LIF (LIF interleukin 6 family cytokine) - Rat Genome Database

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Gene: LIF (LIF interleukin 6 family cytokine) Sus scrofa
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Symbol: LIF
Name: LIF interleukin 6 family cytokine
RGD ID: 13895981
Description: ENCODES a protein that exhibits leukemia inhibitory factor receptor binding (ortholog); signaling receptor binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); astrocyte differentiation (ortholog); blood vessel remodeling (ortholog); ASSOCIATED WITH brain ischemia (ortholog); Cardiomegaly (ortholog); congestive heart failure (ortholog); FOUND IN extracellular space (ortholog); INTERACTS WITH resveratrol
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: leukemia inhibitory factor; leukemia inhibitory factor (cholinergic differentiation factor)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1447,221,560 - 47,238,749 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11447,221,540 - 47,239,513 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21450,263,470 - 50,277,784 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
resveratrol  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (ISO)
astrocyte differentiation  (ISO)
blood vessel remodeling  (IEA,ISO)
decidualization  (IEA,ISO)
embryo implantation  (IEA,ISO)
immune response  (IEA)
leukemia inhibitory factor signaling pathway  (IBA)
lung alveolus development  (IEA,ISO)
lung development  (ISO)
lung lobe morphogenesis  (IEA,ISO)
lung vasculature development  (IEA,ISO)
maternal process involved in female pregnancy  (ISO)
muscle organ morphogenesis  (IEA,ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of cell population proliferation  (IEA,ISO)
negative regulation of ERK1 and ERK2 cascade  (IEA,ISO)
negative regulation of hormone secretion  (IEA,ISO)
negative regulation of meiotic nuclear division  (IEA,ISO)
neuron development  (IEA,ISO)
positive regulation of astrocyte differentiation  (IEA,ISO)
positive regulation of cell adhesion mediated by integrin  (IEA)
positive regulation of cell population proliferation  (IBA,ISO)
positive regulation of corticotropin secretion  (ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of histone H3-K27 acetylation  (IEA)
positive regulation of macrophage differentiation  (IEA,ISO)
positive regulation of MAPK cascade  (IEA,ISO)
positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis  (IEA)
positive regulation of neuron projection development  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of peptidyl-serine phosphorylation of STAT protein  (IEA)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of protein localization to nucleus  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (IEA)
regulation of cell differentiation  (IBA,ISO)
regulation of metanephric nephron tubule epithelial cell differentiation  (IEA)
regulation of RNA polymerase II regulatory region sequence-specific DNA binding  (IEA,ISO)
retina development in camera-type eye  (ISO)
spongiotrophoblast differentiation  (IEA,ISO)
stem cell differentiation  (IEA,ISO)
stem cell population maintenance  (IEA,ISO)
transdifferentiation  (ISO)
trophoblast giant cell differentiation  (IEA,ISO)
tyrosine phosphorylation of STAT protein  (IEA,ISO)

Cellular Component
cytosol  (IEA)
extracellular space  (IBA,ISO)

Molecular Function

References
Additional References at PubMed
PMID:1740132   PMID:8661698   PMID:10202003   PMID:11474186   PMID:16160035   PMID:18480664   PMID:18537906   PMID:19002603   PMID:22339199   PMID:22920593   PMID:24307388   PMID:24621508  


Genomics

Comparative Map Data
LIF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1447,221,560 - 47,238,749 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11447,221,540 - 47,239,513 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21450,263,470 - 50,277,784 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LIF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2230,240,453 - 30,246,759 (-)EnsemblGRCh38hg38GRCh38
GRCh382230,240,453 - 30,257,487 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372230,636,442 - 30,642,748 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362228,966,441 - 28,972,748 (-)NCBINCBI36hg18NCBI36
Build 342228,960,996 - 28,967,302NCBI
Celera2214,436,129 - 14,442,479 (-)NCBI
Cytogenetic Map22q12.2NCBI
HuRef2213,598,220 - 13,604,620 (-)NCBIHuRef
CHM1_12230,595,573 - 30,601,977 (-)NCBICHM1_1
Lif
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39114,207,568 - 4,222,514 (+)NCBIGRCm39mm39
GRCm39 Ensembl114,207,557 - 4,222,514 (+)Ensembl
GRCm38114,257,568 - 4,272,514 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl114,257,557 - 4,272,514 (+)EnsemblGRCm38mm10GRCm38
MGSCv37114,157,571 - 4,172,517 (+)NCBIGRCm37mm9NCBIm37
MGSCv36114,157,571 - 4,172,517 (+)NCBImm8
Celera114,756,756 - 4,771,684 (+)NCBICelera
Cytogenetic Map11A1NCBI
cM Map112.94NCBI
Lif
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21479,131,049 - 79,140,486 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1479,134,574 - 79,140,482 (+)Ensembl
Rnor_6.01484,482,652 - 84,500,574 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1484,482,674 - 84,500,642 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01485,163,603 - 85,181,855 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41484,887,856 - 84,890,630 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11484,907,000 - 84,909,775 (+)NCBI
Celera1478,044,967 - 78,047,741 (+)NCBICelera
Cytogenetic Map14q21NCBI
Lif
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554554,489,421 - 4,497,940 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554554,489,515 - 4,505,439 (-)NCBIChiLan1.0ChiLan1.0
LIF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12229,078,862 - 29,095,608 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2229,078,862 - 29,095,608 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02211,276,576 - 11,282,972 (-)NCBIMhudiblu_PPA_v0panPan3
LIF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12623,400,226 - 23,418,538 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2623,403,364 - 23,406,851 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2623,274,713 - 23,278,054 (-)NCBI
ROS_Cfam_1.02623,784,273 - 23,806,847 (-)NCBI
UMICH_Zoey_3.12623,489,168 - 23,492,514 (-)NCBI
UNSW_CanFamBas_1.02623,752,037 - 23,755,369 (-)NCBI
UU_Cfam_GSD_1.02623,812,337 - 23,815,691 (-)NCBI
Lif
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118116,317,865 - 116,334,346 (-)NCBI
SpeTri2.0NW_004936904410,043 - 413,256 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LIF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11913,121,261 - 13,127,663 (-)NCBI
ChlSab1.1 Ensembl1913,121,297 - 13,127,679 (-)Ensembl
Vero_WHO_p1.0NW_023666045113,007,597 - 113,025,154 (+)NCBI
Lif
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247476,558,872 - 6,565,207 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 10 2 3 3 1
Below cutoff 2 1 2 1 1 2 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000044908   ⟹   ENSSSCP00000036194
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1447,221,560 - 47,238,749 (-)Ensembl
RefSeq Acc Id: NM_214402   ⟹   NP_999567
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11447,224,796 - 47,227,783 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005670785   ⟹   XP_005670842
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11447,221,540 - 47,239,513 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013983025   ⟹   XP_013838479
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11447,221,540 - 47,232,135 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013983026   ⟹   XP_013838480
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11447,221,540 - 47,229,965 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_005670842   ⟸   XM_005670785
- Peptide Label: isoform X1
- UniProtKB: Q9GKZ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013838479   ⟸   XM_013983025
- Peptide Label: isoform X1
- UniProtKB: Q9GKZ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013838480   ⟸   XM_013983026
- Peptide Label: isoform X1
- UniProtKB: Q9GKZ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_999567   ⟸   NM_214402
- Peptide Label: precursor
- UniProtKB: Q9GKZ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000036194   ⟸   ENSSSCT00000044908


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000040961 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070023224 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000036194 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070039061 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000044908 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070046296 UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/TrEMBL
  Leukemia_IF UniProtKB/TrEMBL
  Leukemia_IF/oncostatin UniProtKB/TrEMBL
  Leukemia_IF/oncostatin_CS UniProtKB/TrEMBL
KEGG Report ssc:399503 UniProtKB/TrEMBL
NCBI Gene LIF ENTREZGENE
PANTHER PTHR10633 UniProtKB/TrEMBL
Pfam LIF_OSM UniProtKB/TrEMBL
PRINTS LEUKAEMIAIF UniProtKB/TrEMBL
PROSITE LIF_OSM UniProtKB/TrEMBL
SMART LIF_OSM UniProtKB/TrEMBL
Superfamily-SCOP SSF47266 UniProtKB/TrEMBL
UniProt A0A4X1VEA0_PIG UniProtKB/TrEMBL
  Q9GKZ8 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:89719 ENTREZGENE