11105,650,178 - 105,708,441 (+)NCBI
ChlSab1.1 Ensembl1105,690,085 - 105,713,010 (+)Ensembl
Vero_WHO_p1.0NW_02366604320,327,613 - 20,378,651 (-)NCBI
Nnmt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247849,765,582 - 9,783,004 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system
High
Medium
Low
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000016420   ⟹   ENSSSCP00000015979
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl941,870,980 - 41,882,760 (+)Ensembl
RefSeq Acc Id: NM_001123146   ⟹   NP_001116618
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1941,871,072 - 41,882,415 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001116618 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABI97169 (Get FASTA)   NCBI Sequence Viewer  
  Q06AV1 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001116618   ⟸   NM_001123146
- UniProtKB: Q06AV1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSSSCP00000015979   ⟸   ENSSSCT00000016420


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000015054 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00055010549 UniProtKB/Swiss-Prot
  ENSSSCG00065035867 UniProtKB/Swiss-Prot
Ensembl Protein ENSSSCP00000015979 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00055016316 UniProtKB/Swiss-Prot
  ENSSSCP00065021128 UniProtKB/Swiss-Prot
Ensembl Transcript ENSSSCT00000016420 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00055020637 UniProtKB/Swiss-Prot
  ENSSSCT00065048879 UniProtKB/Swiss-Prot
InterPro NNMT/PNMT/TEMT_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NNMT_TEMT_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM-dependent_MTases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:100144485 UniProtKB/Swiss-Prot
NCBI Gene NNMT ENTREZGENE
PANTHER PTHR10867 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam NNMT_PNMT_TEMT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF PNMTase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NNMT_PNMT_TEMT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM_MT_NNMT_PNMT_TEMT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53335 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F1SM63_PIG UniProtKB/TrEMBL
  NNMT_PIG UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:90805 ENTREZGENE