HKDC1 (hexokinase domain containing 1) - Rat Genome Database

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Gene: HKDC1 (hexokinase domain containing 1) Sus scrofa
Analyze
Symbol: HKDC1
Name: hexokinase domain containing 1
RGD ID: 13896446
Description: ENCODES a protein that exhibits ATP binding (inferred); catalytic activity (inferred); fructokinase activity (inferred); INVOLVED IN carbohydrate metabolic process (inferred); carbohydrate phosphorylation (inferred); glucose 6-phosphate metabolic process (inferred); ASSOCIATED WITH Dwarfism (ortholog); genetic disease (ortholog); Keratoconus 1 (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); mitochondrion (inferred); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: putative hexokinase HKDC1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1472,283,845 - 72,335,886 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11472,285,941 - 72,343,990 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21478,302,927 - 78,353,257 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202   PMID:37545422  


Genomics

Comparative Map Data
HKDC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1472,283,845 - 72,335,886 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11472,285,941 - 72,343,990 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21478,302,927 - 78,353,257 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HKDC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381069,220,332 - 69,267,552 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1069,220,332 - 69,267,552 (+)EnsemblGRCh38hg38GRCh38
GRCh371070,980,088 - 71,027,308 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361070,650,065 - 70,697,321 (+)NCBINCBI36Build 36hg18NCBI36
Celera1064,255,904 - 64,303,168 (+)NCBICelera
Cytogenetic Map10q22.1NCBI
HuRef1064,980,307 - 65,027,150 (+)NCBIHuRef
CHM1_11071,261,818 - 71,308,763 (+)NCBICHM1_1
T2T-CHM13v2.01070,088,688 - 70,135,592 (+)NCBIT2T-CHM13v2.0
Hkdc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391062,218,916 - 62,259,490 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1062,218,916 - 62,258,270 (-)EnsemblGRCm39 Ensembl
GRCm381062,383,137 - 62,423,711 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1062,383,137 - 62,422,491 (-)EnsemblGRCm38mm10GRCm38
MGSCv371061,845,885 - 61,885,205 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361061,778,494 - 61,817,814 (-)NCBIMGSCv36mm8
Celera1063,486,364 - 63,525,623 (-)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1032.4NCBI
Hkdc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82030,878,037 - 30,917,044 (-)NCBIGRCr8
mRatBN7.22030,335,322 - 30,373,792 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2030,335,628 - 30,373,867 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.02032,018,027 - 32,054,494 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2032,018,673 - 32,052,855 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.02033,805,753 - 33,840,534 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2031,757,004 - 31,794,582 (-)NCBICelera
Cytogenetic Map20q11NCBI
Hkdc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543721,825,397 - 21,868,435 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543721,825,647 - 21,873,698 (-)NCBIChiLan1.0ChiLan1.0
HKDC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2881,366,586 - 81,413,556 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11081,371,908 - 81,418,779 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01065,687,378 - 65,734,281 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11068,220,475 - 68,267,321 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1068,220,475 - 68,267,321 (+)Ensemblpanpan1.1panPan2
HKDC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1420,353,941 - 20,395,429 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl420,353,355 - 20,394,634 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha420,484,075 - 20,525,712 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0420,625,796 - 20,667,351 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl420,625,349 - 20,667,051 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1420,526,423 - 20,567,841 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0420,729,648 - 20,771,687 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0421,073,106 - 21,114,762 (+)NCBIUU_Cfam_GSD_1.0
Hkdc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721360,683,196 - 60,730,681 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365219,175,447 - 9,223,583 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365219,175,916 - 9,223,546 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HKDC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1962,051,098 - 62,099,986 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl962,052,027 - 62,099,221 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604822,791,409 - 22,839,449 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hkdc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247543,511,730 - 3,556,184 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247543,511,947 - 3,556,131 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in HKDC1
1737 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system nervous system renal system reproductive system
High
Medium 5
Low 3 3 19 2 1
Below cutoff 1 4 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000011222   ⟹   ENSSSCP00000010930
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1472,286,132 - 72,335,886 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000058821   ⟹   ENSSSCP00000033705
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1472,283,845 - 72,335,885 (+)Ensembl
RefSeq Acc Id: XM_001928882   ⟹   XP_001928917
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11472,285,941 - 72,343,990 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_001928917   ⟸   XM_001928882
- UniProtKB: A0A286ZQ27 (UniProtKB/TrEMBL),   A0A4X1TKL2 (UniProtKB/TrEMBL),   A0A8D1LUD0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000033705   ⟸   ENSSSCT00000058821
RefSeq Acc Id: ENSSSCP00000010930   ⟸   ENSSSCT00000011222
Protein Domains
Hexokinase C-terminal   Hexokinase N-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000010252 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015025830 UniProtKB/TrEMBL
  ENSSSCG00025077478 UniProtKB/TrEMBL
  ENSSSCG00030025338 UniProtKB/TrEMBL
  ENSSSCG00035012125 UniProtKB/TrEMBL
  ENSSSCG00040018680 UniProtKB/TrEMBL
  ENSSSCG00045024615 UniProtKB/TrEMBL
  ENSSSCG00050024622 UniProtKB/TrEMBL
  ENSSSCG00055028834 UniProtKB/TrEMBL
  ENSSSCG00060013651 UniProtKB/TrEMBL
  ENSSSCG00065066127 UniProtKB/TrEMBL
  ENSSSCG00070009717 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000011222.3 UniProtKB/TrEMBL
  ENSSSCT00000058821 ENTREZGENE
  ENSSSCT00000058821.3 UniProtKB/TrEMBL
  ENSSSCT00015041335.1 UniProtKB/TrEMBL
  ENSSSCT00015041766.1 UniProtKB/TrEMBL
  ENSSSCT00025107723.1 UniProtKB/TrEMBL
  ENSSSCT00025107731.1 UniProtKB/TrEMBL
  ENSSSCT00030035371.1 UniProtKB/TrEMBL
  ENSSSCT00030035387.1 UniProtKB/TrEMBL
  ENSSSCT00035015258.1 UniProtKB/TrEMBL
  ENSSSCT00035015270.1 UniProtKB/TrEMBL
  ENSSSCT00040025508.1 UniProtKB/TrEMBL
  ENSSSCT00040025562.1 UniProtKB/TrEMBL
  ENSSSCT00045041972.1 UniProtKB/TrEMBL
  ENSSSCT00045042236.1 UniProtKB/TrEMBL
  ENSSSCT00050033173.1 UniProtKB/TrEMBL
  ENSSSCT00055057240.1 UniProtKB/TrEMBL
  ENSSSCT00055057363.1 UniProtKB/TrEMBL
  ENSSSCT00060018156.1 UniProtKB/TrEMBL
  ENSSSCT00060018161.1 UniProtKB/TrEMBL
  ENSSSCT00065090748.1 UniProtKB/TrEMBL
  ENSSSCT00065090765.1 UniProtKB/TrEMBL
  ENSSSCT00070018874.1 UniProtKB/TrEMBL
  ENSSSCT00070018882.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.1250 UniProtKB/TrEMBL
  3.30.420.40 UniProtKB/TrEMBL
  3.40.367.20 UniProtKB/TrEMBL
InterPro ATPase_NBD UniProtKB/TrEMBL
  Hexokinase UniProtKB/TrEMBL
  Hexokinase_BS UniProtKB/TrEMBL
  Hexokinase_C UniProtKB/TrEMBL
  Hexokinase_N UniProtKB/TrEMBL
KEGG Report ssc:100153520 UniProtKB/TrEMBL
NCBI Gene HKDC1 ENTREZGENE
PANTHER HEXOKINASE HKDC1 UniProtKB/TrEMBL
  PTHR19443 UniProtKB/TrEMBL
Pfam Hexokinase_1 UniProtKB/TrEMBL
  Hexokinase_2 UniProtKB/TrEMBL
PRINTS HEXOKINASE UniProtKB/TrEMBL
PROSITE HEXOKINASE_1 UniProtKB/TrEMBL
  HEXOKINASE_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF53067 UniProtKB/TrEMBL
UniProt A0A286ZQ27 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1TKL2 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1TKX7_PIG UniProtKB/TrEMBL
  A0A8D1LUD0 ENTREZGENE, UniProtKB/TrEMBL
  F1SUF3_PIG UniProtKB/TrEMBL
VGNC ID VGNC:88894 ENTREZGENE